导师姓名： 张浩 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： 上海交通大学附属第六人民医院门诊5楼骨质疏松与骨病专科
邮编： 200233 邮箱地址： zhanghaozcl@163.com

研究方向 (点击浏览详细信息)
内分泌代谢性骨病

社会任职
中华医学会骨质疏松和骨矿盐分会第六届委员会青年委员会副主任委员
中国老年保健医学研究会骨质疏松分会委员
中华医学会骨质疏松和骨矿盐分会第五届委员会继发性骨质疏松学组委员
中华骨质疏松和骨矿盐疾病杂志编委
上海市医学会骨质疏松专科分会第七届委员会委员
中国老年学和老年医学学会骨质疏松分会内分泌专家委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** P4HB基因新突变导致成骨不全Cole-Carpenter综合征的分子机制研究 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
14ZR** 成骨不全表型多变家系突变基因体细胞镶嵌的检测及外显不全机制研究 上海市自然科学基金面上项目 2014-07~2017-06 10万元 课题负责人
** 成骨不全家系的致病基因突变位点检测及与表型的关系研究 国家自然科学基金青年科学基金 2009-01~2011-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
曹洋嘉,张浩 （通讯作者）,章振林 成骨不全的临床表现与分子遗传学 中华骨质疏松和骨矿盐疾病杂志 2019 12(2):199-205
Cao YJ, Wei Z, Zhang H （通讯作者）, Zhang ZL. Expanding the Clinical Spectrum of Osteogenesis Imperfecta Type V: 13 Additional Patients and Review. Frontiers in Endocrinology 2019 10:375
Cao YJ, Zhang H （通讯作者）, Zhang ZL. Novel mutations in the WNT1, TMEM38B, P4HB, and PLS3 genes in four unrelated chinese families with osteogenesis imperfecta. Endocrine Practice 2019 25(3):230-241
Zhang H, Xu Y, Yue H, Wang C, Gu J, He J, Fu W, Hu W, Zhang Z. Novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta. International Journal of Molecular Medicine 2018 41(6):3662-3670
Zhang H, Yue H, Wang C, Gu J, He J, Fu W, Hu W, Zhang Z. Novel mutations in the SEC24D gene in Chinese families with autosomal recessive osteogenesis imperfecta. Osteoporosis International 2017 28(4):1473-1480
Zhang H, Yue H, Wang C, Hu W, Gu J, He J, Fu W, Hu Y, Li M, Zhang Z. Clinical characteristics and the identification of novel mutations of COL1A1 and COL1A2 in 61 Chinese patients with osteogenesis imperfecta. Molecular Medicine Reports 2016 14(5):4918-4926
Hao Zhang, Chun Wang, Hua Yue, Wei-Wei Hu, Jie-Mei Gu, Jin-Wei He, Wen-Zhen Fu, Yu-Juan Liu,Zeng Zhang, Zhen-Lin Zhang Identification of a novel mutation in the CLCN5 gene in a Chinese Nephrology 2014 19(2):80-3
He J, Zhang H （共同第一作者）, Wang C, Zhang Z, Yue H, Hu W, Gu J, Fu W, Hu Y, Li M, Liu Y, Zheng H, Zhang Z Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women. Journal of Clinical Endocrinology Metab 2014 99(4):E665-73
H. Zhang, J. W. He, C. Wang, Z. Zhang, H. Yue, W. W. Hu, J. M. Gu, Y. Q. Hu, M. Li, W. Z. Fu, Z. L. Zhang Associations of polymorphisms in the SOST gene and bone mineral density in postmenopausal Chinese Women Osteoporosis International 2014 25(12)::2797–2803
Zhang H （共同第一作者）, Ke YH, Wang C, Yue H, Hu WW, Gu JM, Zhang ZL Identification of the Mutations in the Tissue-nonspecific Alkaline Phosphatase Gene in Two Chinese Families with Hypophosphatasia. Archives of Medical Research 2012 43(1):21-30
Zhang ZL, Zhang H （共同第一作者）, Ke YH, Yue H, Xiao WJ, Yu JB, Gu JM, Hu WW, Wang C, He JW, Fu WZ The identification of novel mutations in COL1A1, COL1A2, and LEPRE1 genes in Chinese patients with osteogenesis imperfecta. Journal of Bone and Mineral Metabolism 2012 30(1):69-77
Zhang H, Huang QR, Gu JM, Hu WW, Liu YJ, Hu YQ, Zhang ZL. Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency. Acta Pharmacol Sin 2012 33(4):490-495
Zhang H, Hu YQ, Zhang ZL. Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture Osteoporosis International 2011 22(9):2513-22
Zhang H, He JW, Gao G, Yue H, Yu JB, Hu WW, Gu JM, Hu YQ, Li M, Fu WZ, Liu YJ, Zhang ZL Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families. Acta Pharmacol Sin 2010 31(8):977-983