导师姓名： 宋怀东 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 博士生导师 专业学位导师：
联系方式： 转4255
邮编： 200011 邮箱地址： huaidong_s1966@163.com

研究方向 (点击浏览详细信息)
脂肪细胞的分泌功能和胰岛素抵抗；甲状腺疾病的基础和临床研究

社会任职
卫生部第二届中华医学奖评委委员会 委员
中国遗传学会分子诊断分会 委员
美国内分泌协会Poster竞赛评委
第十届中华内分泌代谢学会基础学组委员
第十一届中华内分泌代谢学会甲状腺学组委员
美国内分泌协会青年委员的Mentor
Annual of Thyroid Disorders编委
中华内分泌代谢病杂志编委
美国内分泌协会Active Member
Journal of Diabetes 编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** UGRP1阳性甲状腺细胞生物学功能及其在AITD发生中的作用 国家自然基金委面上项目 2018-01~2021-12 56万元 课题负责人
2017YFC** 低碘、甲减出生缺陷高危因素POCT 生化免疫检验技术及设备研发 科技部十三五重大研发计划 2017-07~2020-12 375万元 课题负责人
甲亢性周期性麻痹的易感基因的识别、发病分子机制及其预测的分子标志物研究 国家自然科学基金委国际和地区合作项目 2017-01~2020-12 84.6万元 课题负责人
** 环境中碘摄入增加与遗传因素相互作用在自身免疫性甲状腺疾病发生中的作用机制探讨 国家自然基金委重点项目 2015-01~2019-12 320万元 课题负责人
** 在自身免疫性疾病易感位点内识别鉴定Graves病新的致病易感基因 国家自然科学基金委面上项目 2014-01~2017-12 120万元 课题负责人
** 新的脂肪激素SPAR1在食欲调节中的作用和机理研究 国家自然科学基金委 2012-01~2015-12 60万元 课题负责人
C060502 弥漫性甲状腺肿伴甲亢（GD)易感基因识别和鉴定的策略探讨 国家自然基金，面上项目 2010-01~2012-12 35万元 课题负责人
甲亢的基础与临床研究创新团队 上海市教委 2010-01~2012-12 150万元 课题负责人
** 弥漫性甲状腺肿伴甲亢（GD)易感基因识别和鉴定的策略探讨 国家自然科学基金委 2010-01~2012-12 35万元 课题负责人
** UGRP-1在弥漫性甲状腺肿伴甲亢（Graves''病）发生中的作用探讨 国家自然基金委,面上项目 2008-01~2010-12 32万元 课题负责人
2007AA02Z175 人类重要生理功能分泌蛋白的识别及鉴定技术 国家科技部,863项目 2008-01~2010-12 289万元 课题负责人
06XD14016 自身免疫性甲状腺肿伴甲亢易感基因的识别及鉴定 上海市科委,学科带头人 2006-09~2008-09 25万元
** 新的参与胰岛素抵抗发生的脂肪激素/因子的识别和鉴定 国家自然基金委,重点项目 2006-01~2009-12 140万元 课题负责人
LJ06035 自身免疫性甲状腺肿伴甲亢易感基因的定位克隆研究 上海市卫生局,医学领军人才 2006-01~2010-12 50万元 课题负责人
以斑马鱼为模式生物高通量识别鉴定造血及血糖调节过程中关键基因 上海市科委,国际合作 2005-12~2007-12 20万元 课题负责人
** 人新的分泌蛋白/激素OIF在肾上腺表达功能研究 国家自然基金委,面上项目 2005-01~2007-12 21万元 课题负责人
人新的分泌蛋白OIF单抗的制备及其在垂体瘤诊断中 国家教育部,博士点基金 2005-01~2007-12 6万元 课题负责人
04SG43 自身免疫性甲状腺肿伴甲亢易感基因的定位克隆研究 上海市教委,曙光计划 2005-01~2007-12 12万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang RJ, Sun F, Chen F, Fang Y, Yan C Y, Zhang C R, Ying Y X, Wang Z, Zhang CX, Wu FY, Han B, Liang J, Zhao SX, Song HD. （通讯作者） The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism. Mol Cell Endocrinol. 2020 506: 110761
Zhang QY,Liu W,Li L,Du WH,Zuo CL,Ye XP, Zhou Z, Yuan FF, Ma YR, Sun F, Yu SS, Xie HJ, Zhang CR, Ying YX, Yuan GY, Gao GQ, Liang J, Zhao SX, Song HD. （通讯作者） Genetic study in a large cohort supported different pathogenesis of Graves' diseases and Hashimoto's hypothyroidism. J Clin Endocrinol Metab. 2020 105（7）:325
Zhao SX, Liu W, Liang J, Gao GQ, Zhang XM, Yao Y, Wang HN, Yuan FF, Xue LQ, Ma YR, Zhang LL, Ye XP, Zhang QY, Sun F, Zhang RJ, Yang SY, Zhan M, Du WH, Liu BL, Chen X, Song ZY, Li XS, Li P, Ru Y, Zuo CL, Li SX, Han B, Zhu H, Qiao J, Xuan M, Su B, Sun F, Ma JH, Chen JL, Tian HM, Chen SJ, Song HD （通讯作者） Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study. JAMA Netw Open. 2019 2(5):e193348
Ma YR, Zhao SX, Li L, Sun F, Ye XP, Yuan FF, Jiang D, Zhou Z, Zhang QY, Wan YY, Zhang GY, Wu J, Zhang RJ, Fang Y, Song HD. （通讯作者） A weighted genetic risk score using known susceptibility variants to predict Graves' disease risk. J Clin Endocrinol Metab. 2019 104(6):2121-2130.
Zhou Z, Zuo CL, Li XS, Ye XP, Zhang QY, Wang P, Zhang RX, Chen G, Yang JL, Chen Y, Ma QY, Song HD. （通讯作者） Uterus Globulin Associated Protein 1 (UGRP1) Is a Potential Marker of Progression of Graves' Disease Into Hypothyroidism Mol Cell Endocrinol. 2019 494:110492
Lu Li, Ying-xia Ying, Chang-run Zhang, Wei Wang, Yan Li, Yan Feng, Jun Liang, Huai-dong Song （通讯作者）, Yan Wang. Bisphenol A exposure and risk of thyroid nodules in Chinese women: A case-control study. Environment international 2019 126: 321-328.
Yuan FF, Ye XP, Liu W, Xue LQ, Ma YR, Zhang LL, Zhang MM, Sun F, Wan YY, Zhang QY, Zhao SX, Song HD. （通讯作者） Genetic study of early-onset Graves' disease in the Chinese Han population. Clin Genet. 2018 93(1):103-110.
Sun F, Zhang JX, Yang CY, Gao GQ, Zhu WB, Han B, Zhang LL, Wan YY, Ye XP, Ma YR, Zhang MM, Yang L, Zhang QY, Liu W, Guo CC, Chen G, Zhao SX, Song KY, Song HD. The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes Eur J Endocrinol. 2018 178(6):623-633.
Liu W, Zhang QY, Yuan FF, Wang HN, Zhang LL, Ma YR, Ye XP, Zhang MM, Song ZY, Li SX, Du WH, Liang J, Zhang XM, Gao GQ, Zhao SX, Chen FL, Song HD （通讯作者） A dense mapping study of six European AITD susceptibility regions in a large Chinese Han Cohort of Graves' disease. Clin Endocrinol 2018 89(6):840-848.
Zhang LL, Kan M, Zhang MM, Yu SS, Xie HJ, Gu ZH, Wang HN, Zhao SX, Zhou GB, Song HD （通讯作者）, Zheng CX. Multiregion sequencing reveals the intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer. Int J Cancer. 2017 140(1):103-108.
Ye XP, Yuan FF, Zhang LL, Ma YR, Zhang MM, Liu W, Sun F, Wu J, Lu M, Xue LQ, Shi JY, Zhao SX, Song HD （通讯作者）, Liang J, Zheng CX. ITM2A Expands Evidence for Genetic and Environmental Interaction in Graves Disease Pathogenesis. J Clin Endocrinol Metab. 2017 102(2):652-660.
Huang-Ming Cao, Xiao-Ping Ye, Jun-Hua Ma, He Jiang, Sheng-Xian Li, Rong-Ying Li, Xue-Song Li, Cui-Cui Guo, Zhi-Quan Wang, Ming Zhan, Chun-Lin Zuo, Chun-Ming Pan, Shuang-Xia Zhao, Cui-Xia Zheng, Huai-Dong Song （通讯作者） Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling E-Biomedicine 2015 2(11):1718-1724
Liu BL, Yang SY, Liu W, Xue LQ, Chen X, Pan CM, Gu ZH, Zhan M, Zhang XM, Liang J, Gao GQ, Du WH, Yuan GY, Ying R, Zhao SX, Song HD. （通讯作者） Refined association of TSH receptor susceptibility locus to Graves' disease in the Chinese Han population. Eur J Endocrinol. 2014 170(1):109-19.
Liu W, Wang HN, Gu ZH, Yang SY, Ye XP, Pan CM, Zhao SX, Xue LQ, Xie HJ, Yu SS, Guo CC, Du WH, Liang J, Zhang XM, Yuan GY, Li CG, Su Q, Gao GQ, Song HD （通讯作者） Identification of BACH2 as a susceptibility gene for Graves' disease in the Chinese Han population based on a three-stage genome-wide association study. Hum Genet. 2014 2014 May;133(5):661-71.
Zhan, M., Chen, G., Pan, C.M., Gu, Z.H., Zhao, S.X., Liu, W., Wang, H.N., Ye, X.P., Xie, H.J., Yu, S.S., Liang （通讯作者）, J., Gao, G.Q., Yuan, G.Y., Zhang, X.M., Zuo, C.L., Su, B., Huang, W., Ning, G., Chen, S.J., Chen, J.L., Song, H.D. Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Hum Mol Genet. 2014 23(20):5505-17
Xue L, Pan C, Gu Z, Zhao S, Han B, Liu W, Yang S, Yu S, Sun Y, Liang J, Gao G, Zhang X, Yuan G, Li C, Du W, Chen G, Chen J, Song H. （通讯作者） Genetic heterogeneity of susceptibility gene in different ethnic populations: refining association study of PTPN22 for Graves' disease in a Chinese Han population. PLoS One. 2013 8(12):e84514.
Jiang H, Ye XP, Yang ZY, Zhan M, Wang HN, Cao HM, Xie HJ, Pan CM, Song HD, Zhao SX. （通讯作者） Aldosterone directly affects apelin expression and secretion in adipocytes. J Mol Endocrinol. 2013 51(1):37-48.
Zhao SX, Liu W, Zhan M, Song ZY, Yang SY, Xue LQ, Pan CM, Gu ZH, Liu BL, Wang HN, Liang L, Liang J, Zhang XM, Yuan GY, Li CG, Chen MD, Chen JL, Gao GQ, Song HD （通讯作者） A refined study of FCRL genes from a genome-wide association study for Graves' disease. PLoS One. 2013 8(3):e57758
Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, Zhan M, Wang HN, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Du WH, Liu BL, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Huang W, Liang L, Qi L, Chen SJ, Chen Z, Chen JL, Song HD （通讯作者） Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet. 2013 2013 Aug 15;22(16):3347-62.
Xue LQ, Han B, Chen LB, Pan CM, Zhu H, Liu BL, Liu W, Wu WL, Chen MD, Lu YL, Qiao J, Song HD. （通讯作者） Identification of a novel mutation in CYP17A1 gene. Transl Res. 2013 161(1):44-9.
Song ZY, Liu W, Xue LQ, Pan CM, Wang HN, Gu ZH, Yang SY, Cao HM, Zuo CL, Zhang XN, Jiang H, Liu BL, Bi YX, Zhang XM, Zhao SX, Song HD. （通讯作者） Dense mapping of IL2RA shows no association with Graves' disease in Chinese Han population. Clin Endocrinol (Oxf). 2013 79(2):267-74.
Cao HM, Wang ZY, Zhang GW, Liu CF, Pan CM, Zhao SX, Song ZY, Song HD （通讯作者）, Zhang L. Identification of a locus (DSP2) for disseminated superficial porokeratosis at chromosome 12q21.2-24.21. Clin Exp Dermatol. 2012 37(6):672-6.
Han B, Wang ZQ, Xue LQ, Ma JH, Liu W, Liu BL, Wu JJ, Pan CM, Chen X, Zhao SX, Lu YL, Wu WL, Qiao J, Song HD. （通讯作者） Functional study of an aberrant splicing variant of the human luteinizing hormone (LH) receptor. Mol Hum Reprod. 2012 18(3):129-35.
Song ZY, Liu W, Xue LQ, Pan CM, Wang HN, Gu ZH, Yang SY, Cao HM, Zuo CL, Zhang XN, Jiang H, Liu BL, Bi YX, Zhang XM, Zhao SX, Song HD. （通讯作者） Dense mapping of IL2RA shows no association with Graves' disease in Chinese Han population. Clin Endocrinol (Oxf). 2012 doi: 10.1111/cen.12115.
Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Xue LQ, Shen M, Liu W, Xie F, Yang SY, Wang HF, Shi JY, Sun WW, Du WH, Zuo CL, Shi JX, Liu BL, Guo CC, Zhan M, Gu ZH, Zhang XN, Sun F, Wang ZQ, Song ZY, Zou CY, Sun WH, Guo T, Cao HM, Ma JH, Han B, Li P, Jiang H, Huang QH, Liang L, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Chen Z, Chen JL, Chen SJ, Huang W, Song HD （通讯作者） A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet. 2011 43(9):897-901.
Ma QY, Zhang XN, Jiang H, Wang ZQ, Zhang HJ, Xue LQ, Chen MD, Song HD. （通讯作者） Mimecan in pituitary corticotroph cells may regulate ACTH secretion and the HPAA. Mol Cell Endocrinol. 2011 341(1-2):71-7.
Xu C, Zhang L, Chen N, Su B, Pan CM, Li JY, Zhang GW, Liu Z, Sheng Y, Song HD. （通讯作者） A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12 approximately 12.3 in a Chinese family. J Cutan Pathol. 2010 37(7):758-63.
Ma JH, Shen SH, Zhang GW, Zhao DS, Xu C, Pan CM, Jiang H, Wang ZQ, Song HD. （通讯作者） Identification of a locus for autosomal dominant high myopia on chromosome 5p13.3-p15.1 in a Chinese family. Mol Vis. 2010 16:2043-54.
Zhao SX, Pan CM, Cao HM, Han B, Shi JY, Liang　J, Gao GQ, PengYD, Su　Q, Chen JL, Zhao JJ, Song HD. （通讯作者） Association of the CTLA4 Gene with Graves' Disease in the Chinese Han Population. PLoS One. 2010 5(3):e9821.
Qiao J, Chen X, Zuo CL, Gu YY, Liu BL, Liang J, Lu YL, Tang JF, Wu YX, Chen MD, Chen JL, Wu WL, Song HD. （通讯作者） Identification of steroid biosynthetic defects in genotype-proven heterozygous individuals for 17alpha-hydroxylase/17,20- lyase deficiency. Clin Endocrinol (Oxf). 2010 72(3):312-9.
Ma QY, Zuo CL, Ma JH, Zhang XN, Ru Y, Li P, Pan CM, Liu Z, Cao HM, Chen MD, Song HD. （通讯作者） Glucocorticoid up-regulates mimecan expression in corticotroph cells. Mol Cell Endocrinol. 2010 321(2):239-44
Li P, Sun F, Cao HM, Ma QY, Pan CM, Ma JH, Zhang XN, Jiang H, Song HD （通讯作者）, Chen MD. Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: Adiponectin regulates steroidogenesis. Biochem Biophys Res Commun. 2009 390(4):1208-13.
Qiao J, Han B, Liu BL, Chen X, Ru Y, Cheng KX, Chen FG, Zhao SX, Liang J, Lu YL, Tang JF, Wu YX, Wu WL, Chen JL, Chen MD, Song HD. （通讯作者） A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. Hum Mutat. 2009 30(9):E855-65.
Song HD （通讯作者）, Liang J, Shi JY, Zhao SX, Liu Z, Zhao JJ, Peng YD, Gao GQ, Tao J, Pan CM, Shao L, Cheng F, Wang Y, Yuan GY, Xu C, Han B, Huang W, Chu X, Chen Y, Sheng Y, Li RY, Su Q, Gao L, Jia WP, Jin L, Chen MD, Chen SJ, Chen Z, Chen JL. Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. Hum Mol Genet. 2009 18(6):1156-1170.
Li RY, Li XS, Shao L, Wu ZY, Du WH, Li SX, Zhao SX, Chen KM, Chen MD, Song HD. （通讯作者） Influence of visceral adiposity on ghrelin secretion and expression in rats during fasting. J Mol Endocrinol. 2009 42(1):67-74.
Xu C, Wei M, Su B, Hua XW, Zhang GW, Xue XP, Pan CM, Liu R, Sheng Y, Lu ZG, Jin LR, Song HD. （通讯作者） Ile90Met, a novel mutation in the cardiac troponin T gene for familial hypertrophic cardiomyopathy in a Chinese pedigree. Genet Res. 2008 90(5):445-50.
Yuan GY, Chen X, Ma QY, Qiao J, Li RY, Li XS, Li SX, Tang JF, Zhou LB, Song HD （通讯作者）, Chen MD. C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes. J Endocrinol. 2007 194(2):275-81.
Li RY, Zhang QH, Liu Z, Qiao J, Zhao SX, Shao L, Xiao HS, Chen JL, Chen MD, Song HD. （通讯作者） Effect of short-term and long-term fasting on transcriptional regulation of metabolic genes in rat tissues. Biochem Biophys Res Commun. 2006 344(2):562-70.
Hu SM, Li F, Yu HM, Li RY, Ma QY, Ye TJ, Lu ZY, Chen JL, Song HD. （通讯作者） The Mimecan Gene Expressed in Human Pituitary and Regulated by PIT-1 as a Marker for Diagnosing Pituitary Tumors. J Clin Endocrinol Metab 2005 90(12):6657-6664
Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, Zheng HJ, Chern SW, Cheng F, Pan CM, Xuan H, Chen SJ, Luo HM, Zhou DH, Liu YF, He JF, Qin PZ, Li LH, Ren YQ, Liang WJ, Yu YD, Anderson L, Wang M, Xu RH, Wu XW, Zheng HY Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A. 2005 102(7):2430-5.
Song HD, Sun XJ, Deng M, Zhang GW, Zhou Y, Wu XY, Sheng Y, Chen Y, Ruan Z, Jiang CL, Fan HY, Zon LI, Kanki JP, Liu TX, Look AT, Chen Z. Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A. 2004 101(16):16240-16245.
Li RY, Song HD （通讯作者）, Shi WJ, Hu SM, Yang YS, Tang JF, Chen MD, Chen JL. Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes. J Mol Endocrinol 2004 33:11-19
Epidemiology group: Jian-Feng He, ? Guo-Wen Peng, Jun Min, De-Wen Yu, Wen-Jia Liang, Shu-Yi Zhang, Rui-Heng Xu? Virology group: Huan-Ying Zheng, ? Xin-Wei Wu, ? Jun Xu, Zhan-Hui Wang, Ling Fang, Xin Zhang, Hui Li, Xin-Ge Yan, Jia-Hai Lu, Zhi-Hong Hu, Ji-C Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China. Science . 2004 303(5664):1666-9
Hu W, Yan Q, Shen DK, Liu F, Zhu ZD, Song HD （共同第一作者）, Xu XR, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley PJ, McManus DP, Xue CL, Feng Z, Chen Z, Han ZG. Evolutionary and biomedical implications of a Schistoma Japonicum complementary DNA resource. Nat Genet 2003 35(2):139-47
Hu RM, Han ZG, Song HD （共同第一作者）, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL. Gene expression profiling in human tissues of hypothalamus-pituitary-adrenal axis by expressed sequence tags (ESTs) and full-length cDNA cloning. Proc Natl Acad Sci USA. 2000 97：9543－9548
Zhang XN, Xue LQ, Jiang H, Yang SY, Song HD （通讯作者）, Ma QY. The mechanism of mimecan transcription induced by glucocorticoid in pituitary corticotroph cells Mol Cell Biochem. 360(1-2):321-8.