导师姓名： 顾俊 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 心血管病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： forrestgu@126.com
邮编： 200011 邮箱地址： forrestgu@126.com

研究方向 (点击浏览详细信息)
心肌病，心力衰竭
心律失常基础与临床研究

社会任职
上海市医学会内科分会青年委员会副主任委员
中国医师协会心血管医师分会预防与康复学组成员
中国老年学会老年医学委员会高尿酸及痛风专家委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 神经酰胺通过Rab7a抑制线粒体自噬和脂性自噬参与糖尿病心肌脂毒性的机制研究 国家自然科学基金面上项目 2021-01~2024-12 55万元 课题负责人
20ZR** Irisin/UCP-2/EndMT途径介导有氧运动拮抗阿霉素 致心肌纤维化的机制研究 上海市科委自然科学基金 2020-07~2023-06 20万元 课题负责人
JYLJ201803 高血压左室肥厚合并无症状高尿酸血症患者降尿酸治疗对左室舒张功能的随机对照研究 上海交通大学医学院附属第九人民医院临+项目 2019-01~2021-12 20万元 课题负责人
** MicroRNA-21通过调控心外膜脂肪棕色化参与糖尿病致心房纤维化的机制研究 国家自然科基金面上项目 2017-01~2020-12 55万元 课题负责人
** 白藜芦醇对阿霉素致心肌自噬的保护作用及机制探讨 上海市科委 2014-08~2017-09 20万元 课题负责人
2013-2-12 PPARγ激动剂对持续性房颤电复律术后疗效的干预作用 中国医师协会 2013-01~2014-06 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jun Gu （共同第一作者）, Yang Zhuo, Tian-jiao Liu, Jie Li, Zhao-fang Yin, Zuo-jun Xu, Li Fan, Qing He, Kan Chen, Hua-su Zeng, Xiao-fei Wang, Yu-qi Fan, Jun-feng Zhang, Fu-you Liang, Chang-qian Wang Balloon Deflation Strategy during Primary Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Clinical Trial and Numerical Simulation-Based Analysis Cardiology Research and Practice 2020 doi.org/10.1155/2020/**
Jun Gu, Jian-An Pan, Hao Lin , Jun-Feng Zhang , Chang-Qian Wang. Characteristics, prognosis and treatment response in distinct phenogroups of heart failure with preserved ejection fraction Int J Cardiol 2020 doi:10.1016/j.ijcard.2020.08.065.Online aheadof print
Li Fan , Jian-An Pan, Hao Lin , Chang-Qian Wang , Jun-Feng Zhang , Jun Gu （通讯作者） Optimal management of blood glucose, blood pressure and atrial fibrillation to reduce the risk of heart failure with preserved ejection fraction. Intern Med J 2020 doi: 10.1111/imj.15006. Online ahead of print.
Pan JA, Lin H, Wang CQ, Zhang JF, Gu J （通讯作者） Association between long-term prescription of febuxostat and the progression of heart failure with preserved ejection fraction in patients with hypertension and asymptomatic hyperuricemia Heart Vessels 2020 35(10):1446-1453
Gu J, Yin ZF, Zhang HL, Fan YQ, Zhang JF, Wang CQ Characteristics and outcomes of transitions among heart failure categories: a prospective observational cohort study ESC Heart Fail 2020 doi: 10.1002/ehf2.12619. [Epub ahead of print]
Gu J, Yin ZF, Pan JA, Zhang JF, Wang CQ Visit-to-visit variability in low-density lipoprotein cholesterol isassociated with adverse events in non-obstructive coronary artery disease Anatol J Cardiol 2019 22:117-24
Gao L, Zeng H, Zhang T, Mao C, Wang Y, Han Z, Chen K, Zhang J, Fan Y, Gu J （通讯作者）, Wang C MicroRNA-21 deficiency attenuated atherogenesis and decreased macrophage infiltration by targeting Dusp-8 Atherosclerosis 2019 291:78-86
Pan JA, Tang Y, Yu JY, Zhang H, Zhang JF, Wang CQ, Gu J （通讯作者） miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity Cell Death Dis 2019 10(9):668
Gu J, Yin ZF, Zhang JF, Wang CQ Association between long-term prescription of metformin and the progression of heart failure with preserved ejection fraction in patients with type 2 diabetes mellitus and hypertension Int J Cardiol 2019 doi: 10.1016/j.ijcard.2019.11.087. [Epub ahead of print]
Gu J, Pan JA, Fan YQ, Zhang HL, Zhang JF, Wang CQ. Prognostic impact of HbA1c variability on long-term outcomes in patients with heart failure and type 2 diabetes mellitus. Cardiovasc Diabetol 2018 17(1):96
Gu J, Fan YQ, Zhang JF, Wang CQ Association of hemoglobin A1c variability and the incidence of heart failure with preserved ejection fraction in patients with type 2 diabetes mellitus and arterial hypertension. Hellenic J Cardiol 2018 59(2):91-97
Gu J, Fan YQ, Zhang HL, Zhang JF, Wang CQ. Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension. J Clin Hypertens (Greenwich) 2018 20(3):560-567
Gu J, Fan YQ, Zhang HL, Pan JA, Yu JY, Zhang JF, Wang CQ Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion. Biochem Pharmacol 2018 150:202-213
Gu J, Hu W, Song ZP, Liu X, Zhang DD PPARγ agonist use and recurrence of atrial fibrillation after successful electrical cardioversion Hellenic J Cardiol 2017 58(5):387-390
Gu J, Fan YQ, Zhang JF, Wang CQ. Impact of long-term glycemic variability on development of atrial fibrillation in type 2 diabetic patients. Anatol J Cardiol 2017 18(6):410-416
Gu J, Fan YQ, Bian L, Zhang HL, Xu ZJ, Zhang Y, Chen QZ, Yin ZF, Xie YS, Wang CQ Long-term prescription of beta-blocker delays the progression of heart failure with preserved ejection fraction in patients with hypertension: A retrospective observational cohort study Eur J Prev Cardiol. 2016 Epub ahead of print
Jun Gu, Yu-qi Fan, Zhi-hua Han, Li Fan, Ling Bian, Hui-li Zhang, Zuo-jun Xu, Zhao-fang Yin, Yu-shui Xie, Jun-feng Zhang, Chang-qianWang Association between long-term prescription of aldosterone antagonist and the progression of heart failure with preserved ejection fraction in hypertensive patients International Journal of Cardiology 2016 220:56-60
Jun Gu, Wei Hu, Zhi-ping Song, Yue-guang Chen, Da-dong Zhang, Chang-qianWang Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity International Immunopharmacology 2016 32:1-7
Jun Gu, Wei Hu, Zhi-Ping Song, Yue-Guang Chen, Da-Dong Zhang and Chang-Qian Wang Rapamycin Inhibits Cardiac Hypertrophy by Promoting Autophagy via the MEK/ERK/Beclin-1Pathway Front Physiol 2016 7:104
Gu J, Hu W, Liu X, Wang CQ Pioglitazone Improves Endothelial Function in Patients with Paroxysmal Atrial Fibrillation and Type 2 Diabetes Mellitus Following Catheter Ablation Int J Clin Cardiol 2015 2:046
Gu J, Hu W, Zhang DD Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity J Cell Mol Med 2015 19(10):2324-8
Gu J, Hu W, Liu X. The value of magnetic resonance imaging in catheter ablation of atrial fibrillation. Clin Cardiol 2015 38(3):190-4
Gu J, Hu W, Liu X Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes. Med Sci Monit Basic Res 2014 20:153-160
Gu J, Liu X, Jiang WF, et al Comparison of catheter ablation and surgical ablation in patients with long-standing persistent atrial fibrillation and rheumatic heart disease: A four-year follow-up study. Int J Cardiol 2013 168:5372-5377
Gu J, Liu X, Wang QX, et al Beneficial effects of pioglitazone on atrial structural and electrical remodeling in vitro cellular models. J Mol Cell Card 2013 65;1-8
Gu J, Liu X, Tan H, et al Impact of chronic obstructive pulmonary disease on procedural outcomes and quality of life in patients with atrial fibrillation undergoing catheter ablation J Cardiovasc Electrophysiol 2013 24:148-154
Gu J,Song ZP, Gui DM, et al Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude mice by heme oxygenase-1 Induction. Cardiovasc Toxicol 2012 12:341-349.
Gu J, Liu X, Tan H, et al Extensive antiarrhythmic drugs after catheter ablation of persistent atrial fibrillation. Acta Cardiol 2012 67:407-414
Gu J, Liu X, Wang QX, et al Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts. Exp Cell Res 2012 318:2105-2015
Gu J, Liu X, Wang X, et al Beneficial effect of pioglitazone on the outcome of catheter ablation in patients with paroxysmal atrial fibrillation and type 2 diabetes mellitus. Europace 2011 13:1256-1261.
Gu J, Hu W, Xiao H, et al. Prophylactic intra-aortic balloon pump reduces C-reactive protein levels and early mortality in high-risk patients undergoing percutaneous coronary intervention. Acta Cardiol 2011 66:499-504
Gu J, Hu W, Xiao H, et al Intra-aortic balloon pump improves clinical prognosis and attenuates C-reactive protein level in acute STEMI complicated by cardiogenic shock. Cardiology 2010 117:75-80
Gu J, Wang CQ, Fan HH, et al. Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intima-injured rats. Journal of Cardiovascular Pharmacology 2006 47:711-721