导师姓名： 倪兆慧 专业代码： 1002Z2
性别： 女 专业名称： 临床中西医结合
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： profnizh@126.com 邮箱地址： profnizh@ 126.com

研究方向 (点击浏览详细信息)
急慢性肾损伤防治的临床与基础研究

社会任职
华东肾脏病协会副主委
上海市医学会肾脏病分会前任主委
中国医促会血液净化工程技术分会常委
上海市肾脏病质量控制中心专家委员会委员和编委
中国中西医结合肾脏疾病专业委员会常务委员兼秘书长
《肾脏病透析与移植》常务编委
《中国血液净化》常务编委
国家自然科学基金评审专家
上海中西医结合肾病专业委员会主任委员
中国医师协会肾脏内科医师分会常委
卫生部及上海市肾病质控中心委员
上海市肾脏病质量控制中心专家委员会委员和编委
卫计委内科医生规培教材副主编
卫生部腹透示范分中心主任
上海交通大学医学院尿毒症诊治中心主任
世界华人肾脏病医师协会副会长
中华医学会肾脏病分会常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** NLRP3炎症体与线粒体自噬cross-talk在对比剂所致急性肾损伤中的作用 国家自然科学基金面上项目 2018-01~2021-12 67.2万元 课题负责人
2015BAI12B05 慢性肾脏疾病的临床研究和推广应用 国家科技支撑计划项目 2017-06~2019-12 20万元 课题参与人
** Caspase-1调节近端肾小管上皮细胞焦亡在对比剂所致急性肾损伤中的作用 国家自然科学基金面上项目 2016-01~2019-12 68.4万元 课题负责人
ZHYY-ZXYJHZX-1-02 基于真实世界的大数据探讨综合医院中西医结合防治慢性肾脏病优化诊疗方案的研究 上海市卫计委 2015-12~2018-12 80万元 课题负责人
2015SQ****5 影响尿毒症患者生存质量和医疗费用的关键血液净化技术的评价及规范建立 中华人民共和国国家卫生和计划生育委员会 2015-01~2017-12 20万元 课题参与人
** NLRP3 炎症体在对比剂所致急性肾损伤发病中的作用和机制研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
2012CB517602 足细胞损伤干预药物的分子机制研究 国家重点基础研究发展计划 2012-01~2016-08 519万元 课题负责人
2011BAI10B04 狼疮性肾炎及血管炎肾损害的诊断与治疗 十二五国家科技支撑计划 2012-01~2015-12 50万元 课题参与人
11DZ** 健脾清化法治疗脾虚湿热型慢性肾衰临床多中 心大样本前瞻性研究 上海市科委，重点科技攻关项目 2011-11~2014-09 20万元 子课题负责人
2011BAI10B08 血液净化质量改进和国产血液净化产品临床应用评价研究 十二五国家科技支撑计划 2011-01~2015-12 60万元 子课题负责人
** 急性肾损伤过氧化物酶体差异表达蛋白及相关抗氧化应激机制的研究 国家自然科学基金面上项目 2011-01~2011-12 10万元 课题负责人
10JC** 慢性肾脏病中西药优化治疗及病因病机探讨 上海市科委基础重点项目 2010-10~2013-09 25万元 课题参与人
PKJ2009-Y12 造影剂肾损伤尿液早期标志蛋白及他汀联合黄芪防治作用的研究 浦东新区科技发展基金创新资金 2009-06~2011-05 20万元 课题负责人
PW2007D-3 造影剂肾病尿液早期诊断标志物的研究 浦东新区社发局，重点协作项目 2007-08~2010-06 10万元 课题负责人
06BZ028 造影剂肾损伤蛋白质谱差异表达的研究 上海市教委发展基金 2007-01~2008-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Min L, Wang Q, Cao L, Zhou W, Yuan J, Zhang M, Che X, Mou S, Fang W, Gu L, Zhu M, Wang L, Yu Z, Qian J, Ni Z （通讯作者） Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathy Oncotarget 2017 ahead of print
Zhou Y, Zhang J, Zhang W, Ni Z （通讯作者） Association of adiponectin with peripheral arterial disease and mortality in nondiabetic hemodialysis patients: Long-term follow-up data of 7 years J Res Med Sci 2017 eCollection
Li S, Wang L, Zhang M, Zhou W, Fang W, Wang Q, Qi C, Mou S, Shao X, Ni Z （通讯作者） Clinical Predictors of Response to Prednisone Plus Cyclophosphamide in Patients nephron clinical practice 2017 135;87-96
Shen J, Wang L, Jiang N, Mou S, Zhang M, Gu L, Shao X, Wang Q, Qi C, Li S, Wang W, Che X, Ni Z （通讯作者） NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis Sci Rep 2016 2016 Oct 10;6:34682.
Ding L, Shao X, Cao L, Fang W, Yan H, Huang J, Gu A, Yu Z, Qi C, Chang X, Ni Z （通讯作者） Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study BMJ Open 2016 2016 Oct 26;6(10):e012967
Jin S, Zhu M, Yan J, Fang Y, Lu R, Zhang W, Zhang Q, Lu J, Qi C, Shao X,Zhang H, Jiang R, Ni Z （通讯作者） Serum sclerostin level might be a potential biomarker for arterial stiffness in prevalent hemodialysis patients Biomark Med. 2016 10(7):689-99
Jin H, Fang W, Zhu M, Yu Z, Fang Y, Yan H, Zhang M, Wang Q, Che X, Xie Y （通讯作者）, Urgent-Start Peritoneal Dialysis and Hemodialysis in ESRD Patients: Complications and Outcomes PLoS One 2016 8;11(11):e**
Yijun Zhou, Jiwei Zhang, Mingli Zhu, Renhua Lu, Yongmei Wang, Zhaohui Ni （通讯作者） Plasma Pentraxin 3 Is Closely Associated with Peripheral Arterial Disease in Hemodialysis Patients and Predicts Clinical Outcome: A 6-Year Follow-Up Blood Purif 2015 39:266–273
Chaojun Qi, Ling Wang, Minfang Zhang, Xinghua Shao, Xinbei Chang, Zhuping Fan, Qin Cao, Shan Mou, Qin Wang, Yucheng Yan, Gary Desir, Zhaohui Ni （通讯作者） Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis PLOS ONE 2015 10(9): e**.
Na Jiang, Zhen Zhang, Wei Fang, Jiaqi Qian, Shan Mou, Zhaohui Ni （通讯作者） High Peritoneal Glucose Exposure Is Associated with Increased Incidence of Relapsing and Recurrent Bacterial Peritonitis in Patients Undergoing Peritoneal Dialysis Blood Purif 2015 40:72–78
Zhang M, Yan J, Zhu M, Ni Z （通讯作者） Fibroblast growth factor 23 predicts coronary calcification and poor prognosis in patients with chronic kidney disease stages 3-5D Ann Clin Lab Sci 2015 45(1):17-22
Minfang Zhang, Zhaohui Ni （通讯作者）, Wenyan Zhou, Jiaqi Qian Undercarboxylated osteocalcin as a biomarker of subclinical atherosclerosis in non-dialysis patients with chronic kidney disease J Biomed Sci 2015 (2015) 22:75
Beili Shi, Ling Wang, Shan Mou, Minfang Zhang, Qin Wang, Chaojun Qi, Liou Cao, Xiajing Che, Wei Fang, Leyi Gu, Yucheng Yan, Jiaqi Qian, Zhaohui Ni （通讯作者） Identification of mannose-binding lectin as a mechanism in progressive immunoglobulin A nephropathy Int J Clin Exp Pathol 2015 8(2):1889-1899
Wanpeng Wang, Shan Mou, Ling Wang, Minfang Zhang, Xinghua Shao, Wei Fang, Renhua Lu, Chaojun Qi, Zhuping Fan, Qin Cao, Qin Wang, Yan Fang, Zhaohui Ni （通讯作者） Up-regulation of Serum MiR- 130b-3p Level is Associated with Renal Damage in Early Lupus Nephritis Sci Rep 2015 5:12644
Xiajing Che, Qin Wang, Yuanyuan Xie, Weijia Xu, Xinghua Shao, Shan Mou, Zhaohui Ni （通讯作者） Astragaloside IV suppresses transforming growth factor-b1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-kB signaling pathways Biochem Bioph Res Co 2015 464:1260-1266
LIOU CAO, SHAN MOU, WEI FANG, LEYI GU, JIAYING HUANG, AIPING GU, JIAQI QIAN, ZHAOHUI NI （通讯作者） Hyperleptinaemia, insulin resistance and survival in peritonealdialysis patients Nephrology 2015 20 : 617–624
Liou Cao , Shan Mou , Wei Fang , Chaojun Qi , Xinbei Chang , Leyi Gu , Jiaqi Qian , Zhaohui Ni （通讯作者） Correlational studies on insulin resistance and leptin gene polymorphisms in peritoneal dialysis patients Iran J Basic Med Sci 2015 18(9):878-886
Chaojun Qi, Ling Wang, Minfang Zhang, Xinghua Shao, Xinbei Chang, Zhuping Fan, Qin Cao, Shan Mou, Qin Wang, Yucheng Yan, Gary Desir, Zhaohui Ni （通讯作者） Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis PLOS ONE 2015 10(9): e**
Zhaohui Ni, Yanhong Yuan, Qin Wang, Liou Cao, Xiajing Che, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Shan Mou Time-averaged albumin predicts the long-term prognosis of IgA nephropathy patients who achieved remission J Transl Med 2014 12:194
Minfang Zhang, Chaojun Qi, Liou Cao, Jiaqi Qian, Zhaohui Ni （通讯作者） Metabolic Syndrome Is Correlated With Carotid Atherosclerosis in Patients With Lupus Nephritis Am J Med Sci 2014 348(6):486–491
Yijun Zhou, Zhaohui Ni （通讯作者）, Jiwei Zhang, Weiming Zhang, Qingwei Wu, Guijuan Shen, Yongmei Wang, Jiaqi Qian Plasma pentraxin 3 may be a better marker of peripheral artery disease in hemodialysis patients than C-reactive protein Vasc Med 2013 18(2):85–91
Shan Mou, Jialin Li, Zanzhe Yu, Qin Wang, Zhaohui Ni （通讯作者） Keto acid-supplemented low-protein diet for treatment of adult patients with hepatitis B virus infection and chronic glomerulonephritis J Int Med Res 2013 41(1):129–137
Mou S, Wang Q, Li J, Shi B, Ni Z （通讯作者） Urinary excretion of liver-type fatty acid-binding protein as a marker of progressive kidney function deterioration in patients with chronic glomerulonephritis Clinica Cimica Acta 2012 (413):187-191
Zhou W, Ni Z （通讯作者）, Yu Z, Shi B, Wang Q Brain natriuretic peptide is related to carotid plaques and predicts atherosclerosis in pre-dialysis patients with chronic kidney disease Eur J Intern Med 2012 23(6):539-544
Shi B, Ni Z （通讯作者）, Cao L, Zhou M, Mou S, Wang Q, Zhang M, Fang W, Yan Y, Qian J Serum IL-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in IgA nephropathy Mediat Inflamm 2012 2012:728417
Shi B, Ni Z, Cai H, Zhang M, Mou S （通讯作者）, Wang Q, Cao L, Yu Z, Yan Y, Qian J High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis J Biomed Biotechnol 2010 373-426
Mou S, Wang Q, Shi B, Gu L, Ni Z （通讯作者） Hepatocyte growth factor ameliorates progression of interstitial injuries in tubular epithelial cells Scand J Urol Nephrol 2010 44(2):121-128
Wang L, Ni Z （通讯作者）, Xie Z, Yang F, He B, Liu J, Dai H, Qian J, Jia M Analysis of the urine proteome of human contrast-induced kidney injury using two-dimensional fluorescence differential gel electrophoresis/matrix-assisted laser desorption time-of-flight mass spectrometry/liquid chromatography mass spectrometry Am J Nephrol 2010 31(1):45-52
Shi B, Ni Z （通讯作者）, Zhou W, Yu Z, Gu L, Mou S, Fang W, Wang Q, Cao L, Yan Y, Qian J Circulating levels of asymmetric dimethylarginine are an independent risk factor for left ventricular hypertrophy and predict cardiovascular events in pre-dialysis patients with chronic kidney disease Eur J Intern Med 2010 21(5):444-448
Mou S, Wang Q, Shi B, Gu L, Ni Z （通讯作者） Hepatocyte growth factor suppresses transforming growth factor-beta-1 and type III collagen in human primary renal fibroblasts Kaohsiung J Med Sci 2009 25(11):577-587
Yu Z, Ni Z （通讯作者）, Gu L, Lin A, Fang W, Yao Q, Lindholm B, Qian J Adiponectin is related to carotid artery plaque and a predictor of cardiovascular outcome in a cohort of non-diabetic peritoneal dialysis patients Blood Purif 2008 26(4):386-93
Wang L, Ni Z （通讯作者）, He B, Gu L, Liu J, Dai H, Qian J Urinary IL-18 and NGAL as early predictive biomarkers of acute kidney injury in contrast induced nephropathy after coronary angiography Nephron Clin Pract 2008 108(3):176-181