导师姓名： 高维强 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 200127 邮箱地址： weiqgao@yahoo.com

研究方向 (点击浏览详细信息)
1.肿瘤生成机制及肿瘤干细胞研究; 2.干细胞和组织再生修复；3.耳聋和内耳毛细胞再生4.细胞分裂模式和干细胞干性维持

社会任职
《中华耳科学杂志》编委会编委
Journal of Experimental Biology and Medicine, 杂志编委会编委
Cells 杂志编委会编委
Clinical Medicine Insights: Ear, Nose and Throat杂志编委会编委
Annals of Neurological Disorders and Stroke 杂志编委会编委
《肿瘤》杂志编委会副主编
Journal of Developmental Biology and Regenerative Medicine 杂志编委会编委
The Open Prostate Cancer Journal杂志编委会编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2017YFA** 细胞周期和细胞分裂模式对干细胞多能性维持与分化 科技部 2017-07~2021-12 2000万元 课题负责人
** 前列腺癌微环境中的免疫细胞亚群和特异分泌因子对其去势抵抗的作用及机制研究 国家自然科学基金 2017-01~2021-12 275万元 课题负责人
** 细胞对称与不对称分裂在Pten丢失引起的前列腺癌中的作用机制 国家自然科学基金面上项目 2014-01~2016-12 75万元 课题负责人
** 细胞对称与不对称分裂在Pten丢失引起的前列腺癌中的作用机制 上海市肿瘤研究所癌基因及相关基因国家重点实验室自主课题 2013-03~2017-12 75万元 课题负责人
2013CB945600 神经前体细胞的命运决定、分化及环路形成的调控机制 13.科技部国家重大科学计划项目 2013-01~2017-12 170万元 课题参与人
2012CB966800 干细胞分裂模式和干细胞干性维持的机制研究 科技部 2012-01~2016-12 3000万元 课题负责人
** 前列腺癌雄激素非依赖性中肿瘤干细胞和上皮间质转化的参与及其机制 国家自然科学基金重点项目 2012-01~2016-12 260万元 课题负责人
002 新型有丝分裂相关蛋白Ska1作为前列腺癌治疗靶点的机制研究 高等学校博士学科点专项科研基金 2012-01~2012-12 12万元 课题负责人
上海市浦江人才计划 基于CRISP3作为前列腺癌新型生物标记物及其潜在诊疗应用的研究 上海市浦江人才计划 2012-01~2013-12 20万元 课题负责人
91-11-06 毒蕈碱受体1和3-前列腺癌新型诊疗靶点与作用机制研究 上海市肿瘤研究所癌基因及相关基因国家重点实验室课题 2011-10~2014-09 30万元 课题负责人
无 新型抗血管生成药物靶向治疗卵巢癌的研究 上海交通大学理工交叉研究基金 2011-01~2012-12 25万元 课题负责人
无 干细胞分裂模式和干细胞干性维持的机制研究 上海交通大学重大项目及创新团队培育基金 2011-01~2012-12 20万元 课题负责人
YG2010ZD207 新型杂化水凝胶复合骨髓间充质干细胞的骨组织工程研究 上海交通大学医工交叉研究基金 2010-06~2012-05 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang X, Xu H, Cheng C, Ji Z, Zhao H, Sheng Y, Li X, Wang J, Shu Y, He Y, Fan L, Dong B, Xue W, Wai Chua C, Wu D, Gao WQ （通讯作者）, He Zhu H. Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate. Nature Communications 2020 11(1):706
Liu M, Sun T, Li N, Peng J, Fu D, Li W, Li L, Gao WQ. （通讯作者） BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration. Nature Communications 2019 10(1):4614.
Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Zhang K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J, Li L, Gao WQ （通讯作者）, Zhu HH The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nature Communications 2019 10(1):3353
Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W, Gao WQ （通讯作者） Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ 2019 26(11):2479-2492
Wang M, Luo W, Zhang Y, Yang R, Li X, Guo Y, Zhang C, Yang R, Gao WQ （通讯作者） Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling. Cell Death Differ. 2019 Sep 17. doi: 10.1038/s41418-019-0415-5. [Epub ahead of print]
Zhou PJ, Wang X, An N, Wei L, Zhang L, Huang X, Zhu HH, Fang YX, Gao WQ. （通讯作者） Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes Oncogene 2019 38(12):2192-2205
Wang M, Luo W, Zhang Y, Yang R, Li X, Guo Y, Zhang C, Yang R, Gao WQ （通讯作者） Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling. Cell Death Differ. 2019 Sep 17. doi: 10.1038/s41418-019-0415-5. [Epub ahead of print]
Cheng C, Ji Z, Sheng Y, Wang J, Sun Y, Zhao H, Li X, Wang X, He Y, Yao J, Wang L, Zhang C, Guo Y, Zhang J, Gao WQ* （通讯作者）, Zhu HH* Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKK?/TBK1/NF-κB signaling Theranostics 2018 8(17):4633-4648
Wang C, Chen J, Zhang Q, Li W, Zhang S, Xu Y, Wang F, Zhang B, Zhang Y, Gao WQ （通讯作者） Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy. Cell Research 2018 28(11):1103-1117
Zhang K, Guo Y, Wang X, Zhao H, Ji Z （通讯作者）, Cheng C, Li L, Fang Y, Xu D, Zhu HH, Gao WQ. WNT/β-catenin Directs the Self Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells cancer research 2017 2017 Feb 16. doi: 10.1158/0008-5472.CAN-16-1887.
Wang M, Li X, Zhang J, Yang Q, Chen W （通讯作者）, Jin W, Huang YR, Yang R, Gao WQ. AHNAK2 is a Novel Prognostic Marker and Oncogenic Protein for Clear Cell Renal Carcinoma Theranostics 2017 2017 Feb 27;7(5):1100-1113.
Guo Y1, Cui J1, Ji Z2, Cheng C2, Zhang K2, Zhang C1, Chu M1, Zhao Q3, Yu Z3, Zhang Y3, Fang YX1, Gao WQ1 （通讯作者）,2, Zhu HH1. miR-302/367/LATS2/YAP Pathway is essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance Oncogene 2017 2017 Jul 24. doi: 10.1038/onc.2017.240.
Qianqian Chen, Yizhou Quan, Naitao Wang, Chengying Xie, Zhongzhong Ji, Hao He, Renjie Chai, Huawei Li, Shankai Yin, Y. Eugene Chin, Xunbin Wei, Wei-Qiang Gao （通讯作者） Inactivation of STAT3 signaling impairs hair cell differentiation in the developing mouse cochlea Stem cell reports 2017 Stem?Cell?Reports.?2017 Jul 11;?9(1): 231–246
Zhu HH, Zhuang G, Gao WQ. （通讯作者） A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. J Pathol. 2016 2016 Jan;238(1):3-6.
Qin Y, Gao WQ. （通讯作者） Concise Review: Patient-Derived Stem Cell Research for Monogenic Disorders. Stem Cells. 2016 2016 Jan;34(1):44-54.
Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH1, Gao WQ （通讯作者） Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2016 2016 Mar 10;35(10):1271-82.
Zhang C, Ji Z, Wang M, Zhang W, Yang R, An H, Yang R, van Abel D, van Dijk M, Yang X, Ou G, Zhu HH, Gao WQ. （通讯作者） Stox1 as a Novel Transcriptional Suppressor of Math1 during Cerebellar Granule Neurogenesis and Medulloblastoma Formation Cell death and differentiation 2016 2016 Dec;23(12):2042-2053.
Wang Y, Yang H, Yang Q, Yang J, Wang H, Xu H, Gao WQ （通讯作者） Chemical conversion of mouse fibroblasts into functional dopaminergic neurons Experimental Cell Research 2016 2016 Oct 1;347(2):283-92.
Wang N, Dong BJ, Quan Y, Chen Q, Chu M, Xu J, Xue W, Huang YR, Yang R, Gao WQ. （通讯作者） Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016 2016 May 10;6(5):668-78.
Rong Yang, Minglei Wang, Jia Wang,Xingxu Huang,Ru Yang and Wei-Qiang Gao Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling Stem Cell Reports 2015 5(5):816-28
Yiren Qin, Jilong Qin,Chikai Zhou, Jinsong Li, and Wei-Qiang Gao （通讯作者） Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer Cell Cycle 2015 14(8):1282-90
Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ （通讯作者） Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene 2015 doi: 10.1038/onc.2015.184
Fang YX, Chang YL, Gao WQ. （通讯作者） microRNA targeting prostate cancer stem cells Experimental Biology and Medicine 2015 2015 Aug;240(8):1071-8.
Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, Gao WQ. （通讯作者） Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt clinical cancer research 2015 2015 Oct 15;21(20):4676-85.
Yizhou Quan1,2*, Li Xia3*, Jiaxiang Shao1,2, Shankai Yin3, C. Yan Cheng4 （通讯作者）, Weiliang Xia1,2& Wei-Qiang Gao1,2 Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway scientific reports 2015 5 : 8181
Li Wang, Kaiqing Zhang, Helen He Zhu and Wei-Qiang Gao Autonomous assembly of epithelial structures by subrenal implantation of dissociated embryonic inner-ear cells Neuroreport 2015 26(8):473-7
Yiren Qin, Chikai Zhou, Nianhong Wang, Hao Yang, and Wei-Qiang Gao （通讯作者） Conversion of Adipose Tissue-Derived Mesenchymal Stem Cells to Neural Stem Cell-Like Cells by a Single Transcription Factor, Sox2 Cell Reprogram 2015 17(3):221-6
Wenjun Liu1, *, Hailong Wu1, *, Lili Chen1, Yankai Wen1 （通讯作者）, Xiaoni Kong1, Wei-Qiang Gao1 Park7 interacts with p47phox to direct NADPH oxidasedependent ROS production and protect against sepsis Cell Research 2015 2015 Jun;25(6):691-706.
Yang R, Wang M, Wang J, Huang X, Yang R, GaoWQ （通讯作者） Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports. 2015 2015 Nov 10;5(5):816-28.
Naitao Wang, Ming Yao, Jin Xu, Yizhou Quan, Kaiqing Zhang, Ru Yang, and Wei-Qiang Gao （通讯作者） Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt Clinical Cancer Research 2015 21(20):4676-85
Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao WQ （通讯作者） CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer. Cancer Res. 2015 2015 Oct 15;75(20):4312-21
Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, Gao WQ. （通讯作者） Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt Clin Cancer Res. 2015 2015 Oct 15;21(20):4676-85.
Xiaowei Nie, Kaiqing Zhang, Li Wang, Guangshuo Ou, He Zhu and Wei-Qiang Gao Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway Cell Prolif 2015 48(2):209-20
Huiming Xu,1,2?Yonghui Wang,1,2?Zuping He （通讯作者）,1?Hao Yang,1,*?and?Wei-Qiang Gao1,2,3,* Direct Conversion of Mouse Fibroblasts to GABAergic Neurons with Combined Cell Cycle 2015 2015 Aug 3; 14(15): 2451–2460
Qin Y, Qin J, Zhou C, Li J, Gao WQ. （通讯作者） Generation of Embryonic Stem Cells from Mouse Adipose-tissue Derived Cells via Somatic Cell Nuclear Transfer Cell Cycle 2015 2015;14(12):1985
Xu H, Tsang KS, Wang Y,Gao WQ （通讯作者） Unfolded Protein Response Is Required for the Definitive Endodermal Specification of Mouse Embryonic Stem Cells via Smad2 and β-Catenin Signaling. J Biol Chem 2014 289(38):26290-301
Chu M, Chang Y, Li P, Guo Y （通讯作者）, Zhang K, Gao W Androgen receptor is negatively correlated with the methylation-mediated transcriptional repression of miR-375 in human prostate cancer cells Oncology Reports 2014 31: 34-40, 2014
Qin Y, Zhou P, Zhou C,Gao WQ （通讯作者） The adipose-derived lineage-negative cells are enriched mesenchymal stem cells and promote limb ischemia recovery in mice. Stem Cells Dev. 2014 23(4):363-71
Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY and Gao WQ. Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat. Stem Cell Reports. 2014 2014 Jun 19;3(1):101-14.
Li J, Xuan JW, Khatamianfar V, Valiyewa F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ. （通讯作者） SKA1 overexpression promotes centriole over duplication, centrosome amplification and prostate tumorigenesis. J Pathol. 2014 2014 Oct;234(2):178-89.
Chu M, Chang Y, Wang N, Li W, Li P, Gao WQ. （通讯作者） Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells Exp Biol Med 2014 2014 Apr 24;239(7):823-828.
Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. （通讯作者） TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53. Gastroenterology. 2014 2014 Jul 18. pii: S0016-5085(14)00917-2.
Wang J, Zhu HH, Chu M, Liu Y （通讯作者）, Zhang C, Liu G, Yang X, Yang R, Gao WQ Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nature Communications 2014 5:4758.
Fang YX, Gao WQ （通讯作者） Roles of microRNAs during prostatic tumorigenesis and tumor progression Oncogene 2014 33(2):135-47
Chu M, Chang Y, Wang N, Li W （通讯作者）, Li P, Gao WQ Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells Exp Biol Med 2014 239(7):823-828.
Li J, Xuan JW, Khatamianfar V, Valiyeva F, Moussa M （通讯作者）, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis. J Pathol. 2014 234(2):178-89
Zhou Z, Ji Z, Wang Y, Li J （通讯作者）, Cao H, Zhu HH, Gao WQ. TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53. Gastroenterology 2014 147:1043–1054
Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ （通讯作者） Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nat Commun. 2014 2014 Aug 28;5:4758.
Ping Li,Jia Wang,Mingliang Chu,Kaiqing Zhang,Ru Yang and Wei-Qiang Gao Zeb1 promotes androgen independence of prostate cancer via induction of stem cell-like properties Exp Biol Med (Maywood) 2014 239(7):813-822
Zhu HH, Luo X, Zhang K, Cui J, Zhao H, Ji Z, Zhou Z, Yao J, Zeng L, Ji K, Gao WQ, Zhang ZY, Feng GS Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci U S A 2014 112(43):13342-7
Li J, Tang Y, Wang Y, Tang R （通讯作者）, Jiang W, Yang GY, Gao WQ Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rats Stem Cell Reports 2014 3(1):101-14
Fang, Y and Gao W-Q. （通讯作者） Roles of microRNAs during prostatic tumorigenesis and tumor progression Oncogene 2014 2014, 33,135-147
Ping Li,Ru Yang and Wei-Qiang Gao Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer Mol Cancer 2014 13:55
Zhang C, Guo Y, Cui J, Zhu HH, Gao WQ （通讯作者） Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration Biomed Res Int 2013 2013:576472