导师姓名： 孟祥军 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： meng_xiangjun@yahoo.comxiangjunmeng@aliyun.com
邮编： 200011 邮箱地址： meng_xiangjun@yahoo.com

研究方向 (点击浏览详细信息)
慢性胃病与消化系肿瘤的防治

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于特异性多肽CBP-DWS靶向化疗结肠癌的研究 国家自然科学基金委 2019-01~2022-12 57万元 课题负责人
qt1265 诱导型原发性肝癌基因敲除斑马鱼模型的制作 上海市科委 2014-07~2017-08 40万元 课题负责人
** LKB1/APMK调控有氧酵解信号途径诱导结肠癌细胞凋亡机制的研究 国家自然科学基金面上项目 2013-01~2016-12 70万元 课题负责人
** TRB3 对肝癌细胞凋亡的影响及其机理的研究 国家自然科学基金面上项目 2011-01~2013-12 33万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Shi L, Hu F, Duan Y, Wu W, Dong J, Meng X, Zhu X, Liu B Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy. ACS Nano 2020 doi: 10.1021/acsnano.9b09032
Liang Y, Zhu D, Hou L, Wang Y, Huang X, Zhou C, Zhu L, Wang Y, Li L, Gu Y, Luo M, Wang J, Meng X （通讯作者） MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. British journal of cancer 2020 doi: 10.1038/s41416-019-0703-3
Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X （通讯作者） Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway. Journal of Cancer 2019 10(24):6037-6047
Luo XY, Meng XJ （通讯作者）, Cao DC, Wang W, Zhou K, Li L, Guo M, Wang P. Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes Stem Cell Res Ther 2019 10(1):16. doi: 10.1186/s13287-018-1122-8
Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X. （通讯作者） Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway. Oncogene 2019 doi: 10.1038/s41388-019-1035-8
Hou, L, Zhu, D, Liang, Y, Tian X, Li, L, Wang, P, et al. Meng X Identification of a specific peptide binding to colon cancer cells from a phage-displayed peptide library British journal of cancer 2018 118: 79-87.
Wang, Y, Weng, X, Wang, L, Hao, M, Li, Y, Hou, L （通讯作者）, et al. Meng X. Wang J HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk The Journal of clinical investigation 2018 128: 5235-5250
Li, Y, Zhu, D, Hou, L （通讯作者）, Hu, B, Xu, M, and Meng, X TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells Oncology letters 2018 15: 1343-1349
Hao, M, Weng, X, Wang, Y, Sun, X （通讯作者）, Yan, T, Li, Y, et al. Meng X. Wang J Targeting CXCR7 improves the efficacy of breast cancer patients with tamoxifen therapy Biochemical pharmacology 2018 147: 128-140
Zhu D, Hou L, Hu B, Zhao H, Sun J, Wang J, Meng X. （通讯作者） Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate. Scientific Reports 2016 2016 Nov 22;6:37478. doi: 10.1038/srep37478
Zhao H, He Z, Huang D, Gao J, Gong Y, Wu H, Xu A, Meng X （通讯作者）, Li Z Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International 2016 2016:**
Zhao H, Zhu F, Sun J, Meng X. （通讯作者） Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians. Tumour Biol. 2014 35(3):2111-6
Zhu F, Zhao H, Tian X, Meng X. （通讯作者） Association between tumor necrosis factor-α rs** polymorphism and risk of gastric cancer: a meta-analysis. Tumour Biol. 2014 35(3):1799-803
Xu X, Li B, Huang P, Wan X, Qin Y, Zhou L, Liu H, Bai H, Gao Y, Wang C, Meng X. （通讯作者） Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1α signaling. Mol Med Rep. 2013 8(5):1379-84
Li B, Wan X, Zhu Q, Li L, Zeng Y, Hu D, Qian Y, Lu L, Wang X, Meng X （通讯作者） Net expression inhiobits the growth of of pancreatic ductal adenocarcinoma cell PL45 in vitro and in vivo Plos One 2013 8(2)e57818 doi:10.1371
Hu B, Tian X, Sun J, Meng X. （通讯作者） Evaluation of individual and combined applications of serum biomarkers for diagnosis of hepatocellular carcinoma: a meta-analysis. Int J Mol Sci. 2013 14(12):23559-80. doi: 10.3390
Vidimar V, Meng X （共同第一作者）, Klajner M, Licona C, Fetzer L, Harlepp S, Hébraud P, Sidhoum M, Sirlin C, Loeffler JP, Mellitzer G, Sava G, Pfeffer M, Gaiddon C. Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity Biochemical Pharmacology 2012 84(11):1428-36
Benosman S, Meng X （共同第一作者）, Von Grabowiecki Y, Palamiuc L, Hritcu L, Gross I, Mellitzer G, Taya Y, Loeffler JP, Gaiddon C. Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons The Journal of Biological Chemistry 2011 ;286(50):43013-25
Fetzer L, Boff B, Ali M, Xiangjun M, Collin JP, Sirlin C, Gaiddon C, Pfeffer M. Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier. Dalton Transaction 2011 40(35):8869-78
Meng X, Leyva ML, Jenny M, Gross I, Benosman S, Fricker B, Harlepp S, Hébraud P, Boos A, Wlosik P, Bischoff P, Sirlin C, Pfeffer M, Loeffler JP, Gaiddon C. A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Research 2009 69(13):5458-66
Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D. Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc Natl Acad Sci U S A. 2008 105(7):2521-6
Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P. Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. The Journal of Investigative Dermatology 2007 127(5):1250-60