导师姓名： 孙青芳 专业代码： 100210
性别： 女 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： rjns123@163.com
邮编： 邮箱地址： rjns123@163.com

研究方向 (点击浏览详细信息)
垂体腺瘤的临床分子生物学研究

社会任职
上海市垂体瘤研究中心专家委员
上海市医师协会神经外科分会委员
中国垂体瘤协作组专家委员
中华医学会神经外科分会女子神经外科委员会：副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SFRP2-Wnt/β-catenin信号通路在库欣病发生中的作用及机制研究 国家自然科学基金面上项目 2018-01~2021-12 54万元 课题负责人
** 垂体性库欣病的临床分子生物学研究 国家自然科学基金 2013-01~2016-12 70万元 课题负责人
10JC** 脑出血神经元损伤诱导的炎症反应导致基质金属蛋白酶对血脑屏障破坏的机制研究 上海市科委基础重点 2010-07~2013-07 30万元 课题负责人
08ZR** 垂体性Cushing蛋白表达和修饰的研究 上海市科委、自然基金 2009-01~2011-12 10万元 课题负责人
06ZR14064 Schwannomin在肿瘤抑制作用中的信号通路 上海市科委,自然基金 2006-09~2008-08 8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jie Ren, Yong Yang, Jun Xue, Zhiyu Xi, Liangyun Hu, Si-Jian Pan, Qingfang Sun （通讯作者） Long noncoding RNA SNHG7 promotes the progression and growth of glioblastoma via inhibition of miR-5095. Biochem Biophys Res Commun. 2018 0006-291X:712-718
JIE REN, FANGFANG JIAN, HONG JIANG, YUHAO SUN, SIJIAN PAN, CHANGWEI GU, XIAO CHEN, WEIQING WANG, GUANG NING, LIUGUAN BIAN, QINGFANG SUN （通讯作者） Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling. Int J Oncol. 2018 1019-6439:1934-1946
Si-Jian Pan a, Jie Ren, Hong Jiang, Wei Liu, Liang-Yun Hu, Yi-Xin Pan, Bomin Sun, Qing-Fang Sun, Liu-Guan Bian （通讯作者） MAGEA6 promotes human glioma cell survival via targeting AMPKα1. Cancer Lett. 2018 0304-3835:21-29
Yong Yang,Jie Ren,Yuhao Sun,Yuan Xue,Zhijian Zhang,Aihua Gong,Baofeng Wang,Zhihong Zhong, Zhenwen Cui,Zhiyu Xi,Guo-yuan Yang, Qingfang Sun （通讯作者）,Liuguan Bian A connexin43/YAP axis regulates astroglial mesenchymal transition in hemoglobin induced astrocyte activation. Cell Death Differ. 2018 1350-9047:1870-1884
Hong Jiang,Jie Ren,Na-Ying He,Chang Liu,Yu-Hao Sun,Fang-Fang Jian,Liu-Guan Bian,Jian-Kang Shen,Fu-Hua Yan,Si-Jian Pan,Qing-Fang Sun （通讯作者） Volumetric magnetic resonance imaging analysis in patients with short-term remission of Cushing's disease. clinical endocrinology 2017 may 5
Zhihong Zhong, Wei Fu, Yuhao Sun, Qingfang Sun, Liuguan Bian Giant isolated transcranial Rosai-Dorfman disease with diffuse involvement of nasal and paranasal tissues: case report and literature review BRITISH JOURNAL OF NEUROSURGERY 2017 3:1-3
Jiang H, He NY, Sun YH, Jian FF, Bian LG, Shen JK, Yan FH, Pan SJ, Sun QF （通讯作者） Altered spontaneous brain activity in Cushing's disease: a resting-state functional MRI study Clin Endocrinol 2017 86(3):367-376
Jiang H, He NY, Sun YH, Jian FF, Bian LG, Shen JK, Yan FH, Pan SJ, Sun QF （通讯作者） Altered gray and white matter microstructure in Cushing's disease: A diffusional kurtosis imaging study Brain Res 2017 15;1665:80-87
Jian Fang-Fang, Li Yun-Feng, Chen Yu-Fan, Jiang Hong, Chen Xiao, Zheng Li-Li, Zhao Yao, Wang Wei-Qing, Ning Guang, Bian Liu-Guan, Sun Qing-Fang （通讯作者） Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells. Med J (Engl) 2016 129(17):2102-8
Zhengxing Xie,Ping Han,Zhenwen Cui,Baofeng Wang,Zhihong Zhong,Yuhao Sun,Guoyuan Yang,Qingfang Sun,Liuguan Bian Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis Cellular and Molecular Neurobiology 2016 36(8):1343-1351
Fangfang Jian1, Yufan Chen, Guang Ning, Wei Fu, Hao Tang, Xiao Chen, Yao Zhao, Lili Zheng, Sijian Pan, Weiqing Wang, Liuguan Bian, Qingfang Sun （通讯作者） Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway oncotarget 2016 23;7(8):9175-87
Jiang H, Liu W, Zhan SK, Pan YX, Bian LG, Sun B, Sun QF （通讯作者）, Pan SJ GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings plos one 2016 17;11(8):e**
Baofeng Wang,Zhenwen Cui,Zhihong Zhong,Yuhao Sun,Guo-Yuan Yang,Qingfang Sun,Liuguan Bian The role and regulatory mechanism of IL-1β on the methylation of the NF2 gene in benign meningiomas and leptomeninges MOLECULAR CARCINOGENESIS 2016 55(12):2268-2277
Xie Zhengxing,Cui Zhenwen,Sun Yuhao,Zhong Zhihong,Bian Liuguan,Qingfang Sun Management of traumatic carotid artery dissection: initial experience of a single center Neurosurgical Review 2016 39(3):393-9
Zhenwen Cui,Zhihong Zhong,Yong Yang,Baofeng Wang,Yuhao Sun,Qingfang Sun,Guo-yuan Yang,Liuguan Bian Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity journal of biochemical and molecular toxicology 2016 30(8):396-403
Fangfang Jian, Yanan Cao, Liuguan Bian, Qingfang Sun （通讯作者） USP8: a novel therapeutic target for Cushing's disease Endocrine 2015 7(11):1673-1678
Sijian Pan, Yuebing Wu, Shang Cai, Yixin Pan, Wei Liu, Liuguan Bian, Bomin Sun, Qingfang Sun （通讯作者） Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progression Biochemical and Biophysical Research Communications 2015 458(3):476-82
陈宇凡,建方方,陈晓,王卫庆,宁光,卞留贯,孙青芳 （通讯作者） 年龄因素对库欣病临床特征影响的相关研究. 中华神经外科杂志 2015 31(5): 472-476.
Sijian Pan, Shikun Zhan, Yixin Pan, Wei Liu,Liuguan Bian, Bomin Sun, Qingfang Sun （通讯作者） Tetraspanin 8-Rictor-Integrin α3 Complex Is Required for Glioma Cell Migration Int J Mol Sci 2015 16(3):5363-5374
Jian F,Cao Y, Bian L, Sun Q. （通讯作者） USP8: a novel therapeutic target for Cushing’s disease. Endocrine 2015 50(2): 292-296.
Cui,Z.,Z.Zhong,B.Wang （共同第一作者）,Q.Sun,C.Zhong,and L.Bian Coexistence of spontaneous spinal and undiagnosed cranial subdual hematomas. J Craniofac Surg 2015 26(2): p. e118-9.
Cui, Z., B. Wang, Z. Zhong （共同第一作者）, Y. Sun, Q. Sun, G. Yang, and L. Bian Impact of antibiotic- and silver-impregnated external ventricular drains on the risk of infections: A systematic review and meta-analysis. Am J Infect Control 2015 43(7): p. e23-32.
Wang, B.F., Z.W. Cui, Z.H. Zhong, Y.H. Sun （共同第一作者）, Q.F. Sun, G.Y. Yang, and L.G. Bian Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression. Acta Pharmacol Sin 2015 36(8): p. 939-48.
Sijian Pan, Shikun Zhan, Weizhong Ji, Yixin Pan, wei Liu, Dian You Li, Peng Huang, Xiaoxiao Zhang, Chunyan Cao, Jin Zhang, Liuguan Bian, Bomin Sun, Qingfang Sun （通讯作者） Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7 SCI rep 2015 6(11): 123-132
Jian Fang, Bian Liuguan, Sun Shouyue, Yang Jun, Chen Xiao, Chen Yufan, Ma Qinyun, Miao Fei, Wang Weiqing, Ning Guang, Sun Qingfang （通讯作者） Surgical biopsies in patients with central diabetes insipidus and thickened pituitary stalks. Endocrine 2014 47(1):325-35
Chen Yufan, Mei X, Jian Fangfang, Ma Qinyun, Chen Xiao, Bian Liuguan, Sun Qingfang （通讯作者） Gender and magnetic resonance imaging classification-related differences in clinical and biochemical characteristics of Cushing’s disease: a single-centre study. Chin Med J (Engl) 2014 127(22):3948-3956
Tao BB, He H, Shi XH, Wang CL, Li WQ, Li B, Dong Y, Hu GH, Hou LJ, Luo C, Chen JX, Chen HR, Yu YH, Sun QF （通讯作者）, Lu YC. Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade. J Clin Neurosci 2013 20(5):717-20
Chen YF, Li YF, Chen X, Sun QF （通讯作者） *. Neurophychiatric disorders and cognitive dysfunction in patients with Cushing’s disease. Chin Med J (Engl). 2013 126(16):3156-60
He XY, liu XJ, Chen X, Bian LG, Zhao WG, Shen JK, Sun QF （通讯作者） gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells Biochem Biophys Res Commun 2013 435(3):397-402
Shi X, Tao B, He H, Sun Q （通讯作者）, Fan C, Bian L, Zhao W, Lu YC. MicroRNAs-based network: a novel therapeutic agent in pituitary adenoma. Med Hypotheses. 2012 78(3):380-4
Sun Y, Sun Q （共同第一作者）, Fan C, Shen J, Zhao W, Guo Y, Su T, Wang W, Ning G, Bian L. Diagnosis and Therapy for Cushing's Disease with Negative Dynamic MRI finding: a single-centre experience. Clin Endocrinol 2011 2(12):1365-2265
Shi X, Sun Q （通讯作者）, Bian L, Zhao W, Shen J, Wang W, Ning G Assessment of bilateral inferior petrosal sinus sampling in the diagnosis and surgical treatment of the ACTH-dependent Cushing's syndrome: a comparison with other tests. Neuro Endocrinol Lett. 2011 32(6):865-73.
Sun Y, Sun Q （共同第一作者）, Fan C, Shen J, Zhao W, Guo Y, Su T, Wang W, Ning G, Bian L. Diagnosis and Therapy for Cushing's Disease with Negative Dynamic MRI finding: a single-centre experience. Clin Endocrinol 2011 2(12):1365-2265
Sijian Pan1, Bengeng Pei2, Chen-Ran Zhang3, Changyan Fan1, Liu-Guan Bian1 and Qing-Fang Sun1* Effect of hypoxia-inducible factor 1-alpha (HIF-1α) on proliferation and apoptosis of adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma cells. African Journal of Biotechnology 2011 10 (38):7510-7517
Changyan Fan[1] Xiuhua Shi[2] Qingfang Sun[2] Liuguan Bian[2] Weiguo Zhao[2] Jiankang Shen[2] Hua Zhang[3] Tingwei Su[4] Weiqing Wang[4] Xiaoying Li[4] Guang Ning[4] Liang Kong[1] Lingling Hu[1] Bilateral inferior petrosal sinus sampling for the treatment of Cushing's disease Data from 52 cases from one institute over an eight-year period NEURAL REGENERATION RESEARCH 2011 28(8):1673-5374
Changwei Gu[1] Qingfang Sun[2] Jiang Zhu[3] Liuguan Bian[2] Weiguo Zhao[2] Jiankang Shen[2] Heng Gao[1] Dongxia Feng[1] Identification and analysis of a minority fraction in a U87 cell line Do side-population cells represent bona fide stem cell-like cancer cells? NEURAL REGENERATION RESEARCH 2009 11(1):1673-5374