导师姓名： 牟姗 专业代码： 1002Z2
性别： 女 专业名称： 临床中西医结合
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： shan_mou@ 126.com

研究方向 (点击浏览详细信息)
中西医结合延缓肾脏病进展的机制研究

社会任职
上海中西医结合学会肾病专业委员会副主任委员兼秘书
上海市医学会肾脏病分会副主任委员
上海市医师协会中西医结合科医师分会副会长
上海市浦东新区医学会肾内科专委会主任委员
中国中西医结合学会肾病青年委员会副主任委员
中华中医药学会肾病分会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SENP1调控CD4+T细胞分化及在缺血再灌注肾损伤中的作用及机制 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** SENP1通过HIF1α调控巨噬细胞极化在缺血再灌注肾损伤中的作用及机制 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
16XD** 基于KIM-1调控巨噬细胞 功 能探索黄芪防治急性肾损伤后肾纤维化的机制研究 上海市科技委员会上海市优秀学术带头人 2016-05~2019-12 68.4万元 课题负责人
** 黄芪甲苷调控Th17和Treg细胞分化防治肾损伤 的机制研究 国家自然基金 2016-01~2019-12 68.4万元 课题负责人
2014DFT30090 急性肾损伤防治的超声集成技术评价体系的建立和应用 港澳台科技合作专项项目 2014-04~2017-04 100万元 课题负责人
** 基于内源性KIM-1/TIM-4 通路探讨黄芪甲苷防治肾纤维化的机制 国家自然基金面上项目 2014-01~2017-12 73万元 课题负责人
益气通络法防治急性肾损伤后肾脏纤维化的前瞻性研究 上海市科委中医引领项目 2012-10~2015-09 10万元 课题负责人
** 从黄芪干预肾纤维化的分子机制探讨“久病入络”的理论基础 国家自然基金 2012-01~2014-12 25万元 课题负责人
2010L063A 慢性肾脏病中西医结合防治方案及临床优化研究用 上海市卫生局基金 2010-10~2012-08 3万元 课题负责人
** KIM1 参与糖尿病肾病进展的机理以及黄芪的延缓作用 教育部留学回国人员科研基金 2010-08~2011-12 3万元 课题负责人
09DZ** 急性肾损伤中西医结合干预方案及疗效评价研究 上海市科委项目资助 2009-06~2012-06 10万元 课题负责人
06XJ21016 黄芪延缓慢性肾脏疾病进展及防治早期心血管并发症的研究 校基金,自然科学 2006-10~2008-12 2万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yao Xu, Xiao Dong Yuan, Jia Jin Wu, Ruo Yang Chen, Lei Xia, Ming Zhang, Cong Hui Han, Shan Mou （通讯作者） The N6-methyladenosine mRNA Methylase METTL14 Promotes Renal Ischemic Reperfusion Injury via Suppressing YAP1 J Cell Biochem 2020 121 (1), 524-533
Tian L,Shao X, Xie Y, Wang Q, Che X, Zhang M, Xu W ,Xu Y, Ni Z, Mou S （通讯作者） Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway Cell Physiol Biochem 2017 41 2 769~783
Wei Yan, Yao Xu, Yanhong Yuan, Lei Tian, Qin Wang, Yuanyuan Xie, Xinghua Shao, Ming Zhang, Zhaohui Ni, Shan Mou （通讯作者） Renoprotective Mechanisms of Astragaloside IV in Cisplatin-Induced Acute Kidney Injury Free Radic Research 2017 51 (7-8), 669-683
Xie Y,Wang Q,Wang C, Qi C, Ni Z, Mou S （通讯作者） igh urinary excretion of kidney injury molecule-1 predicts adverse outcomes in acute kidney injury: a case control study Crit Care 2016 20 1 286
Wu H, Huang T, Ying L, Han C, Li D, Xu Y, Zhang M, Mou S （通讯作者）, Dong Z MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis Cell Physiol Biochem 2016 40 6 1692~1705
Yanhong Yuan, Chunlin Wang, Xinhua Shao,Qin Wang, Xiajing Che, Minfang Zhang,Yuanyuan Xie, Lei Tian,Zhaohui Ni,Shan Mou （通讯作者） Urinary retinol-binding protein as a risk factor of poor prognosis in acute-on-chronic renal injury J Nephrol 2016 DOI 10.1007/s40620-016-0331-4
Xiajing Che, Qin Wang, Yuanyuan Xie, Weijia Xu, Xinghua Shao, Shan Mou （通讯作者）, Zhaohui Ni Astragaloside IV suppresses transforming growth factor-b1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-kB signaling pathways Biochemical and Biophysical Research Communications 2015 1260e1266
Yanhong Yuan, Xiajing Che, Zhaohui Ni, Yifei Zhong, Yinghui Qi, Xinhua Shao, Qin Wang, Liou Cao, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Lei Tian,Shan Mou （通讯作者） Association of Relapse with Renal Outcomes under the Current Therapy Regimen for IgA Nephropathy: A Multi-Center Study PLOS ONE 2015 September 15
Lei Tian, Xinghua Shao, Yuanyuan Xie, Ling Wang, Qin Wang, Xiajing Che, Zhaohui Ni , Shan Mou （通讯作者） The long-term efficacy and safety of immunosuppressive therapy on the progression of IgA nephropathy: a meta-analysis of controlled clinical trials with more than 5-year follow-up Expert Opin. Pharmacother. 2015 (2015) 16(8)
Yao Xu, Yuanyuan Xie, Xinghua Shao, Zhaohui Ni, Shan Mou （通讯作者） L-FABP: A novel biomarker of kidney disease Clinica Chimica Acta 2015 2015
Yanhong Yuan, Qin Wang, Zhaohui Ni, Xiajing Che, Liou Cao, Xinghua Shao, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Wenyan Zhou, Lei Tian and Shan Mou Long-term kidney survival analyses in IgA nephropathy patients under steroids therapy: a case control study J Transl Med 2015 13:186
Yuanyuan Xie, Wei Xue, Xinghua Shao, Xiajing Che, Weijia Xu, Zhaohui Ni, Shan Mou （通讯作者） Analysis of a Urinary Biomarker Panel for Obstructive Nephropathy and Clinical Outcomes plosone 2014 e112865
Zhaohui Ni, Yanhong Yuan, Qin Wang, Liou Cao, Xiajing Che, Minfang Zhang, Yuanyuan Xie, Chaojun Qi, Shan Mou （通讯作者） Time-averaged albumin predicts the long-term prognosis of IgA nephropathy patients who achieved remission Journal of Translational Medicine 2014 2014, 12:194
Xiajing Che, Yuanyuan Xie, Chunlin Wang, Qin Wang, Minfang Zhang, Chaojun Qi, Zhaohui Ni, Shan Mou （通讯作者） Blood HCO3- concentration predicts the long-term prognosis of acute kidney injury patients Biomark. Med. 2014 8(10), 1219–1226
Xinghua Shao., Lei Tian., Weijia Xu, Zhen Zhang, Chunlin Wang, Chaojun Qi, Zhaohui Ni, Shan Mou* （通讯作者） Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-Analysis plosone 2014 e84131
Qin Wang, Xinghua Shao, Weijia Xu, Chaojun Qi, Leyi Gu, Zhaohui Ni, and Shan Mou （通讯作者） Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells Ren Fail, 2014 2014; 36(3): 400–406
Yuanyuan Xie, Weijia Xu, Qin Wang, Xinghua Shao, Zhaohui Ni, Shan Mou （通讯作者） Urinary excretion of liver-type FABP as a new clinical marker for the progression of obstructive nephropathy Biomarkers Med. 2014 (2014) 8(4), 543–556
Weijia Xu, Xinghua Shao, Lei Tian, Leyi Gu, Minfang Zhang, Qin Wang, Bei Wu, Ling Wang, Jufang Yao, Xiaoping Xu, Shan Mou （通讯作者）, and Zhaohui Ni Astragaloside IV Ameliorates Renal Fibrosis via the Inhibition of Mitogen-Activated Protein Kinases and Antiapoptosis In Vivo and In Vitro J Pharmacol Exp Ther 2014 350:552–562
WEI XUE, YUANYUAN XIE, QIN WANG,WEIJIA XU, SHAN MOU and ZHAOHUI NI （通讯作者） Diagnostic performance of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for acute kidney injury in an obstructive nephropathy patient Nephrology 2014 19 (2014) 186–194
Qin Wang, Shan Mou （通讯作者）, Weijia Xu, Chaojun Qi and Zhaohui N Predicting Mortality in Microscopic Polyangiitis with Renal Involvement:A Survival Analysis Based on 64 Patients Ren Fail 2013 35(1):82-87
Mou S, Li J, Yu Z, Wang Q and Ni Z Keto acid-supplemented low-protein diet for treatment of adult patients with hepatitis B virus infection and chronicglomerulonephritis J Int Med Res 2013 41(1):129-137
Qin Wang, Shan Mou （通讯作者）, Weijia Xu, Chaojun Qi and Zhaohui Ni Predicting Mortality in Microscopic Polyangiitis with Renal Involvement: A Survival Analysis Based on 64 Patients Renal Failure, 2013 2013; 35(1): 82–87
谢园园,倪兆慧,薛蔚,蒋晨,徐维佳,牟姗 （通讯作者） 尿L?FABP和NGAL在梗阻性肾病所致急性肾损伤诊断及其肾脏预后预测中的价值 中国肾脏病杂志 2013 29(1):21-26
Shan Mou, Jialin Li, Zanzhe Yu, Qin Wang and Zhaohui Ni Keto acid-supplemented low-protein diet for treatment of adult patients with hepatitis B virus infection and chronic glomerulonephritis Journal of International Medical Research 2013 41(1)
徐维佳,李佳琳,王琴,施蓓莉,牟姗 （通讯作者）,倪兆慧 尿肝型脂肪酸结合蛋白预测慢性肾小球肾炎进展的价值 中华肾脏病杂志 2012 28(4):272-275
徐维佳,牟姗 （通讯作者）,王琴,施蓓莉,顾乐怡,倪兆慧 黄芪甲苷对高糖诱导的肾小管上皮细胞损伤的保护作用 中国中西医结合肾病杂志 2012 13(9):765-769
周慧,牟姗 （通讯作者）,杨海芸,王琴,施蓓莉,顾乐怡,杭瑛,倪兆慧 免疫法粪便隐血试验预测慢性肾脏病患者预后的意义 中华肾脏病杂志 2012 2012.28(6):429-434
王琴,牟姗 （通讯作者）,严玉澄,顾乐怡,朱铭力,周文彦,施蓓莉,倪兆慧 院内慢性肾脏病基础上急性肾损伤207例临床调查 中国实用内科杂志 2012 32(11):874-877
王琴,陈慧,徐维佳,牟姗 （通讯作者）,张敏芳,顾乐怡,戚超君,倪兆慧 黄芪注射液治疗慢性肾脏病基础上急性肾损伤的临床研究 中国中西医结合肾病杂志 2012 13(10):865-868
Shan Mou, Qin Wang, Wei Fang, Aiwu Lin, Beili Shi, Liou Cao, Wenyan Zhou, Jiaqi Qian and Zhaohui Ni Change in cardiovascular disease status in peritoneal dialysis patients: a 5-year single-center experience Ren Fail 2012 34(1):28-34
Shan Mou, Qin Wang, Wei Fang, Aiwu Lin, Beili Shi, Liou Cao, Wenyan Zhou, Jiaqi Qian and Zhaohui Ni Change in Cardiovascular Disease Status in Peritoneal Dialysis Patients: A 5-Year Single-Center Experience Renal Failure, 2012 34(1): 28–34, (2012)
Shan Mou , Qin Wang, Jialin Urinary excretion of liver-type fatty acid-binding protein as a marker of progressive kidney function deterioration in patients with chronic glomerulonephritis Clinica Chimica Acta 2012 413(1-2):187-191
Shan Mou （通讯作者）, Qin Wang, Jialin Li, Beili Shi, Zhaohui Ni Urinary excretion of liver-type fatty acid-binding protein as a marker of progressive kidney function deterioration in patients with chronic glomerulonephritis Clinica Chimica Acta 2012 413 (2012) 187–191