导师姓名： 杨程德 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 风湿病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： yangchengde@sina.com
邮编： 200025 邮箱地址： yangchengde@sina.com

研究方向 (点击浏览详细信息)
成人斯帝尔病发病机制
系统性红斑狼疮和抗磷脂综合征的研究

社会任职
中国医师学会风湿病专业委员会 常务委员
上海医学会风湿病专业委员会 主任委员
中华风湿病学杂志 编委
中华医学会风湿病专业委员会 常务委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** I型干扰素诱导的GAS6/AXL通路的活化在抗磷脂综合征中促进血栓形成的研究 国家自然基金委，面上项目 2019-01~2022-12 57万元 课题负责人
** 基于高通量蛋白质芯片技术的免疫易栓症临床新型抗体标志物的筛选和初步应用 上海市科委，医学引导项目 2017-06~2020-06 20万元 课题负责人
** 抗磷脂抗体诱导中性粒细胞释放NETs致抗磷脂综合征肾病的机制研究 国家自然基金委，面上项目 2017-01~2020-12 57万元 课题负责人
** I型干扰素通路活化天然免疫细胞参与血栓形成在抗磷脂综合征发病机制中的研究 国家自然基金委,面上项目 2014-01~2017-12 70万元 课题负责人
11DJ** 痛风和高尿酸血症发生机制与干预策略 上海市科委 2012-01~2014-12 30万元 子课题负责人
** 抗磷脂抗体对肾内生性补体和组织因子表达的影响在抗磷脂肾病中的发病作用 国家自然基金委,面上项目 2011-01~2011-12 10万元 课题负责人
** B淋巴细胞发育阶段的自身耐受关卡点的异常在APS发病机制中的意义 国家自然基金委,面上项目 2008-01~2010-12 31万元 课题负责人
07ZZ30 抗磷脂抗体在SLE患者动脉粥样硬化发病机制中的意义 上海市教委,发展基金 2007-01~2009-12 10万元 课题负责人
04SG45 抗磷脂抗体在血栓和动脉粥样硬化发病机制中的意义 上海市教委,曙光计划 2005-01~2007-12 12万元 课题负责人
** 高亲和力抗纤溶酶自身抗体在APS发病机制中的意义 国家自然基金委,面上项目 2004-01~2006-12 21万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu T, Gu J, Wan L, Hu Q, Teng J, Liu H, Cheng X, Ye J, Su Y, Sun Y, Zhou J, Norman GL, Wang X, Yang C （通讯作者）, Shi H. "Non-criteria" antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort. Arthritis Res Ther 2020 22(1):33.
Teng J, Dai J, Su Y, Zhou Z, Chi H, Wan L, Meng J, Wang Z, Wang F, Ma Y, Hu Q, Cheng X, Liu H, Ye J, Shi H, Sun Y, Yang C （通讯作者）, Wang X Detection of IgM and IgG antibodies against SARS-CoV-2 in patients with autoimmune diseases. Lancet Rheumatol 2020 Jul;2(7):e384-e385
Wang Z, Chi H, Sun Y, Teng J, Feng T, Liu H, Cheng X, Ye J, Shi H, Hu Q, Jia J, Liu T, Wan L, Zhou Z, Qiao X, Yang C, Su Y Serum sTREM-1 in adult-onset Still's disease: a novel biomarker of disease activity and a potential predictor of the chronic course. Rheumatology (Oxford) 2020 2020 Apr 10
Chi H, Jin H, Wang Z, Feng T, Zeng T, Shi H, Wu X, Wan L, Teng J, Sun Y, Liu H, Cheng X, Ye J, Hu Q, Zhou Z, Gu J, Jia J, Liu T, Qiao X, Yang C （通讯作者）, Su Y Anxiety and depression in adult-onset Still's disease patients and associations with health-related quality of life Clin Rheumatol 2020 May 23
Jia J, Yang L, Cao Z, Wang M, Ma Y, Ma X, Liu Q, Teng J, Shi H, Liu H, Cheng X, Ye J, Su Y, Sun Y, Chi H, Liu T, Wang Z, Wan L, Yang C （通讯作者）, Hu Q Neutrophil-derived lipocalin-2 in adult-onset Still's disease: a novel biomarker of disease activity and liver damage. Rheumatology (Oxford) 2020 Aug 7
Teng J, Zhou Z, Wang F, Sun Y, Liu HL, Cheng X, Su Y, Shi H, Yang C, Ye J. Do 2019 European League against rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus also indicate the disease activity?. Ann Rheum Dis. 2020 Mar 2
Hu Q, Wang M, Jia J, Teng J, Chi H, Liu T, Liu HL, Cheng X, Ye J, Su Y, Sun Y, Zhou Z, Wan L, Wang Z, Wang F, Shi H, Yang C. （通讯作者） Tofacitinib in refractory adult-onset Still's disease: 14 cases from a single centre in China. Ann Rheum Dis 2020 79(6):842-844
Zhou Z, Ye J, Teng J, Liu H, Cheng X, Sun Y, Su Y, Chi H, Wang F, Yang C, Jin W （通讯作者） Clinical characteristics of infective endocarditis in patients with antineutrophil cytoplasmic antibody or antiphospholipid antibody: a retrospective study in Shanghai BMJ Open 2020 10(2):e031512
Teng J, Ye J, Zhou Z, Lu C, Chi H, Cheng X, Liu H, Su Y, Shi H, Sun Y, Yang C （通讯作者） A comparison of the performance of the 2019 European League Against Rheumatism/American College of Rheumatology criteria and the 2012 Systemic Lupus International Collaborating Clinics criteria with the 1997 American College of Rheumatology classification criteria for systemic lupus erythematous in new-onset Chinese patients Lupus 2020 29(6):617-624
Liu T, Gu J, Wan L, Hu Q, Teng J, Liu H, Cheng X, Ye J, Su Y, Sun Y, Chi H, Zhou Z, Jia J, Wang Z, Zhou J, Norman GL, Wang X, Yang C, Shi H （通讯作者） Anti-β2GPI domain 1 antibodies stratify high risk of thrombosis and late pregnancy morbidity in a large cohort of Chinese patients with antiphospholipid syndrome. Thromb Res 2020 Jan;185:142-149
Li Z, Liu HL, Chen J, Zeng T, He L, Li M, Luo C, Liu S, Ding TT, Yimaiti K, Teng J, Li X, Ding Y, Cheng X, Zhou J, Ye J, Ji J, Su YT, Shi H, Sun Y, Gao C, Hu Q, Chi H, Yuan X, Zhou Z, Wang D, Wang K, Li CG, Sun Y, Niu Y, Chen LJ, Xu J, Wu L, Zhou Z, Pan D, Niu H, Shi Y, Yang C （通讯作者） Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals Ann Rheum Dis 2020 79(1):161-163
Meng J, Chen L, Hou J, Chi H, Wang Z, Yang C （通讯作者）, Su Y Probable catastrophic antiphospholipid syndrome secondary to chronic myelomonocytic leukaemia in an adult patient and a mini review Lupus 2020 29(10):1287-1291
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB. Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism. Front Pharmacol 2019 10:855
Li Z, Liu HL, Chen J, Zeng T, He L, Li M, Luo C, Liu S, Ding TT, Yimaiti K, Teng J, Li X, Ding Y, Cheng X, Zhou J, Ye J, Ji J, Su YT, Shi H, Sun Y, Gao C, Hu Q, Chi H, Yuan X, Zhou Z, Wang D, Wang K, Li CG, Sun Y, Niu Y, Chen LJ, Xu J, Wu L, Zhou Z, Pan D, Niu H, Shi Y, Yang C. （通讯作者） Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals. Ann Rheum Dis 2019 Aug 30
Hu Q, Shi H, Zeng T, Liu H, Su Y, Cheng X, Ye J, Yin Y, Liu M, Zheng H, Wu X, Chi H, Zhou Z, Jia J, Sun Y, Teng J, Yang C. （通讯作者） Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still's disease. Arthritis Res Ther 2019 21(1):9
Xin-yao Wu1 & Min Yang2 & Yue-sheng Xie3 & Wei-guo Xiao4 & Jin Lin5 & Bin Zhou6 & Xin Guan7 & Cai-nan Luo8 &Nan Che9 & Xing-zhen Liu10 & Chao Wang11 & Jia-lin Teng1 & Xiao-bing Cheng1 & Jun-na Ye1 & Yu-tong Su1 & Hui Shi1 &Yu-feng Yin1 & Meng-ru Liu1 & Yue Sun1 & Qiong-Yi Hu1 & Zhuo-chao Zhou1 & Hui-hui Chi1 & Yi Liu2 & Xiao Zhang3 &Jin-wei Chen7 & Miao-jia Zhang9 & Dong-bao Zhao10 & Cheng-de Yang1（通讯作者） & Li-jun Wu8 & Hong-lei Liu1 Causes of death in hospitalized patients with systemic lupus erythematosus: a 10-year multicenter nationwide Chinese cohort Clin Rheumatol 2019 Jan;38(1):107-115
Jia J, Shi H, Liu M, Liu T, Gu J, Wan L, Teng J, Liu H, Cheng X, Ye J, Su Y, Sun Y, Gong W, Yang C （通讯作者）, Hu Q. Cytomegalovirus Infection May Trigger Adult-Onset Still's Disease Onset or Relapses. Front Immunol 2019 10:898
Sun Y, Wang Z, Chi H, Hu Q, Ye J, Liu H, Cheng X, Shi H, Zhou Z, Teng J, Yang C （通讯作者）, Su Y. Elevated serum levels of interleukin-10 in adult-onset Still's disease are associated with disease activity. Clin Rheumatol 2019 Jun 21
Chi H, Wang Z, Yang C, Su Y. MS score in systemic juvenile idiopathic arthritis: suitable for routine use? Ann Rheum Dis 2019 2019 Aug 2
Hu Q, Gong W, Gu J, Geng G, Li T, Tian R, Yang Z, Zhang H, Shao L, Liu T, Wan L, Jia J, Yang C （通讯作者）, Shi Y, Shi H. Plasma microRNA Profiles as a Potential Biomarker in Differentiating Adult-Onset Still's Disease From Sepsis. Front Immunol 2019 9:3099
Zhou Z, Teng J, Sun Y, Liu H, Cheng X, Su Y, Yang C （通讯作者）, Ye J. Characteristics of pregnancy complications and treatment in obstetric antiphospholipid syndrome in China. Clin Rheumatol 2019 2019 Jul 9
Chi H, Teng J, Wang Z, Yang C, Su Y. Do the 2019 EULAR/ACR SLE classification criteria close the door on certain groups of SLE patients? Ann Rheum Dis 2019 2019 Sep 16
Shi H, Zheng H, Yin YF, Hu QY, Teng JL, Sun Y, Liu HL, Cheng XB, Ye JN, Su YT, Wu XY, Zhou JF, Norman GL, Gong HY, Shi XM, Peng YB, Wang XF, Yang CD. （通讯作者） Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome. Clin Chem Lab Med 2018 Mar 28;56(4):614-624.
Chi H, Liu D, Sun Y, Hu Q, Liu H, Cheng X, Ye J, Shi H, Yin Y, Liu M, Wu X, Zhou Z, Teng J, Yang C （通讯作者）, Su Y. Interleukin-37 is increased in adult-onset Still's disease and associated with disease activity. Arthritis Res Ther. 2018 Mar 22;20(1):54.
Hu Q, Sun Y, Li Y, Shi H, Teng J, Liu H, Cheng X, Ye J, Su Y, Yin Y, Liu M, Wang J, Yang C. （通讯作者） Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker. BMC Immunol 2018 19(1):38
Xin-yao Wu, Yu-feng Yin, Jia-lin Teng, Li-wei Zhang, Cheng-de Yang （通讯作者） IgMk paraprotein from gammopathy patient can bind to cardiolipin and interfere with coagulation assay: a case report BMC Immunology 2017 18(1):32
Ling-yue Sun,Zong-ye Cai,Jun Pu,Jian Li,Jie-yan Shen,Cheng-de Yang （通讯作者）,and Ben He 5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77 Inflammation 2017 Jun;40(3):806-817
Hu Q, Liu J, Wang Y, Wang J, Shi H, Sun Y, Wu X, Yang C （通讯作者）, Teng J. Delayed-onset of progressive pseudorheumatoid dysplasia in a Chinese adult with a novel compound WISP3 mutation: a case report. BMC Med Genet. 2017 Dec 15;18(1):149.
Hui Shi#, Junna Ye#, Jialin Teng#, Yufeng Yin, Qiongyi Hu, Xinyao Wu, Honglei Liu, Xiaobing Cheng, Yutong Su,Mengru Liu, Juanfang Gu, Ting Lu, HaoJie Chen, Hui Zheng, Yue Sun* and Chengde Yang* Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients. Arthritis Research & Therapy 2017 19(1):52
HONG-LEI LIU, CHENG-DE YANG （通讯作者） PET/CT Imaging in Fever of Unknown Origin: A Case of Relapsing Polychondritis The Journal of Rheumatology 2017 44(7):1098
Shi H#, Teng JL #, Sun Y, Wu XY, Hu QY, Liu HL, Cheng XB, Yin YF, Ye JN, Chen PP, Yang CD* （通讯作者） Clinical characteristics and laboratory findings of 252 Chinese patients with anti-phospholipid syndrome: comparison with Euro-Phospholipid cohort Clinical rheumatology 2017 36(3)：599-608
Ting Li, Liyang Gu, Xiaodong Wang, Li Guo, Hui Shi, ChengdeYang & Sheng Chen （通讯作者） A Pilot Study on Tocilizumab for Treating Refractory Adult-Onset Still's Disease Sci Rep 2017 Oct 18;7(1):13477
Bing Han, Liqiong Xue, Chengde Yang （通讯作者） Giant gouty tophi in the hands The Lancet Diabetes & Endocrinology 2016 S2213-8587(15)00420-9
LuyuYang*, Zheng Dong*, Jingru zhou, Yanyun Ma, Weilin Pu, Dongbao Zhao,Hongjun He, Hengdong Ji, YajunYang, Xiaofeng Wang, Xia Xu, Yafei Pang,Hejian Zou, Li Jin, ChengdeYang & Jiucun Wang （通讯作者） Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia Scientific Reports 2016 6:27279
Chunmei Ying, Yongli Li,Yaping Wang, Bing Zheng,Chengde Yang （通讯作者） Investigation of the molecular epidemiology of Acinetobacter baumannii isolated from patients and environmental contamination The Journal of Antibiotics 2015 68(9):562-7
Ying CM, Yao DT, Ding HH, Yang CD （通讯作者） Infective endocarditis with antineutrophil cytoplasmic antibody: report of 13 cases and literature review PLoS One 2014 25;9(2):e89777
Chuan-Yin Sun, Yan Shen, Xiao-Wei Chen, Yu-Cheng Yan, Feng-Xia Wu, Ming Dai, Ting Li, and Cheng-De Yang. （通讯作者） The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression International Journal of Rheumatology 2013 2013:954292
Zeng T, Li SJ, Ao W, Zheng H, Wu FX, Chen Y, Yang CD （通讯作者） The detection of autoantibodies to ATP-binding cassette transporter A1 and its role in the pathogenesis of atherosclerosis in patients with systemic lupus erythematosus Clin Biochem 2012 45(16-17):1342-6
Shen Y, Sun CY, Wu FX, Chen Y, Dai M, Yan YC, Yang CD. （通讯作者） Association of intrarenal B-cell infiltrates with clinical outcome in lupus nephritis: a study of 192 cases Clin Dev Immunol 2012 2012:967584
Zeng T, Li SJ, Ao W, Zheng H, Wu FX, Chen Y, Yang CD （通讯作者） The detection of autoantibodies to ATP-binding cassette transporter A1 and its role in the pathogenesis of atherosclerosis in patients with systemic lupus erythematosus. Clin Biochem. 2012 16-17
Shen Y, Sun CY, Wu FX, Chen Y, Dai M, Yan YC （通讯作者）, Yang CD. Association of intrarenal B-cell infiltrates with clinical outcome in lupus nephritis: a study of 192 cases. Clin Dev Immunol. . 2012 2012:967584
Chen Y, Chen GL, Zhu CQ, Lu X, Ye S, Yang CD （通讯作者） Severe systemic lupus erythematosus in emergency department: a retrospective single-center study from China. Clin Rheumatol. 2011 30(11):1463-9
Chen XW, Shen Y, Sun CY, Wu FX, Chen Y, Yang CD （通讯作者） Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro. Arthritis Res Ther. 2011 31;13-R9
Ao W, Zheng H, Chen XW, Shen Y, Yang CD （通讯作者） Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis. Rheumatol Int. 2011 31(7):865-9
Chen XW, Shen Y, Sun CY, Wu FX, Chen Y, Yang CD （通讯作者） Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro. Arthritis Res Ther. 2011 31;13-R9
Shen Y, Chen XW, Sun CY, Dai M, Yan YC, Yang CD （通讯作者） Association between anti-beta2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases. Lupus. 2010 19(10):1195-203.
Zheng H, Chen Y, Ao W, Shen Y, Chen XW, Dai M, Wang XD, Yan YC, Yang CD. （通讯作者） Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases. Arthritis Res Ther. 2009 11(3):9-13
Zhou WJ, Yang CD. The causes and clinical significance of fever in systemic lupus erythematosus: a retrospective study of 487 hospitalised patients. Lupus. 2009 18(9):807-12
Zeng T, Zou YQ, Wu MF, Yang CD. （通讯作者） Clinical features and prognosis of adult-onset still's disease: 61 cases from China. J Rheumatol. 2009 36(5):1026-31
Zheng H, Chen Y, Ao W, Shen Y, Chen XW, Dai M, Wang XD, Yan YC, Yang CD. （通讯作者） Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases. Arthritis Res Ther. 2009 11(3):9-13
Zeng T, Zou YQ, Wu MF, Yang CD. （通讯作者） Clinical features and prognosis of adult-onset still's disease: 61 cases from China. J Rheumatol. 2009 36(5):1026-31
Ye S, Yang CD. （通讯作者） Central nervous system infections in the systemic vasculitides. Curr Opin Neurol. 2008 21(3):342-6.
Zou YQ, Lu LJ, Li SJ, Zeng T, Wang XD, Bao CD, Chen SL, Yang CD （通讯作者） The levels of macrophage migration inhibitory factor as an indicator of disease activity and severity in adult-onset Still's disease. Clin Biochem. 2008 41(7-8):519-24.
Qian J, Yang CD. （通讯作者） Hemophagocytic syndrome as one of main manifestations in untreated systemic lupus erythematosus: two case reports and literature review. Clin Rheumatol. 2007 26(5):807-10.
Yang CD （通讯作者）, Wang XD, Ye S, Gu YY, Bao CD, Wang Y, Chen SL. Clinical features, prognostic and risk factors of central nervous system infections in patients with systemic lupus erythematosus. Clin Rheumatol. 2007 26(6):895-901
Chen XX, Gu YY, Li SJ, Qian J, Hwang KK, Chen PP, Chen SL, Yang CD. （通讯作者） Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetaKK, Chen PP, Chen SL, Yang CDl loss in mice. J Immunol. 2007 178(8):5351-6.