导师姓名： 叶晓峰 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 胸心外
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： 上海市瑞金二路197号，10号楼7楼，瑞金医院心脏外科
邮编： 200025 邮箱地址： xiaofengye@hotmail.com

研究方向 (点击浏览详细信息)
心血管组织工程
心脏镜
新型高分子材料的转化医学研究

社会任职
中国医师协会心血管外科青年委员
中华胸心血管外科青年委员
国家微创心血管外科专业委员会 委员
中国医师协会重症医学专业委员会委员
Annals of Thoracic Surgery, Biomaterials, Tissue Engineering, Journal of Tissue Engineering, Regenerative Medicine, Acta Biomaterialia, Artifical Organ等SCI 杂志审稿人
上海医师协会心血管外科分会委员
美国胸外科医师协会（STS ）国际委员
国际组织工程和再生医学学会（TERMIS ）会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
12754 上海交通大学医学院高峰高原计划 研究型医师 上海交通大学 2017-01~2019-12 100万元 课题负责人
** MYDGF介导的微环境影响心梗后hPSC-CMs移植的机制研究 国家自然科学基金面上项目 2017-01~2020-12 58万元 课题参与人
LK1618 纤维材料改性国家重点实验室 开放课题 东华大学 2016-12~2018-12 5万元 课题负责人
** 可降解3D微支架积木引导hPSC-CMs的兴奋收缩耦联及对左室功能的研究 国家自然科学基金面上项目 2016-01~2019-12 78万元 课题负责人
15ZR** 可降解3D微支架积木引导干细胞来源心肌细胞的兴奋收缩耦联及对左室功能的研究 上海市自然科学基金 2015-01~2017-12 10万元 课题负责人
** 雌激素受体与SDF-1/CXCR4信号通路交互作用调节骨髓源性内皮祖细胞修复梗死心肌的分子机制研究 国家自然科学基金青年项目 2013-01~2015-12 24万元 课题参与人
** 经SDF-1α修饰的脱细胞心脏支架内重建血管网促进构建组织工程心肌的基础研究 国家自然科学基金面上项目 2012-01~2012-12 14万元 课题参与人
R01HL107503-01 Scalable Units for Building Vascularized Cardiac Grafts NIH R01 2011-01~2016-12 **万元 课题参与人
** 原始瓣膜间质细胞重构SDF-1α/CD90抗体修饰脱细胞带瓣管道的机制研究 国家自然科学基金青年项目 2011-01~2013-12 20万元 课题负责人
54890 新型组织工程瓣膜的研究 上海交通大学医学院附属瑞金医院优秀青年教师 2010-01~2013-12 3万元 课题负责人
20298 瓣膜间质细胞在组织工程瓣膜重构中的机制研究 上海市高校青年教师 2009-01~2012-12 2万元 课题负责人
** 生物信号调控天然支架组织工程瓣膜力学强度 国家自然科学基金面上项目 2004-01~2006-12 20万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Zhize Yuan, Yung-Hao Tsou, Xue-Qing Zhang, Shixing Huang, Yang Yang, Mingzhu Gao, William Ho, Qiang Zhao*, Xiaofeng Ye* and Xiaoyang Xu* （通讯作者） Injectable citrate-based hydrogel as an angiogenic biomaterial im-proves cardiac repair after myocardial infarction. ACS Applied Materials & Interfaces. 2019 11(42):38429-38439
Dong Lei, Yang Yang, Zenghe Liu, Binqian Yang, Wenhui Gong, Shuo Chen, Shaofei Wang, Lijie Sun, Benyan Song, Huixia Xuan, Xiumei Mo, Binbin Sun, Sen Li, Qi Yang, Shixing Huang, Shiyan Chen,b Yiding Mb, Wenguang Liu, Chuanglong He, Bo Zhu,f Eric M. Jeffries, Feng-Ling Qing, Xiaofeng Ye （通讯作者）,* Qiang Zhao*, Zhengwei You* 3D printing of biomimetic vasculature for tissue regeneration Materials Horizon. 2019 doi: 10.1039/C9MH00174C
Yang Y, Lei D, Zou H, Huang S, Yang Q, Li S, Qing F, Ye X* （通讯作者）, You Z, Zhao Q. Hybrid electrospun rapamycin-loaded small-diameter decellurized vascular grafts effectively inhibit intimal hyperplasia. Acta Biomaterialia. 2019 97:321-332.
Pengxiong Zhu, Xiaofeng Ye, Anqing Chen, Jun Liu, Zhe Wang, Mi Zhou, Qiang Zhao Does the Site of Coronary Endarterectomy Have an Impact on the Clinical Outcomes and Graft Patency? Interactive CardioVascular and Thoracic Surgery 2019 29 (3), 402-408
Yang Yang Dong Lei Shixing Huang Qi Yang Benyan Song Yifan Guo Ao Shen Zhize Yuan Sen Li Feng‐Ling Qing Xiaofeng Ye* Zhengwei You* Qiang Zhao* Elastic 3D‐Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction Advanced Healthcare Materials 2019 doi.org/10.1002/adhm.
Dong Lei, Yang Yang, Shuo Chen, Zenghe Liu, Song Benyan, Ao Shen, Binqian Yang, Sen Li, Zhize Yuan, Quan Qi, Lijie Sun, Yifan Guo, Han Zuo, Shixing Huang, Qi Yang, Xiumei Mo, Chuanglong He, Bo Zhu, Eric Jeffries, Feng-Ling Qing,* Xiaofeng Ye （通讯作者）,* Qiang Zhao* and Zhengwei You*. A general strategy of 3D printing thermosets for diverse applications. Materials Horizon. 2018 doi:10.1039/C8MH00937F.
Li H, Yuan Z, Li S, Qi Q, Liu J, Zhou M, Cai J, Chen A, Wang Z, Ye X （通讯作者）, Zhao Q. Plasma levels of matrix metalloproteinase 9 in patients undergoing off-pump coronary artery bypass grafting. J Thorac Dis. 2017 9(4):1100-1106.
王敏, 龚文辉, 黄鹏, 李森, 叶晓峰 （通讯作者）, 游正伟 一种新型可降解蓝光固化医用粘合剂的合成及其性能研究 合成化学 2017 25(7): 585-590.
Qi Q, Lu L, Li H, Yuan Z, Chen G, Lin M, Ruan Z, Ye X （通讯作者）, Xiao Z, Zhao Q. Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction. Int J Nanomedicine. 2017 12:4835-4848.
Yuan Z, Li H, Qi Q, Gong W, Chen Q, Dong R, Zhang Y, Li J, Zhou M, Cai J, Wang Z, Chen A, Ye X* （通讯作者）, Zhao Q. Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pumpcoronary artery bypass grafting. Sci Rep. 2016 6:28221. doi: 10.1038/srep28221.
Gong W, Cai J, Wang Z, Chen A, Ye X, Li H, Zhao Q. Robot-assisted coronary artery bypass grafting improves short-term outcomes compared with minimally invasive direct coronary artery bypass grafting. J Thorac Dis. 2016 8(3):459-68.
Ye X, Wang H, Gong W, Li S, Li H, Wang Z, Zhao Q. Impact of decellularization on porcine myocardium as scaffold for tissue engineered heart tissue. J Mater Sci Mater Med. 2016 27(4): 70. doi: 10.1007/s10856-016-5683-8.
Sen Li,* Wenhui Gong,* Quan Qi,* Zezhe Yuan, Anqing Chen, Jun Liu, Junfeng Cai, Mi Zhou, Zhe Wang,corresponding author Xiaofeng Ye （通讯作者）,corresponding author and Qiang Zhaocorresponding author Outcomes of off-pump versus on-pump coronary artery bypass graft surgery in patients with severely dilated left ventricle. Ann Transl Med. 2016 4(18):340.
Gong W, Li S, Lei D, Huang P, Yuan Z, You Z, Ye X* （通讯作者）, Zhao Q. Tissue-engineered mitral valve chordae tendineae: Biomechanical and biological characterization of decellularized porcine chordae. J Mech Behav Biomed Mater. 2015 56:205-217.
Gong W, Ye X, Wang Z, Li S, Zhao Q. Fatal bleeding due to sternal steel wire fracture following open-heart surgery. J Thorac Dis. 2015 7(10):E517-E519.
Gong W, Ye X, Wang Z, Sun Y, Zhao Q. Two balls around aortic root: multiple huge unruptured aneurysms of the Valsalva sinus. Eur Heart J Cardiovasc Imaging. 2015 16(8):827.
Gong W, Lei D, Li S, Huang P, Qi Q, Sun Y, Zhang Y, Wang Z, You Z, Ye X* （通讯作者）, Zhao Q. Hybrid small-diameter vascular grafts: Anti-expansion effect of electrospun poly ε-caprolactone on heparin-coated decellularized matrices. Biomaterials. 2015 76:359-370.
Zhou JX, Ye X# （共同第一作者）, Wang Z, Liu J, Zhang BS, Qiu JP, Sun YJ, Li HQ, Zhao Q. Development of Decellularized Aortic Valvular Conduit Coated by Heparin-SDF-1α Multilayer. Ann Thorac Surg. 2015 99(2):612-8.
Ye E Biomechanical properties of the thoracic aneurysmal wall; Differences between Bicuspid Aortic Valve (BAV) and Tricuspid Aortic Valve (TAV) patients. Ann Thorac Surg. 2014 98(1):71.
Hu X, Wang HZ, Liu J, Chen AQ, Ye X* （通讯作者）, Zhao Q. A novel role of sympathetic activity in regulating mitral valve prolapse. Circ J. 2014 78(6):1486-93.
Gong W, Ye X, Shi K, Zhao Q. Primary malignant pericardial mesothelioma-a rare cause of superior vena cava thrombosis and constrictive pericarditis. J Thorac Dis. 2014 6(12): E272-5.
Ye X#, Lu L, Kolewe ME, Kearon K, Fischer KM, Coppeta J, Freed LE. Scalable Unite for Building Cardiac Tissue. Adv Mater. 2014 26(42):7202-8.
Kolewe ME, Park H, Gray C, Ye X, Langer R, Freed LE. 3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture. Adv Mater. 2013 25(32):4459-65.
Ye X#, Wang H, Zhou J, Li H, Liu J, Wang Z, Chen A, Zhao Q. The effect of Heparin-VEGF multilayer on the biocompatibility of decellularized aortic valve with platelet and endothelial progenitor cells. Plos One. 2013 8(1):e54622.
Ye X#, Lu L, Kolewe ME, Park H, Larson BL, Kim ES, Freed LE. A Biodegradable Microvessel Scaffold as a Framework to Enable Vascular Support of Engineered. Biomaterials. 2013 34(38):10007-15.
Li H, Liu J, Ye X, Zhang X, Wang Z, Chen A, Zhou M, Zhao Q. m17β-Estradiol enhances the recruitment of bone marrow-derived endothelial progenitor cells into infarcted myocardium by inducing CXCR4 expression. Int J Cardiol. 2013 162(2):100-6.
Ye X#, Hu X, Wang H, Liu J, Zhao Q. Polyelectrolyte multilayer film on decellularized porcine aortic valve can reduce the adhesion of blood cells without affecting the growth of human circulating progenitor cells. Acta Biomater. 2012 8(3):1057-67.
Hu X, Zhao Q, Ye X. Autonomic regulation of mechanical properties in porcine mitral valve cusps. Arq Bras Cardiol. 2012 98(4):321-328.
Zhao Q, Ye X. Pulmonary thromboembolism in a patient with rheumatic mitral valve stenosis: a fortuitous association? Ann Thorac Surg. 2011 92(6):2263-6.
Zhao Q, Ye X. Additive value of adult bone-marrow-derived cell transplantation to conventional revascularization in chronic ischemic heart disease: a systemic review and meta-analysis. Expert Opin Biol Ther. 2011 11(12):1569-79.
Ye X#, Zhao Q, Sun X, Li H. Enhancement of mesenchymal stem cell attachment to decellularized porcine aortic valve scaffold by in vitro coating with antibody against CD90: a preliminary study on antibody-modified tissue-engineered heart valve. Tissue Eng Part A. 2009 15(1):1-11.