导师姓名： 卞留贯 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： rj11118@163.com
邮编： 200025 邮箱地址： blg11118@rjh.com.cn

研究方向 (点击浏览详细信息)
脑血管病、脑肿瘤的临床和基础研究

社会任职
中国垂体瘤协作组委员
上海市医学会神经外科分会副主任委员
上海市中西医结合学会神经内分泌专业委员会委员
中华医学会神经外科学分会全国委员
上海市抗癌协会神经肿瘤专业委员会常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Connexin43在脑出血外胚间充质干细胞移植后线粒体转移中的机制研究 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
** 缝隙链接蛋白在脑出血后神经干细胞移植治疗中的调控作用 国家自然科学基金 2018-01~2021-12 54万元 课题负责人
** 铁过载损伤机制及Hmox1基因的条件控制表达技术在脑出血后神经干细胞移植中的研究 国家自然科学基金 2015-01~2018-12 70万元 课题负责人
12JC** 脑膜瘤NF2基因相关肿瘤抑制靶点的筛选与鉴定 上海市科委基础重点 2012-12~2014-12 50万元 课题负责人
脑出血诱导的炎症反应导致基质金属蛋白酶对血脑屏障破坏的机制研究 上海市科委生物医药重点 2010-09~2013-09 20万元 课题负责人
09JC** 脑缺血再灌注损伤后beclin-1介导自噬激活的调控机制 上海市科委"创新行动计划"基础研究重点项目 2009-09~2011-08 30万元 课题负责人
04QMX1414 Merlin在听神经瘤中抑瘤作用机制研究 上海市科委科技启明星跟踪计划 2004-09~2007-12 15万元 课题负责人
00QB14024 Merlin在听神经瘤中抑瘤作用机制研究 上海市科委科技启明星计划 2001-01~2004-12 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen X, Liang H, Xi Z, Yang Y, Shan H, Wang B, Zhong Z, Xu C, Yang GY, Sun Q, Sun Y, Bian L. （通讯作者） BM-MSC Transplantation Alleviates Intracerebral Hemorrhage-Induced Brain Injury, Promotes Astrocytes Vimentin Expression, and Enhances Astrocytes Antioxidation via the Cx43/Nrf2/HO-1 Axis Front Cell Dev Biol. 2020 8:302.
Xu CX, Jiang H, Zheng RZ, Sun YH, Sun QF, Bian LG. （通讯作者） Impaired brain network architecture in Cushing’s disease based on graph theoretical analysis Aging 2020 12(6):5168-5182
Chen X, Xu CX, Liang H, Xi Z, Pan J, Yang Y, Sun Q, Yang G, Sun Y, Bian L. Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway. Aging 2020 12(7): p. 6306-6323.
Chen X, Zhang B, Pan S, Sun Q, Bian L. （通讯作者） Chordoid Glioma of the Third Ventricle: A Case Report and a Treatment Strategy to This Rare Tumor. Front Oncol. 2020 10:502.
Zhong Z, Fu W, Sun Y, Sun Q, Bian L. （通讯作者） Reversible and the Irreversible Structural Alterations on Brain After Resolution of Hypercortisolism in Cushing's Disease Br J Neurosurg. 2019 33(3):299-301.
Xi Z, Hu X, Chen X, Yang Y, Ren J, Wang B, Zhong Z, Sun Y, Yang GY, Sun Q, Bian L. （通讯作者） Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral hemorrhage Eur J Pharmacol 2019 854:128-138.
Chen X, Xi Z, Liang H, Sun Y, Zhong Z, Wang B, Bian L （通讯作者）, Sun Q. Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling?in vitro Front Neurosci. 2019 13:760.
Zhong Z, Sun Y, Wang B, Sun Q, Yang G, Bian L. （通讯作者） Involvement of mitogen-activated protein kinase pathways in ferrous iron-induced aquaporin-4 expression in cultured astrocytes. Neurotoxicology 2019 73:142-149
Ren J, Gu C, Yang Y, Xue J, Sun Y, Jian F, Chen D, Bian L （通讯作者）, Sun Q. TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease. J Cell Mol Med 2019 23(6):4097-4110.
Yang Y, Ren J, Sun Y, Xue Y, Zhang Z, Gong A, Wang B, Zhong Z, Cui Z, Xi Z, Yang GY, Sun Q, Bian L. （通讯作者） A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation. Cell Death Differ. 2018 25(10):1870-1884
Yang Y, Xi Z, Xue Y, Ren J, Sun Y, Wang B, Zhong Z, Yang GY, Sun Q, Bian L. （通讯作者） Hemoglobin pretreatment endows rat cortical astrocytes resistance to hemin-induced toxicity via Nrf2/HO-1 pathway. Exp Cell Res. 2017 361(2):217-224.
Pan SJ, Ren J, Jiang H, Liu W, Hu LY, Pan YX, Sun B, Sun QF, Bian LG. （通讯作者） MAGEA6 promotes human glioma cell survival via targeting AMPKα1. Cancer Lett. 2017 412:21-29
Zhong Z, Fu W, Sun Y, Sun Q, Bian L. （通讯作者） Giant isolated transcranial Rosai-Dorfman disease with diffuse involvement of nasal and paranasal tissues: case report and literature review. Br J Neurosurg. 2017 33(3):299-301
Xie Z, Cui Z, Sun Y, Zhong Z, Bian L （通讯作者）, Sun Q. Management of traumatic carotid artery dissection: initial experience of a single center Neurosurg Rev. 2016 39(3):393-9
Wang B, Cui Z, Zhong Z, Sun Y, Yang GY, Sun Q, Bian L. （通讯作者） The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges. Mol Carcinog 2016 55(12):2268-2277
Jian F, Chen Y, Ning G, Fu W, Tang H, Chen X, Zhao Y, Zheng L, Pan S, Wang W, Bian L （通讯作者）, Sun Q. Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway. Oncotarget 2016 7(8):9175-87
Cui Z, Zhong Z, Yang Y, Wang B, Sun Y, Sun Q, Yang GY, Bian L （通讯作者） Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity. J Biochem Mol Toxicol 2016 30(8):396-403
Xie Z, Han P, Cui Z, Wang B, Zhong Z, Sun Y, Yang G, Sun Q, Bian L. （通讯作者） Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis Cell Mol Neurobiol 2016 36(8):1343-1351
Cui Z, Wang B, Zhong Z, Sun Y, Sun Q, Yang G, Bian L. （通讯作者） Impact of antibiotic- and silver-impregnated external ventricular drains on the risk of infections: A systematic review and meta-analysis Am J Infect Control 2015 43(7):e23-32
Wang BF, Cui ZW, Zhong ZH, Sun YH, Sun QF, Yang GY,Bian LG. （通讯作者） Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression. Acta Pharmacol Sin 2015 36(8):939-948
Cui ZW, Xie ZX, Wang BF, Zhong ZH, Chen XY, Sun YH, Sun QF, Yang GY, Bian LG. （通讯作者） Carvacrol protects neuroblastoma SH-SY5Y cells against Fe(2+)-induced apoptosis by suppressing activation of MAPK/JNK-NF-κB signaling pathway. Acta Pharmacol Sin 2015 36(12):1426-1436
Cui Z, Zhong Z, Wang B, Sun Q, Zhong C,Bian L. （通讯作者） Coexistence of spontaneous spinal and undiagnosed cranial subdual hematomas. J Craniofac Surg 2015 26(2):e118-9
Zhong Z, Sun Y, Zhou H, Sun Q, Bian L （通讯作者） A new choice of minimally invasive surgery for intracerebral hemorrhage in the striatocapsular regions based on computed tomography scans. J Craniofac Surg 2014 25(4):1195-9
Zhong Z, Sun Y, Lin D, Sun Q, Bian L. （通讯作者） Surgical treatment of brain tumor coexisted with intracranial aneurysm--case series and review of the literature. Neurosurg Rev 2013 36(4):645-56
Dai MC, Zhong ZH, Sun YH, Sun QF, Wang YT, Yang GY, Bian LG. （通讯作者） Curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis. Neurosci Lett 2013 536:41-6
Sun Y, Liu Y, Watts LT, Sun Q, Zhong Z, Yang GY, Bian L. （通讯作者） Genetic Associations of Angiotensin-Converting Enzyme with Primary Intracerebral Hemorrhage: A Meta-analysis. PLoS One 2013 8(6):e67402.
Zhong Z, Wang B, Dai M, Sun Y, Sun Q, Yang G, Bian L. （通讯作者） Carvacrol alleviates cerebral edema by modulating AQP4 expression after intracerebral hemorrhage in mice. Neurosci Lett 2013 555:24-9
Sun Yuhao, Sun Qingfang, Fan Changyan, Shen Jiankang, Zhao Weiguo, Guo Yan, Su Tingwei, Wang Weiqing, Ning Guang, Bian Liuguan （通讯作者） Diagnosis and Therapy for Cushing's Disease with Negative Dynamic MRI finding: a single-centre experience Clin Endocrinol (Oxf) 2012 76(6):868-76
Sun Yuhao, Sun Qingfang, Shen Jiankang, Wu Huachen, Guan Yongjing, Gong Kan, Bian Liuguan （通讯作者） Cauda equina hemangioblastoma at L5 vertebral level related to von Hippel-Lindau disease Br J Neurosurg 2012 26(4):576-7
Sun Yuhao, Dai Minchao, Wang Yongting, Wang Wenjing, Sun Qingfang, Yang Guo-Yuan, Bian Liuguan （通讯作者） Neuroprotection and sensorimotor functional improvement by curcumin after intracerebral hemorrhage in mice J Neurotrauma 2011 28(12):2513-2521
Bian Liu-Guan （通讯作者）, Sun Qing-Fang, Wu Hua-Cheng, Jiang Hong, Sun Yu-Hao, Shen Jian-Kang Primary choroid plexus papilloma in the pituitary fossa: case report and literature review Acta Neurochir (Wien) 2011 153(4):851-857
Shi Xiuhua, Sun Qingfang, Bian Liuguan （通讯作者）, Zhao Weiguo, Shen Jiankang, Wang Weiqing, Ning Guang Assessment of Bilateral Inferior Petrosal Sinus Sampling in the diagnosis and transsphenoidal surgical treatment of the ACTH-dependent Cushing's syndrome Neuro Endocrinol Lett 2011 32(6):865-873
Changyan Fan, Xiuhua Shi, Qingfang Sun, Liuguan Bian （通讯作者）, Weiguo Zhao, Jiankang Shen, Hua Zhang, Tingwei Su, Weiqing Wang, Xiaoying Li, Guang Ning,Liang Kong, Lingling Hu Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Neural Regeneration Research 2011 6(28):2203-2210
Bian LG （通讯作者）, Bertalanffy H, Sun QF, Shen JK. Intramedullary cavernous malformations: clinical features and surgical technique via hemilaminectomy. Clin Neurol Neurosurg 2009 111(6):511-7
Bian LG （通讯作者）, Sun QF, Tirakotai W, Zhao WG, Bertalanffy H, Shen JK. Surgical Management of PICA Aneurysm and Incidental Facial Nerve Schwannoma: Case Report Skull Base 2007 17(2):145-51
Bian LG （通讯作者）, Sun QF, Tirakotai W, Zhao WG, Shen JK, Luo QZ, Bertalanffy H. Loss of heterozygosity on chronmosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells Chin Med J (Engl) 2005 118(18):1517-24
Bian LG （通讯作者）, Tirakotai W, Sun QF, Zhao WG, Shen JK, Luo QZ. Molecular genetics alterations and tumor behavior of sporadic vestibular schwannoma from the People's Republic of China J Neurooncol 2005 73(3):253-60
Bian LG （通讯作者）, Sun QF, Zhao WG, Shen JK, Tirakotai W, Bertalanffy H. Temporal bone chondroblastoma: a review Neuropathology 2005 25(2):159-64
Bian LG, Zhang TX, Zhao WG, Shen JK, Yang GY. Increased endothelin-1 in the rabbit model of middle cerebral artery occlusion Neurosci Lett 1994 174(1):47-50