导师姓名： 林厚文 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： franklin67@126.com
邮编： 200127 邮箱地址： linhouwen@renji.com

研究方向 (点击浏览详细信息)
海洋药物研究

社会任职
中国药学会海洋药物专业委员会副主任委员
上海市海洋湖沼学会海洋生物技术专委会副主任委员
中国生化与分子生物学会海洋生化与分子生物学分会候任理事长
中国微生物学会海洋微生物学专业委员会委员
世界中医药学会联合会中药分析专业委员会理事
上海市药学会常务理事
中国心胸血管麻醉学会心血管药学分会副主任委员
上海市药学会海洋药物专业委员会主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018YFC** 深海动植物药物先导化合物高效挖掘与候选药物成药性研究 国家科学技术部 2018-08~2021-12 2367万元 课题负责人
** 海绵细胞内共生微生物组及其天然产物生物合成资源发掘 国家自然科学基金-海外及港澳****合作研究基金 2018-01~2021-12 180万元 课题负责人
U** 台海海绵共生体中抗肿瘤干细胞激酶抑制剂的发现及作用机制 国家自然科学基金重点支持项目 2017-01~2020-12 215万元 课题负责人
** 西沙海绵共生微生物中抗肿瘤先导化合物的发现 国家自然科学基金 2015-01~2018-12 79万元 课题负责人
** 抗烧伤感染金樱子叶有效成分群的候选新药研究 上海市科委科技支撑项目 2013-09~2016-09 60万元 课题负责人
2013AA092902 远海大型生物全新天然产物的发现与药物先导化合物优化 国家863课题 2013-01~2015-12 80万元 课题负责人
** 天然药物化学 国家****科学基金 2013-01~2016-12 280万元 课题负责人
2013ZX**-017 抗耐药菌感染金樱子叶有效部位的候选药物研究 国家新药创制科技重大专项 2013-01~2015-12 150万元 课题负责人
抗肿瘤候选药物海洋苔虫大环内酯B-19的成药性研究 上海市科委科技支撑项目 2012-09~2015-09 30万元 课题负责人
12XD** 基于西沙特殊生境海绵资源的抗肿瘤药物先导物的发现及其作用机制研究 上海市优秀学术带头人计划 2012-07~2014-06 40万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wei-Hua Jiao,Qi-Hang Xu,Jie Cui,Ru-Yi Shang,Yun Zhang,Jia-Bao Sun,Qi Yang,Ke-Chun Liub,Hou-Wen Lin （通讯作者） Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria Organic Chemistry Frontiers 2020 7, 368-373
Mengxuan Chen, Yizhen Yan, Hengju Ge, Wei-Hua Jiao, Zhizhen Zhang, Hou-Wen Lin （通讯作者） Pseudoceroximes A–E and Pseudocerolides A–E – Bromotyrosine Derivatives from a Pseudoceratina sp. Marine Sponge Collected in the South China Sea European Journal of Organic Chemistry 2020 17,2583
Xian-Xian Miao, Meng-Xuan Chen, Hong-Rui Zhu, Fan Sun, Li-Li Hong, Wen-Hui Wu, Hou-Wen Lin （通讯作者）, Fan Yang New polyketides and norterpenoids from the marine sponge Diacarnus megaspinorhabdosa Tetrahedron 2020 76:131062
Yaoyao Shen, Fan Sun, Liu Zhang, Yijia Cheng, Hongrui Zhu, Shu-Ping Wang, Wei-Hua Jiao, Peter F. Leadlay, Yongjun Zhou, Hou-Wen Lin （通讯作者） Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase Journal of Biological Chemistry 2020 295(16):5509-5518
Yu-Han Gui, Li Liu, Wei Wu, Yun Zhang, Zhi-Li Jia, Yong-Ping Shi, Hao-Tian Kong, Ke-Chun Liu, Wei-Hua Jiao, Hou-Wen Lin （通讯作者） Discovery of nitrogenous sesquiterpene quinone derivatives from sponge Dysidea septosa with anti-inflammatory activity in vivo zebrafish model Bioorganic Chemistry 2020 2020, 94:103435
Wei-Hua Jiao,Qi-Hang Xu, Guang-Bo Ge, Ru-Yi Shang, Hong-Rui Zhu, Hong-Yan Liu, Jie Cui, Fan Sun, Hou-Wen Lin （通讯作者） Flavipesides A?C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013 Organic Letters 2020 22(5):1825-1829
Wei-Hua Jiao,Jing Li,Meng-Meng Zhang,Jie Cui,Yu-Han Gui,Yun Zhang,Jing-Ya Li,Ke-Chun Liu, Hou-Wen Lin （通讯作者） Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa Organic Letters 2019 21, 6190?6193
Ying Wu, Lei Liu, Hai-Feng Chen, Wei-Hua Jiao, Fan Sun, Li-Yun Liu, Hong-Rui Zhu, Shu-Ping Wang, Hou-Wen Lin. （通讯作者） Fuscasins A-D,Cycloheptapeptides from the Marine Sponge Phakellia fusca Journal of Natural Product 2019 82(4): 970-979
Yu-Han Gui,Wei-Hua Jiao,Mi Zhou,Yun Zhang,De-Quan Zeng,Hong-Rui Zhu,Ke-Chun Liu,Fan Sun,Hai-Feng Chen,Hou-Wen Lin （通讯作者） SeptosonesA-C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons Organic Letters 2019 21(3):767-770
Yuan Gao,Fan Yang,Fan Sun,Lei Liu,Bo Liu,Shu-Ping Wang,Chun-Wei Cheng,Hongze Liao,Hou-Wen Lin （通讯作者） Total Synthesis of Aaptamine,Demethyloxyaaptamine, and Their 3-Alkylamino Derivatives Organic Letters 2019 18(21):1430-1433
Yongjun Zhou,Xiao Lin,Chunmin Xu,Yaoyao Shen,Shu-Ping Wang,Hongze Liao,Lei Li,Hai Deng,Hou-Wen Lin(*)Hou-Wen Lin （通讯作者） Investigation of Penicillin Binding Protein(PBP)-like Peptide Cyclase and Hydrolase in SurugamideNon-ribosomal Peptide Biosynthesis Cell Chemical Biology 2019 26(5):737-744
Zhi-Chun Gu#, Ling-Yun Zhou#, Long Shen, Chi Zhang, Jun Pu, Hou-Wen Lin(*) （通讯作者）, Xiao-Yan Liu(*) Non-vitamin K Antagonist Oral Anticoagulants versus Warfarin at Risk of Fractures: A Systematic Review and Meta-analysis of Randomized Controlled Trials Frontiers in Pharmacology 2018 9: 348
Jing Li, Wei Wu, Fan Yang, Li Liu, Shu-Ping Wang, Wei-Hua Jiao,* Shi-Hai Xu,* Hou-Wen Lin(*) （通讯作者） Popolohuanones G-I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans Chemistry & biodiversity 2018 Apr 10
Li Liu#, Wei Wu, Jing Li, Wei-Hua Jiao, Li-Yun Liu, Jie Tang, Lei Liu, Fan Sun(*),Bing-Nan Han(*), Hou-Wen Lin(*) （通讯作者） Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling Biomedicine and Pharmacotherapy 2018 417-425
Fan Yang#, Yan-Yun Li#, Jie Tang#, Fan Sun#, Hou-Wen Lin(*) （通讯作者） New 4-methylidene sterols from the marine sponge Theonella swinhoei Fitoterapia 2018 Mar 11
Bin Wu, Suhua Zhang, Hou-Wen Lin, Shan Mou(*) Prevention of renal failure in Chinese patients with newly diagnosed type 2 diabetes: A cost-effectiveness analysis J DIABETES INVEST 2018 9(1):152-161
Jingtang Liu, Binbin Gu, Lianjuan Yang, Fan Yang,* Hou-Wen Lin(*) （通讯作者） New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus Aspergillus violaceofuscus Frontiers In Chemistry 2018 14 June
Wei-Hua Jiao,Bao-Hui Cheng,Guo-Dong Chen,Guo-Hua Shi,Jing Li,Tian-Yong Hu,Hou-Wen Lin. （通讯作者） Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria Organic Letters 2018 20(10): 3092-3095
Hui-Xiang Li#, Qian Zhang#, Xin Jin, Xiao-Wen Zou, Yue-Xuan Wang, De-Xiang Hao,Feng-Hua Fu, Wei-Hua Jiao, Cui-Xia Zhang, Hou-Wen Lin(*) （通讯作者） Keiichi Matsuzaki and Feng Zhao(*).Dysifragilone A inhibits LPS?induced RAW264.7 macrophage activation by blocking the p38 MAPK signaling pathway Molecular Medicine Reports 2018 17: 674-682
Yongjun Zhou# , Xiao Lin#, Simon R. Williams, Liyun Liu, Yaoyao Shen, Shu-Ping Wang, Fan Sun, Shihai Xu, Hai Deng, Peter F. Leadlay, Hou-Wen Lin(*) （通讯作者） Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase ACS Chem. Biol. 2018 13 (8), pp 2153–2160
Bin-Bin Gu, Wei Wu,Fu-Rong Jiao,Wei-hua Jiao,Lei Li,Fan Sun,Shu-Ping Wang,Fan Yang,Hou-Wen Lin. （通讯作者） Aspersecosteroids A and B, Two 11(9 → 10)-abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D?1 Organic Letters 2018 20(24): 7957~7960
Bin-Bin Gu#, Wei Wu#, Li-Yun Liu, Jie Tang, Ya-Jun Zeng, Shu-Ping Wang,Fan Sun, Lei Li, Fan Yang, Hou-Wen Lin(*) （通讯作者） 3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Eupenicillium sp. 6A-9, a Fungus Isolated from the Marine Sponge Plakortis simplex European Journal of Organic Chemistry 2018 48-59
Bin Wu, Hou-Wen Lin, Ruoyan Gai Tobe, Le Zhang, Ben He(*) Ticagrelor versus clopidogrel in East-Asian patients with acute coronary syndromes: a meta-analysis of randomized trials J Comp Eff Res 2018 7(3):281-291
Wei-Hua Jiao#, Zeinab Khalil, Pradeep Dewapriya, Angela A. Salim, Hou-Wen Lin, Robert J. Capon(*) Trichodermides A–E: New Peptaibols Isolated from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16 Journal of Natural Products 2018 Mar 12
Yu-chen Liu, Zhen-hua Wang, Ruoyan Gai Tobe, Hou-wen Lin(*) （通讯作者）, Bin Wu(*) Cost Effectiveness of Daclatasvir Plus Asunaprevir Therapy for Chinese Patients with Chronic Hepatitis C Virus Genotype 1b Clinical Drug Investigation 2018 Volume 38, Issue 5, pp 427–437
Bing-Nan Han(*), Ting-Ting Liang, Lawrence Jordan Keen, Ting-Ting Fan, Xiao-Dan Zhang, Lin Xu, Qi Zhao, Shu-Ping Wang, Hou-Wen Lin(*) （通讯作者） Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity Organic Letter 2018 Feb 2;20(3):578-581
Wei-Hua Jiao#, Bao-Hui Cheng, Guo-Dong Chen, Guo-Hua Shi, Jing Li, Tian-Yong Hu, Hou-Wen Lin(*) （通讯作者） Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria Organic Letter 2018 20 (10), pp 3092–3095
Chi Zhang, Zhi-chun Gu, Long Shen, Xian-yan Liu, Hou-wen Lin(*) （通讯作者） A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer’s Disease Treatment Current Pharmaceutical Biotechnology 2017 18(14):1124-1131
Li-Li Hong(#), Hao-Bing Yu(#), Jie Wang, Wei-Hua Jiao, Bao-Hui Cheng, Fan Yang, Yong-Jun Zhou, Bin-Bin Gu, Shao-Jiang Song(*), Hou-Wen Lin.(*) （通讯作者） Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne Scientific Reports 2017 7:43138
Jing-Tang Liu, Wei Wu, Min-Jia Cao, Fan Yang(*), Hou-Wen Lin(*) （通讯作者） Trienic α-pyrone and ochratoxin derivatives from a sponge-derived fungus Aspergillus ochraceopetaliformis Natural Product Research 2017 Nov 13:1-7
Bin Wu, Maobai Liu, Te Li, Houwen Lin （通讯作者）, Hua Zhong(*) An economic analysis of high-dose imatinib, dasatinib, and nilotinib for imatinib-resistant chronic phase chronic myeloid leukemia in China Medicine (Baltimore) 2017 Jul; 96(29): e7445
Li-Li Hong(#), Jia-Bao Sun(#), Fan Yang, Man Liu, Jie Tang, Fan Sun, Wei-Hua Jiao, Shu-Ping Wang, Wei Zhang(*), Hou-Wen Lin(*) （通讯作者） New Diterpene Alkaloids from the Marine Sponge Agelas mauritiana RSC Advances 2017 7: 23970-23976
Wei-Hua Jiao#, Li-Li Hong#, Jia-Bao Sun#, Shu-Juan Piao, Guo-Dong Chen, Hai Deng, Shu-Piing Wang, Fan Yang, Hou-Wen Lin(*) （通讯作者） (?)-Hippolide J, a Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne European Journal of Organic Chemistry 2017 3421?3426
Wei-Hua Jiao, Bao-Hui Cheng, Guo-Hua Shi, Guo-Dong Chen, Bin-Bin Gu, Yong-Jun Zhou, Li-Li Hong, Fan Yang, Zhi-Qiang Liu, Shu-Qi Qiu, Zhi-Qiang Liu, Ping-Chang Yang(*), Hou-Wen Lin(*) （通讯作者） Dysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa Scientific Reports 2017 Aug 21;7(1):8947
Xiang-Rong Tian(#), Yan-Qing Gao(#), Xiao-Lin Tian, Jiao Li, Hai-Feng Tang, Yu-Shan Li, Hou-Wen Lin （通讯作者）, Zhi-Qing Ma(*) New Cytotoxic Secondary Metabolites from Marine Bryozoan Cryptosula pallasiana Marine Drugs 2017 15(4), 120
Zhichun Gu, Chi Zhang, AnhuaWei, Min Cui, Jun Pu, Hou-Wen Lin(*) （通讯作者）,Xiaoyan Liu(*) Incidence and risk of respiratory tract infection associated with specific drug therapy in pulmonary arterial hypertension: a systematic review Scientific Reports 2017 Nov 24;7(1):16218
Bin-Bin Gu, Jie Tang, Shu-Ping Wang, Fan Sun, Fan Yang, Lei Li, Ying Xu, Hou-Wen Lin(*) （通讯作者） Structure, Absolute Configuration, and Variable-Temperature 1H-NMR Study of (±)-Versiorcinols A-C, Three Racemates of Diorcinol Monoethers from the Sponge-Associated Fungus Aspergillus versicolor 16F-11 RSC Advances 2017 2017,7, 50254
Xiao-yu Yan, Xiao-hua Gu, Zhen-xing Xu, Hou-wen Lin, Bin Wu(*) Cost-Effectiveness of Different Strategies for the Prevention of Venous Thromboembolism After Total Hip Replacement in China ADV THER 2017 2(34):466-480
Jie Wang(#), Feng-Rong Mu(#), Wei-Hua Jiao(*), Jian Huang, Li-Li Hong, Fan Yang, Ying Xu, Shu-Ping Wang, Fan Sun, Hou-Wen Lin(*) （通讯作者） Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge Journal of Natural Products 2017 80 (9):2509-2514
Ya-Ting Sun(#), Bin Lin, Sheng-Ge Li, Man Liu, Yong-Jun Zhou, Ying Xu(*), Hui-Ming Hua(*), Hou-Wen Lin.(*) （通讯作者） New bromopyrrole alkaloids from the marine sponge Agelas sp Tetrahedron 2017 73 (2017) 2786-2792
Jing Li(#), Bin-Bin Gu(#), Fan Sun, Jian-Rong Xu, Wei-Hua Jiao, Hao-Bin Yu, Bin-Nan Han, Fan Yang(*), Xi-Chun Zhang(*),Hou-Wen Lin(*) （通讯作者） Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper Journal of Natural Product 2017 80(5):1436-1445
Yan Zhu(#), Yan Wang(#), Bin-Bin Gu, Fan Yang, Wei-Hua Jiao, Gan-Hai Hu, Hao-Bing Yua, Bing-Nan Han, Wei Zhang, Yang Shen*(*), Hou-Wen Lin(*) （通讯作者） Antifungal bromopyrrole alkaloids from the South China Sea sponge Agelas sp. Tetrahedron 2016 72, 2964-2971
Fan Yang, Ru-Ping Wang, Bin Xu, Hao-Bing Yu, Guo-Yi Ma, Guang-Fei Wang, Shu-Wen Dai, Wei Zhang, Wei-Hua Jiao, Shao-Jiang Song(*), Hou-Wen Lin(*) （通讯作者） New antimalarial norterpene cyclic peroxides from Xisha Islandssponge Diacarnus megaspinorhabdosa Bioorganic & Medicinal Chemistry Letters 2016 26(8):2084-2087
Li-Jian Ding, Wei Yuan, Xiao-Jian Liao, Bing-Nan Han, Shu-Ping Wang, Zhi-Yong Li,Shi-Hai Xu(*), Wei Zhang(*), Hou-Wen Lin(*) （通讯作者） Oryzamides A?E, Cyclodepsipeptides from the Sponge-Derived Fungus Nigrospora oryzae PF18 Journal of Natural Products 2016 79(8): 2045-2052
Wei-Zhuo Tang, Zhong-Zhen Yang, Fan Sun, Shu-Ping Wang, Fan Yang, Hou-Wen Lin(*) （通讯作者） Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp. Journal of Asian Natural Products Research 2016 1-6
Giuseppina Chianese, Hao-Bing Yu, Fan Yang, Carmina Sirignano, Paolo Luciano, Bing-Nan Han, Shabana Khan, Hou-Wen Lin(*) （通讯作者） Orazio Taglialatela-Scafati(*),PPAR Modulating Polyketides from a Chinese Plakortis simplex and Clues on the Origin of Their Chemodiversity Journal of Organic Chemistry 2016 81(12):5135-5143
Wei-Hua Jiao(#), Guo-Hua Shi(#), Ting-Ting Xu(#), Guo-Dong Chen, Bin-Bin Gu, Zhuo Wang, Shuang Peng, Shu-Ping Wang, Jia Li, Bing-Nan Han, Wei Zhang, Hou-Wen Lin(*) （通讯作者） Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge Journal of Natural Products 2016 79 (2): 406-411
Wei-Hua Jiao,Ting-Ting Xu,Bin-Bin Gu,Guo-Hua Shi,Yan Zhu,Fan Yang,Bing-Nan Han,Shu-Ping Wang,Yu-Shan Li,Wei Zhang,Jia Li, Hou-Wen Lin* （通讯作者） Bioactive sesquiterpene quinols and quinones from the marine sponge Dysidea avara RSC Adv. 2015 5: 87730–87738
Jiao W. H., Xu T. T., Zhao F., Gao H., Shi G. H., Wang J., Hong L. L., Yu H. B., Li Y. S., Yang F., Lin H.W.* （通讯作者） Dysifragilones A–C, Unusual Sesquiterpene Aminoquinones and Inhibitors of NO Production from the South China Sea Sponge Dysidea fragilis. European Journal of Organic Chemistry 2015 (5), 960-966
Giuseppina Chianese, Bin-Bin Gu, Fan Yang, Wei-Hua Jiao, Yue-Wei Guo, Hou-Wen Lin* （通讯作者）,Orazio Taglialatela-Scafati* Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex. RSC Adv. 2015 5, 63372–63376
Yu H.B., Yang F.,Li Y.Y., Gan J.H., Jiao W.H., Lin H.W.* （通讯作者） Cytotoxic Bryostatin Derivatives from the South China Sea Bryozoan Bugula neritina. Journal of Natural Products 2015 78 (5), 1169–1173
Li Q. L., Zhang P. P., Wang P. Q., Yu H. B.,Hu W. Z., Wu W. H., Chen S. S., Zhang X., Chen F., Zhang J. P., Chu Z. Y., Lin H. W. （通讯作者） The Cytotoxic and Mechanistic Effects of Aaptamine on Hepatocellular Carcinoma Anti-cancer agents in medicinal chemistry 2015 15 (3), 291-297
Qiu J., Zhao B.B., Zhong W.X., Shen Y.M*, Lin H.W.* （通讯作者） Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIa inhibitors as anticancer agents. European Journal of Medicinal Chemistry 2015 94, 427-435
Ding L. J., Gu B. B., Jiao W. H., Yuan W., Li Y. X., Tang W. Z., Yu H. B., Liao X. J., Han B. N., Li Z. Y.,* Xu S. H.,* Lin H. W.* （通讯作者） New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04. Marine Drugs 2015 13, 5579-5592
Jiao W. H., Chen G. D., Gao H., Li J., Gu B. B., Xu T. T., Yu H. B., Shi G. H., Yang F., Yao X. S., Lin H. W. （通讯作者） (+/-)-Quassidines I and J, Two Pairs of Cytotoxic Bis-beta-carboline Alkaloid Enantiomers from Picrasma quassioides Journal of natural products 2015 78 (1), 125-130
Yu H. B., Yang F., Sun F., Li J., Jiao W. H., Gan J. H., Hu W. Z., Lin H. W. （通讯作者） Aaptamine Derivatives with Antifungal and Anti-HIV-1 Activities from the South China Sea Sponge Aaptos aaptos Marine drugs 2014 12 (12), 6003-6013
Yang F., Zou Y. K., Wang R. P., Hamann M. T., Zhang H. J., Jiao W. H., Han B. N., Song S. J., Lin H. W. （通讯作者） Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa Marine drugs 2014 12 (8), 4399-4416
Yang F., Gan J. H., Liu X. Y., Lin H. W. （通讯作者） Scalarane sesterterpenes from the Paracel Islands marine sponge Hyrtios sp. Natural product communications 2014 9 (6), 763-764
Piao S.J, JiaoW.H,Yang F,Yi Y.H, Di Y.T, Han B.N,Lin H.W （通讯作者） New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne. Marine drugs 2014 12(7):4096-4109
Jiao W.H,Xu T.T,Yu H.B, Chen G.D,Huang X.J,Yang F, Li Y.S,Han B.N,Liu X.Y*,Lin H.W* （通讯作者） Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara Journal of Natural Products 2014 77 (2):346-350
Zhan K. X., Jiao W. H., Yang F., Li J., Wang S. P.,Li Y. S., Han B. N., Lin H. W. （通讯作者） Reniochalistatins A-E, Cyclic Peptides from the Marine Sponge Reniochalina stalagmitis Journal of natural products 2014 77 (12), 2678-2684
Yu H. B., Yang F., Sun F., Ma G. Y., Gan J. H., Hu W. Z., Han B. N., Jiao W. H., Lin H. W. （通讯作者） Cytotoxic aaptamine derivatives from the South China Sea sponge Aaptos aaptos Journal of natural products 2014 77 (9), 2124-2129
Jiao W. H., Li J., Liu Q., Xu T. T., Shi G. H., Yu H. B., Yang F., Han B. N., Li M., Lin H. W. （通讯作者） Dysidinoid A, an unusual meroterpenoid with anti-MRSA activity from the South China Sea sponge Dysidea sp. Molecules 2014 19 (11), 18025-18032
Chianese G., Persico M., Yang F., Lin H. W. （通讯作者）, Guo Y. W., Basilico N., Parapini S., Taramelli D., Taglialatela-Scafati O., Fattorusso C. Endoperoxide polyketides from a Chinese Plakortis simplex: further evidence of the impact of stereochemistry on antimalarial activity of simple 1,2-dioxanes Bioorganic & medicinal chemistry 2014 22 (17), 4572-4580
Jiao W.H,Xu T.T,Yu H.B,Mu F.R,Li J,Li Y.S,Yang F,Han B.N,Lin H.W （通讯作者） Dysidaminones A-M, Cytotoxic and NF-κB Inhibitory Sesquiterpene Aminoquinones from the South China Sea Sponge Dysidea fragilis RSC Advances 2014 4(00):9236-9246
Gan J.H,Xu C.H,Yu H.B,Lin H.W （通讯作者）,Zhou Q,Sun S.Q Rapid Discrimination of China Sponges by Tri-step Infrared Spectroscopy: A Preliminary Study Journal of Molecular Structure 2014 1069(00):147-151
Min Yan,Yan Zhu,Hong-Jun Zhang,Wei-Hua Jiao,Bing-Nan Han,Zhao-Xi Liu,Feng Qiu,Wan-Sheng Chen,Hou-Wen Lin （通讯作者） Anti-inflammatory secondary metabolites from the leaves of Rosalaevigata Bioorganic & Medicinal Chemistry 2013 21(11):3290-3297
Wang Y.W,Zhang J.B,Wang Q.X,Zhang T,Yang Y,Yi Y.H,Gao G.X,Dong H.J,Zhu H.F,Li Y, Lin H.W （通讯作者）,Tang H.F,Chen X.Q Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases European Journal of Pharmacology 2013 718:340-349
Yang F,Ji R.H,Li J,Gan J.H,Lin H.W （通讯作者） N-Containing Metabolites from the Marine Sponge Agelasclathrodes Natural Product Communications 2013 8 (12):1713-1714
Shu-Juan Piao,Yun-Long Song,Wei-Hua Jiao,Fan Yang,Xiang-Fang Liu,Wan-Sheng Chen,Bing-Nan Han,Hou-Wen Lin （通讯作者） Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne Organic Letters 2013 15(14):3526-3529