导师姓名： 赵任 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zhaorensurgeon@aliyun.com/rjzhaoren@139.com
邮编： rjzhaoren@139.com 邮箱地址： zhaorensurgeon@aliyun.com

研究方向 (点击浏览详细信息)
结直肠肿瘤基础研究与微创临床诊疗

社会任职
中国医师协会结直肠肿瘤专业委员会单孔腹腔镜学组主任委员
上海市抗癌协会副理事长
Fellow of the American College of Surgeons（美国外科学院院士），中国医师协会外科学分会结直肠专业委员会常委，中国医师协会肛门直肠疾病分会常委，中国抗癌协会大肠癌专委会委员，上海市医学会普外科专业委员会委员、肛肠学组副组长，上海市抗癌协会大肠癌专业委员会副组长，上海医院协会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2019SY058 单孔腹腔镜技术在结直肠手术中应用及推广 上海市卫健委 2019-07~2022-06 80万元 课题负责人
18DZ** 溶瘤病毒抗肿瘤药物安柯瑞上市后临床再评价研究 上海市科学技术委员会 2018-10~2021-10 60万元 课题负责人
18ZR** Cortactin蛋白脯氨酸富集结构域磷酸化修饰在结直肠癌肝转移中的作用与相关机制研究 上海市科学技术委员会 2018-06~2021-05 30万元 课题负责人
16CR3064B 减孔腹腔镜和单孔腹腔镜技术在结直肠恶性肿瘤中的临床研究 上海市申康中心市级医院临床技能与创新项目 2016-12~2019-06 30万元 课题负责人
上海市卫计委重点课题优化手术联合放疗治疗局部复发性直肠癌的应用研究 上海市卫计委重点课题 2016-01~2018-12 15万元 课题负责人
** 晚期结直肠癌患者化疗疗效预测 上海市科委项目 2014-06~2017-09 10万元 课题负责人
/ 伺机性筛查和减孔腹腔镜手术在结直肠肿瘤中的应用 上海市申康中心郊区三级医院临床能力建设项目 2013-10~2016-09 15万元 课题负责人
** cortactin及相关肌动蛋白装配在大肠癌休眠/增殖转换中的作用研究 国家自然基金委,面上项目 2013-01~2016-12 70万元 课题负责人
** cortactin差异表达与大肠癌转移的相关性研究 国家自然基金委,面上项目 2008-01~2010-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang Y, Ji X, Liu K, Shi Y, Wang C, Li Y, Zhang T, He Y, Xiang M, Zhao R. （通讯作者） Exosomal miR-200c-3p negatively regulates the migraion and invasion of lipopolysaccharide (LPS)-stimulated colorectal cancer (CRC) BMC Mol Cell Biol 2020 Jun 29;21(1):48.
Wang C, Feng H, Cheng X, Liu K, Cai D, Zhao R. （通讯作者） Potential Therapeutic Targets of B7 Family in Colorectal Cancer Front Immunol 2020 May 5;11:681.
Feng H, Jin Z, Liu K, Peng Y, Jiang S, Wang C, Hu J, Shen X, Qiu W, Cheng X, Zhao R. （通讯作者） Identification and validation of critical alternative splicing events and splicing factors in gastric cancer progression J Cell Mol Med 2020 2020 Sep 16.
Feng H, Liu K, Shen X, Liang J, Wang C, Qiu W, Cheng X, Zhao R. （通讯作者） Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5 + colorectal cancer Cell Death Dis 2020 Oct 24;11(10):916
Jiang Y, Liu K, Shi Y, Li Y, Ji X, Zhao R. （通讯作者） Correlation Research of Thymidine Synthase Expression in Circulating Tumor Cell and Clinical Characteristics of Colon Cancer Ann Clin Lab Sci 2020 Jul;50(4):439-446.
Jiang Y, Yan X, Liu K, Shi Y, Wang C, Hu J, Li Y, Wu Q, Xiang M, Zhao R. （通讯作者） Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods BMC Cancer 2020 2020 Oct 19;20(1):1012.
Rahmy S, Cheng X, Wang M, Feng H, Qiu W, Zhao R （通讯作者）, Lu X. Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice Biochem Biophys Res Commun 2020 May 7;525(3):614-619.
Cheng X, Jin Z, Ji X, Shen X, Feng H, Morgenlander W, Ou B, Wu H, Gao H, Ye F, Zhang Y, Peng Y, Liang J, Jiang Y, Zhang T, Qiu W, Lu X, Zhao R. （通讯作者） ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet-derived growth factor BB International Journal of Cancer 2019 2019 Jan 16. doi: 10.1002/ijc.32071.
Shi Y, Song Z, Gu Y, Zhang Y, Zhang T, Zhao R. （通讯作者） Short-Term Outcomes of Three-Port Laparoscopic Right Hemicolectomy Versus Five-Port Laparoscopic Right Hemicolectomy: With a Propensity Score Matching Analysis J Invest Surg 2019 Apr 4;1-6.
Jiang Y, Song Z, Cheng X, Liu K, Shi Y, Wang C, Li Y, Ji X, Zhao R. （通讯作者） Clinical and oncological outcomes of single-incision vs. conventional laparoscopic surgery for rectal cancer Surg Endosc 2019 Dec 19. doi: 10.1007/s00464-019-07317-5.
Jing X, Wang XJ, Zhang T, Zhu W, Fang Y, Wu H, Liu X, Ma D, Ji X, Jiang Y, Liu K, Chen X, Shi Y, Zhang Y, Shi M, Qiu W, Zhao R. （通讯作者） Cell-Cycle-Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Cancer Research 2019 2019 Sep 15;79(18):4650-4664
Feng S, Cheng X, Zhang L, Lu X, Chaudhary S, Teng R, Frederickson C, Champion MM, Zhao R, Cheng L, Gong Y, Deng H, Lu X. Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers. Proc Natl Acad Sci U S A(PNAS) 2018 2018 Oct 2;115(40):10094-10099
Wu HX, Cheng X, Jing XQ, Ji XP, Chen XZ, Zhang YQ, He YG, Liu K, Ye F, Sun HX, Gao HJ, Song ZJ, Wu H, Zhang XJ, Zhang T, Zhao R. （通讯作者） LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer Biochim Biophys Acta 2018 2018 Sep;1864(9 Pt B):2769-2784.
Cheng X, Feng H, Wu H, Jin Z, Shen X, Kuang J, Huo Z, Chen X, Gao H, Ye F, Ji X, Jing X, Zhang Y, Zhang T, Qiu W, Zhao R. （通讯作者） Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer Cancer Letters 2018 2018 Sep 1;431:105-114
Jing X, Wu H, Cheng X, Chen X, Zhang Y, Shi M, Zhang T, Wang X, Zhao R. （通讯作者） MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer. Scand J Gastroenterol 2018 53(8):964-971.
Song Z, Li Y, Liu K, Jiang Y, Shi Y, Ji X, Zhang T, Wu H, Shi Y, Zhao R. （通讯作者） Clinical and oncologic outcomes of single-incision laparoscopic surgery for right colon cancer: a propensity score matching analysis. Surgical Endoscopy 2018 2018 Jul 24. doi: 10.1007/s00464-018-6370-2
Zhang Xiaojian ,Liu Kun ,Zhang Tao,Wang Zhenlei,Qin Xuan,Jing Xiaoqian,Wu Haoxuan,Ji Xiaopin,He Yonggang,Zhao Ren （通讯作者） Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway Oncotarget 2017 8（1）：1541~1554
Cheng X, Wu H, Jin ZJ, Ma D, Yuen S, Jing XQ, Shi MM, Shen BY, Peng CH, Zhao R （通讯作者）, Qiu WH. Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior Scientific Reports 2017 7(1):12362.
Zhao R# ,Cai Z,Li S,Cheng Y,Gao H,Liu F,Wu S,Liu S,Dong Y,Zheng L,Zhang W,Wu X,Yao X Expression and clinical relevance of epithelial and mesenchymal markers in circulating tumor cells from colorectal cancer Oncotarget 2017 8（6）：9293~9302
Yang LS ,Zhang XJ ,Xie YY,Sun XJ, Zhao R （通讯作者）,Huang QH SUMOylated MAFB promotes colorectal cancer tumorigenesis Oncotarget 2016 7（50）：83488~83501
Wu Huo ,Cheng Xi ,Ji Xiaopin ,He yonggang,Jing Xiaoqian,Wu Haoxuan,Zhao Ren （通讯作者） Cortactin contributes to the tumorigenicity of colorectal (*) cancer by promoting cell proliferation Oncology Reports 2016 36（6）：3497~3503
Deng Yanhong ,Chi Pan,Lan Ping,Wang Lei,Chen Weiqing,Cui Long,Chen Daoda,Cao Jie,Wei Hongbo,Peng Xiang,Huang Zonghai,Cai Guanfu,Zhao Ren,Huang Zhongcheng,Xu Lin,Zhou Hongfeng,Wei Yisheng,Zhang Hao,ZhengJian,Huang Yan,Zhou Zhiyang,Cai Yue,Kang Liang,Huang Meijin,PengJunsheng,Ren Donglin,Wang Jianping Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial Journal of Clinical Oncology 2016 34 (27）：3300
Wu Huo ,Jing Xiaoqian ,Cheng Xi ,He Yonggang,Hu Lei,Wu Haoxuan,Ye Feng,Zhao Ren （通讯作者） Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway Oncotarget 2016 7（45）：73402~73413
Wang Zhenlei ,Ma Bin,Ji Xiaopin,Deng Yang,Zhang Tao,Zhang Xiaojian,Gao Haoji,Sun Hanxing,Wu Haoxuan,Chen Xianze,Zhao Ren （通讯作者） MicroRNA (*) -378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF Cancer Cell International 2015 15：40
Jiang Yimei ,Ji Xiaopin,Zhao Shengguang,Jin Yening,Zhao Ren （通讯作者） Laparoscopic Resection with Intraoperative Radiotherapy for Local Advanced Rectal Cancer: A Preliminary Case Report JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 2013 23（3）：267~270
Ji X1, Li J, Zhu L, Cai J, Zhang J, Qu Y, Zhang H, Liu B, Zhao R （通讯作者）, Zhu Z. CHD1L promotes tumor progression and predicts survival in colorectal carcinoma. Journal of Surgical Research 2013 185(1):84-91
Yimei J, Ren Z （通讯作者）,Lu X,Huan Z, A comparison between the reference values of MRI and EUS and their usefulness to surgeons in rectal cancer Rev Med Pharmacol Sci 2012 16 (15): 2069-2077
Zhao Ren ,Zhu Jianwei,Ji Xiaopin,Cai Jianhua,Wan Fangjun,Li Qing,Zhong Baoliang,Tucker Steven,Wang Daoyuan, A Phase II Study of Irinotecan and Capecitabine for Patients with Unresectable Liver-only Metastases from Colorectal Cancer JAPANESE JOURNAL OF CLINICAL ONCOLOGY 2010 40（1）：10~16