导师姓名： 朱正纲 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海交通大学医学院附属瑞金医院、上海消化外科研究所
邮编： 200025 邮箱地址： zzg1954@hotmail.com

研究方向 (点击浏览详细信息)
胃肠道肿瘤综合治疗

社会任职
中华医学会外科学分会委员
上海医学会副会长
中国外科医师协会(CCS)副主任委员
上海市疾病控制中心胃癌专业委员会主任委员
中国抗癌协会常务理事、全国胃癌专业委员会名誉主任委员
中国医师协会常委
中国医师协会外科医师分会副主委、上消化道外科医师专委会主任委员
上海市抗癌协会副理事长兼胃肠道肿瘤专业委员会主任委员
上海市外科学会名誉主任委员
The American College of Surgeon (FACS)委员
中华医学会外科学分会胃肠外科学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
14DZ** 上海市胃肿瘤重点实验室 上海市科学技术委员会 2014-07~2017-06 150万元 课题负责人
2012ZD005 上海市重中之重重点学科—胃肠肿瘤 教育部 2012-11~2015-10 200万元 课题负责人
12zz102 胃癌细胞中miR-126表达的分子调控机制研究 市教委重点 2012-01~2014-12 16万元 课题负责人
10JC** 胃癌早期诊断的血清标志物筛查及其临床前研究 市科委 2011-10~2013-09 30万元 主要责任人
** Gli1在胃癌中的作用及其表观遗传学调控研究 国家自然科学基金 2011-01~2013-12 33万元 主要责任人
09DZ** 上海市胃肿瘤重点实验室 市科委 2009-09~2011-08 200万元 主要责任人
09DZ** 胃癌早期诊断与治疗的多中心研究 市科委 2009-07~2012-06 400万元 主要责任人
** SerpinB5促进胃癌发生发展作用机制的研究 国家自然基金委,面上项目 2008-01~2010-12 29万元 课题负责人
07JC14041 胃癌早期诊治的基础研究 上海市科委,重点基础研究 2007-12~2009-11 120万元 课题负责人
2006AA02A402(A02) 胃癌规范化标本库的建立及预后判断分子标志谱的鉴定 2007-01~2010-12 75万元 子课题负责人
LJ06043 胃肠道肿瘤的早期诊断和综合治疗的临床与基础研究 上海市卫生局,医学领军人才 2006-01~2010-12 50万元 课题负责人
肿瘤相关基因MPS-1调控下游基因的筛选及其功能研究 国家教育部,博士点基金 2006-01~2008-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang J, Chen X, Su L, Li P, Cai Q, Liu B, Wu W, Zhu Z. （通讯作者） MicroRNA-126 inhibits cell proliferation in gastric cancer by targeting LAT-1. Biomed Pharmacother. 2015 72:66-73.
Huang J, Zhang L, He C, Qu Y, Li J, Zhang J, Du T, Chen X, Yu Y, Liu B, Zhu Z. （通讯作者） Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer. Oncotarget. 2015 6(3):1652-65.
Chang Q, Zhang L, He C, Zhang B, Zhang J, Liu B, Zeng N, Zhu Z. （通讯作者） HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif. Oncotarget. 2015 2015 Oct 23.
Li P, Shan JX, Chen XH, Zhang D, Su LP, Huang XY, Yu BQ, Zhi QM, Li CL, Wang YQ, Tomei S, Cai Q, Ji J, Li JF, Chouchane L, Yu YY, Sun FZ, Xu ZH, Liu BY, Zhu ZG. （通讯作者） Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res. 2015 25:588-603.
J. Zhang, J. Y. Huang, Y. N. Chen, F. Yuan, H. Zhang, F. H. Yan, M. J. Wang, G. Wang, M. Su, G Lu, Y. Huang, H. Dai, J. Ji, J. Zhang, J. N. Zhang, Y. N. Jiang, S. J. Chen （通讯作者）, Z. G. Zhu, Y. Y. Yu Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma. Sci Rep. 2015 5: 13750.
Wang J, Su L, Chen X, Li P, Cai Q, Yu B, Liu B, Wu W, Zhu Z. （通讯作者） MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF. Biomed Pharmacother. 2014 68(5):557-64.
Liu W, Yang Q, Liu B, Zhu Z. （通讯作者） Serum proteomics for gastric cancer. Clin Chim Acta. 2014 431C:179-184.
Huang J, Li J, Qu Y, Zhang J, Zhang L, Chen X, Liu B, Zhu Z. （通讯作者） The expression of claudin 1 correlates with β-catenin and is a prognostic factor of poor outcome in gastric cancer. Int J Oncol. 2014 44(4):1293-301.
Chen Y, Zhu Z （通讯作者）, Yu Y. Novel methodologies in analysis of small molecule biomarkers and living cells. Tumour Biol. 2014 35(10):9469-77.
Zhao Y, Huang J, Zhang L, Qu Y, Li J, Yu B, Yan M, Yu Y, Liu B, Zhu Z. （通讯作者） MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. BMC Cancer. 2014 14:34.
Wang J, Chen X, Li P, Su L, Yu B, Cai Q, Li J, Yu Y, Liu B, Zhu Z. （通讯作者） CRKL promotes cell proliferation in gastric cancer and is negatively regulated by miR-126. Chem Biol Interact. Chem Biol Interact. 2013 206(2):230-238.
Li Q, Gao Y, Xu ZG, Jiang H, Yu YY, Zhu ZG. （通讯作者） Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer. Clin Exp Med. 2013 13(1):11-9.
Liu Y, Ye Z, Xi W, Ma T, Shi M, Yang L, Zhu Z （通讯作者）, Zhang J. Efficacy and safety of docetaxel plus oxaliplatin and capecitabine in the first line treatment of advanced gastric adenocarcinoma. Biomed Res Int. 2013 2013:971096.
Li P, Chen X, Su L, Li C, Zhi Q, Yu B, Sheng H, Wang J, Feng R, Cai Q, Li J, Yu Y, Yan M, Liu B, Zhu Z. （通讯作者） Epigenetic Silencing of miR-338-3p Contributes to Tumorigenicity in Gastric Cancer by Targeting SSX2IP. PLoS One. 2013 8(6):e66782.
Zhao Y., Li CL., Wang M.,Su LP.,Qu Y.,Li JF, Yu BQ., Yan M.,Yu YY., Liu BY.,Zhu ZG. （通讯作者） Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer. PLoS One. 2013 8(7):e69756
Wang J, Chen X, Su L, Li P, Liu B, Zhu Z. （通讯作者） LAT-1 functions as a promotor in gastric cancer associated with clinicopathologic features. Biomed Pharmacother. 2013 67(8):693-9.
Zhao J, Li P, Feng H, Wang P, Zong Y, Ma J, Zhang Z, Chen X, Zheng M, Zhu Z （通讯作者）, Lu A. Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration, invasion, adhersion and angiogenesis. J Transl Med. 2013 11:288.
Li C, Li JF, Cai Q, Qiu QQ, Yan M, Liu BY, Zhu ZG. （通讯作者） MiRNA-199a-3p: A Potential Circulating Diagnostic Biomarker for Early Gastric Cancer. J Surg Oncol. 2013 108(2):89-92.
Tang X, Li J, Yu B, Su L, Yu Y, Yan M, Liu B, Zhu Z. （通讯作者） Osteopontin splice variants differentially exert clinicopathological features and biological functions in gastric cancer. Int J Biol Sci. 2013 9(1):55-66.
Lei KF, Liu BY, Jin XL, Guo Y, Ye M, Zhu ZG. （通讯作者） Prognostic value of nuclear maspin expression for adjuvant 5-fluorouracil-based chemotherapy in advanced gastric cancer. Exp Ther Med. 2012 3(6):993-998.
Liu WT, Liu BY, Cai Q, Li JF, Chen XH, Zhu ZG. （通讯作者） Proteomic identification of serum biomarkers for gastric cancer using multi-dimensional liquid chromatography and 2D differential gel electrophoresis. Clin Chim Acta. 2012 413(13-14):1098-106.
Ke-Feng Lei, Bing-Ya Liu, Xiao-Qing Zhang, Xiao-Long Jin, Yan Guo, Min Ye, Zheng-Gang Zhu. （通讯作者） Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors. Exp Ther Med. 2012 3(1):109-116.
Yao XX, Sah BK, Yan M, Chen MM, Zhu ZG. Radical gastrectomy with combined splenectomy: unnecessary. Hepatogastroenterology. 2011 25(107-108):1067-70.
Li C, Mei JW, Yan M, Chen MM, Yao XX, Yang QM, Zhou R, Zhu ZG. Nasogastric Decompression for Radical Gastrectomy for Gastric Cancer: A Prospective Randomized Controlled Study. Dig Surg. 2011 28(3):167-172.
Zheng YN, Chen L, Li JF, Yu BQ, Su LP, Chen XH, Yu YY, Yan M, Liu BY, Zhu ZG. Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis. Clinical Biochemistry 2011 44:1405-11.
Jiang JL, Liu W, Guo XB, Zhang R, Zhi Q, Zhang JN, Chen XH, Li J, Zhang J, Gu QL, Liu BY, Zhu ZG, Yu YY. IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer. Oncogene. 2011 30:4498-4508.
Yan C （共同第一作者）, Zhu ZG, Yan M, Zhang H, Pan ZL, Chen J, Xiang M, Chen MM, Liu BY, Yin HR, Lin YZ. Size of the largest lymph node visualized on multi-detector-row computed tomography (MDCT) is useful in predicting metastatic lymph node status of gastric cancer. J Int Med Res. 2010 38(1):22-33.
Li C （共同第一作者）, Yan M, Chen J, Xiang M, Zhu ZG, Yin HR, Lin YZ. Surgical resection with hyperthermic intraperitoneal chemotherapy for gastric cancer patients with peritoneal dissemination. J Surg Oncol. 2010 102(5):361-5.
Li C, Yan M, Chen J, Xiang M, Zhu ZG, Yin HR, Lin YZ Survival benefit of non-curative gastrectomy for gastric cancer patients with synchronous distant metastasis J Gastrointest Surg 2010 14(2):282-8
Feng RH, Chen XH, Yu YY, Su LP, Yu BQ, Li JF, Cai Q, Yan M, Liu BY, Zhu ZG. miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Letters 2010 298:50-63.
Guo X, Liu W, Pan Y, Ni P, Ji J, Guo L, Zhang J, Wu J, Jiang J, Cheng X, Cai Q, Li J, Zhang J, Gu Q, Liu B, Zhu Z, Yu Y. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma Oncogene 2010 29(27):3908-20
Sah BK, Chen MM, Yan M, Zhu ZG Reoperation for early postoperative complications after gastric cancer surgery in a Chinese hospital World J Gastroenterol 2010 16(1):98-103
Birendra KS, Chen MM, Peng YB, Feng XJ, Yan M, Liu By, Fan QS, Zhu ZG. Does testosterone prevent early postoperative complications after gastrointestinal surgery? World J Gastroenterol 2009 15(44):5604-5609
Sah BK, 陈明敏,燕敏,朱正纲 Gastric cancer surgery: Billroth I or Billroth II for distal gastrectomy? BMC Cancer 2009 9:428-435
Sah BK, Zhu ZG, Chen MM, Xiang M, Chen J, Yan M, Lin YZ Effect of surgical work volume on postoperative complication: superiority of specialized center in gastric cancer treatment Langenbecks Arch Surg 2009 394(1):41-7
Li C, Yan M, Chen J, Xiang M, Zhu ZG, Lin YZ Prognostic influence of sub-stages according to pTNM categories in patients with stage IV gastric cancer J Surg Oncol 2009 99:324-328
Sah BK, Zhu ZG, Wang XY, Yang QM, Chen MM, Xiang M, Chen J, Yan M. Post-operative complications of gastric cancer surgery: female gender at high risk. Eur J Cancer Care (Engl) 2009 18(2):202-8
Yan C, Zhu ZG, Yan M, Zhang H, Pan ZL, Chen J, Xiang M, Chen MM, Liu BY, Yin HR, Lin YZ. Value of multidetector-row computed tomography in the preoperative T and N staging of gastric carcinoma: a large-scale Chinese study. J Surg Oncol 2009 100(3):205-14
Hao Y, Yu Y, Wang L, Yan M, Ji J, Qu Y, Zhang J, Liu B, Zhu Z* IPO-38 is identified as a novel serum biomarker of gastric cancer based on clinical proteomics technology. J Proteome Res. 2008 7(9):3668-77
Liu W, Liu B, Xin L, Zhang Y, Chen X, Zhu Z*, Lin Y. Down-regulated expression of complement factor I: A potential suppressive protein for gastric cancer identified by serum proteome analysis. Clin Chim Acta. 2007 377(1-2):119-26.
Wang YW, Qu Y, Li JF, Chen XH, Liu BY, Gu QL, Zhu ZG*. In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity. Clin Cancer Res. 2006 12(16):4965-73