导师姓名： 沈节艳 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： shenjieyan@renji.com
邮编： 200127 邮箱地址： dr_jyshen@sina.cn

研究方向 (点击浏览详细信息)
肺动脉高压、冠心病的临床研究

社会任职
中华医学会心血管病分会肺血管组副组长。上海医学会心血管病分会第十届、十一届、十二届委员兼肺循环学组组长。全国心血管疾病介入诊疗技术培训项目培训基地导师。中国冠脉复杂病变PCI先锋训练营培训导师。中国医师协会心脏重症专家委员会常委。中国医师协会心血管内科医师分会肺血管组副组长。上海市肺栓塞和静脉血栓防治联盟常委。2006 年加入美国国际肺高压协会，任临床研究专员（PHA-PHCR）。同年被录入美国的亚洲名人录（Who’s who in Asia）。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 肺动脉高压中miR-125a-5p-增强子-FPR1/2通路调控右心肥厚的机制研究 国家级 2020-01~2023-12 55万元 课题负责人
2017PYM03 肺动脉高压中miR-133通过cdc42调控右心肥厚的机制研究 院级 2017-11~2020-10 15万元 课题负责人
NSFS-122 肺动脉高压中miR-125a-5p调控TGF-β1介导的肺血管重塑的机理研究 国家级 2016-01~2019-12 60万元 课题负责人
RJKY15-06 结缔组织病相关性肺动脉高压的临床研究 结缔组织病-15横向 2015-01~2017-12 9.39万元 课题负责人
2011BAI11B15 肺循环疾病及其心功能的研究 国家十二.五科技攻关项目 2011-03~2015-12 10万元 课题参与人
** 阿司匹林对肺动脉高压的作用机制研究 上海市卫生局,局级课题 2008-01~2009-12 3万元 课题负责人
2006BAI01A07 提高肺动脉 高压诊治水平的研究 国家十一.五科技攻关项目 2007-01~2008-12 8万元 课题参与人
06HX21016 万他维治疗中国原发性（特发性）肺动脉高压的临床研究 横向课题 2006-09~2008-08 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiang Zhang,Xueming Zhang,Jieyan Shen （通讯作者）,.. Effects of Fasudil on Patients with Pulmonary Hypertension Associated with Left Ventricular Heart Failure with Preserved Ejection Fraction: A Prospective Intervention Study. Can Respir J. 2018 2018 Mar 26;2018:**.
Zongye Cai, Jian Li, Jieyan Shen （通讯作者） MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-beta1 and IL-6/STAT3 signaling pathways. Experimental & molecular medicine. 2018 2018;50(4):45
JIan Li,Menghui Yang,Qi Zhuang,Jieyan Shen （通讯作者） Prevalence and prognosis of portopulmonary hypertension in 223 liver transplant recipients. Canadian Respiratory Journal 2018 Article ID **,
Ling-yue Sun, Zong-ye Cai, Jun Pu, Jian Li,Jie-yan Shen （通讯作者）, Cheng-de Yang, and Ben He1 5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77 Inflammation, 2017 40(3):
Jie-yan Shen, Zong-ye Cai, Ling-yue Sun, Cheng-de Yang, Ben He The Application of Intravascular Ultrasound to Evaluate Pulmonary Vascular Properties and Mortality in Patients with Pulmonary Arterial Hypertension J Am Soc Echocardiogr 2016 29:158-65
Sun LY, Zhao H, Kang Y, Shen XD, Cai ZY, Shen JY(Corresponding author) （通讯作者）, Two-dimensional echocardiography in the assessment of long-term prognosis in patients with Pulmonary Arterial Hypertension PloS one. 2014 2014;9:e114443
Zeng WJ, Xiong CM, Zhao L, Shan GL, Liu ZH, Xue F, Gu Q, Ni XH, Zhao ZH, Cheng XS, Wilkins MR, He JG,Wang GY, Cao H, Zhou DX, Zhang GC, Zhu XY, Zhang DZ, Shen JY, Chen C, Huang SA, Wang DJ, Wang LM, Wu GQ, Yang YH, Wang LH, Wu H, Cheng ZZ, Ji YQ, Tian HY, Atorvastatin in pulmonary arterial hypertension (APATH) study Eur Respir J, 2012 40(1):67-74
Shen LH, Wan F , Shen L, Ding S,Gong XR,Qiao ZQ,Du YP,Song W,Shen JY ,Jin SX,Pu J,Yao TB,Jiang LS,Li WZ,Zhou GW ,Liu SW,Han YL ,He B Pharmacoinvasive therapy for ST elevation myocardial infarction in China: a pilot study J Thromb Thrombolysis 2012 33(1):101–108
Xiong CM, Lu XL, Shan GL, Wu BX, Zhu XY, Wu GH, Zeng XF, Guo T, Liu ZH, Ni XH, Cheng XS, Gu Q, Zhao ZH, Tian HY, Li WM, Zhang DZ, Zhang C, Li MT, Liu HM, Guo YJ, Shen JY, Zhang WJ, Liu S, Zhou DX, Bao CD, Huang SA, Chen JY, Wu WF, Huang K, Li CL, Wang LH, Oral sildenafil therapy for Chinese patients with pulmonary arterial hypertension: a multicenter study J Clin Pharmacol, 2012 52(3):425-31
Jing ZC, Yu ZX, Shen JY, Wu BX, Xu KF, Zhu XY, Pan L, Zhang ZL, Liu XQ, Zhang YS, Jiang X, Galiè N Vardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled study Am J Respir Crit Care Med, 2011 183(12):1723-9
PU J, SHAN PR, DING S, QIAO ZQ, JIANG LS, SONG W, DU YP,SHEN JY, SHEN LH, JIN SX,HE B Factors affecting thrombolysis in myocardial infarctionmyocardial perfusion frame count: insights of myocardialtissue-level reperfusion from a novel index for assessingmyocardial perfusion Chinese Medical Journal 2011 124(6):873-878
Shen L, Shen JY(co-first author) （共同第一作者）, Pu J, He B Aspirin Attenuates Pulmonary Arterial Hypertension in Rats by Reducing Plasma 5-Hydroxytryptamine Levels Cell Biochem Biophys, 2011 61(1):23-31
Shen Jie-yan （通讯作者）,Yao Tian-bao,Liu Hui,He Ben,Bruch Leonhard A right heart catheterization algorithm for differential diagnosis of pulmonary arterial Heart 2011 97：A228-A229
Shen JieYan ,Du YongPing,Song Wei,Liu JianPing,Jin ShuXuan,Bu Jun,He Ben ,Efficacy of coronary(#) Efficacy of coronary angioplasty on long-term outcome in elderly Chinese patients with ST elevated myocardial Cell Biochemistry and Biophysics， 2010 57（2-3）：59-65
Ding S, Pu J, Qiao ZQ, Shan P, Song W, Du Y, Shen JY, Jin SX, Sun Y, Shen L, Lim YL, He B. TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis Catheter Cardiovasc Interv. 2010 75(5):722-32
Jing ZC, Strange G, Zhu XY, Zhou DX, Shen JY, Gu H, Yang ZK, Pan X, Xiang MX, Yao H, Zhao DB, Dalton BS, Zhang ZL, Wang Y, Cheng XS, Yang YJ Efficacy, safety and tolerability of bosentan in Chinese patients with pulmonary arterial hypertension J Heart Lung Transplant 2010 29(2):150-6
Ding S, Pu J, Qiao ZQ, Shan P, Song W, Du Y, Shen JY, Jin SX, Sun Y, Shen L, Lim YL, He B. TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis Catheter Cardiovasc Interv. 2010 75(5):722-32
Shen JY, He B, Wang BY Effects of lipo-prostaglandin E1 on pulmonary hemodynamics and clinical outcomes in patients with pulmonary arterial hypertension Chest, 2005 128(2):714-9
Shen JY,Chen SL ,Wu YX, Pulmonary Hypertension in Systrmic Lupus Erythematosus Rheumatol Int 1999 18：147-151