导师姓名： 王宁荐 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： 制造局路639号2号楼5楼内分泌科
邮编： 200011 邮箱地址： wnj486@126.com

研究方向 (点击浏览详细信息)
代谢病发生发展的环境遗传交互及机制研究

社会任职
上海医学会内分泌学分会青年委员兼秘书
中华医学会内科学分会青年委员会委员
中国康复医学会修复重建专业委员会委员
美国内分泌学会会员，年会审稿人，Mentor
美国糖尿病学会专业会员
Diabetes，Diabetes Care等杂志审稿人

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
/ 2020年上海高校中青年教师国外访学进修计划 2020年上海高校中青年教师国外访学进修计划 2021-01~2021-12 15万元 课题负责人
SHDC2020CR4006 维生素D水平对2型糖尿病风险的前瞻性临床评价 促进市级医院临床技能与临床创新三年行动计划（2020-2022年）重大临床研究项目 2021-01~2022-12 50万元 课题负责人
/ 上海市人才发展资金 上海市人才发展资金 2021-01~2023-12 30万元 课题负责人
20ZR** 基于多组学分析内分泌干扰物铅暴露在脂代谢紊乱中的机制研究 上海市2020年度“科技创新行动计划”自然科学基金项目 2020-07~2023-06 20万元 课题负责人
19XJ11007 生命早期营养不良继而成年营养过剩致糖脂代谢感应网络重塑的机制研究 上海交通大学医学院优青推进项目 2019-05~2022-04 5万元 课题负责人
** 生命早期营养不良后成年营养过剩诱导的非酒精性脂肪性肝病跨代遗传模型研究 上海市2019年度“科技创新行动计划”实验动物研究领域项目 2019-04~2022-03 30万元 课题负责人
2017YQ053 中国特殊营养史糖脂代谢紊乱的机制研究 上海市卫生和计划生育委员会优秀青年人才培育项目 2017-07~2020-06 30万元 课题负责人
20164Y0079 同位素示踪平台下生命早期营养不良和成年营养过剩的脂代谢紊乱研究 上海市卫生和计划生育委员会科研课题青年项目 2017-01~2019-12 4万元 课题负责人
** 生命早期饥饿和成年饱食糖代谢稳态失衡的同位素示踪研究 国家自然科学基金青年科学基金项目 2017-01~2019-12 34万元 课题负责人
** 环境污染铅暴露对机体脂代谢紊乱调控机制的研究 上海市科学技术委员会国际合作重点项目 2016-07~2019-06 30万元 课题负责人
jyyq** / 上海交通大学医学院附属第九人民医院优秀青年骨干 2016-01~2018-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Y, Yu Y, Wan H, Chen Y, Xia F, Zhang W, Zhang K, Gu X, Zhang Y, Lin Z, Yu Y, Wang N （通讯作者）, Lu Y. Lower eGFR is associated with increased probability of liver fibrosis in Chinese diabetic patients Diabetes Metab Res Rev 2020 Feb 4:e3294. doi: 10.1002/dmrr.3294
Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang （通讯作者）, Minghao Guo, Yingli Lu The Unique Association Between the Level of Peripheral Blood Monocytes and the Prevalence of Diabetic Retinopathy: A Cross-Sectional Study J Transl Med 2020 Jun 22;18(1):248
Wan H, Wang Y, Xiang Q, Fang S, Chen Y, Chen C, Zhang W, Zhang H, Xia F, Wang N （通讯作者）, Lu Y. Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference Cardiovasc Diabetol. 2020 Jul 31;19(1):118
Wan H, Wang Y, Chen Y, Fang S, Zhang W, Xia F, Wang N （通讯作者）, Lu Y. Different associations between serum urate and diabetic complications in men and postmenopausal women Diabetes Res Clin Pract 2020 Feb;160:108005. doi: 10.1016/j.diabres.2020.108005
Wang N, Wang Y, Chen X, Zhang W, Chen Y, Xia F, Wan H, Li Q, Jiang B, Hu B, Lu Y. Bone Turnover Markers and Probable Advanced Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Men and Postmenopausal Women With Type 2 Diabetes Front Endocrinol (Lausanne) 2020 Jan 28;10:926. doi: 10.3389/fendo.2019.00926
Chi Chen, Qi Chen, Bin’en Nie,Haojie Zhang, Hualing Zhai, Li Zhao,Pu Xia, Yingli Lu, Ningjian Wang （通讯作者） Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005–2014 Diabetes Care (IF 15.6) 2020 Volume 43, May 2020
Wang Y, Wan H, Chen C, Chen Y, Xia F, Han B, Li Q, Wang N （通讯作者）, Lu Y Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood Nutr Diabetes 2020 DOI: 10.1038/s41387-020-0121-x
Wang Y, Weng P, Wan H, Zhang W, Chen C, Chen Y, Cai Y, Guo M, Xia F, Wang N （通讯作者）, Lu Y. Economic status moderates the association between early-life famine exposure and hyperuricemia in adulthood. J Clin Endocrinol Metab 2020 Aug 13:dgaa523
Ningjian Wang （通讯作者）, Yuying Wang, Haojie Zhang, Yuyu Guo, Chi Chen, Wen Zhang, Heng Wan, Junli Han, Yingli Lu Association of Bone Mineral Density With Nine Urinary Personal Care and Consumer Product Chemicals and Metabolites: A National-Representative, Population-Based Study Environ Int (IF 7.943) 2020 Jun 22;142:105865
Wang N, Wang Y, Zhang W, Chen Y, Chen X, Wang C, Li Q, Chen C, Jiang B, Lu Y C-peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes Diabetes Metab Res Rev 2019 Jul 27:e3210. doi: 10.1002/dmrr.3210
Wang Y, Wan H, Chen Y, Xia F, Zhang W, Wang C, Fang S, Zhang K, Li Q, Wang N （通讯作者）, Lu Y Association of C-peptide with diabetic vascular complications in type 2 diabetes Diabetes Metab 2019 Apr 23. pii: S1262-3636(19)30064-3. doi: 10.1016/j.diabet.2019.04.004
Lv C, Chen C, Chen Q, Zhai H, Zhao L, Guo Y, Wang N. （通讯作者） Multiple pregnancies and the risk of diabetes mellitus in postmenopausal women Menopause 2019 May 6. doi: 10.1097/GME.1349.
Zhao L, Zhu C, Lu M, Chen C, Nie X, Abudukerimu B, Zhang K, Ning Z, Chen Y, Cheng J, Xia F, Wang N （通讯作者）, Jensen MD, Lu Y The key role of a glucagon-like peptide-1 receptor agonist in body fat redistribution J Endocrinol 2019 Feb 1;240(2):271-286
Chen C, Zhao L, Ning Z, Li Q, Han B, Cheng J, Chen Y, Nie X, Xia F, Wang N （通讯作者）, Lu Y. Famine exposure in early life is associated with visceral adipose dysfunction in adult females. Eur J Nutr 2019 May 11. doi: 10.1007/s00394-018-1707-0.
Chen C, Chen Y, Weng P, Xia F, Li Q, Zhai H, Wang N （通讯作者）, Lu Y. Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study Nutr J 2019 Oct 28;18(1):61. doi: 10.1186/s12937-019-0494-7.
Chen C, Zhai H, Cheng J, Weng P, Chen Y, Li Q, Wang C, Xia F, Wang N （通讯作者）, Lu Y Causal link between vitamin D and total testosterone in men: A mendelian randomization analysis J Clin Endocrinol Metab (IF 5.79) 2019 Aug 1;104(8):3148-3156
Ningjian Wang, Chiyu Wang, Xiaoman Chen, Heng Wan, Yi Chen, Chi Chen, Bing Han, Yingli Lu Vitamin D, prediabetes and type 2 diabetes: bidirectional Mendelian randomization analysis European Journal of Nutrition 2019 May 10 doi.org/10.1007/s00394-019-01990-x
Zhang K, Kuang L, Xia F, Chen Y, Zhang W, Zhai H, Wang C, Wang N （通讯作者）, Lu Y Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway Aging Cell (IF=7.346) 2019 Jun 26:e12997.
Wan H, Wang Y, Zhang K, Chen Y, Fang S, Zhang W, Wang C, Li Q, Xia F, Wang N （通讯作者）, Lu Y ASSOCIATIONS BETWEEN VITAMIN D AND MICROVASCULAR COMPLICATIONS IN MIDDLE-AGED AND ELDERLY DIABETIC PATIENTS Endocr Pract 2019 Apr 23. doi: 10.4158/EP-2019-0015
Wang C, Zhang W, Wang Y, Wan H, Chen Y, Xia F, Zhang K, Wang N （通讯作者）, Lu Y Novel associations between sex hormones and diabetic vascular complications in men and postmenopausal women: a cross-sectional study Cardiovasc Diabetol (IF 5.95) 2019 Jul 31;18(1):97
Han B, Li Q, Wang N （共同第一作者）, Chen Y, Zhu C, Chen Y, Xia F, Cang Z, Lu M, Meng Y, Chen C, Lu Y. Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People. Int J Endocrinol 2018 Mar 6;2018:**.
Zhao L, Zhu C, Chen Y, Chen C, Cheng J, Xia F, Wang N （通讯作者）, Lu Y LH/FSH Ratio Is Associated With Visceral Adipose Dysfunction in Chinese Women Older Than 55 Front Endocrinol (Lausanne) 2018 Aug 2;9:419.
Han B, Chen Y, Cheng J, Li Q, Zhu C, Chen Y, Xia F, Wang N （通讯作者）, Lu Y Comparison of the Prevalence of Metabolic Disease Between Two Types of Urbanization in China Front Endocrinol (Lausanne) 2018 Nov 12;9:665.
Chen Y, Wang N （共同第一作者）, Chen Y, Li Q, Han B, Chen C, Zhai H, Lu Y The association of non-alcoholic fatty liver disease with thyroid peroxidase and thyroglobulin antibody: A new insight from SPECT-China study Autoimmunity 2018 2018 Jul 17:1-7
Wang N, Chen C, Zhao L, Chen Y, Han B, Xia F, Cheng J, Li Q, Lu Y. Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis. EBioMedicine (IF 6.68) 2018 Feb;28:187-193.
Chen C, Xia F, Chen Y, Zhang K, Cheng J, Li Q, Han B, Zhao L, Zhu C, Wang N （通讯作者）, Lu Y Association Between Thyroid-Stimulating Hormone and Renal Function: a Mendelian Randomization Study Kidney Blood Press Res 2018 Jul 17;43(4):1121-1130.
Wang N, Ning Z, Xia F, Chen C, Cheng J, Chen Y, Lu Y. Exposure to famine in early life and chronic kidney diseases in adulthood. Nutr Diabetes 2018 Jan 15;8(1):4
Wang N, Lu M, Chen C, Xia F, Han B, Li Q, Cheng J, Chen Y, Zhu C, Jensen MD, Lu Y Adiposity genetic risk score modifies the association between blood lead level and body mass index J Clin Endocrinol Metab (IF 5.79) 2018 2018 Sep 7. doi: 10.1210/jc.2018-00472
Wang N, Cheng J, Ning Z, Chen Y, Han B, Li Q, Chen C, Zhao L, Xia F, Lin D, Guo L, Lu Y. Type 2 Diabetes and Adiposity Induce Different Lipid Profile Disorders: A Mendelian Randomization Analysis. J Clin Endocrinol Metab (IF 5.79) 2018 May 1;103(5):2016-2025.
Chen C, Zhai H, Huang G, Cheng J, Xia F, Zhao L, Chen Y, Chen Y, Han B, Li Q, Jiang B, Wang N （通讯作者）, Lu Y Is lower low-density lipoprotein cholesterol associated with lower androgen and erectile dysfunction in men? Nutr Metab Cardiovasc Dis 2018 Dec;28(12):1304-1310
Zhao L, Chen Y, Xia F, Abudukerimu B, Zhang W, Guo Y, Wang N （通讯作者）, Lu Y. A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota. Front Endocrinol (Lausanne) 2018 May 17;9:233.
Cheng J, Han B, Li Q, Xia F, Zhai H, Wang N （通讯作者）, Jensen M, Lu Y. Testosterone: Relationships with Metabolic Disorders in Men-An Observational Study from SPECT-China. Int J Endocrinol 2018 2017;2017:**.
Fang S, Huang Y, Wang N, Zhang S, Zhong S, Li Y, Sun J, Liu X, Wang Y, Gu P, Li B, Zhou H, Fan X Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab 2018 Dec 3. doi: 10.1210/jc.2018-01626
Zhao L, Huang G, Xia F, Li Q, Han B, Chen Y, Chen C, Lin D, Wang N （通讯作者）, Lu Y. Neck circumference as an independent indicator of visceral obesity in a Chinese population. Lipids Health Dis 2018 Apr 17;17(1):85.
Wang N, Shao H, Chen Y, Xia F, Chi C, Li Q, Han B, Teng Y, Lu Y. Follicle-Stimulating Hormone, Its Association with Cardiometabolic Risk Factors, and 10-Year Risk of Cardiovascular Disease in Postmenopausal Women. J Am Heart Assoc 2017 Aug 30;6(9).
Wang N, Cheng J, Han B, Li Q, Chen Y, Xia F, Jiang B, Jensen MD, Lu Y. Exposure to severe famine in the prenatal or postnatal period and the development of diabetes in adulthood: an observational study. Diabetologia 2017 Feb;60(2):262-269
Wang N, Wang X, Li Q, Han B, Chen Y, Zhu C, Chen Y, Lin D, Wang B, Jensen MD, Lu Y. The famine exposure in early life and metabolic syndrome in adulthood. Clin Nutr 2017 Feb;36(1):253-259
Zhao L, Cang Z, Sun H, Nie X, Wang N （通讯作者）, Lu Y. Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease. BMC Endocr Disord 2017 Feb 28;17(1):13
Han B, Wang X, Wang N （共同第一作者）, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Pu X, Cang Z, Zhu C, Lu M, Meng Y, Guo H, Chen C, Tu W, Li B, Hu L, Wang B, Lu Y. Investigation of vitamin D status and its correlation with insulin resistance in a Chinese population. Public Health Nutr 2017 Jun;20(9):1602-1608
Nie X, Chen Y, Chen Y, Chen C, Han B, Li Q, Zhu C, Xia F, Zhai H, Wang N （通讯作者）, Lu Y. Lead and cadmium exposure, higher thyroid antibodies and thyroid dysfunction in Chinese women. Environ Pollut 2017 Nov;230:320-328.
Zhao L, Cheng J, Chen Y, Li Q, Han B, Chen Y, Xia F, Chen C, Lin D, Yu X, Wang N （通讯作者）, Lu Y. Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population. Nutr Metab (Lond) 2017 Oct 10;14:64.
Ning Z, Zhang K, Zhao L, Lu Y, Sun H, Chen C, Nie X, Lu M, Wang N （通讯作者）, Lu Y. Exacerbation of liver steatosis following exposure to famine and overnutrition. Mol Nutr Food Res 2017 Oct;61(10)
Sun H, Wang N （共同第一作者）, Chen C, Nie X, Han B, Li Q, Zhu C, Chen Y, Xia F, Chen Y, Zhai H, Jiang B, Hu B, Lu Y. Cadmium exposure and its association with serum uric acid and hyperuricemia. Sci Rep 2017 Apr 3;7(1):550
Chen C, Xu H, Chen Y, Chen Y, Li Q, Hu J, Liang W, Cheng J, Xia F, Wang C, Han B, Zheng Y, Jiang B, Wang N （通讯作者）, Lu Y. Iodized Salt Intake and Its Association with Urinary Iodine, Thyroid Peroxidase Antibodies, and Thyroglobulin Antibodies Among Urban Chinese. Thyroid 2017 Dec;27(12):1566-1573.
Zhen Cang, Ningjian Wang （共同第一作者）, Qin Li, Bing Han, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Xiaoqi Pu, Chaoxia Zhu, Meng Lu, Chi Chen, Dongping Lin, Weiping Tu, Bin Li, Ling Hu, Yingli Lu. Study of the cut-off level of ALT and TG to predict the risk of nonalcoholic fatty liver disease in eastern China Int J Clin Exp Med 2017 10(5):8223-8229
Sun H, Wang N （共同第一作者）, Nie X, Zhao L, Li Q, Cang Z, Chen C, Lu M, Cheng J, Zhai H, Xia F, Ye L, Lu Y. Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation. PLoS One 2017 Jan 20;12(1):e**
Zhai H, Chen C, Wang N （通讯作者）, Chen Y, Nie X, Han B, Li Q, Xia F, Lu Y. Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization. Environ Health 2017 Aug 31;16(1):93
Chen C, Li Q, Nie X, Han B, Chen Y, Xia F, Zhai H, Wang N （通讯作者）, Lu Y. Association of lead exposure with cardiovascular risk factors and diseases in Chinese adults. Environ Sci Pollut Res Int 2017 Oct;24(28):22275-22283.
Wang N, Zhang K, Han B, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Zhai H, Jiang B, Shen Z, Lu Y. Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women. Endocrine 2017 Jun;56(3):649-657
Wang N, Zhai H, Han B, Li Q, Chen Y, Chen Y, Xia F, Lin D, Lu Y. Visceral fat dysfunction is positively associated with hypogonadism in Chinese men. Sci Rep 2016 Jan 22;6:19844
Wang N, Kuang L, Han B, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Cang Z, Zhu C, Lu M, Meng Y, Guo H, Chen C, Lin D, Lu Y. Follicle-stimulating hormone associates with prediabetes and diabetes in postmenopausal women. Acta Diabetol 2016 Apr;53(2):227-36
Nie X, Wang N （共同第一作者）, Chen Y, Chen C, Han B, Zhu C, Chen Y, Xia F, Cang Z, Lu M, Meng Y, Jiang B, D Jensen M, Lu Y. Blood cadmium in Chinese adults and its relationships with diabetes and obesity. Environ Sci Pollut Res Int 2016 Sep;23(18):18714-23
Wang N, Zhai H, Zhu C, Li Q, Han B, Chen Y, Zhu C, Chen Y, Xia F, Lin D, Lu Y. Combined Association of Vitamin D and Sex Hormone Binding Globulin With Nonalcoholic Fatty Liver Disease in Men and Postmenopausal Women: A Cross-Sectional Study. Medicine (Baltimore) 2016 Jan;95(4):e2621
Wang N, Chen Y, Ning Z, Li Q, Han B, Zhu C, Chen Y, Xia F, Jiang B, Wang B, Wang X, Jensen MD, Lu Y. Exposure to Famine in Early Life and Nonalcoholic Fatty Liver Disease in Adulthood. J Clin Endocrinol Metab 2016 May;101(5):2218-25
Wang N, Li Q, Han B, Chen Y, Zhu C, Chen Y, Xia F, Lu M, Meng Y, Guo Y, Ye L, Sui C, Kuang L, Lin D, Lu Y. Follicle-stimulating hormone is associated with non-alcoholic fatty liver disease in Chinese women over 55?years old. J Gastroenterol Hepatol 2016 Jun;31(6):1196-202
Zhu H, Wang N （共同第一作者）, Han B, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Cang Z, Lu M, Chen C, Lin D, Lu Y. Low Sex Hormone-Binding Globulin Levels Associate with Prediabetes in Chinese Men Independent of Total Testosterone. PLoS One 2016 Sep 1;11(9):e**
Sun H, Wang N （共同第一作者）, Cang Z, Zhu C, Zhao L, Nie X, Cheng J, Xia F, Zhai H, Lu Y. Modulation of Microbiota-Gut-Brain Axis by Berberine Resulting in Improved Metabolic Status in High-Fat Diet-Fed Rats. Obes Facts 2016 2016;9(6):365-378
Chen C, Wang N （共同第一作者）, Zhai H, Nie X, Sun H, Han B, Li Q, Chen Y, Cheng J, Xia F, Zhao L, Zheng Y, Shen Z, Lu Y. Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study. Sci Rep 2016 Nov 29;6:37809
Chen C, Wang N （共同第一作者）, Nie X, Han B, Li Q, Chen Y, Zhai H, Zhu C, Chen Y, Xia F, Lu M, Lin D, Lu Y. Blood Cadmium Level Associates with Lower Testosterone and Sex Hormone-Binding Globulin in Chinese men: from SPECT-China Study, 2014. Biol Trace Elem Res 2016 May;171(1):71-8
Wang N, Wang X, Han B, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Cang Z, Zhu C, Lu M, Meng Y, Chen C, Lin D, Wang B, Jensen MD, Lu Y. Is Exposure to Famine in Childhood and Economic Development in Adulthood Associated With Diabetes? J Clin Endocrinol Metab 2015 Dec;100(12):4514-23
Wang N, Han B, Li Q, Chen Y, Chen Y, Xia F, Lin D, Jensen MD, Lu Y. Vitamin D is associated with testosterone and hypogonadism in Chinese men: Results from a cross-sectional SPECT-China study. Reprod Biol Endocrinol 2015 Jul 16;13:74
Gu T, Jiang B, Wang N （共同第一作者）, Xia F, Wang L, Gu A, Xu F, Han Y, Li Q, Lu Y. New insight into ectopic thyroid glands between the neck and maxillofacial region from a 42-case study. BMC Endocr Disord 2015 Nov 18;15:70
Wang N, Chen C, Nie X, Han B, Li Q, Chen Y, Zhu C, Chen Y, Xia F, Cang Z, Lu M, Meng Y, Zhai H, Lin D, Cui S, Jensen MD, Lu Y. Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study. Sci Rep 2015 Dec 14;5:18299
Wang N, Jiang P, Lu Y. Is fluorine-18 fluorodeoxyglucose positron emission tomography useful for detecting bladder lesions? A meta-analysis of the literature. Urol Int 2014 92(2):143-9
Wang N, Zhai H, Lu Y. Is fluorine-18 fluorodeoxyglucose positron emission tomography useful for the thyroid nodules with indeterminate fine needle aspiration biopsy? A meta-analysis of the literature. J Otolaryngol Head Neck Surg 2013 Sep 1;42:38