导师姓名： 于颖彦 专业代码： 100210
性别： 女 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师：
联系方式： ruijinhospitalyyy@163.com
邮编： 200025 邮箱地址： yingyan3y@hotmail.com

研究方向 (点击浏览详细信息)
胃癌诊治标志物及其转化医学研究

社会任职
诊断学理论与实践杂志编委
转化医学杂志编委
中华胃肠外科杂志编委
中国抗癌协会胃癌专业委员会委员
中华病理学杂志编委
国际癌症基因组联盟（ICGC）委员会委员
World J Gastrointestinal Oncol编委
上海市抗癌协会胃肠肿瘤专业委员会委员
中国医药生物技术协会慢病分会委员
中国抗癌协会肿瘤样本整合研究分会委员
中国医药生物技术协会生物样本库分会常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 多图源胃癌智能辅助诊断系统设计与开发 上海市科委西医临床重点项目 2018-06~2021-06 50万元 课题负责人
** ALDH2*2对胃黏膜的保护作用减弱致胃癌高发的分子机制及生物学特性 国家自然科学基金委 2018-01~2021-12 57万元 课题负责人
2017YFC** 规范化大型胃癌队列的建立及其可用性研究 国家重点研发计划 2017-01~2020-12 280万元 课题负责人
YG2017ZD01 基于胃癌复杂表型及微生物组学多样性的大数据平台建设 上海交通大学医工交叉重点项目 2017-01~2019-12 50万元 课题负责人
2017-05-HP-C1086-012 胃癌普筛检测试剂盒 张江专项发展基金重点项目 2016-12~2019-12 70万元 子课题负责人
2016YFC** 消化道肿瘤诊疗生物标志物验证及应用研究 国家重点研发计划 2016-09~2020-12 40万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Duan Z, Qiao Y, Lu J, Lu H, Zhang W, Yan F, Sun C, Hu Z, Zhang Z, Li G, Chen H, Xiang Z, Zhu Z, Zhao H, Yu Y （通讯作者）, Wei C. HUPAN: a pan-genome analysis pipeline for human genomes. Genome Biology 2019 20:149
Xing R Zhou Y, Yu J, Yu Y （共同第一作者）, Nie Y, Luo W, Yang C, Xiong T,Wu WK, Li Z, Bing Y, Lin Z, Zhang Y, Hu Y, Roy B, Li L, Huang P, Zhang M, Zhang G, Yang Y, Hu X, Zhou R, Han L, Yang C, Huang S, Huang S, Gao Q, Yin Y, Zhang X, Yang H, Wang J, Wu K, Fan D, Tang G, Dou J, Zhu Z, Ji J, Fang X and Lu Y. Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer. Nat Commun 2019 10(1):2037
Xiang Z, Chen W, Zhang J, Song S, Xia G, Huang X, Xie J, Yu Y （通讯作者）, Zhang Q. Identification of discrepancy between CTLA4 expression and activation of CTLA4 pathway in gastric cancer. Immunopharmacol Immunotoxicol 2019 41(3): 386-393
Song S, Xiang Z, Li J, Ji J, Yan R, Zhu Z, Yu Y （通讯作者） A novel citrullinated modification of histone 3 and its regulatory mechanisms related to IPO-38 antibody-labeled protein. Front Oncol 2019 9: 304
Xiang Z, Yu Y. （通讯作者） Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases. Front Med 2019 13（1）：24-31
Xiang Z, Song S, Zhu Z, Sun W, Gifts JE, Sun S, Li QS, Yu Y （通讯作者）, Li KK. LncRNAs GIHCG and SPINT1-AS1 Are Crucial Factors for Pan-Cancer Cells Sensitivity to Lapatinib. Front Genet 2019 10: 25
Xiang Z, Li J, Song S, Wang J, Cai W, Hu W, Ji J, Zhu Z, Zang L, Yan R, Yu Y. （通讯作者） positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis. Journal of Experimental & Clinical Cancer Research 2019 38:314
Song S, Yu Y （通讯作者） Progression on citrullination of proteins in gastrointestinal cancer. Front Oncol 2019 9:15
Xiang Z, Huang X, Wang J, Zhang J, Ji J, Yan R, Zhu Z, Cai W, Yu Y. （通讯作者） Cross-database analysis reveals sensitive biomarkers for combined therapy for ERBB2+ gastric cancer. Front Pharm 2018 9:861
Zhang J, Liu XY, Yu GZ, Liu L, Wang JJ, Chen XY, Bian YH, Ji Y, Zhou XY, Chen YN, Ji J, Xiang Z, Guo L, Fang JY, Sun YH, Cao H, Zhu ZG, Yu YY. （通讯作者） UBE2C is a potential biomarker of intestinal-type gastric cancer with chromosomal instability. Front Pharm 2018 9:847
Liu X, Zhang J, Liu L, Jiang Y, Ji J, Yan R, Zhu Z, Yu Y. （通讯作者） Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes tumorigenesis and metastasis of gastric cancer. Biochim Biophys Acta Mol Basis Dis 2018 1864(9): Part B, 2835-2844
Yu Y. （通讯作者） Molecular classification and precision therapy of cancer: immune checkpoint inhibitors. Front Med 2018 12:229-235
Jiang Y, Yu Y. （通讯作者） Transgenic and gene knockout mice in gastric cancer research. Oncotarget 2017 8(2):3696-3710
Jiang Y, Qi X, Liu X, Zhang J, Ji J, Zhu Z, Ren J, Yu Y. （通讯作者） Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis. Oncotarget 2017 8(20): 33444
Duan Y, Gao Y, Zhang J, Chen Y, Jiang Y, Ji J, Zhang J, Chen X, Yang Q, Su L, Zhang J, Liu B, Zhu Z, Wang L, Yu Y. （通讯作者） Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress. Free Radic Biol Med 2016 93:165-176
Chen Y, Zhang J, Guo L, Liu L, Wen J, Xu L, Yan M, Li Z, Zhang X, Jiang J, Ji J, Zhang J, Wei Cai, Zhuang H, Wang Y, Zhu Z, Yu Y （通讯作者） A characteristic biosignature for discrimination of gastric cancer from healthy population by high throughput GC-MS analysis. Oncotarget 2016 7(52) :87496
Wang C, Zhang J, Cai M, Zhu Z, Yu Y （通讯作者）, Zhang X. DBGC：A Database of Human Gastric Cancer. PLoS ONE 2015 10(11):e**
Zhang J, Huang JY, Chen YN, Yuan F, Zhang H, Yan FH, Wang MJ, Wang G, Su M, Lu G, Huang Y, Dai H, Ji J, Zhang J, Zhang JN, Jiang YN, Chen SJ, Zhu ZG, Yu YY. （通讯作者） Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma. Sci Rep 2015 5:13750
Zhi Q, Guo X, Guo L, Zhang R, Jiang J, Ji J, Zhang J, Zhang J,Chen X,Cai Q,Li J,Liu B, Zhu Z, Yu Y. （通讯作者） Oncogenic miR-544 is an important molecular target in gastric cancer. Anti-Cancer Agents Med Chem. 2013 13(2):270
Yu Y. （通讯作者） Translational Medicine is Promoting Cross-talk of Interdiscipline. Anticancer Agents Med Chem. 2013 13(2):193
Liu L , Wang ZW, Ji J, Zhang JN, Yan M, Zhang J, Liu BY, Zhu ZG, Yu YY. （通讯作者） A Cohort Study and Meta-Analysis between Histopathological Classification and Prognosis of Gastric Carcinoma. Anti-Cancer Agents Med Chem. 2013 13(2):227
Pan S, Wang Z, Chen Y, Ji J, Zhang J, Li J, Cai Q, Liu B, Zhu Z, Yu Y. （通讯作者） Inactivation of tumor suppressor gene HIC1 in gastric cancer is reversed via small activating RNAs. Gene 2013 521(1):102
Yu Y （通讯作者）, Zhu Z. Cell Dormancy and Tumor Refractory. Anticancer Agents Med Chem. 2013 13(2):199
Wang Z , Liu L , Ji J, Zhang J, Yan M, Zhang J, Liu B, Zhu Z, Yu Y. （通讯作者） ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis Int J Mol Sci 2012 13(10):13308-13321
Wang Z, Zhang L, Guo Z, Liu L, Ji J, Zhang J, Chen X, Liu B, Zhang J, Ding Q, Wang X, Zhao W, Zhu Z, Yu Y. （通讯作者） A unique feature of iron loss via close adhesion of Helicobacter pylori to host erythrocytes PLoS ONE 2012 7(11):50314-50318
Zhi QM, Chen XH, Ji J, Zhang JN, Li JF, Cai Q, Liu BY, Gu QL, Zhu ZG, Yu YY. （通讯作者） Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer cell lines Biomed Pharmocother 2011 65 (7):509-515
Guo XB, Guo L, Zhi QM, Ji J, Jiang JL, Zhang RJ, Zhang JN, Zhang J, Chen XH, Cai Q, Li JF, Yan M, Gu QL, Liu BY, Zhu ZG, Yu YY. （通讯作者） H. pylori induces promoter hypermethylation and downregulates gene expression of IRX1 transcription factor on human gastric mucosa J Gastroentrol Hepatol 2011 26(10):1685-1690
Jiang J, Liu W, Guo X, Zhang R, Zhi Q, Ji J, Zhang J, Chen X, Li J, Zhang J, Gu Q, Liu B, Zhu Z, Yu Y. （通讯作者） IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer Oncogene 2011 30 (44):4498-508
Guo X, Guo L, Ji J, Zhang J, Zhang J, Chen X, Cai Q, Li J, Gu Q, Liu B, Zhu Z, Yu Y. （通讯作者） miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer Biochem Biophys Res Commun 2010 398(1):1-6
Yu YY, Zhu ZG. Significance of biological resource collection and tumor tissue bank creation. WJGO 2010 2(1):5-8
Guo X, Liu W, Pan Y, Ni P, Ji J, Guo L, Zhang J, Wu J, Jiang J, Chen X, Cai Q, Li J, Zhang J, Gu Q, Liu B, Zhu Z, Yu Y. （通讯作者） Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma Oncogene 2010 29(27):3908-20
Hao Y, Yu YY （通讯作者）, Wang LS, Yan M, Ji J, Qu Y, Zhang J, Liu BY, Zhu ZG. IPO-38 is identified as a novel serum biomarker of gastric cancer based on clinical proteomics technology. J Proteome Res 2008 7(9):3668-3677