导师姓名： 崔龙 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属新华医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： **
邮编： 200092 邮箱地址： longcuidr@126.com

研究方向 (点击浏览详细信息)
结直肠癌发生发展中分子与免疫机制的研究
结直肠癌相关生物标记物的寻找
结直肠癌治疗新策略、新方法的研究

社会任职
中国医师协会肛肠分会常务委员，副总干事
Techniques In Coloprotology （SCI杂志）编委
中国医师协会肛肠分会炎性肠病专业委员会 主任委员
中华医学会外科分会结直肠外科学组 委员
中华中医药学会肛肠外科分会副会长
《中华消化外科杂志》编委
上海交通大学医学院附属新华医院肛肠外科 主任
上海交通大学结直肠癌诊治中心 主任
中华中医药学会肛肠外科分会 常务理事
《中华胃肠外科杂志》编委
上海市结直肠肿瘤研究中心主任
亚太结直肠肛门外科学会理事
上海市医学会外科专业委员会结直肠肛门外科学组副组长
上海市抗癌协会大肠癌专业委员会 常务委员
欧亚结直肠肛门外科技术联合会委员
上海中西医结合学会肛肠外科专业委员会 副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 转录因子TEAD4促进肠杯状细胞分化及其参与溃疡性结肠炎发生的生物学功能与机制研究 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
无 转录因子TEAD4促结直肠癌淋巴转移的生物学功能与机制研究 上海市科委国际合作项目 2018-10~2021-09 30万元 课题负责人
2014AA020800 结直肠癌疗效与预后判断相关免疫细胞亚群及免疫因子的筛选与干预研究 863计划 2014-01~2016-12 1100万元 课题负责人
** Mir-29a在结直肠癌肝转移中的作用机制及相关信号通路研究 国家自然科学基金 2014-01~2016-12 62万元 课题负责人
11DZ** 高强度聚焦超声(HIFU)治疗晚期直肠癌的前瞻性随机对照研究 上海市科委 2011-11~2014-09 50万元 课题负责人
XBR** 基于粪便核酸检测的大肠癌早期筛查新策略 上海市卫生局 2011-11~2014-12 50万元 课题负责人
10DJ** 结直肠癌分子分型关键基因mRNA和蛋白表达谱及其与临床病理相关性研究 上海市科委 2010-09~2013-09 40万元 课题负责人
09JC** 大肠癌癌前病变分子机制和易患性分子标志物的研究 上海市科委"创新行动计划"基础研究重点项目 2009-09~2011-08 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhehui Zhu, Jinglue Song, Yuegui Guo, Zhenyu Huang, Xiaojian Chen, Xuening Dang, Yuji Huang, Yuhan Wang, Weijun Ou, Yili Yang, Wei Yu, Chen-Ying Liu, Long Cui （通讯作者） LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer Oncogene 2020 online
Song J, Chen W, Cui X, Huang Z, Wen D, Yang Y, Yu W, Cui L （通讯作者）, Liu CY. CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer Theranostics 2020 10(5):2327-2341.
Wen D, Wang G, Huang Z, Cui X, Song J, Zhu Z, Cui L （通讯作者） Reduced Frequency and Prognostic Significance of Ring Finger Protein 43 Nucleotide Polymorphisms in a Chinese Colorectal Cancer Cohort DNA Cell Biol 2019 2019 Jun;38(6):541-548
Xu W, Zhu Y, Shen W, Ding W, Wu T, Guo Y, Chen X, Zhou M, Chen Y, Cui L, Du P Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer J Int Med Res 2019 2019 May;47(5):1829-1842.
Wei Z, Song J, Wang G, Cui X, Zheng J, Tang Y, Chen X, Li J, Cui L （通讯作者）, Liu CY, Yu W Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis Nat Commun 2018 2018 Oct 26;9(1):4468.
Wu T, Wang G, Chen W, Zhu Z, Liu Y, Huang Z, Huang Y, Du P, Yang Y, Liu CY, Cui L （通讯作者） Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions Cell Death Dis. 2018 2018 Feb 22;9(3):315
Cui X, Wang G, Shen W, Huang Z, He H, Cui L （通讯作者） Lysyl oxidase-like 2 is highly expressed in colorectal cancer cells and promotes the development of colorectal cancer Oncol Rep 2018 2018 Aug;40(2):932-942
Cui X, Shen W, Wang G, Huang Z, Wen D, Yang Y, Liu Y, Cui L （通讯作者） Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker Am J Transl Res 2018 2018 Nov 15;10(11):3701-3712.
Liu Y, Wang G, Liang Z, Mei Z, Wu T, Cui A, Liu C, Cui L （通讯作者） Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis Thorac Cancer 2018 2018 Jul;9(7):785-793
Wu T, Chen W, Zhong Y, Hou X, Fang S, Liu CY, Wang G, Yu T, Huang YY, Ouyang X, Li HQ, Cui L （通讯作者）, Yang Y. Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of Colorectal Cancer to Proteasome Inhibitor Mol Cancer Ther 2017 2017 Apr;16(4):717-728.
Liu CY, Pobbati AV, Huang Z, Cui L, Hong W Transglutaminase 2 Is a Direct Target Gene of YAP/TAZ-Letter. Cancer Res 2017 2017 Sep 1;77(17):4734-4735.
Mei Z, Wang G, Liang Z, Cui A, Xu A, Liu Y, Liu C, Yang Y, Cui L. （通讯作者） Prognostic value of IRF-2 expression in colorectal cancer. Oncotarget 2017 2017 Jun 13;8(24):38969-38977.
Liu CY, Yu T, Huang Y, Cui L （通讯作者）, Hong W. ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer J Biol Chem 2017 2017 Jun 2;292(22):9420-9430.
Wang G, Shen W, Liu CY, Liu Y, Wu T, Cui X, Yu T, Zhu Y, Song J, Du P, Cui L. （通讯作者） Phosphorylase kinase β affects colorectal cancer cell growth and represents a novel prognostic biomarker J Cancer Res Clin Oncol 2017 2017 Jun;143(6):971-980
Y Liu, G Wang, Y Yang, Z Mei, Z Liang, A Cui, T Wu, C-Y Liu, and L Cui （通讯作者） Increased TEAD4 expression and nuclear localization in colorectal cancer promotes epithelial-mesenchymal transition and metastasis in a YAP indepent manner Oncogene 2016 35(21):2789-800
Liu CY, Chan SW, Guo F, Toloczko A, Cui L （通讯作者）, Hong W. MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget 2016 2016 Mar 22;7(12):13706-16.
Yunxiang Zhu, Andong Xu, Jinming Li, Jihong Fu, GuanghuiWang, Yili Yang,Long Cui （通讯作者）, and Jiwei Sun, Fecal miR-29a and miR-224 as the noninvasive biomarkers for colorectal cancer cancer biomarkers 2016 16(2):259-64.
Liang Z, Ding W, Chen W, Wang Z, Du P, Cui L. Therapeutic Evaluation of Biofeedback Therapy in the Treatment of Anterior Resection Syndrome After Sphincter-Saving Surgery for Rectal Cancer Clin Colorectal Cancer 2016 2016 Sep;15(3):e101-7.
Lin Y,Wu TY,Yao QQ,Zi SM,Cui L. （通讯作者） LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway ONCOLOGY LETTERS 2015 9: 2859-2863
Ang Cui, Zubing Mei, Long Cui （通讯作者） Anal malignant proliferative trichilemmoma: report of a rare case with review of literature Int J Clin Exp Pathol 2015 8(3):3349-3353
Li J, Yang M, Cui L （通讯作者） Perianal swelling pain related to presacral giant cystic lesion[J] Gastroenterology 2014 146(2):e3
Z Mei, Y Liu, C Liu, A Cui, Z Liang, G Wang, H Peng, L Cui （通讯作者）, and C Li Tumour-infiltrating inflammation and prognosis in colorectal cancer:|systematic review and meta-analysis British Journal of Cancer 2014 (2014) 110, 1595–1605
Tang W, Zhu Y, Gao J,et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4 Br J Cancer 2014 Jan 21;110(2):450-8
Mei Z,Liu Y,Liu C,Cui L （通讯作者） Response to comment on 'Tumour-infiltrating inflammation and prognosis|in colorectal cancer: systematic review and meta-analysis' British Journal of Cancer 2014 2372-2373
Shiyong Huang, XiaoMing Zhong, Jun Gao, Rongfeng Song, Hongyu Wu,Shuming Zi, Shijie Yang, Peng Du, Long Cui （通讯作者）, Chun Yang, and Zikang Li Coexpression of SFRP1 and WIF1 as a Prognostic Predictor of Favorable Outcomes in Patients with Colorectal Carcinoma BioMed Research International 2014 Volume 2014, Article ID 256723, 8 pages
Zu-Bing Mei, Zhi-Jiang Zhang, Chen-Ying Liu, Yun Liu, Ang Cui, Zhong-Lin Liang, Guang-Hui Wang, Long Cui （通讯作者） Survival Benefits of Metformin for Colorectal Cancer Patients with|Diabetes: A Systematic Review and Meta-Analysis PLoS ONE 2014 9(3): e91818
Zhu Y, Tang W, Liu Y, et al. CCX-CKR expression in colorectal cancer and patient survival The International journal of biological markers 2013 2013: 0-0
朱鹏程, 梁中林, 王光辉, 等 血浆降钙素原对结直肠癌术后肠梗阻中的预测作用 中国普通外科杂志 2013 22(010): 1319-1323
Zhu P, Jiang H, Fu J,et al. Cytokine levels in abdominal exudate predict prolonged postoperative ileus following surgery for colorectal carcinoma ONCOLOGY LETTERS 2013 Sep;6(3):835-839
朱鹏程,梁中林,崔龙 腹腔引流液中的细胞因子在早期预测结直肠癌术后肠梗阻中的作用 结直肠肛门外科杂志 2013 19(2)
Zhu P, Liang Z, Fu J,et al. Procalcitonin in abdominal exudate to predit prolonged postoperative ileus following colorectal carcinoma surgery Int J Biol Markers 2013 Jun 28;28(2):187-91
丁文俊, 崔龙 全结直肠切除回肠储袋肛管吻合术治疗溃疡性结肠炎[J] 中华胃肠外科杂志 2013 16(007): 694-695
吴庭玉,崔龙,刘辰莹,等 白介素22活化STAT3信号通路促进结直肠癌细胞的增殖及其可能机制 中国肿瘤生物治疗杂志 2013 20(3).284-288