导师姓名： 陈天璐 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： chentianlu@sjtu.edu.cn

研究方向 (点击浏览详细信息)
生物/医学信息学；代谢组学；转化医学

社会任职
中国生物物理学会代谢组学分会会员
上海市生物信息学会会员
欧盟玛丽居里****

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于“代谢物组-微生物组深度关联分析策略”的2型糖尿病进展模式和 国家自然科学基金委 2020-01~2023-12 56万元 课题负责人
2019YFA** 不同发育阶段肠道菌群特征及其对发育的影响 子课题 科技部 2019-12~2024-11 1700万元 子课题负责人
18DZ** 上海市重大疾病临床生物样本实体库专业技术服务平台 上海市研发平台专项 2018-04~2021-03 100万元 课题参与人
** 基于“半聚焦”代谢组学策略的主要消化系统肿瘤共有和特有代谢模式研究 国家自然科学基金委 2016-01~2018-12 20万元 课题负责人
292183 Cognitive-Networks-Enabled Transnational Proactive Healthcare (CoNHealth) 欧盟 2012-04~2016-03 60万元 课题负责人
10ZR** 基于代谢组学信息融合的三种恶性肿瘤特征代谢物组研究 上海市科委 2010-04~2012-03 10万元 课题负责人
2007CB914700 代谢性疾病的蛋白质功能与代谢组学研究 国家科技部 2009-01~2011-12 1500万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Xia Zhang; Yuping Yang; Juan Su; Xiaojiao Zheng; Chongchong Wang; Shaoqiu Chen; Jiajian Liu; Yingfang Lv; Shihao Fan; Aihua Zhao; Tianlu Chen; Wei Jia; Xiaoyan Wang Age-related compositional changes and correlations of gut microbiome, serum metabolome and immune factor in rats GeroScience 2020 online
D.D. Liang, M.C. Li, R.M. Wei, J.Y. Wang, Y.T. Li, W. Jia, T.L. Chen* （通讯作者） A Strategy for Inter-correlation Identification between Metabolome and Microbiome Analytical Chemistry 2019 91(22): 14424-14432
Yitao Li, Xiaojiao Zheng, Wei Jia, Tianlu Chen （通讯作者） MCEE 2.0 - more options and enhanced performance Analytical and Bioanalytical Chemistry 2019 10.1007/s00216-019-01874-3
Yijun You, Dandan Liang, Runmin Wei, Mengci Li, Yitao Li, Jingye Wang, Xiaoyan Wang, Xiaojiao Zheng, Wei Jia, Tianlu Chen （通讯作者） Evaluation of Metabolite-Microbe Correlation Detection Methods Analytical Biochemistry 2019 567(2019): 106-111
Tianlu Chen, Yijun You, Guoxiang Xie, Xiaojiao Zheng, Aihua Zhao, Jiajian Liu, Qing Zhao, Shouli Wang, Fengjie Huang, Cynthia Rajani, Congcong Wang, Shaoqiu Chen, Yan Ni, Herbert Yu, Youping Deng, Xiaoyan Wang, and Wei Jia, Strategy for Association Study on Intestinal Microbiome and Brain Metabolome across Lifespan of Rats Analytical Chemistry 2018 90(4): 2475-2483
游懿君,梁丹丹,陈天璐 （通讯作者） 四种相关分析方法在菌群和代谢物相关研究中的性能比较 转化医学杂志 2018 7(2): 93-96
Xiaojiao Zheng, Kejun Zhou, Yunjing Zhang, Xiaolong Han, Aihua Zhao, Jiajian Liu, Chun Qu, Kun Ge, Fengjie Huang, Brenda Hernande, Herbert Yu, Jun Panee, Tianlu Chen, Weiping Jia, and Wei Jia Food withdrawal alters the gut microbiota and metabolome in mice FASEB Journal 2018 32(9):4878-4888
Rummin Wei, Jingye Wang, Mingming Du, Erik Jia, Shaoqiu Chen, Tianlu Chen, Yan Ni Missing value imputation approach for mass spectrometry-based metabolomics data Scientific reports 2018 8(1):663
Li Yitao, Li Mengci, Ni Yan, Jia Wei, Chen Tianlu （通讯作者） MCEE: A Data Preprocessing Approach for Metabolic Confounding Effect Elimination Analytical and Bioanalytical Chemistry 2018 410(11):2689-2699
Mengci Li, Shouli Wang, Guoxiang Xie, Xiaohui Ma, Tianlu Chen （通讯作者）, Wei Jia polyPK: An R Package for Pharmacokinetic Analysis of Multi-component Drugs Using a Metabolomics Approach bioinformatics 2018 34(10): 1792–1794
Runmin Wei, Jingye Wang, Eric Jia, Tianlu Chen, Yan Ni, Wei Jia GSimp: A Gibbs Sampler Based Left-censored Missing Value Imputation Approach for Metabolomics Studies PLOS computational biology 2018 14(1): e**
Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia Bile acid is a significant host factor shaping the gut microbiome of diet induced obese mice BMC Biology 2017 15:120
王守丽,谢国祥,赵爱华,陈天璐 （通讯作者）,贾伟 黄芪汤对人体代谢的影响及其在疾病防治中的辅助作用 医学研究杂志 2017 46(8): 26-30
Guoxiang Xie, Shouli Wang, Hua Zhang, Aihua Zhao, Jiajian Liu, Yueming Ma, Ke Lan, Yan Ni, Changxiao Liu, Ping Liu, Tianlu Chen(co- corresponding author) （通讯作者）, Wei Jia Poly-Pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers Clinical Pharmacology and Therapeutics 2017 doi: 10.1002/cpt.784.
Linjing Zhao, Xiaojing Ma, Aihua Zhao, Yuqian Bao, Jiajian Liu, Tianlu Chen, Guoxiang Xie, Jun Panee, Mingming Su, Herbert Yu, Congrong Wang, Cheng Hu, Weiping Jia, Wei Jia A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals Scientific Reports 2016 1
Haoyong Yu, Yan Ni, Yuqian Bao, Pin Zhang, Aihua Zhao, Tianlu Chen, Guoxiang Xie, Yinfang Tu, Lei Zhang, Mingming Su,Li Wei, Wei Jia, and Weiping Jia Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients J Clin Endocrinol Metab 2016 doi: 10.1210/jc.2015-2884
Xiaojiao Zheng, Tianlu Chen, Aihua Zhao, Xiaoyan Wang, Guoxiang Xie, Fengjie Huang, Jiajian Liu, Qing Zhao, Shouli Wang, Chongchong Wang, Mingmei Zhou, Jun Panee, Zhigang He, Wei Jia The Brain Metabolome of Male Rats across the Lifespan Scientific Reports 2016 10.1038/srep24125
Zhao, Linjing; Zhao, Aihua; Chen, Tianlu; Chen, Wenlian; Liu, Jiajian; Wei, Runmin; Su, Jing; Tang, Xuelan; Liu, Keyi; Zhang, Ran; Xie, Guoxiang; Panee, Jun ; Qiu, Mingfeng; Jia, Wei Global and Targeted Metabolomics Evidences of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats Journal of Proteome Research 2016 1
Tianlu Chen, Yan Ni, Xiaojing Ma, Yuqian Bao, Jiajian Liu, Fengjie Huang, Cheng Hu, Guoxiang Xie, Aihua Zhao, Weiping Jia*, Wei Jia*, Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations Scientific Reports 2016 20594
王守丽,卫润民,黄凤杰,赵琳静,赵爱华,陈天璐 （通讯作者） 游离脂肪酸结构信息和保留时间相关性及预测模型的建立 上海交通大学学报医学版 2016 36(1):1-4
Haoyong Yu, Yan Ni, Yuqian Bao, Pin Zhang, Aihua Zhao, Tianlu Chen, Guoxiang Xie, Yinfang Tu, Lei Zhang, Mingming Su,Li Wei, Wei Jia, Weiping Jia Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients J Clin Endocrinol Metab 2015 100(11):4222-30
卫润民,黄凤杰,谢夑,池逸,郑晓皎,赵爱华,陈天璐 （通讯作者） 代谢物批量定量工具的开发与应用 上海交通大学学报医学版 2015 35(1):1-4
Lei Cai, Tianlu Chen, Jinglei Yang, Kejun Zhou, Xiaomei Yan, Wenzhong Chen, Liya Sun, Linlin Li, Shengying Qin, Peng Wang, Ping Yang, Donghong Cui, Margit Burmeister, Lin He1, Wei Jia, Chunling Wan Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population scientific reports 2015 5:15013
Tianlu Chen, Guiyun Tian, Weiwei Quan Pooled sample-based workflow and software for medical data calibration 8th International Symposium on Medical Information and Communication Technology 2014 Italy, April
Jiang-Han Wang, Wen-Lian Chen, Jun-Min Li, Song-Fang Wu, Tian-Lu Chen, Yong-Mei Zhu, Wei-Na Zhang,Yang Li, Yun-Ping Qiu, Ai-Hua Zhao, Jian-Qing Mi, Jie Jin, Yun-Gui Wang, Qiu-Ling Ma, He Huang, De-Pei Wu,Qin-Rong Wang, Yan Li, Xiao-Jing Yan, Jin-Song Yan, Jian-Yong Li, Shuai Wang, Xiao-Jun Huang,Bing-Shun Wang, Wei Jia*, Yang Shen*, Zhu Chen, and Sai-Juan Chen Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China PNAS 2013 110(42): 17017-17022
Zhang Y, Wu Y, Chen T, Yao L, Liu J, Pan X, Hu Y, Zhao A, Xie G, Jia W Assessing the Metabolic Effects of Aromatherapy in Human Volunteers Evidence-Based Complementary and Alternative Medicine 2013 2013(356381)
T.L. Chen, Y. Cao, Y. Zhang, J. Liu, Y. Bao, C. Wang, W. Jia, and A. Zhao Random Forest in Clinical Metabolomics for Phenotypic Discrimination and Biomarker Selection Evidence-Based Complementary and Alternative Medicine 2013 2981(83):-
J.L. Yang, T.L. Chen (co-first author) （共同第一作者）, L.Y. Sun, Z.M. Zhao, X. Qi, K.J. Zhou, Y. Cao, X.Y. Wang, Y.P. Qiu, M.M. Su, A.H. Zhao, P. Wang, P. Yang, J.L. Wu, G.Y. Feng, L. He, W. Jia*, and C.L. Wan Potential metabolite markers of schizophrenia Molecular Psychiatry 2013 2013(18):67-78
Miao Jiang, Tianlu Chen (co-first author) （共同第一作者）, Hui Feng, Yinan Zhang, Li Li, Aihua Zhao, Xuyan Niu, Fei Liang, Minzhi Wang, Junping Zhan, Cheng Lu, Xiaojuan He, Lianbo Xiao, Wei Jia, Aiping Lu Serum Metabolic Signatures of Four Types of Human Arthritis Journal of Proteome Research 2013 8(12):769-779
Tan B, Qiu Y, Zou X, Chen T, Xie G, Cheng Y, Dong T, Zhao L, Feng B, Hu X, Xu LX, Zhao A, Zhang M, Cai G, Cai S, Zhou Z, Zheng M, Zhang Y, Jia W. Metabonomics identifies serum metabolite markers of colorectal cancer Journal of Proteome Research 2013 12(6):3000-9
L.X. Duan, T.L. Chen (co-first author) （共同第一作者）, M. Chen, Y.Q. Zhou, G.H. Cui, A.H. Zhao, W. Jia, L.Q.Huang, X.Q. Qi Use of metabolomics approach to characterize Chinese medicinal material Huangqi Molecular Plant 2012 5(2):376-386
李芬, 赵爱华, 杨景雷, 陈天璐 （通讯作者） 基于多种判别分析的原发性肝肿瘤代谢谱分析 上海交通大学学报医学版 2012 32(1):77-81
T.L. Chen, G.X. Xie, X. Y. Wang, J. Fan, Y.P. Qiu, X.J. Zheng, X. Qi, Y. Cao, M.M. Su, X.Y. Wang, L. X. Xu, Yun Y. P. Liu, W. Jia Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma Molecular & Cellular Proteomics 2011 10(11):1-13