导师姓名： Carola Vinuesa 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： carola.vinuesa@anu.edu.au or cpi.admin@anu.edu.au
邮编： 2601 邮箱地址： carola.vinuesa@anu.edu.au

研究方向 (点击浏览详细信息)
Understand disease pathogenesis genes and pathways of SLE to improve diagnosis and treatment

社会任职
澳大利亚科学院院士 Fellow Australian Academy of Science in 2015
自身免疫中心咨询委员会顾问-Baylor免疫学研究所炎症与基因组医学中心 Advisory Board, Autoimmunity Centre of Excellence; Baylor Institute for Immunology Research (BIIR) Centre for Inflammation & Genomic Medicine
澳大利亚国家卫生和医学研究委员会妇女健康和科学研究工作委员会成员 Member of NHMRC Women in Health and Science Research (WiHS) working committee
澳大利亚免疫学会成员 Member of the Australasian Society of Immunology
上海交通大学顾问教授
美国免疫学家协会会员 Member of the American Association of Immunologists

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** ROQUIN基因家族的罕见突变在罕见免疫炎症及自身免疫疾病发生发展中的作用 国自然面上项目 2019-01~2022-12 65万元 课题负责人
** 自噬相关基因功能突变的筛选鉴定及其在SAPHO综合征中的作用机制研究 国自然面上项目 2018-01~2021-12 65万元 课题参与人
Dissecting pathways leading to Type-1 interferon in Systemic Lupus Erythematosus NSFC Research Fund for International Young Scientists 2018-01~2019-12 37.98万元 课题参与人
804.001.16 鉴定系统性红斑狼疮的致病单基因／致病寡基因 学科建设与人才培养启动经费 2016-10~2019-12 1000万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Prabhu S, Cockburn IA,Vinuesa CG （通讯作者） HIV Immunogens: Affinity Is Key Immunity 2018 48(1):11-13
Papa I, Saliba D, Ponzoni M, Bustamante S, Canete PF, Gonzalez-Figueroa P, McNamara HA, Valvo S, Grimbaldeston M, Sweet RA, Vohra H, Cockburn IA, Meyer-Hermann M, Dustin ML, Doglioni C, Vinuesa CG. （通讯作者） TFH-derived dopamine accelerates productive synapses in germinal centres Nature 2017 547 (7663): 318-323
Gorosito Serran M,Tosello Boari J, Fiocca Vernengo F, Beccaria CG, Ramello MC, Bermejo DA, Cook AG, Vinuesa CG,Montes CL,Acosta Rodriguez EV, Gruppi A Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi Front Immunol 2017 8:1548
Vinuesa CG, Linterman MA, Yu D, MacLennan IC Follicular Helper T cells Annu Rev Immunol 2016 34:335-68
Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG （通讯作者） Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis Nat Commun 2015 6:6253
Pratama A, Srivastava M, Williams NJ, Papa I, Lee SK, Dinh XT, Hutlof A, Jordan MA, Zhao JL, Casellas R, Athanasopoulos V, Vinuesa CG （通讯作者） MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres Nat Commun 2015 6:6436
Jiang S, Shen N,Vinuesa CG （通讯作者） Posttranscriptional T cell gene regulation to limit T follicular helper cells and autoimmunity Curr Opin Immunol 2015 37:21-27
Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG （通讯作者）, Athanasopoulos V. Attenuation of AMPK signalling by ROQUIN promotes T follicular helper cell formation Elife 2015 4 e08698
Ueno H, Banchereau J, Vinuesa CG （通讯作者） Pathophysiology of T follicular helper cells in humans and mice Nat Immunol 2015 16(2):142-52
Ellyard JI, Jerjen R, Martin JL, Lee AY, Field MA, Jiang SH, Cappello J, Naumann SK, Andrews TD, Scott HS, Casarotto MG, Goodnow CC, Chaitow J, Pascual V, Hertzog P, Alexander SI, Cook MC, Vinuesa CG （通讯作者） Identification of a pathogenic variant in TREX1 in early-on-set cerebral systemic lupus erythematosus by Whole-exome sequencing Arthritis Rheumatol 2014 66(12):3382-6
He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG （通讯作者）, Mackay CR, Li Z, Yu D Circulating Precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure Immunity 2013 39(4):770-781
Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, Fitch J, Botelho NK, Chang PP, Hu X, Hogan JJ, Mana P, Bernal D, Korner HC, Yu D, Goodnow CC, Cook MC, Vinuesa CG （通讯作者） Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling Tfh cell accumulation and systemic inflammation Immunity 2013 38(4):669-80
Lee SK, Silva DG, Martin JL, Pratama A, Hu X, Chang PP, Walters G, Vinuesa CG （通讯作者） Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers Immunity 2012 37: 880-892
Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG （通讯作者） Dysregulation of immune homeostasis in autoimmune diseases Nature Medicine 2012 18: 42-47
Linterman MA,Pierson W, Lee SK, Kallies A, Kawamoto S, Rayner TF, Srivastava M, Divekar DP, Beaton L, Hogan JJ, Fagarasan S, Liston A, Smith KG, Vinuesa CG （通讯作者） Foxp3+ follicular regulatory T cells control the germinal center response Nature Medicine 2011 17: 975-982
Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG （通讯作者） Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor gens CD28 and ICOS Immunity 2009 30: 228-241
Vinuesa CG, Rigby RJ, Yu D Logic and extent of miRNA-mediated control of autoimmune gene expression International Reviews of Immunology 2009 28:112-138
Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG （通讯作者） Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA Nature 2007 450: 299-303
Vinuesa CG （通讯作者）, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, White B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity Nature 2005 435: 452-458
Goodnow CC, Sprent J, Fazekas B, Vinuesa CG （通讯作者） Cellular and genetic mechanisms of self tolerance and autoimmunity Nature 2005 435: 590-597