导师姓名： 赵双霞 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： zhaozhao1215@126.com

研究方向 (点击浏览详细信息)
甲状腺疾病的基础和临床、遗传性内分泌代谢病的发病机制研究

社会任职
上海市中西医结合学会青年委员会常委
美国甲状腺协会（American Thyroid Association, ATA）通讯会员
上海市医学会内科分会青年委员会委员
美国内分泌协会通讯会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 新的先天性甲减致病基因EIF4B的识别及其致病分子机制的研究 国家自然科学基金委面上项目 2019-01~2022-12 57万元 课题负责人
** 采用全外显子组测序技术识别鉴定甲状腺功能亢进伴周期性麻痹的致病基因和致病位点 国家自然科学基金委面上项目 2016-01~2019-12 78万元 课题负责人
XYQ** 在自身免疫性疾病易感位点内识别鉴定Graves病新的致病易感基因 上海市卫生及计划生育委员会“新优青”计划 2014-01~2016-12 30万元 课题负责人
** 弥漫性甲状腺肿伴甲亢新的易感位点6q27区段内致病基因和致病SNP位点的识别和功能研究 国家自然科学基金委青年项目 2012-01~2014-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li XS, Yan CY, Fan YJ, Yang JL*, Zhao SX* （通讯作者） NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in the Chinese population Ann Transl Med 2020 8(6): 290
Zhang QY#, Liu W#, Li L#, Du WH#, Zuo CL#, Ye XP#, Zhou Z, Yuan FF, Ma YR, Sun F, Yu SS, Xie HJ, Zhang CR, Ying YX, Yuan GY, Gao GQ, Liang J, Zhao SX* （通讯作者）, Song HD* Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves' Disease and Hashimoto's Hypothyroidism J Clin Endocrinol Metab 2020 105(7)
Yan CY#, Ma YR#, Sun F, Zhang RJ, Fang Y, Zhang QY, Wu FY, Zhao SX* （通讯作者）, Song HD* Candidate gene associations reveal sex-specific Graves' disease risk alleles among Chinese Han populations Mol Genet Genomic Med 2020 e1249
Zhang RJ, Sun F, Chen F, Fang Y, Yan C Y, Zhang C R, Ying Y X, Wang Z, Zhang CX, Wu FY, Han B, Liang J, Zhao SX*, Song HD* （通讯作者） The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism Mol Cell Endocrinol 2020 506: 110761.
Zhao SX#, Liu W#, Liang J#, Gao GQ#, Zhang XM#, Yao Y#, Wang HN, Yuan FF, Xue LQ, Ma YR, Zhang LL, Ye XP, Zhang QY, Sun F, Zhang RJ, Yang SY, Zhan M, Du WH, Liu BL, Chen X, Song ZY, Li XS, Li P, Ru Y, Zuo CL, Li SX, Han B, Zhu H, Qiao J, Xuan M, Su B, Sun F, Ma JH, Chen JL, Tian HM, Chen SJ, Song HD*; China Consortium for the Genetics of Autoimmune Thyroid Disease Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study JAMA Netw Open 2019 2(5):e193348
Ma YR#, Zhao SX# （共同第一作者）, Li L#, Sun F, Ye XP, Yuan FF, Jiang D, Zhou Z, Zhang QY, Wan YY, Zhang GY, Wu J, Zhang RJ, Fang Y, Song HD* A weighted genetic risk score using known susceptibility variants to predict Graves' disease risk J Clin Endocrinol Metab 2019 104(6):2121-2130
Yuan FF#, Ye XP#, Liu W, Xue LQ, Ma YR, Zhang LL, Zhang MM, Sun F, Wan YY, Zhang QY, Zhao SX* & Song HD* （通讯作者） Genetic Study of Early-onset Graves' Disease in the Chinese Han Population Clin Genet 2018 93(1):103-110
Sun F#, Zhang JX#, Yang CY#, Gao GQ#, Zhu WB, Han B, Zhang LL, Wan YY, Ye XP, Ma YR, Zhang MM, Yang L, Zhang QY, Liu W, Guo CC, Chen G*, Zhao SX* （通讯作者）, Song KY*, Song HD* The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes European journal of endocrinology 2018 178(6): 623-633
Liu Bing-Li(#),Yang Shao-Ying(#),Liu Wei,Xue Li-Qiong,Chen Xia,Pan Chun-Ming,Gu Zhao-Hui,ZhanMing,Zhang Xiao-Mei,Liang Jun,Gao Guan-Qi,Du Wen-Hua,Yuan Guo-Yue,Ying Ru,Zhao Shuang-Xia(*) （通讯作者）,Song Huai-Dong(*) Refined association of TSH receptor susceptibility locus to Graves' disease in the Chinese Han population European journal of endocrinology 2014 170（1）：109-19
Zhan Ming(#),Chen Gang(#),Pan Chun-Ming(#),Gu Zhao-Hui(#),Zhao Shuang-Xia(#) （共同第一作者）,Liu Wei(#),WangHai-Ning,Ye Xiao-Ping,Xie Hui-Jun,Yu Sha-Sha,Liang Jun,Gao Guan-Qi,Yuan Guo-Yue,ZhangXiao-Mei,Zuo Chun-Lin,Su Bin,Huang Wei,Ning Guang,Chen Sai-Juan,Chen Jia-Lun,SongHuai-Dong Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese population Human Molecular Genetics 2014 23（20）：5505-17
Jiang He(#),Ye Xiao-Ping(#),Yang Zhong-Yin(#),Zhan Ming,Wang Hai-Ning,Cao Huang-Min,Xie Hui-Jun,Pan Chun-Ming,Song Huai-Dong,Zhao Shuang-Xia(*) （通讯作者） Aldosterone directly affects apelin expression and secretion in adipocytes Journal of Molecular Endocrinology 2013 51（1）：37-48
Zhao Shuang-Xia(#),Xue Li-Qiong(#),Liu Wei(#),Gu Zhao-Hui(#),Pan Chun-Ming(#),Yang Shao-Ying(#),ZhanMing,Wang Hai-Ning,Liang Jun,Gao Guan-Qi,Zhang Xiao-Mei,Yuan Guo-Yue,Li Chang-Gui,Du Wen-Hua,LiuBing-Li,Liu Li-Bin,Chen Gang,Peng Yong-De,Peng Y. D.,Zhao Jia-Jun,Ning Guang,Huang Wei,LiangLiming,Qi Lu,Chen Sai-Juan,Chen Zhu,Chen Jia-Lun,Song Huai-Dong(*), Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis Human Molecular Genetics 2013 22（16）：3347-62
Zhao Shuang-Xia(#),Liu Wei,Zhan Ming,Song Zhi-Yi,Yang Shao-Ying,Xue Li-Qiong,Pan Chun-Ming,GuZhao-Hui,Liu Bing-Li,Wang Hai-Ning,Liang Liming,Liang Jun,Zhang Xiao-Mei,Yuan Guo-Yue,LiChang-Gui,Chen Ming-Dao,Chen Jia-Lun,Gao Guan-Qi,Song Huai-Dong A refined study of FCRL genes from a genome-wide association study for Graves' disease PLos One 2013 8（3）：e57758
Zhao Shuang-Xia(#),Tsui Shanli,Cheung Anthony,Douglas Raymond S,Smith Terry J,Banga J Paul(*),,,2011,。 Orbital fibrosis in a mouse model of Graves' disease induced by genetic immunization of thyrotropin receptor cDNA The Journal of endocrinology 2011 210（3）：369-77
Chu Xun(#),Pan Chun-Ming(#),Zhao Shuang-Xia(#) （共同第一作者）,Liang Jun(#),Gao Guan-Qi(#),Zhang Xiao-Mei(#),YuanGuo-Yue,Li Chang-Gui,Xue Li-Qiong,Shen Min,Liu Wei,Xie Fang,Yang Shao-Ying,Wang Hai-Feng,ShiJing-Yi,Sun Wei-Wei,Du Wen-Hua,Zuo Chun-Lin,Shi Jin-Xiu,Liu Bing-Li,Guo Cui-Cui,Zhan Ming,GuZhao-Hui,Zhang Xiao-Na,Sun Fei,Wang Zhi-Quan,Song Zhi-Yi,Zou Cai-Yan,Sun Wei-Hua,Guo Ting,CaoHuang-Ming,Ma Jun-Hua,Han Bing,Li Ping,Jiang He,Huang Qiu-Hua,Liang Liming,Liu Li-Bin,ChenGang,Su Qing,Peng Yong-De,Zhao Jia-Jun,Ning Guang(*),Chen Zhu(*),Chen Jia-Lun(*),Chen Sai-Juan(*),Huang Wei(*),Song Huai-Dong(*) A genome-wide association study identifies two new risk loci for Graves' Nature Genetics 2011 43（9）：897-901
Zhao Shuang-Xia(#),Pan Chun-Ming(#),Cao Huang-Ming(#),Han Bing,Shi Jing-Yi,Liang Jun,GaoGuan-Qi,Peng Yong-De,Su Qing,Chen Jia-Lun,Zhao Jia-Jun,Song Huai-Dong(*),,,2010, Association of the CTLA4 gene with Graves' disease in the Chinese Han population PLos One 2010 5（3）：e9821
Song HD(*)(#), Liang J(#), Shi JY(#), Zhao SX(#) （共同第一作者）, Liu Z(#), Zhao JJ(#), Peng YD, Gao GQ, Tao J, Pan CM, Shao L, Cheng F, Wang Y, Yuan GY, Xu C, Han B, Huang W, Chu X, Chen Y, Sheng Y, Li RY, Su Q, Gao L, Jia WP, Jin L, Chen MD, Chen SJ, Chen Z, Chen JL. . Hum Mol Genet. 2009 Mar 15; Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease Human Molecular Genetics 2009 18(6):1156-70.
Zheng CX(*)(#), Zhao SX(#) （共同第一作者）, Wang P(#), Yu HM, Wang CF, Han B, Su B, Xiang Y, Li XS, Li SX, Ma QY, Zhang RX, Wan HY, Song HD Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC Oncol Rep. 2009 22(5):1057-61