导师姓名： 朱金水 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： Email:zhujs1803@163.com
邮编： 200233 邮箱地址： zhujs1803@hotmail.com

研究方向 (点击浏览详细信息)
1.胃癌基础与临床 2.肠病的基础与临床研究

社会任职
教育部国家重点学科及创新团队评审委员会委员、中国胶囊内镜及肠病专家委员会主任委员 、中华医学科技进步奖评审委员会委员、国家卫健委消化专科基地评审委员会委员、亚太肝病学会委员、欧洲胃肠学会委员、中华医学会肿瘤免疫学会名誉主任委员、中国欧美同学会消化医师协会副秘书长、中国中西医结合消化学会常委、中华消化杂志编委、中国炎症性肠病中西医结合学会副主任委员、上海中西医结合学会消化学会主任委员、上海市中西医结合学会理事、上海医师协会消化分会顾问，上海市医学会消化学会、医疗事故鉴定委员会等委员
上海交通大学附属第六人民医院消化学科带头人、消化科主任

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
18DZ** 胶囊式内窥镜系统在食管疾病患者复查随访中的应用研究 上海市科委---医工创新重点合作项目 2018-10~2021-10 15万元 课题负责人
** 小肠疑难疾病的数字化内镜影像诊断研究 上海市科委 2017-08~2020-08 20万元 课题负责人
** 长链非编码RNA AK023391介导氧化苦参碱调控胃癌的分子机制研究 国家自然科学基金（面上项目） 2016-01~2019-12 68.4万元 课题负责人
** LATS1转导对胃癌细胞内Hippo-YAP信号通路的分子调控机理 国家自然科学基金（面上项目） 2013-01~2016-12 60万元 课题负责人
重度联合免疫缺陷裸鼠原位胃癌肝转移移植模型的建立及应用初探 上海市科委重点项目 2010-05~2012-12 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen W, Zhang J, Li C, Pan Q, Wu J, Fan L, Chen C, Huang X, Teng F, Zhu J （通讯作者） Is dextran sulfate sodium a good inducer of acute experimental enteritis? Int J Immunopathol Pharmacol. 2019 33
Chen W, Da W, Li C, Fan H, Liang R, Yuan J, Huang X, Yang R, Zhang J, Zhu J. （通讯作者） Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis. Int Immunopharmacol. 2019 71:259-266.
Zhang J, Hou L, Liang R, Chen X, Zhang R, Chen W, Zhu J. （通讯作者） CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. Mol Cancer. 2019 18(1):80
Chen XY, Zhang J, Zhu JS. （通讯作者） The role of m6A RNA methylation in human cancer Mol Cancer. 2019 18(1):103
Chen W, Fan H, Liang R, Zhang R, Zhang J, Zhu J. （通讯作者） Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitis by regulating fatty acid degradation and microbial dysbiosis. J Cell Mol Med. 2019 9: 8810?8818
Fan H, Chen W, Zhu J （通讯作者）, Zhang J, Peng S. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 76:105909
Liu H,Liu Y,Chen XY,Zhang J,Zhu JS （通讯作者） Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis Molecular cancer（IF:10.679） 2018 17（1）：151-166
Zhang J, Jin M, Chen X, Zhang R, Huang Y, Liu H, Zhu J. （通讯作者） Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer. Cell Prolif 2018 doi: 10.1111/cpr.12444. [Epub ahead of print]
Huang YX, Zhang J, Hou LD, Wang G, Liu H, Zhang R, Chen XY, Zhu JS* （通讯作者） LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway J Exp Clin Cancer Res 2017 36(1):194
Zhang J, Zhu JS* （通讯作者） Comment on response to "Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer," Cancer Lett 2017 388(2017): 208-219
Wang G, Huang YX, Zhang R, Hou LD, Liu H, Chen XY, Zhu JS* （通讯作者）, Zhang J Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC?7901 cells partly via miR?200a?mediated downregulation of β-catenin pathway Int J Oncol 2017 51(5):1563-1573
Zhang J, Liu H, Hou LD, Wang G, Zhang R, Huang YX, Chen XY, Zhu JS* （通讯作者） Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression Molecular cancer 2017 16(1): 151
R Zhang, G Wang, P-F Zhang, J Zhang*, Y-X Huang, Y-M Lu, W Da, Q Sun, J-S Zhu* （通讯作者） Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway J Cell Mol Med 2017 21(6):1117-1127
Chu SJ, Zhang J, Zhang R, Lu WW, Zhu JS. （通讯作者） Evolution and functions of stanniocalcins in cancer. Int J Immunopathol Pharmacol. 2015 28(1): 14-20
Lu WW, Zhang R, Zhu JS （通讯作者）, Xia LQ, Zhang J, et al. Oxymatrine and cancer therapy European Journal of Inflammation 2015 13(3): 148-153.
Wang G, Feng CC, Chu SJ, Zhang R, Lu YM, Zhu JS （通讯作者）, Zhang J. Toosendanin inhibits growth and induces apoptosis in colorectal cancer cells through suppression of AKT/GSK‐3β/β‐catenin pathway. Int J Oncol. 2015 47(5): 1767-1774.
Xia LQ, Zhu JS （通讯作者）, Zhang J. Knockdown of YAP1 inhibits growth and invasion of gastric cancer cells via signaling pathway. European J Inflammation. 2014 12(4): 312-319.
Zhang J, Zhang R , Lu WW, Zhu JS （通讯作者） Clinical significance of HMGB1 expression in human gastric cancer. Int.Immunopathol.Pharmacol. 2014 27(4): 543-551.
L.Q. XIA, R. ZHANG, J.S. ZHU （通讯作者）, J. ZHANG, W.W. LU and N.W.CHEN. SILENCING OF YAP GENE INHIBITS METASTASIS IN A SEVERE COMBINED IMMUNE DEFICIENCY MICE ORTHOTOPIC IMPLANTATION GASTRIC CANCER MODEL EUROPEAN JOURNAL OF INFLAMMATION. 2014 12(3): 503-510.
Lu YM, Zhu MY, Chen W, Yin L, Zhu JS （通讯作者）, Chen NW, Chen WX. Oleanolic acid induces appotosis of MKN‐28 cells via AKT and JNK signaling pathways. J Pharmaceutical. 2014 52(6): 789-795.
Zhang J, Zhu JS （通讯作者）, Zhang R. Inhibition of phosphoinositide 3‐kinase/Akt pathway decreases hypoxia inducible factor‐1. Oncology Letters. 2014 7(5): 1401-1407
J Zhang, J‐S Zhu （通讯作者）, Chen WX. Knockdown of HMGB1 inhibits growth and invasion of gastric cancer cells through the NF‐κB pathway in vitro and in vivo. Int J Oncology. 2014 11(1): 645-649.
Da W, Zhu J‐S （通讯作者）, Jin Y. Adalimumab for Crohn's disease after infliximab treatment failure: a systematic review. Eur J Gastroenterol. 2013 25(8): 885-891.
J Zhang, J‐S Zhu （通讯作者）, Y‐C Yang, Z Zhou, W‐X Chen. N‐W Chen. Enhancing the therapeutic effects of ethyl pyruvate on gastric cancer through knockdown of YAP1 expression. Eur J Inflamm. 2013 11(1): 123-132.
Da W, J‐S Zhu. （通讯作者） Efficacy and safety of certolizumab pegol for Crohn's disease: a systematic review and meta‐analysis. ADV IN THER. 2013 30(5): 541-553.
Zhang J,Zhu JS （通讯作者）,Zhou Z,Yang YC Inhibitory Effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo Oncology Report (IF:1.83) 2012 27:1511-1519
J Zhang, JS Zhu （通讯作者）, Z Zhou, WX Chen, NW Chen Therapeutic effects of ethyl pyruvate on growth and metastasis in a severe combined immunodeficiency mice orthotopic implantation model Eur J Inflamm (IF: 5.23) 2012 10:25-32
J Zhang, Y‐C Yang, J‐S Zhu （通讯作者）, Z Zhou, W‐X Chen. Clinicopathologic characteristics of YES‐associated protein 1 overexpression and its relationship to tumor biomarkers in gastric cancer. Int J Immunopath Ph. 2012 25:977-987.
J zhang, ZP Xu, JS Zhu （通讯作者）, YC Yang, Z Zhou, WX Chen, NW Chen Expression of Yes-associated protein in gastric cancer and inhibitory effects of its knockdown on gastric cancer cell proliferation and metastasis Int J Immunopath Ph （不俗论文，IF：2.99） 2012 25:557-64