上海交通大学医学院导师教师师资介绍简介-郑民华

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导师姓名：郑民华专业代码： 100210
性别：男专业名称：外科学
培养单位：附属瑞金医院三级学科/
专业领域：普外
导师类型：博士生导师专业学位导师：兼
联系方式：
邮编： 200025 邮箱地址： zmhtiger@yeah.net

研究方向 (点击浏览详细信息)
消化道肿瘤的微创治疗和基础研究

社会任职
Endoscopic and Laparoscopic Surgeons of Asia （ELSA）理事
International Federation of Societies of Endoscopic Surgeons 理事
中华医学会外科学分会常委
中国医师协会内镜医师分会第三届委员会常务委员
上海市抗癌协会大肠癌专业委员会常委
上海市医师协会普外科医师分会第二届委员会委员
中国研究型医院学会微创外科学专业委员会副主任委员
中华医学会外科学分会腹腔镜与内镜外科学组组长
中国医师协会外科医师分会微创外科医师委员会副主任委员
上海医学会外科分会微创外科学组组长
中国抗癌协会大肠癌专业委员会委员
中国医师协会内镜医师分会腹腔镜专业委员会副主任委员
中国抗癌协会大肠癌专业委员会腹腔镜外科学组组长
中国医师协会结直肠肿瘤专业委员会外科专业委员会副主任委员
中国抗癌协会腔镜与机器人外科专委会副主任委员
中国研究型医院学会机器人与腹腔镜外科专业委员会顾问

科研项目项目编号项目名称课题来源起止年月批准经费承担职责
2018CR008 腹腔镜辅助经肛全系膜切除术治疗直肠癌的安全性及可行性前瞻性多中心随机对照研究瑞金医院临床研究资助项目 2019-01~2021-12 180万元课题负责人
** 以微创外科PLUS理念为核心的“沉浸式”西部腹腔镜技术提升计划上海市科委 2018-04~2019-03 10万元课题负责人
2017YFC** 全维微创手术执行臂的构型优化和工艺化制备科技部国家重点研发计划 2017-07~2020-12 200万元课题负责人
** 腹腔镜手术智能扶镜机械臂的设计与研究上海市科学技术委员会 2017-06~2020-06 40万元课题负责人
16CR1011A 腹腔镜右半结肠癌标准化关键技术确立的临床比较研究申康重大疾病临床技能提升项目 2016-12~2019-06 180万元课题负责人
** NDRG1调控结直肠癌转移相关膜蛋白内吞与转运的机制研究国家自然科学基金委员会 2016-01~2019-12 68.4万元课题负责人
2013SY010 微创技术在胃肠道肿瘤早诊早治中的应用上海市卫生计生委 2014-01~2016-12 50万元课题负责人
13JC** NDRG1对结直肠癌肿瘤干细胞的影响及其临床意义上海市科委基础研究重大重点项目 2013-09~2016-09 40万元课题负责人
上海市临床医学中心建设计划上海市微创外科临床医学中心上海市卫生和计划生育委员会 2013-01~2016-12 200万元课题负责人
2012AA021103 腹盆腔外科LESS和NOTES关键技术临床应用研究及推广国家高技术研究发展计划（863计划） 2012-01~2015-12 500万元课题负责人
腹腔镜结肠全系膜切除术(CME)治疗结肠癌的手术规范化研究上海市科委 2011-01~2013-12 20万元课题负责人
结直肠癌早期诊断糖基化蛋白标志物的寻找及腹腔镜结肠全系膜切除术治疗结肠癌的规范化研究上海市科委 2011-01~2013-12 60万元课题负责人
上海市领军人才上海市科委 2010-01~2012-12 100万元课题负责人

学术论文作者论文标题期刊名出版年卷期页码
Xiao Yang, Ming Liu, Mengmeng Li, Sen Zhang, Hong Hiju, Jing Sun, Zhihai Mao, Minhua Zheng & Bo Feng （通讯作者） Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology Mol Cancer, 2020 2020, 19(1): 64.
Galiya Yesseyeva,Batuer Aikemu, Hiju Hong,Chaoran Yu, Feng Dong, Jing Sun, Lu Zang, Minhua Zheng* （通讯作者）, Junjun Ma* Prefoldin subunits (PFDN1-6) serve as poor prognostic markers in gastric cancer Biosci Rep, 2020 2020, 40(2).
Xiao Yang, Sen Zhang, Changyu He, Pei Xue , Luyang Zhang , Zirui He , Lu Zang , Bo Feng , Jing Sun , Minhua Zheng （通讯作者） METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST Mol Cancer 2020 2020, 19(1): 46.
ZiruiHe,SenZhang,PeiXue,XialinYan,LeqiZhou, JianwenLi,MingliangWang, AiguoLu,JunjunMa,LuZang,HijuHong, FengDong, HaoSu,JingSun, LuyangZhang,MinhuaZheng （通讯作者）, BoFeng Completely medial access by page-turning approach for laparoscopic right hemi-colectomy: 6-year-experience in single center Surg Endosc 2019 2019, 33(3): 959-965.
Sen Zhang, Chaoran Yu, Xiao Yang, Hiju Hong, Jiaoyang Lu , Wenjun Hu, Xiaohui Hao, Shuchun Li, Batuer Aikemu, Guang Yang, Zirui He, Luyang Zhang, Pei Xue, Zhenghao Cai , Junjun Ma, Lu Zang, Bo Feng, Fei Yuan, Jing Sun, Minhua Zheng （通讯作者） N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21 J Exp Clin Cancer Res 2019 2019 Dec 12;38(1):490.
Chaoran Yu , Xiaohui Hao, Sen Zhang, Wenjun Hu, Jianwen Li, Jing Sun and Minhua Zheng Characterization of the prognostic values of the NDRG family in gastric cancer[J]. Therap Adv Gastroenterol Therap Adv Gastroenterol, 2019 2019, 12: **58507.
Chaoran Yu, Hiju Hong , Sen Zhang, Yaping Zong, Junjun Ma, Aiguo Lu , Jing Sun, Minhua Zheng （通讯作者） Identification of key genes and pathways involved in microsatellite instability in colorectal cancer Mol Med Rep, 2019 2019, 19(3): 2065-2076.
Yu C,Hong H, Lu J, Zhao X, Hu W, Zhang S, Zong Y, Mao Z, Li J, Wang M, Feng B, Sun J, Zheng M （通讯作者） Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer. Technol Cancer Res Treat. 2018 2018 Jan，
Yu C, Xue P, Zhang L, Pan R, Cai Z, He Z, Sun J, Zheng M. （通讯作者） Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer. World J Surg Oncol. 2018 2018 Aug 22;16(1):174.
Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, We, Lu A, Wang M, Zheng M （通讯作者）, Ji J, Sun J. The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells. Oncogene. 2017 2017 Jul 27;36(30):4323-4335.
Feng B, Lu J, Zhang S, Yan X, Li J, Xue P, Wang M, Lu A, Ma J, Zang L, Dong F, He Z, Yue F, Sun J, Hong X, Zheng M. （通讯作者） Laparoscopic abdominoperineal excision with trans-abdominal individualized levator transection: interim analysis of a randomized controlled trial. Colorectal Dis. 2017 2017 Jul;19(7):O246-O252.
Jiaoyang Lu,Taotao Jiao, Yanmei Li,Minhua Zheng （通讯作者）, Xuefeng Lu, Facilitating retroflexed endoscopic full-thickness resection through loop-mediated or rope-mediated countertraction (with videos) Gastrointestinal Endoscopy, 2016 2016, 83(1):223-228.
Min-Hua Zheng, Sen Zhang, Bo Feng Complete mesocolic excision: Lessons from anatomy translating to better oncologic outcome World J Gastrointest Oncol. 2016 15; 8(3): 235–239
Pan R, Sichang Zheng2*, Wei Cai1, Zhengting Wang2, Zheng M （通讯作者） Retrospective study on the effect of laparoscopic and open total mesorectal excision for middle/low T3 rectal cancer. Int J Clin Exp Med 2016 2016;9(11):21708-21715
Xiongzhi Wangpu, Jiaoyang Lu, Ruxing Xi, Fei Yue, Sumit Sahni, Kyung Chan Park, Sharleen Menezes, Michael L.H. Huang, Minhua Zheng （通讯作者）, Zaklina Kovacevic, Des R. Richardson Targeting the metastasis suppressor, N-Myc downstream regulated gene-1, with novel di-2-pyridylketone thiosemicarbazones: Suppression of tumor cell migration and cell-collagen adhesion by inhibiting focal adhesion kinase/paxillin signaling. Mol Pharmacol 2016 89(5): 521–540.
Song HQ, Xiang Kang,Jing Sun,ab Xiabin Jing,Zehua Wang, Lesan Yan,Ruogu Qi and Zheng M Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation. Chem Commun (Camb). 2016 2016 Feb 7;52(11):2281-3.
Wang P, Zhao J, Yang X, Guan S, Feng H, Han D, Lu J, Ou B, Jin R, Sun J, Zong Y, Feng B, Ma J, Lu A, Zheng M. （通讯作者） PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization. Med Oncol 2015 32(12):264
Wangpu X, Yang X, Zhao J, Lu J, Guan S, Lu J, Kovacevic Z, Liu W, Mi L, Jin R, Sun J, Yue F, Ma J, Lu A, Richardson DR, Wang L, Zheng M. （通讯作者） The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44. Oncotarget. 2015 20;6(32):33893-911.
Song H, Li W, Qi R, Yan L, Jing X, Zheng M （通讯作者）, Xiao H. Delivering a photosensitive transplatin prodrug to overcome cisplatin drug resistance. Chem Commun (Camb). 2015 21;51(57):11493-5.
Lu J, Jiao T, Li Y, Liu Y, Wang Y, Wang Y, Zheng M （通讯作者）, Lu X. Heading toward the right direction--solution package for endoscopic submucosal tunneling resection in the stomach. PLoS One. 2015 23;10(3)
Liu W, Yue F, Zheng M （通讯作者）, Merlot A, Bae DH, Huang M, Lane D, Jansson P, Lui GY, Richardson V, Sahni S, Kalinowski D, Kovacevic Z, Richardson DR. The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget. 2015 20;6(11):8851-74.
Jin R, Liu W, Menezes S, Yue F, Zheng M （通讯作者）, Kovacevic Z, Richardson DR. The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci. 2014 15;127(Pt 14):3116-30
Lu J, Jiao T, Zheng M （通讯作者）, Lu X. Endoscopic resection of submucosal tumors in muscularis propria: the choice between direct excavation and tunneling resection. Surg Endosc. 2014 28(12):3401-7
Quan Y, Jin R, Huang A, Zhao H, Feng B, Zang L, Zheng M. （通讯作者） Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1. Cancer Biol Ther. 2014 15(7):878-87.
Haiqin Song, Haihua Xiao, Minhua Zheng （通讯作者）, * ab Ruogu Qi, cd Lesan Yan cdand Xiabin Jing * A biodegradable polymer platform for co-delivery of clinically relevant oxaliplatin and gemcitabine Journal of Materials Chemistry B 2014 2, 6560–6570
Lu J, Zheng M （通讯作者）, Jiao T, Wang Y, Lu X. Transcardiac tunneling technique for endoscopic submucosal dissection of gastric fundus tumors arising from the muscularis propria. Endoscopy. 2014 46(10):888-92.
Zhao H, Dong T, Zhou H, Wang L, Huang A, Feng B, Quan Y, Jin R, Zhang W, Sun J, Zhang D, Zheng M. （通讯作者） miR-320a suppresses colorectal cancer progression by targeting Rac1. Carcinogenesis. 2014 35(4):886-95
Huang A, Zhao H, Quan Y, Jin R, Feng B, Zheng M. （通讯作者） E2A predicts prognosis of colorectal cancer patients and regulates cancer cell growth by targeting miR-320a. PLoS One. 2014 13;9(1)
Lu A, Wangpu X, Han D, Feng H, Zhao J, Ma J, Qu S, Chen X, Liu B, Zheng M. （通讯作者） TXNDC9 expression in colorectal cancer cells and its influence on colorectal cancer prognosis. Cancer Invest. 2013 30(10):721-6.
Huang A, Zhou H, Zhao H, Quan Y, Feng B, Zheng M. （通讯作者） TMPRSS4 correlates with colorectal cancer pathological stage and regulates cell proliferation and self-renewal ability. Cancer Biol Ther. 2013 1;15(3):297-304.
Mao Z, Sun J, Feng B, Ma J, Zang L, Dong F, Zhang D, Zheng M. （通讯作者） The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. Med Oncol. 2013 30(4):712
Zou X, Feng B, Dong T, Yan G, Tan B, Shen H, Huang A, Zhang X, Zhang M, Yang P, Zheng M （通讯作者）, Zhang Y. Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics 2013 6;94:473-85.
Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M （通讯作者）, Kovacevic Z, Richardson DR. Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway. Mol Pharmacol. 2013 83(2):454-69.
Huang A, Zhou H, Zhao H, Quan Y, Feng B, Zheng M. （通讯作者） High expression level of TMPRSS4 predicts adverse outcomes of colorectal cancer patients. Med Oncol. 2013 30(4):712
Zhao H, Huang A, Li P, Quan Y, Feng B, Chen X, Mao Z, Zhu Z, Zheng M. （通讯作者） E2A suppresses invasion and migration by targeting YAP in colorectal cancer cells. J Transl Med 2013 26;11:317.
Feng B, Sun J, Ling TL, Lu AG, Wang ML, Chen XY, Ma JJ, Li JW, Zang L, Han DP, Zheng MH （通讯作者） Laparoscopic complete mesocolic excision (CME) with medial access for right-hemi colon cancer: feasibility and technical strategies. Surg Endosc 2012 26(12):3669-75
Zhou HM, Feng B, Zhao HC, Zheng MH （通讯作者） Antitumor effects of hyperthermic CO2 pneumoperitoneum on human gastric cancer cells. Asian Pac J Cancer Prev 2012 13(1):117-22
Feng B, Dong TT, Wang LL, Zhou HM, Zhao HC, Dong F, Zheng MH （通讯作者） Colorectal cancer migration and invasion initiated by microRNA-106a. PLoS One 2012 7(8):43452-43452
Zhang Z, Wang J, Shen B, Peng C, Zheng M （通讯作者） The ABCC4 gene is a promising target for pancreatic cancer therapy Gene 2012 ;491(2):194-9
Zhu QL, Feng B, Lu AG, Wang ML, Hu WG, Li JW, Mao ZH, Zheng MH （通讯作者） Laparoscopic low anterior resection for rectal carcinoma: complications and management in 132 consecutive patients World J Gastroenterol 2012 16(36):4605-10
Lu A, Wangpu X, Han D, Feng H, Zhao J, Ma J, Qu S, Chen X, Liu B, Zheng MH （通讯作者） TXNDC9 Expression in Colorectal Cancer Cells and Its Influence on Colorectal Cancer Prognosis. Cancer Invest 2012 30(10):721-6
Zhou HM, Dong TT, Wang LL, Feng B, Zhao HC, Fan XK, Zheng MH （通讯作者） Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition World J Gastroenterol 2012 18(21):2640-8
Chen Z, Zhang D, Yue F, Zheng M （通讯作者）, Kovacevic Z, Richardson DR The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem 2012 287(21):17016-28
Dong TT, Zhou HM, Wang LL, Feng B, Lv B, Zheng MH （通讯作者） Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines. Ann Surg Oncol 2011 18(6):1797-804
Cai W, Wang ZT, Wu L, Zhong J, Zheng MH （通讯作者） Laparoscopically assisted resections of small bowel stromal tumors are safe and effective. J Dig Dis 2011 12(6):443-7
Ma JJ, Hu WG, Zang L, Yan XW, Lu AG, Wang ML, Li JW, Feng B, Zhong J, Zheng MH （通讯作者） Laparoscopic gastric resection approaches for gastrointestinal stromal tumors of stomach. Surg Laparosc Endosc Percutan Tech 2011 21(2):101-5
Zheng MH （通讯作者）, Feng B, Hu CY, Lu AG, Wang ML, Li JW, Hu WG, Zang L, Mao ZH, Dong TT, Dong F, Cai W, Ma JJ, Zong YP, Li MK. Long-term outcome of laparoscopic total mesorectal excision for middle and low rectal cancer. Minim Invasive Ther Allied Technol 2010 19(6):329-39
Zang L, Hu WG, Yan XW, Zhang T, Ma JJ, Ye Q, Feng B, Wang ML, Lu AG, Li JW, Zhong J, Zheng MH （通讯作者） Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A 2010 20(6):521-5
Feng B, Zhu QL, Xia Y, Lu AG, Wang ML, Li JW, Hu WG, Zang L, Mao ZH, Dong F, Ma JJ, Zheng MH （通讯作者） Direct and indirect costs and long-term survival of laparoscopic anterior resection for rectal cancer. Med Sci Monit 2010 16(12):97-102
Ye Q, Wang TF, Peng YF, Xie J, Feng B, Qiu MY, Li LH, Lu AG, Liu BY, Zheng MH Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. Oncol Rep 2010 23(2):429-36
Li LH, Zheng MH, Luo Q, Ye Q, Feng B, Lu AG, Wang ML, Chen XH, Su LP, Liu BY P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. Int J Oncol 2010 37(4):951-62

上海交通大学医学院导师教师师资介绍简介-郑民华

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