导师姓名： 牟姗 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 肾病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市浦东新区浦建路160号
邮编： 200127 邮箱地址： shan_mou@126.com

研究方向 (点击浏览详细信息)
急慢性肾脏疾病的防治

社会任职
上海中西医结合学会肾病专业委员会副主任委员兼秘书
中国中西医结合学会肾病青年委员会副主任委员
中华中医药学会肾病分会委员
上海市浦东新区医学会肾内科专委会主任委员
上海市医学会肾病分会副主任委员
上海市医师协会中西医结合科医师分会副会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SENP1调控CD4+T细胞分化及在缺血再灌注肾损伤中的作用及机制 国家自然基金面上项目 2020-01~2023-12 55万元 课题负责人
** SENP1通过HIF1α调控巨噬细胞极化在缺血再灌注肾损伤中的作用及机制 国家自然基金面上项目 2018-01~2021-12 55万元 课题负责人
16XD** 基于KIM-1调控巨噬细胞 功 能探索黄芪防治急性肾损伤后肾纤维化的机制研究 上海市科技委员会上海市优秀学术带头人 2016-05~2019-04 40万元 课题负责人
** 黄芪甲苷调控Th17和Treg细胞分化防治肾损伤的机制研究 国家自然基金面上项目 2016-01~2019-12 68.4万元 课题负责人
** 急性肾损伤后肾纤维化小鼠模型的构建研究 上海市科委项目资助 2014-07~2016-06 40万元 课题负责人
2014DFT30090 急性肾损伤防治的超声集成技术评价体系的建立和应用 港澳台科技合作专项项目 2014-04~2017-04 100万元 课题负责人
** 基于内源性KIM-1/TIM-4 通路探讨黄芪甲苷防治肾纤维化的机制 国家自然基金面上项目 2014-01~2017-12 73万元 课题负责人
益气通络法防治急性肾损伤后肾脏纤维化的前瞻性研究 上海市科委中医引领项目 2012-10~2015-09 10万元 课题负责人
** 从黄芪干预肾纤维化的分子机制探讨“久病入络”的理论基础 国家自然基金 2012-01~2014-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yao Xu, Xiao Dong Yuan, Jia Jin Wu, Ruo Yang Chen, Lei Xia, Ming Zhang, Cong Hui Han, Shan Mou （通讯作者） The N6-methyladenosine mRNA Methylase METTL14 Promotes Renal Ischemic Reperfusion Injury via Suppressing YAP1 J Cell Biochem 2020 121 (1), 524-533
Tian L, Shao X,Xie Y,Wang Q,Che X, Zhang M, Xu W, Xu Y, Ni Z, Mou S （通讯作者） Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway Cell Physiol Biochem 2017 41 2 769~783
Wei Yan, Yao Xu, Yanhong Yuan, Lei Tian, Qin Wang, Yuanyuan Xie, Xinghua Shao, Ming Zhang, Zhaohui Ni, Shan Mou （通讯作者） Renoprotective Mechanisms of Astragaloside IV in Cisplatin-Induced Acute Kidney Injury Free Radic Research 2017 51 (7-8), 669-683
Wu H, Huang T, Ying L, Han C, Li D, Xu Y, Zhang M, Mou S （通讯作者）, Dong Z MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis Cell Physiol Biochem 2016 40 6 1692~1705
Yuan Y, Wang C, Shao X, Wang Q, Che X, Zhang M, Xie Y, Tian L, Ni Z, Mou S （通讯作者） Urinary retinol-binding protein as a risk factor of poor prognosis in acute-on-chronic renal injury J Nephrol 2016 Jul 7
Xie Y, Wang Q,Wang C, Qi C, Ni Z, Mou S （通讯作者） igh urinary excretion of kidney injury molecule-1 predicts adverse outcomes in acute kidney injury: a case control study Crit Care 2016 20 1 286
Tian L, Shao X, Xie Y, Wang L, Wang Q, Che X, Ni Z, Mou S. （通讯作者） The long-term efficacy and safety of immunosuppressive therapy on the progression of IgA nephropathy: a meta-analysis of controlled clinical trials with more than 5-year follow-up. Expert Opin Pharmacother. 2015 16(8):1137-47.
Yuan Y, Che X, Ni Z, Zhong Y, Qi Y, Shao X, Wang Q, Cao L, Zhang M, Xie Y, Qi C, Tian L, Mou S （通讯作者） Association of Relapse with Renal Outcomes under the Current Therapy Regimen for IgA Nephropathy: A Multi-Center Study PLoS One 2015 10(9):e**
Xu Y, Xie Y, Shao X, Ni Z, Mou S. （通讯作者） L-FABP: A novel biomarker of kidney disease. Clin Chim Acta. . 2015 20;445:85-90
Che X, Wang Q, Xie Y, Xu W, Shao X, Mou S （通讯作者）, Ni Z. Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2015 464(4):1260-6
Yuan Y, Wang Q, Ni Z, Che X, Cao L, Shao X, Zhang M, Xie Y, Qi C, Zhou W, Tian L, Mou S. （通讯作者） Long-term kidney survival analyses in IgA nephropathy patients under steroids therapy: a case control study. J Transl Med. 2015 13:186
Wang Q, Shao XH, Xu WJ, Qi CJ, Gu LY, Ni ZH, Mou S （通讯作者） Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells Ren Fail 2014 36(3):400-6
Xie Y, Xue W, Shao X, Che X, Xu W, Ni Z, Mou S （通讯作者） Analysis of a Urinary Biomarker Panel for Obstructive Nephrology and Clinical Outcomes Plos One 2014 9(11):e112865
Xie YY, Xu WJ, Wang Q, Shao XH, Ni ZH, Mou S （通讯作者） Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy Biomarkers Med 2014 8(4)：543–556
Che X, Xie Y, Wang C, Wang Q, Zhang M, Qi C, Ni Z, Mou S （通讯作者） Blood HCO3- concentration predicts the long-term prognosis of acute kidney injury patients Biomarkers in Medicine 2014 8(10):1219-26
Xue W, Xie YY, Wang Q, Xu WJ, Mou S （通讯作者） Diagnostic performance of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for acute kidney injury in an obstructive nephropathy patient Nephrology 2014 19:186–194
Ni Z, Yuan Y, Wang Q, Cao L, Che X, Zhang M, Xie Y, Qi C, Mou S （通讯作者） Time-averaged albumin predicts the long-term prognosis of IgA nephropathy patients who achieved remission Journal of Translational Medicine 2014 10;12(1):194
Xu W, Shao X, Tian L, Gu L, Zhang M, Wang Q, Wu B, Wang L, Yao J, Xu X, Mou S （通讯作者）, Ni Z Astragaloside IV Ameliorates Renal Fibrosis via the Inhibition of Mitogen-Activated Protein Kinases and Antiapoptosis In Vivo and In Vitro Journal of Pharmacology and Experimental Therapeutics 2014 350(3):552-562
Shao XH, Tian L, Xu WJ, Zhang Z, Wang CL, Qi CJ, Mou S （通讯作者） Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-Analysis PLoS ONE 2014 9(1): e84131
Wang Q, Mou S （通讯作者）, Xu W, Qi C, Ni Z. Predicting mortality in microscopic polyangiitis with renal involvement: a survival analysis based on 64 patients. Ren Fail. 2013 35(1):82-87.
Mou S, Li J, Yu Z, Wang Q, Ni Z. Keto acid-supplemented low-protein diet for treatment of adult patients with hepatitis B virus infection and chronic glomerulonephritis. J Int Med Res. 2013 41(1):129-137.
Mou S, Wang Q, Fang W, Lin A, Shi B, Cao L, Zhou W, Qian J, Ni Z Change in cardiovascular disease status in peritoneal dialysis patients: a 5-year single-center experience Ren Fail 2012 34(1):28-34
Qin Wang, Shan Mou （通讯作者）, Weijia Xu, Chaojun Qi and Zhaohui Ni Predicting Mortality in Microscopic Polyangiitis with Renal Involvement:A Survival Analysis Based on 64 Patients Ren Fail 2012 35(1):82-7
Mou S, Wang Q, Li J, Shi B, Ni Z Urinary excretion of liver-type fatty acid-binding protein as a marker of progressive kidney function deterioration in patients with chronic glomerulonephritis Clin Chim Acta 2012 413(1-2):187-91
Mou S, Wang Q, Liu J, Che X, Zhang M, Cao L, Zhou W, Ni Z Prevalence of non-diabetic renal disease in patients with type 2 diabetes Diabetes Res Clin Pract 2010 87(3):354-9