导师姓名： 吴哲褒 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： -666091
邮编： 200025 邮箱地址： @qq.com

研究方向 (点击浏览详细信息)
颅脑肿瘤的临床和基础研究

社会任职
中国垂体瘤协作组秘书
中国脑垂体救助计划发起人
中国神经科学协会神经肿瘤分会委员
上海市医师协会神经外科分会第二届委员会委员
浙江省医学会神经外科分会青年委员会副主任委员
中华医学杂志和中华神经外科杂志特约审稿专家
中华医学杂志英文版编委
上海市医学会神经外科专科分会第十届委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** KBTBD7介导的DRD2泛素化降解对泌乳素瘤药物治疗敏感性的调控机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** H19阻止ATG7泛素化降解增敏卡麦角林疗效的机制研究 国家自然科学基金面上项目 2017-01~2020-12 52万元 课题负责人
** 侵袭海绵窦泌乳素腺瘤的撤药安全性研究 上海交通大学医学院“双****-研究型医师” 2016-07~2019-06 100万元 课题负责人
** 自噬在卡麦角林治疗中的作用及新机制探索 国家自然科学基金面上项目 2015-01~2018-12 70万元 课题负责人
2013T60418 5-HT受体在卡麦角林治疗溴隐亭耐药泌乳素腺瘤中的作用 第六批中国博士后科学基金特别资助 2013-06~2013-11 15万元 课题负责人
** lncRNA316686对NGFR的调控机制研究 国家自然科学基金面上项目 2013-01~2016-12 70万元 课题负责人
2012M520829 lncRNA316686在泌乳素腺瘤药物治疗中的作用及机制研究 中国博士后科学基金第52批面上资助 2012-06~2013-08 5万元 课题负责人
R** 吴哲褒研究团队 浙江省自然科学基金****基金 2010-01~2013-12 30万元 课题负责人
** 腺病毒介导D2S基因和溴隐亭联合治疗垂体无功能腺瘤的实验研究 国家自然科学基金青年基金项目 2009-01~2011-12 25万元 课题负责人
2007C33028 泌乳素腺瘤药物治疗的敏感性研究 浙江省科技计划项目 2007-04~2009-12 17万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu YT, Liu F, Cao L, Xue L, Gu WT, Zheng YZ, Tang H, Wang Y, Yao H, Zhang Y, Xie WQ, Ren BH, Xiao ZH, Nie YJ, Hu R, Wu ZB. （通讯作者） The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment. Acta Neuropathol 2020 doi: 10.1007/s00401-020-02180-4.
Lin S, Zhang A, Zhang X, Wu ZB （通讯作者） Treatment of Pituitary and Other Tumours with Cabergoline: New Mechanisms and Potential Broader Applications. Neuroendocrinology 2020 doi: 10.1159/
Zhang Y, Liu YT, Tang H, Xie WQ, Yao H, Gu WT, Zheng YZ, Shang HB, Wang Y, Wei YX, Wu ZR, Wu ZB （通讯作者） Exosome-transmitted lncRNA H19 inhibits the growth of pituitary adenoma. J Clin Endocrinol Metab 2019 104(12):6345-6356
Zhong HP, Tang H, Zhang Y, Luo Y, Yao H, Cheng Y, Gu WT, Wei YX, Wu ZB （通讯作者） Multidisciplinary team efforts improve the surgical outcomes of sellar region lesions during pregnancy Endocirne 2019 66:477-484
Yao H, Tang H, Zhang Y, Zhang QF, Liu XY, Liu YT, Gu WT, Zheng YZ, Shang HB, Wang Y, Huang JY, Wei YX, Zhang X, Zhang J, Wu ZB （通讯作者） DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma Cancer Lett 2019 459:135-144.
Huang HY, Lin SJ, Zhao WG, Wu ZB （通讯作者） Cabergoline versus bromocriptine for the treatment of giant prolactinomas: A quantitative and systematic review. Metab Brain Dis 2018 33(3):969-976
Huang HY, Zhai W, Tang H, Hui GZ, Wu ZB （通讯作者） Cabergoline for the treatment of bromocriptine-resistant invasive giant prolactinomas Endocirne 2018 62(2):464-469
Wu ZR, Yan L, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B, Wu ZB （通讯作者） Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours Nat Commun 2018 9(1):4624
Xia MY, Lou XH, Lin SJ, Wu ZB （通讯作者） Optimal timing of dopamine agonist withdrawal in patients with hyperprolactinemia: a systematic review and meta-analysis. Endocirne 2018 59(1):50-61
Leng ZG, Lin SJ, Wu ZR, Guo YH, Cai L, Shang HB, Tang H, Xue YJ, Lou MQ, Zhao W, Le WD, Zhao WG, Zhang X, Wu ZB. （通讯作者） Activation of DRD5 (Dopamine Receptor D5) Inhibits Tumor Growth by Autophagic Cell Death Autophagy 2017 14:1-16
Cai L, Leng ZG, Guo YH, Lin SJ, Wu ZR, Su ZP, Lu JL, Wei LF, Zhuge QC, Jin K, Wu ZB （通讯作者） Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas Endocrine 2016 52(3):641-51
Wu ZR, Zhang Y, Cai L, Lin SJ, Su ZP, Wei YX, Shang HB, Yang WL, Zhao WG, Wu ZB. （通讯作者） Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup Int J Endocrinol 2016 2016:**
Lin SJ, Leng ZG, Guo YH, Cai L, Cai Y, Li N, Shang HB, Le WD, Zhao WG, Wu ZB. （通讯作者） Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline Oncotarget 2015 6(36):39329-41
Wu ZB （通讯作者）, Cai L, Lin SJ, Leng ZG, Guo YH, Yang WL, Chu YW, Yang SH, Zhao WG Heat shock protein 47 promotes glioma angiogenesis Brain Pathol 2015 doi: 10.1111/bpa.12256
Cai L1, Leng ZG1, Guo YH1, Lin SJ2, Wu ZR1, Su ZP1, Lu JL1, Wei LF1, Zhuge QC1, Jin K3, Wu ZB4 （通讯作者）,5. Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas. Endocrine 2015 DOI 10.1007/s12020-015-0824-2
Wu ZB,Cai L, Qiu C,Zhang AL,Lin SJ,Yao Y,Xu J,Zhou LF CTL responses to HSP47 associated with the prolonged survival of patients with glioblastomas Neurology 2014 82:1261-1265
Wu ZB* （通讯作者）, Li WQ, Lin SJ, Wang CD, Cai L, Lu JL, Chen YX, Su ZP, Shang HB, Yang WL, Zhao WG MicroRNA expression profile of bromocriptine-resistant prolactinomas. Mol Cell Endocrinol. 2014 395:10-18
Huang L, Wu ZB* （共同第一作者）, Zhuge Q, Zheng W, Shao B, Wang B, Sun F, Jin K Glial scar formation occurs in the human brain after ischemic stroke Int J Med Sci 2014 11(4):344-8
Qiang Li,Zhipeng Su,Jie Liu,Lin Cai,Jianglong Lu,Shaojian Lin,Zhengkun Xiong,Weiqiang Li,Weiming Zheng,Jinsen Wu,Qichuan Zhuge,Zhebao Wu （通讯作者） Dopamine receptor D2S gene transfer improves the sensitivity of GH3 rat pituitary adenoma cells to bromocriptine Mol Cell Endocrinology 2014 382(1):377-384
吴哲褒 （通讯作者） 应重视垂体催乳素腺瘤的药物治疗（述评） 中华医学杂志 2014 94(31):2404-2405.
Zhe Bao Wu, Chao Qiu, An Li Zhang, Lin Cai, Shao Jian Lin, Yu Yao, Qi Sheng Tang, Ming Xu, Wei Hua, Yi Wei Chu, Ying Mao, Jian Hong Zhu, Jianqing Xu, Liang Fu Zhou. Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma Journal of Immunology Research 2014 131494:1-12
Lou XH*, Wu ZB* （共同第一作者）, Zhang YZ Bromocriptine-induced Brainstem Angulation in a Patient With Invasive Prolactinoma J Clin Endocrinol Metab 2013 98(3):867-868
Yong Chen,Zhi Feng Li,Fei Xiang Zhang,Jian Xian Li,Lin Cai,Qi Chuan Zhuge,Zhe Bao Wu （通讯作者） Gamma knife surgery for patients with volumetric classification of nonfunctioning pituitary adenomas: a systematic review and meta-analysis European J Endocrinology 2013 169(4):487-495
Zhe Bao Wu （共同第一作者）,Lin Cai,Shao Jian Lin,Jiang Long Lu,Yu Yao,Liang Fu Zhou The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas Brain Research 2013 1529:16-25
ZhuGe Q*, Wu Z* （共同第一作者）, Huang L, Zhao B, Zhong M, Zheng W, Chen G, Mao X, Xie L, Wang X, Jin K Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations J Cell Mol Med 2013 17(11):1458-1464
Wu ZB,Cai L,Lin SJ,Xiong ZK,Lu JL,Mao Y,Yao Y,Zhou LF High-mobility group box 2 is associated with prognosis of glioblastoma by promoting cell viability, invasion, and chemotherapeutic resistance Neuro-Oncology 2013 15(9):1264-1275
Yong Chen,Cheng De Wang,Zhi Peng Su,Yun Xiang Chen,Lin Cai,Qi Chuan Zhuge,Zhe Bao Wu （通讯作者） Natural History of Post-Operative Nonfunctioning Pituitary Adenomas: A Systematic Review and Meta-Analysis Neuroendocrinology 2012 96(4):333-42
Su Z, Wang C, Wu J, Jiang X, Chen Y, Chen Y, Zheng W, Zhuge Q, Wu Z （通讯作者）, Zeng Y Expression of dopamine 2 receptor subtype mRNA in clinically nonfunctioning pituitary adenomas Neurol Sci 2012 33(2):275-279.
Zhipeng Su,Xiaolong Jiang,Chengde Wang,Jie Liu,Yunxiang Chen,Qun Li,Jinsen Wu,Weiming Zheng,Qichuan Zhuge,Kunlin Jin,Zhebao Wu （通讯作者） Differential effects of nerve growth factor on expression of dopamine 2 receptor subtypes in GH3 rat pituitary tumor cells Endocrine 2012 42:470-475
CHENGDE WANG,ZHIPENG SU,NADER SANAI,XIANGYANG XUE,LIJUN LU,YUNXIANG CHEN,JINSEN WU,WEIMING ZHENG,QICHUAN ZHUGE,ZHE BAO WU （通讯作者） microRNA expression profile and differentially-expressed genes in prolactinomas following bromocriptine treatment Oncology Reports 2012 27:1312-1320
吴哲褒 （通讯作者） 药物治疗垂体催乳素腺瘤的现状分析（述评） 中华神经外科杂志 2011 27(9):865-867
Zhe Bao Wu,Wei Ming Zheng,Zhi Peng Su,Yong Chen,Jin Sen Wu,Cheng De Wang,Chen Lin,Yan Jun Zeng,Qi Chuan Zhuge Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior J Neuro-Oncology 2010 99(1):25-32
Zhe Bao Wu,Chu Zhong Li,Xu Yi Zong,Zhi Peng Su,Yan Jun Zeng,Ya Zhuo Zhang Correlation of alternative splicing of the D2 dopamine receptor mRNA and estrogen receptor mRNA in the prolactinomas and gonadotrope tumors J Neuro-Oncology 2009 94:135-139
Wu ZB （通讯作者）, Su ZP, Wu JS, Zheng WM, Zhuge QC, Zhong M Five years follow-up of invasive prolactinomas with special reference to the control of cavernous sinus invasion Pituitary 2008 11(1):63-70
Wu ZB （通讯作者）, Yu CJ, Su ZP, Zhuge QC, Wu JS, Zheng WM Bromocriptine treatment of invasive giant prolactinomas involving the cavernous sinus: Results of a long-term follow up J Neurosurg 2006 104(1):54-61
Wu ZB （通讯作者）, Yu CJ, Guan SS Posterior petrous meningiomas: 82 cases. J Neurosurg 2005 102(2):284-289