导师姓名： 王若文 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市浦东新区浦建路160号
邮编： 200127 邮箱地址： wangwrw@shsmu.edu.cn

研究方向 (点击浏览详细信息)
人工碱基, 靶向药物与肿瘤耐药机制

社会任职
中国化学会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于核酸适体的靶向性组合药物体系构建研究及肿瘤耐药性调控 国家自然科学基金委 (面上项目) 2019-01~2022-12 67.5万元 课题负责人
2012CB821600 若干重要元素的有机化学前沿 科技部"973"计划 2012-01~2016-12 3200万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, Ruowen Wang （通讯作者）,* Juan Li,* and Weihong Tan* Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control J. Am. Chem. Soc. 2020 142: 12079-12086
Xingrui Luo, Santhosh Kumar Pailla, Fei Gao, Xing Zheng, Ruowen Wang （通讯作者） Functionalization of amino acids with aryl fluorosulfate for prodrug construction by SuFEx chemistry Tetrahedron 2020 76, 130926
Yang Sun, Fei Gao, Cai Yang, Cheng Jin, Sitao Xie, Cheng Lv, Ding Ding, Da Han, Juan Li, Ruowen Wang* （通讯作者）, Weihong Tan* Construction of Bispecific Aptamer-Drug Conjugate by a Hybrid Chemical and Biological Approach Bioconjugate Chemistry 2020 31:1289-1294
Razack Abdullah, Sitao Xie, Ruowen Wang （通讯作者）, Cheng Jin, Yulin Du, Ting Fu, Juan Li, Jie Tan, Lili Zhang, Weihong Tan Artificial Sandwich Base for Monitoring Single-Nucleobase Changes and Charge-Transfer Rates in DNA Analytical Chemistry 2019 91(3): 2074-2078
Xiaowei Li, Adrian C. Figg, Ruowen Wang, Ying Jiang, Yifan Lyu, Hao Sun, Yuan Liu, Yanyue Wang, I-Ting Teng, Weijia Hou, Ren Cai, Cheng Cui, Long Li, Xiaoshu Pan, Brent S. Sumerlin, Weihong Tan Cross-Linkd Aptamer-Lipid Micelles for Excellent Stability and Specificity in Target-Cell Recognition Angew. Chem. Int. Ed. 2018 57, 11589-11593
Cheng Jin, Hui Zhang, Jianmei Zou, Yan Liu, Lin Zhang, Fengjie Li, Ruowen Wang, Wenjing Xuan, Mao Ye, Weihong Tan Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy Angew. Chem. Int. Ed. 2018 57; 8994-8997
RuoWen Wang, Cheng Jin, Xiaoyan Zhu, Liyi Zhou, Wenjing Xuan, Yuan Liu, Qiaoling Liu, Weihong Tan Artificial Base zT as Functional “Element” for Constructing Photoresponsive DNA Nanomolecules J. Am. Chem. Soc. 2017 139; 9104-9107
Cheng Jin, Ting Fu, RuoWen Wang （通讯作者）, Hui Liu, Jiamei Zou, Zilong Zhao, Mao Ye, Xiaobing Zhang, Weihong Tan Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging Chem. Sci. 2017 8; 7082-7086
RuoWen Wang （通讯作者）, Danqing Lu, Huarong Bai, Cheng Jin, Guobei Yan, Mao Ye, Liping Qiu, Rongshan Chang, Cheng Cui, Hao Liang, Weihong Tan Using modified aptamers for site specific protein–aptamer conjugations Chem. Sci. 2016 7; 2157-2161
RuoWen Wang, Chunming Wang, Yang Cao, Zhi Zhu, Chaoyong Yang, Jianzhong Chen, Feng-Ling Qing, Weihong Tan Trifluoromethylated Nucleic Acid Analogues Capable of Self-Assembly through Hydrophobic Interactions Chem. Sci. 2014 5; 4076-4081
RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Mao Ye, Feng-Ling Qing, Weihong Tan Automated and Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery J. Am. Chem. Soc. 2013 136; 2731-2734
Ruo-Wen Wang, Barry Gold A Facile Synthetic Approach to 7-Deazaguan-ine Nucleosides via a Boc Protection Strategy Org. Lett. 2009 11; 2465-2468
Ruo-Wen Wang, Jun Xu , Oscar Lopez , Mikael Bols, Feng-Ling Qing Difluoromethylenated PolyhydroxylatedPyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation Future Medicinal Chemistry 2009 1; 991-997
Ruo-Wen Wang, Xiao-Long Qiu, Mikael Bols, Fernando Ortega Caballero, Feng-Ling Qing Synthesis and Biological Evaluation of Glycosidase Inhibitors:gem-Difluoro-Methylenated Nojirimycin Analogues J. Med. Chem. 2006 49; 2989-2997
Ruo-Wen Wang, Feng-Ling Qing Highly Stereocontrolled Synthesis of gem-Difluoromethylenated Azasugars: D- and L-1,4,6-Trideoxy-4,4-difluoronojirimycin Org. Lett. 2005 7; 2189-2192