导师姓名： 李璞 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： lipuruijin@126.com

研究方向 (点击浏览详细信息)
炎性微环境对消化系统疾病的影响及机制
表观遗传调控在消化系统疾病中的作用及机制

社会任职
中国医师协会 儿科医师分会胃肠肝病和营养专业委员会 委 员
Current Drug Metabolism 客座编辑
Journal of Translational Medicine 审稿人
Anti-Cancer Agents in Medicinal Chemistry 客座编辑
中国药理学会药物临床试验专业委员会 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海市人才发展资金 上海市人力资源和社会保障局 2019-09~2022-08 30万元 课题负责人
** H.pylori—microRNA-495—TLR4正反馈轴的表观调控机制在胃炎恶变致癌过程中作用的研究 国家自然科学基金 2019-01~2022-12 57万元 课题负责人
** H.pylori感染有道的表观基因组改变在胃炎恶变致癌过程中作用的研究 上海市科学技术委员会 2018-12~2021-11 30万元 课题负责人
836211 广慈卓越青年A类 瑞金医院 2017-07~2020-07 10万元 课题负责人
** H.pylori-DC-SIGN免疫识别与胃上皮细胞转分化的DC样调节功能研究 国家自然科学基金 2014-01~2016-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Gao Y, Ma H, Gao C, Lv Y, Chen X, Xu R, Sun M, Liu X, Lu X, Pei X, Li P. （通讯作者） Tumor-promoting properties of miR-8084 in breast cancer through enhancing proliferation, suppressing apoptosis and inducing epithelial-mesenchymal transition. J Transl Med 2018 16(1):38.
Wei Fang, Yibin Fan, Zhenzong Fa, Jinhua Xu, Hongyu Yu, Pu Li* （通讯作者）, Julin Gu* microRNA-625 inhibits tumorigenicity by suppressing proliferation, migration and invasion in malignant melanoma Oncotarget 2017 Vol. 8, (No. 8), pp: 13253-13263
Sheng H, Chen X, Liu B, Li P* （通讯作者）, Cao W* Omega-3 Polyunsaturated Fatty Acids Enhance Cisplatin Efficacy in Gastric Cancer Cells by Inducing Apoptosis via ADORA1 Anticancer Agents Med Chem. 2016 16(9):1085-92.
Wang Y, Zhi Q, Ye Q, Zhou C, Zhang L, Yan W, Wu Q, Zhang D, Li P* （通讯作者）, Huo K*. SCYL1-BP1 affects cell cycle arrest in human hepatocellular carcinoma cells via Cyclin F and RRM2 Anticancer Agents Med Chem. 2016 16(4):440-6.
Pu Li, Jing-Xuan Shan,Xue-Hua Chen,Di Zhang,Li-Ping Su,Xiu-Ying Huang,Bei-Qin Yu,Qiao-Ming Zhi,Cheng-Long Li,Ya-Qing Wang,Sara Tomei,Qu Cai,Jun Ji,Jian-Fang Li,Lotfi Chouchane,Ying-Yan Yu,Fang-Zhen Sun,Zhi-Heng Xu,Bing-Ya Liu,Zheng-Gang Zhu Epigenetic silencing of microRNA-149 in cancer associated fibroblasts mediates prostaglandin E2/interleukin 6 signaling in the tumor microenvironment. Cell Research 2015 25(5):588-603.
Jing Wu, Xue-hua Chen, Xin-qiong Wang, Yi Yu, Jian-min Ren, Yuan Xiao, Tong Zhou, Pu Li* （通讯作者）, Chun-di Xu* ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion Oncotarget 2015 Vol. 6, No. 14
Hong Sheng, Pu Li （共同第一作者）, Xuehua Chen, Binya Liu, Zhenggang Zhu, Weixin Cao Omega-3 PUFAs induce apoptosis of gastric cancer cells via ADORA1 Frontiers in Bioscience (Landmark) 2014 19, 854-861
Sastry KS, Al-Muftah MA, Li P, Al-Kowari MK, Wang E, Ismail Chouchane A, Kizhakayil D, Kulik G, Marincola FM, Haoudi A, Chouchane L. Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells Cell Death Differentiation 2014 21(12):1936-49
Pu Li, Peng Zhang, Ying Lin, Jingxuan Shan, Jiaqi Wang, Tong Zhou, Zhenggang Zhu, Keke Huo PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation Frontiers in Bioscience (Landmark) 2013 18, 919-927
Jin Zhou, Pu Li （共同第一作者）, Xiaofeng Xue, Songbing He, Yuting Kuang, Hong Zhao, Shaoji Chen, Qiaoming Zhi, Xiaobo Guo Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. Toxicology Letters 2013 222(2):139-45
Pu Li, Xuehua Chen, Liping Su, Chenglong Li, Qiaoming Zhi, Beiqin Yu, Hong Sheng, Junqing Wang, Runhua Feng, Qu Cai, Jianfang Li, Yingyan Yu, Min Yan, Bingya Liu, Zhenggang Zhu Epigenetic Silencing of miR-338-3p Contributes to Tumorigenicity in Gastric Cancer by Targeting SSX2IP PLoS One 2013 8(6): e66782
Wu X, Chen X, Zhou Q, Li P, Yu B, Li J, Qu Y, Yan J, Yu Y, Yan M, Zhu Z, Liu B, Su L Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer Cancer Letters 2013 335(1):128-35
Hongchao Zhao, Ao Huang, Pu Li （共同第一作者）, Yingjun Quan, Bo Feng, Xuehua Chen, Zhihai Mao, Zhenggang Zhu, Minhua Zheng E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells Journal of Translational Medicine 2013 11:317
Junqing Wang, Xuehua Chen, Pu Li （共同第一作者）, Liping Su, Beiqin Yu, Qu Cai, Jianfang Li, Yingyan Yu, Bingya Liu, Zhenggang Zhu CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126 Chem Biol Interact 2013 206(2):230-8.
Li P, Lin Y, Zhang Y, Zhu Z, Huo K. SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma Journal of Translational Medicine 2013 11:52
Jingkun Zhao*, Pu Li* （共同第一作者）, Hao Feng, Puxiongzhi Wang, Yaping Zong, Junjun Ma, Zhuo Zhang, Xuehua Chen,Minhua Zheng, Zhenggang Zhu, Aiguo Lu Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration,invasion, adhersion and angiogenesis Journal of Translational Medicine 2013 11:288