导师姓名： 焦伟华 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 地址：上海市浦建路160号1号楼A306室电话：
邮编： 200127 邮箱地址： weihuajiao@hotmail.com

研究方向 (点击浏览详细信息)
海绵及共附生微生物中活性天然产物研究

社会任职
上海市药学会天然药物专业委员会（2015-）青年委员
上海市”青年科技启明星计划（A类）“（2014）
中国菌物学会菌物化学专业委员会 （2018-）委员
中国药学会海洋药物专业委员会 “海洋药物博士论坛”第一届青年委员会（2015-）委员
SCI期刊《中国化学快报》青年编委会（2019-2022） 委员
上海交通大学 “SMC-晨星青年教师奖励计划（B类）”（2015）
2011 年度辽宁省优秀博士学位论文
SCI期刊《Chinese Journal of Natural Medicines》青年编委会（2019-2021） 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海市人才发展资金计划 上海市人力资源和社会保障局 2019-09~2022-09 30万元 课题负责人
** 海绵共附生Trichoderma属真菌中抗MRSA活性肽类化合物的发现及其构效关系研究 国家自然科学基金 2018-01~2018-12 20万元 课题负责人
** 海绵来源倍半萜醌类NF-κB抑制剂的发现及其抗肿瘤作用机制研究 国家自然科学基金委 2017-01~2019-12 68万元 课题负责人
14QA** 基于IKK-β/NF-κB通路的海绵新型抗肿瘤先导化合物的发现 上海市科委"青年科技启明星项目" 2014-07~2016-06 20万元 课题负责人
** 海绵共生放线菌Streptomyces sp. S10中新型抗骨髓瘤环缩肽的发现与成药性评价 上海市科委 2014-07~2017-06 40万元 课题负责人
** 基于海绵化学防御策略的新型友好型海洋防污剂的发现 国家自然科学基金委 2012-01~2014-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wei-Hua Jiao, Pradeep Dewapriya, Osama Mohamed, Zeinab G. Khalil, Angela A. Salim, Hou-Wen Lin, Robert J. Capon* Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-derived Fungus Trichodema virens CMB-TN16 Journal of Natural Products 2019 2019, 82 (1), 87?95
Wei-Hua Jiao#, Jing Li#, Meng-Meng Zhang, Jie Cui, Yu-Han Gui, Yun Zhang, Jing-Ya Li, Ke-Chun Liu, Hou-Wen Lin* Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa. Organic Letters 2019 21 (16), 6190-6193.
Yu-Han Gui, Wei-Hua Jiao* （通讯作者）, Mi Zhou, Yun Zhang, De-Quan Zeng, Hong-Rui Zhu, Ke-Chun Liu, Fan Sun, Hai-Feng Chen, and Hou-Wen Lin* Septosones A-C, in vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa Organic Letters 2019 21 (3), 767–770
Wei-Hua Jiao# （共同第一作者）, Wei Yuan#, Zhi-Yong Li, Jing Li, Lei Li, Jia-Bao Sun, Yu-Han Gui, Jie Wang, Bo-Ping Ye,* Hou-Wen Lin*. Anti-MRSA Actinomycins D1-D4 from the Marine Sponge-associated Streptomyces sp. LHW52447 Tetrahedron 2018 74 (40), 5914-5919
Jing Li#, Fan Yang#, Zhuo Wang#, Wei Wu, Li Liu, Shu-Ping Wang, Bin-Xin Zhao, Wei-Hua Jiao* （通讯作者）, Shi-Hai Xu*, Hou-Wen Lin*. Unusual Anti-inflammatory Meroterpenoids from the Marine Sponge Dactylospongia sp. Organic & Biomolecular Chemistry 2018 16 (36), 6773–6782
Jie Wang, Li-Yun Liu, Lei Liu, Kai-Xuan Zhan, Wei-Hua Jiao* （通讯作者）, Hou-Wen Lin*. Pellynols M-O, Cytotoxic Polyacetylenic Alcohols from a Niphates sp. Marine Sponge. Tetrahedron 2018 27, 3701-3706.
Jing Li, Wei Wu, Fan Yang, Li Liu, Shu-Ping Wang, Wei-Hua Jiao* （通讯作者）, Shi-Hai Xu*, Hou-Wen Lin* Popolohuanones G-I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans. Chemistry & Biodiversity 2018 e**, DOI: 10.1002/cbdv..
Wei-Hua Jiao, Zeinab Khalil, Pradeep Dewapriya, Angela A. Salim, Hou-Wen Lin, Robert J. Capon* Trichodermides A-E: Acyclic nonapeptides from the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 Journal of Natural Products 2018 81 (4), 976?984.
Wei-Hua Jiao, Bao-Hui Cheng, Guo-Dong Chen, Guo-Hua Shi, Jing Li, Tian-Yong Hu, Hou-Wen Lin* Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria Organic Letters 2018 20 (10), 3092-3095.
Wei-Hua Jiao# （共同第一作者）, Bao-Hui Cheng#, Guo-Hua Shi, Guo-Dong Chen, Bin-Bin Gu, Yong-Jun Zhou, Li-Li Hong, Fan Yang, Zhi-Qiang Liu, Shu-Qi Qiu, Zhi-Gang Liu, Ping-Chang Yang*, Hou-Wen Lin* Dysivillosins A-D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa Scientific Reports 2017 7, 8947
Wei-Hua Jiao# （共同第一作者）, Li-Li Hong#, Jia-Bao Sun#, Shu-Juan Piao, Guo-Dong Chen, Hai Deng, Shu-Piing Wang, Fan Yang, Hou-Wen Lin* (±)-Hippolide J, a Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne European Journal of Organic Chemistry 2017 2017 (24): 3421-3426.
Jie Wang#, Feng-Rong Mu#, Wei-Hua Jiao* （通讯作者）, Jian Huang, Li-Li Hong, Fan Yang, Ying Xu, Shu-Ping Wang, Fan Sun, Hou-Wen Lin* Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge Journal of Natural Products 2017 80 (9), 2509?2514.
Wei-Hua Jiao# （共同第一作者）, Guo-Hua Shi#, Ting-Ting Xu#, Guo-Dong Chen, Bin-Bin Gu, Zhuo Wang, Shuang Peng, Shu-Ping Wang, Jia Li, Bing-Nan Han, Wei Zhang, Hou-Wen Lin* Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge. Journal of Natural Products 2016 79 (2): 406-411.
Wei-Hua Jiao# （共同第一作者）, Guo-Dong Chen#, HaoGao*, Jing Li, Bin-Bin Gu, Ting-Ting Xu, Hao-Bing Yu, Guo-Hua Shi, Fan Yang, Xin-Sheng Yao*, Hou-Wen Lin*. (±)-Quassidines I and J, Two Pairs of Cytotoxic Bis-β-carboline Alkaloid Enantiomers from Picrasmaquassioides Journal of Natural Products 2015 78 (1): 125-130.
Wei-Hua Jiao# （共同第一作者）, Ting-Ting Xu#, Bin-Bin Gu#, Guo-Hua Shi, Yan Zhu, Fan Yang, Bing-Nan Han, Shu-Ping Wang, Yu-Shan Li*, Wei Zhang, Jia Li, Hou-Wen Lin* Bioactive Sesquiterpenequinols and quinones from the marine sponge Dysidea avara RSC Advances 2015 5 (106): 87730-87738.
Wei-Hua Jiao# （共同第一作者）, Ting-Ting Xu#, Feng Zhao, Hao Gao, Guo-Hua Shi, Jie Wang, Li-Li Hong, Hao-Bing Yu, Yu-Shan Li*, Fan Yang, Hou-Wen Lin* Dysifragilones A-C, Unusual SesquiterpeneAminoquinones as Inhibitors of NO Production from the South China Sea Sponge Dysidea fragilis. European Journal of Organic Chemistry 2015 2015 (5): 960-966.
Hao-Bing Yu#, Fan Yang#, Fan Sun, Guo-Yi Ma, Jian-Hong Gan, Wen-Zhen Hu, Bing-Nan Han, Wei-Hua Jiao* （通讯作者）, Hou-Wen Lin* Cytotoxic Aaptamine Derivatives from the South China Sea Sponge Aaptosaaptos. Journal of Natural Products 2014 77 (9): 2124-2129
Wei-Hua Jiao# （共同第一作者）, Jing Li#, Qian Liu, Ting-Ting Xu, Guo-Hua Shi, Hao-Bing Yu, Fan Yang, Bing-Nan Han, Min Li, Hou-Wen Lin* Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp. Molecules 2014 19 (11): 18025-18032.
Wei-Hua Jiao# （共同第一作者）, Ting-Ting Xu#, Hao-Bing Yu,Feng-Rong Mu, Jia Li, Yu-Shan Li, Fan Yang, Bing-Nan Han, Hou-Wen Lin* Dysidaminones A-M, Cytotoxic and NF-κB Inhibitory SesquiterpeneAminoquinones from the South China Sea Sponge Dysidea fragilis RSC Advances 2014 4 (18): 9236-9246
Wei-Hua Jiao, Ting-Ting Xu, Hao-Bing Yu, Guo-Dong Chen, Xiao-Jun Huang, Fan Yang, Yu-Shan Li, Bing-Nan Han, Xiao-Yan Liu*, Hou-Wen Lin* Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara Journal of Natural Products 2014 77 (2): 346-350.
Wei-Hua Jiao# （共同第一作者）, Jing Li#, Qian Liu, Ting-Ting Xu, Guo-Hua Shi, Hao-Bing Yu, Fan Yang, Bing-Nan Han, Min Li, Hou-Wen Lin* Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp. Molecules 2014 19 (11):18025-18032.
Shu-Juan Piao#, Yun-Long Song#, Wei-Hua Jiao# （共同第一作者）, Fan Yang, Xiang-Fang Liu, Wan-Sheng Chen, Bing-Nan Han*, Hou-Wen Lin* Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne Organic Letters 2013 15 (14): 3526-3529.
Wei-Hua Jiao, Xiao-Jun Huang, Ji-Si Yang, Fan Yang, Shu-Juan Piao, Hao Gao, Jia Li, Wen-Cai Ye, Xin-Sheng Yao, Wang-Sheng, Chen, Hou-Wen, Lin* Dysidavarones A-D, New Sesquiterpene Quinones from Marine Sponge Dysidea avara Organic Letters 2012 14 (1): 202-205.
Wei-Hua Jiao, HaoGao, Feng Zhao, Fei He, Guang-Xiong Zhou, Xin-Sheng Yao* A New Sesquilignan and a New Sesterterpenoide from the Stems of PicrasmaquassioidesBennet Chemistry & Biodiversity 2011 8 (6): 1163-1169
Wei-Hua Jiao#, HaoGao#, Feng Zhao, Yu-Min Pan, Guang-Xiong Zhou, Xin-Sheng Yao* Anti-inflammatory Alkaloids from the Stems of PicrasmaquassioidesBENNET Chemical & Pharmaceutical Bulletin 2011 59(3): 359-364.
Wei-Hua Jiao, HaoGao, Chen-Yang Li, Ren-Wang Jiang, Ying Wang, Guang-Xiong Zhou, Xin-Sheng Yao* Quassidines A–D, Bis-β-carboline Alkaloids from the Stems of Picrasmaquassioides. Journal of Natural Products 2010 73 (2): 167-171.
Wei-Hua Jiao, HaoGao, Chen-Yang Li, Guang-Xiong Zhou, Susumu Kitanaka, Atsuko Ohmura, Xin-Sheng Yao* β-carboline Alkaloids from the Stems of Picrasmaquassioides Magnetic Resonance in Chemistry 2010 48 (6): 490-495.