导师姓名： 王长谦 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海交大医学院附属第九人民医院上海市制造局路639号
邮编： 200011 邮箱地址： wcqian@hotmail.com

研究方向 (点击浏览详细信息)
动脉粥样硬化及冠心病防治，冠心病介入治疗

社会任职
上海市心血管病学会委员兼预防学组组长
中国老年学学会老年医学委员会高尿酸与痛风专家委员会副主任委员
国际动脉粥样硬化学会委员
国内大型心血管病会议主席团成员
海峡两岸医药卫生交流协会心血管内科专业委员会常委
中华心血管病学会动脉粥样硬化和冠心病学组委员
上海市医学会内科分会副主任委员
中国医药教育协会专家委员会常委
中国动脉粥样硬化学会委员
《心血管康复医学杂志》常务编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** circRNA-UXS1.40 - microRNA 146a海绵作用在心肌缺血再灌注损伤中的作用研究 国家自然科学基金（面上项目） 2019-01~2022-12 57万元 课题负责人
16CR2034B 醛固酮拮抗剂延缓高血压伴心肌肥厚患者舒张功能减退的随机对照研究 申康疑难疾病 2016-06~2019-12 60万元 课题负责人
JYLJ017 急性ST段抬高心肌梗死介入治疗球囊去充盈策略对心梗预后的影响 九院临+ 2016-01~2019-12 40万元 课题负责人
** 利用“循环系多尺度多物理人体生物力学仿真”模型平台计算冠状动脉临界病变处剪切应力以指导冠脉介入治疗的研究 上海市科委 2015-07~2018-06 30万元 课题负责人
** VSTMI调控单核/巨噬细胞功能及动脉粥样硬化发生发展的体内外研究 国家自然科学基金 2015-01~2018-12 73万元 课题负责人
2014ZYJB0501 慢性心力衰竭一体化管理平台的构建及效果评价 上海市卫计委重要疾病联合攻关重大项目 2015-01~2018-12 80万元 课题负责人
14JC** miR-21对动脉粥样硬化易损/破裂斑块的影响及其机制 上海市科委重点项目 2014-09~2017-08 50万元 课题负责人
20**6 MicroRNA通过诱导自噬而减少血管损伤的作用及其机制研究 教育部博士点基金项目 2014-01~2016-12 12万元 课题负责人
** miR-125a-5p调控单核/巨噬细胞功能及动脉粥样硬化发生发展的实验研究 国家自然科学基金 2013-01~2016-12 70万元 课题负责人
114119a8700 冠心病患者细胞微粒蛋白组学分析及标志物筛选 上海市科委医学引导项目 2011-10~2013-06 15万元 课题负责人
10JC** oxLDL敏感型microRNAs对动脉粥样硬化斑块稳定性的调控 上海市科委重点项目 2010-10~2013-09 15万元 课题负责人
C0701 miR-9对oxLDL激活人单核/巨噬细胞生物学功能的调控 国家自然基金，面上项目 2010-01~2012-12 31万元
** miR-9对oxLDL激活人单核/巨噬细胞生物学功能的调控 国家自然科学基金 2010-01~2012-12 31万元 课题负责人
09XD** microRNA对oxLDL激活人单核/巨噬细胞生物学功能的调控 上海市优秀学科带头人计划 2009-12~2011-12 40万元 课题负责人
07JC14046 内皮功能、耐多药结核病诊断新技术的建立及临床评估的研究 上海市科委,重点基础研究 2007-12~2009-11 50万元 课题负责人
06BZ051 OSAHS对ACS患者急性期预后的影响 上海市教委,发展基金 2007-01~2009-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zeng LF, Tang ZD, Gu J, Wang CQ （通讯作者）, Zhang HL Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis: a prospective observational study of 1053 patients. World J Pediatr 2019 2019 Jul 2
Chen K, Wang C （通讯作者）, Fan Y, Gu J, Han Z, Wang Y, Gao L, Zeng H Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Exp Ther Med 2018 2018 Dec;16(6):4562-4568
Gu J, Fan YQ, Zhang HL, Pan JA, Yu JY, Zhang JF, Wang CQ （通讯作者） Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion. Biochem Pharmacol 2018 150:202-213
Gu J, Pan JA, Fan YQ, Zhang HL, Zhang JF, Wang CQ （通讯作者） Prognostic impact of HbA1c variability on long-term outcomes in patients with heart failure and type 2 diabetes mellitus. Cardiovasc Diabetol 2018 30;17(1):96
Wang Y, Han Z, Fan Y, Zhang J, Chen K, Gao L, Zeng H, Cao J, Wang C （通讯作者） MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway. Cell Physiol Biochem 2017 41(4):1555-1571
Chen Y, Fan Y, Yin Z, Zhang H, Zhang Y, Han Z, Wang C （通讯作者） Coronary computed tomographic angiography for patients with low-to-intermediate risk chest pain: A systematic review and meta-analysis. Oncotarget 2017 8(2):2096-2103
Chen K, Wang CQ （通讯作者）, Fan YQ, Han ZH, Wang Y, Gao L, Zeng HS. Lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system Sheng Li Xue Bao 2017 69(1):55-60
Xue C, Bian L, Xie YS, Yin ZF, Xu ZJ, Chen QZ, Zhang HL, Wang CQ. （通讯作者） Impact of smoking on health-related quality of Life after percutaneous coronary intervention treated with drug-eluting stents: a longitudinal observational study. Health Qual Life Outcomes 2017 15(1):1
Gu J, Fan YQ, Han ZH, Fan L, Bian L, Zhang HL, Xu ZJ, Yin ZF, Xie YS, Zhang JF, Wang CQ. （通讯作者） Association between long-term prescription of aldosterone antagonist and the progression of heart failure with preserved ejection fraction in hypertensive patients. Int J Cardiol. 2016 220:56-60
Gu J, Hu W, Song ZP, Chen YG, Zhang DD, Wang CQ. （通讯作者） Rapamycin Inhibits Cardiac Hypertrophy by Promoting Autophagy via the MEK/ERK/Beclin-1 Pathway. Front Physiol 2016 7:104
Wang Y, Cao J, Fan Y, Xie Y, Xu Z, Yin Z, Gao L, Wang C （通讯作者） Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro. Int J Mol Med 2016 37(6):1567-75
Gu J, Hu W, Song ZP, Chen YG, Zhang DD, Wang CQ （通讯作者） Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity. Int Immunopharmacol 2016 32:1-7
Zhang Z, Chen Y, Zhang T, Guo L, Yang W, Zhang J, Wang C （通讯作者） Role of Myoendothelial Gap Junctions in the Regulation of Human Coronary Artery Smooth Muscle Cell Differentiation by Laminar Shear Stress. Cell Physiol Biochem 2016 39(2):423-37
Gu J, Fan YQ, Han ZH, Fan L, Bian L, Zhang HL, Xu ZJ, Yin ZF, Xie YS, Zhang JF, Wang CQ （通讯作者） Association between long-term prescription of aldosterone antagonist Int J Cardiol 2016 1;220:56-60
Gu J, Fan YQ, Bian L, Zhang HL, Xu ZJ, Zhang Y, Chen QZ, Yin ZF, Xie YS, Wang CQ （通讯作者） Long-term prescription of beta-blocker delays the progression of heart failure with preserved ejection fraction in patients with hypertension: A retrospective observational cohort study. Eur J Prev Cardiol 2016 23(13):1421-8
Gao L, Cheng C, Sparatore A, Zhang H, Wang C （通讯作者） Heart Lung Circ. Hydrogen sulfide inhibits human platelet aggregation in vitro in part by interfering gap junction channels: effects of ACS14, a hydrogen sulfide-releasing aspirin Heart, Lung and Circulation 2015 24(1):77-85
Tian L, Chen K, Cao J, Han Z, Gao L, Wang Y, Fan Y, Wang C （通讯作者） Galectin-3-induced oxidized low-density lipoprotein promotes the phenotypic transformation of vascular smooth muscle cells Mol Med Rep 2015 12(4):4995-5002
Gu J, Hu W, Liu X, Wang CQ （通讯作者） Pioglitazone Improves Endothelial Function in Patients with Paroxysmal Atrial Fibrillation and Type 2 Diabetes Mellitus Following Catheter Ablation J Clin Cardiol 2015 2:4-12
Sun T, Tang G, Tian H, Hu K, Yao S, Su Y, Wang C （通讯作者） Positron emission tomography imaging of cardiomyocyte apoptosis with a novel molecule probe [18F]FP-DPAZn2 Oncotarget 2015 6(31):30579-91
Huang Z, Han Z, Ye B, Dai Z, Shan P, Lu Z, Dai K, Wang C （通讯作者）, Huang W Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes Eur J Pharmacol 2015 762:1-10
Chen K, Wang CQ （通讯作者）, Fan YQ, Xie YS, Yin ZF, Xu ZJ, Zhang HL, Cao JT, Wang Y Application of chrysophanol in zebrafish to reduce dietary introduced lipid and its possible mechanism Int J Clin Exp Med 2015 8(7):10558-67
Gao L, Xu Z, Yin Z, Chen K, Wang C （通讯作者）, Zhang H Association of hydrogen sulfide with alterations of monocyte chemokine receptors, CCR2 and CX3CR1 in patients with coronary artery disease Inflamm Res 2015 64(8):627-35
Chen K, Wang CQ （通讯作者）, Fan YQ, Xie YS, Yin ZF, Xu ZJ, Zhang HL, Cao JT, Han ZH, Wang Y, Song DQ Optimizing methods for the study of intravascular lipid metabolism in zebrafish Mol Med Rep 2015 11(3):1871-6
Zhihua Han, Jiatian Cao, Dongqiang Song, Lei Tian, Kan Chen, Yue Wang, Lin Gao, Zhaofang Yin, Yuqi Fan , Changqian Wang （通讯作者） Autophagy Is Involved in the Cardioprotection Effect of Remote Limb Ischemic Postconditioning on Myocardial Ischemia/Reperfusion Injury in Normal Mice, but Not Diabetic Mice PLoS ONE 2014 9(1): e86838. doi:10.1371
Jiatian Cao, Zhihua Han, Lei Tian, Kan Chen, Yuqi Fan, Bozhi Ye, Weijian Huang, Changqian Wang （通讯作者） Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages Journal of Translational Medicine 2014 12:266-276
Ting Sun, Hua Tian, Changqian Wang （通讯作者） A Survey of Congenital Heart Disease and Other Organic Malformations Associated with Different Types of Orofacial Clefts in Eastern China PLoS ONE 2013 8(1): e54726. doi:10.1371
Yuqi Fan, Liansheng Wang,Yuanmin Li, Zhaofang Yin, Zuojun Xu, Changqian Wang （通讯作者） Quantification of Endothelial Microparticles on Modified Cytometric Bead Assay and Prognosis in Chest Pain Patients Circulation Journal 2013 doi: 10.1253/circj.CJ-13-0488
Junfeng Zhang, Zongqi Zhang, David Y. Zhang, Jianbing Zhu, Tiantian Zhang, Changqiang Wang （通讯作者） microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway PLoS ONE 2013 8(12): e83294. doi:10.1371
Kan Chen, Chang-Qian Wang(responsible author) （通讯作者）, Yu-Qi Fan, Yu-Shui Xie, Zhao-Fang Yin, Zuo-Jun Xu, Hui-Li Zhang, Jia-Tian Cao, Zhi-Hua Han, Yue Wang, and Dong-Qiang Song The Evaluation of Rapid Cooling As an Anesthetic Method for the Zebrafish ZEBRAFISH 2013 DOI: 10.1089/zeb.2012.0858
K. CHEN, R.-J. JIANG, C.-Q. WANG(responsible author) （通讯作者）, Z.-F. YIN, Y.-Q. FAN, J.-T. CAO,Z.-H. HAN, Y. WANG, D.-Q. SONG Predictive value of plasma galectin-3 in patients with chronic heart failure European Review for Medical and Pharmacological Sciences 2013 17: 1005-1011
Dongqiang Song, Yuanmin Li, Jiatian Cao, Zhihua Han, Lin Gao, Zuojun Xu, Zhaofang Yin, Guifang Wang, Yuqi Fan, Changqian Wang （通讯作者） Effect of Iron Deficiency on c-kit+ Cardiac Stem Cells In Vitro. PLoS ONE 2013 8(6): e65721
S Meng, J-T Cao, B Zhang, Q Zhou, C-X Shen, C.-Q. Wang （通讯作者） Downregulation of microRNA-126 in endothelial progenitor cells from diabetespatients, impairs their functional properties, via target gene Spred-1 Journal of Molecular and Cellular Cardiology 2012 53:64-72
Huili Zhang, Changfa Guo, Duojiao Wu, Alian Zhang, Ting Gu, Liansheng Wang,Changqian Wang （通讯作者） Hydrogen Sulfide Inhibits the Development ofAtherosclerosis with Suppressing CX3CR1 and CX3CL1Expression PLoS ONE | www.plosone.org 2012 7(e41147):1-18
S Meng, L-S Wang,Z-Q Huang, Q Zhou, Y-G Sun, J-T Cao, Y-G Li and C-Q Wang Berberine ameliorates in_ammation in patients with acute coronary syndrome following percutaneous coronary intervention Clinical and Experimental Pharmacology and Physiology 2012 doi: 10.1111/j.1440-1681
Shi CZ, Zhang XP, Lv ZW, Zhang HL, Xu JZ, Yin ZF, Yan YQ, Wang CQ （通讯作者） Adipose tissue-derived stem cells embedded with eNOS restore cardiac function in acute myocardial infarction model Int J Cardiol 2012 12;154(1):2-8
Shu Meng, JiaTian Cao, LianSheng Wang, Qing Zhou, YiGang Li, ChengXing Shen,XiaoPing Zhang, ChangQian Wang （通讯作者） MicroRNA 107 Partly Inhibits Endothelial Progenitor CellsDifferentiation via HIF-1b PLoS ONE | www.plosone.org 2012 7(e40323):1-7
Huili Zhang, Alian Zhang, Changfa Guo, Chunzhi Shi, Yang Zhang, Qing Liu, Anna Sparatore,Changqian Wang （通讯作者） S-diclofenac Protects against Doxorubicin-InducedCardiomyopathy in Mice via Ameliorating Cardiac GapJunction Remodeling PLoS ONE | www.plosone.org 2011 6(e26441):1-13
YUQI FAN,SHU MENG,YUE WANG, TIATIAN CAO,CHANGQIAN WANG （通讯作者） Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-κB signaling pathway INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2011 27:607-615
YUE WANG, ZHOUQING HUANG,LIANSHENG WANG, SHU MENG, YUQI FAN,TING CHEN, JIATIAN CAO, RUJIA JIANG,CHANGQIAN WANG （通讯作者） The anti-malarial artemisinin inhibits pro-inflammatorycytokines via the NF-κB canonical signaling pathwayin PMA-induced THP-1 monocytes INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2011 27:233-241
Zhouqing Huang , Liansheng Wang, Shu Meng, Yue Wang, Ting Chen, Changqian Wang （通讯作者） Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38pathway activation in PMA-induced macrophages International Journal of Cardiology 2011 146:153-158
Yue W, Huang ZQ, Wang CQ (responsible author) （通讯作者）, Wang LS, Shu M, Zhang YC, Ting C, Fan YQ. Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages. Clinical and Experimental Pharmacology and Physiology 2011 38:11-18
Ting Chen, Zhouqing Huang, Liansheng Wang, Yue Wang, Feizhen Wu , Shu Meng,Changqian Wang （通讯作者） MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake and ORP9 expression in oxLDL-stimulated monocyte/macrophages Cardiovascular Research 2009 83（1）：131–139
S Meng, L Fang, C-Q Wang （通讯作者）, L-S Wang, M-T Chen and X-H Huang Impact of obstructive sleep apnoea on clinical characteristics and outcomes in patients with acute coronary syndrome following percutaneous coronary intervention Int J Cardiol 2009 37(5): 1343-1353
Jiang M, Wang B, Wang C （通讯作者） In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1alpha-modified EPC for angiogenesis) Int J Biochem Cell Biol 2008 40（10）：2284-2295
Huang Z, Wang C （通讯作者）, Wei L Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells Biochem Biophys Res Commun 2008 374（3）:517-521
Jiang M, Wang B, Wang C （通讯作者） Angiogenesis by transplantation of HIF-1 alpha modified EPCs into ischemic limbs J Cell Biochem 2008 103（2）:321-334
Heng Ge, Jun-feng Zhang, Chang-qian Wang （通讯作者） Inhibitory effect of PPAR on the Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARγ Vascul Pharmacol 2007 46（1）：114-121
JunFeng Zhang, Heng Ge, ChangQian Wang （通讯作者） Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells Int J Cardiol 2007 117（2）： 373-380
Jiang M, Wang B, Wang C （通讯作者） Inhibition of hypoxia-inducible factor-1alpha and endothelial progenitor cell differentiation by Adenoviral transfer of small interfering RNA in vitro J Vasc Res 2006 43（4）：511-521
J Gu, HH Fan,CQ Wang （通讯作者） Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intima-injured rats J Cardiovasc Pharmacol 2006 47（5）: 711-721