导师姓名： 陈小华 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 传染病
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市宜山路600号第六人民医院感染病科
邮编： 200233 邮箱地址： chenxiaohua2000@163.com

研究方向 (点击浏览详细信息)
病毒性肝炎发病机制及免疫治疗

社会任职
担任《世界华人消化杂志》编委
上海市中西医结合器官纤维化委员会委员
上海市医学会感染病分学青年委员
中国医促会临床微生物与感染分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 树突状细胞来源的exosome胞内转运泛素化修饰的丁肝病毒抗原诱导T细胞分化在抑制HDV复制中的作用及免疫机制研究 国家自然科学基金 2018-01~2021-12 51万元 课题负责人
17ZR** 富含分子伴侣Tapasin的骨髓树突状细胞来源外泌体诱导T细胞分化在乙肝病毒免疫清除中的作用及机制研究 上海市科委 2017-05~2020-04 20万元 课题负责人
基于高通量等离子体纳米金基质的抗体检测平台对HDV感染患者的筛选及临床应用研究 上海市卫计委 2017-01~2019-12 5万元 课题负责人
** 分子伴侣 Tapasin 修饰经胞内转运的CTL 表位肽诱导特异性CTL 的机制研究 国家自然科学基金 2011-01~2013-12 19万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hu X, Tang Z, Ma S, Yu Y, Chen X （通讯作者）, Zang G Tripartite motif-containing protein 7 regulates hepatocellular carcinoma cell proliferation via the DUSP6/p38 pathway. Biochem Biophys Res Commun. 2019 511(4):889-895.
Mahale P, Aka P, Chen X （共同第一作者）, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR. Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia. J Viral Hepat 2019 26(6):738-749.
Ma S, Chen X, Tan Q, Dai S, Li D, Wu S, Yu Y, Zang G, Tang Z. An Engineered DC-Targeting Lentivector Induces Robust T Cell Responses and Inhibits HBV Replication in HBV Transgenic Mice via Upregulating T Cell Autophagy. Cell Physiol Biochem. 2018 48(3):1041-1059
Zhang Y, Tao R, Wu SS, Xu CC, Wang JL, Chen J, Yu YS, Tang ZH, Chen XH （通讯作者）, Zang GQ TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A. J Exp Clin Cancer Res. 2018 37(1):116
Wu S, Chen X （共同第一作者）, Tang Y, Zhang Y, Li D, Chen J, Wang J, Tang Z, Zang G, Yu Y. Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo. Acta Biochim Biophys Sin. 2018 50(2):181-190.
Mahale P, Aka PV, Chen X, Liu P, Fram BJ, Wang AS, Simenel S, Tseng FC, Chen S, Edlin BR, Glenn JS, O'Brien TR. Hepatitis D Viremia Among Injection Drug Users in San Francisco. J Infect Dis. 2018 217(12):1902-1906.
Ma S, Chen X, Tan Q, Li D, Dai S, Wu S, Yu Y, Zang G, Tang Z. An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells. Cell Cycle. 2018 2018.**
Tan Q, Ma S, Hu J, Chen X, Yu Y, Tang Z, Zang G. Adenovirus Vector Harboring the HBcAg and Tripeptidyl Peptidase II Genes Induces Potent Cellular Immune Responses In Vivo. Cell Physiol Biochem. 2017 41(2):423-438.
Zhang Y, Wu SS, Chen XH, Tang ZH, Yu YS, Zang GQ. Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation in Hepatitis B Virus-Associated Hepatocellular Carcinoma. Med Sci Monit. 2017 23:5202-5210.
Xiaohua Chen1 （共同第一作者）,Odgerel Oidovsambuu,Ping Liu,Rosslyn Grosely1,Menashe Elazar,Virginia D.Winn,Benjamin Fram,Zhang Boa,Hongjie Dai,Bekhbold Dashtseren,Dahgwahdorj Yagaanbuyant,Zulkhuu GendenNaranbaatar Dashdorj,Andreas Bungert,Naranjargal Dashdorj,Jeffrey S.Glenn A novel quantitative microarray antibody capture (Q-MAC) assay identifies an extremely high HDV prevalence amongst HBV infected Mongolians. Hepatology 2017 66(6):1739-1749.
Tan Q, Ma S, Hu J, Chen X, Yu Y, Zang G, Tang Z. Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling. Biomed Pharmacother. 2016 84:1954-1958.
YUYAN TANG,JIELING WANG,YI ZHANG, MENG ZHUO, LINLIN SONG,ZHENGHAO TANG,GUOQING ZANG, XIAOHUA CHEN （通讯作者）,YONGSHENG YU Correlation between low Tapasin expression and impaired CD8+ T-cell function in patients with chronic hepatitis B Mol Med Rep 2016 14(4):3315-3322.
Xiao-Hua CHEN, Yun-Chao GAO, Yi ZHANG, Zheng-Hao TANG, Yong-Sheng YU, Guo-Qing ZANG TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT Rev. Inst. Med. Trop. Sao Paulo 2015 57(3):273-275
Tang YY, Tang ZH, Zhang Y, Zhuo M, Zang GQ, Chen XH （通讯作者）, Yu YS. The Fusion Protein of CTP-HBcAg18-27-Tapasin Mediates the Apoptosis of CD8+T Cells and CD8+ T Cell Response in HLA-A2 Transgenic Mice Hepat Mon 2014 14(2):e16161.
Chen X （共同第一作者）, Tang Y, Zhang Y, Zhuo M, Tang Z, Yu Y, Zang G. Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo. Lab Invest. 2014 94(5):478-490
Chen X, Lu H, Gao Y. FDG PET/CT showing erythema nodosum associated with tuberculous lymphadenitis. Clin Nucl Med. 2013 38(12):992-993.
唐余燕, 余永胜, 卓 萌, 臧国庆, 汤正好, 陈小华 （通讯作者） 胞质转导肽-HBcAg18-27-Tapasin体外诱导HBV转基因小 鼠髓源性树突状细胞成熟及在T淋巴细胞增殖中的作用 世界华人消化杂志 2013 21(2): 122-129
Chen X, Liu H, Tang Z, Yu Y, Zang G. The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide. Acta Biochim Biophys Sin 2013 45(3):203-12.
Chen X, Lai J, Pan Q, Tang Z, Yu Y, Zang G. The delivery of HBcAg via Tat-PTD enhances specific immune response and inhibits Hepatitis B virus replication in transgenic mice. Vaccine 2010 28(23):3913-3919
Chen X, Yu Y, Pan Q, Tang Z, Han J, Zang G. Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen. Acta Biochim Biophys Sin 2008 112(45):14302-14311