导师姓名： 傅国香 专业代码： 100203
性别： 女 专业名称： 老年医学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： fuguoxiang888@163.com
邮编： 200233 邮箱地址： fuguoxiang888@163.com

研究方向 (点击浏览详细信息)
衰老相关心血管疾病的分子机制研究

社会任职
中华行为医学分会行为评估与诊断学组委员
中国医疗保健国际交流促进会会员
国家自然科学基金同行评审专家
上海市科学技术评审专家
上海老年医学会青年委员
中国女医师协会老年医学专业委员
全科临床医学基地培训导师

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** mTORC1/OPN信号通路在cathepsin L缺乏诱导血管衰老中的作用与机制 国家自然科学基金面上项目 2019-01~2022-12 56万元 课题负责人
SHDC12017X21 不同危险因素对血管衰老的影响 申康医院发展中心临床研究培育项目 2017-12~2020-12 30万元 课题负责人
** Cathepsin L通过SIRT1/p66Shc途径调控血管内皮细胞衰老的机制研究 国家青年自然科学基金 2015-01~2017-12 22万元 课题负责人
** 急性肺损伤时局部ACE2-Ang1-7-Mas受体轴的调控作用及其信号转导机制 国家自然科学基金面上项目 2013-01~2016-12 60万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Jun Xu, Yujie Deng, Yi Wang, Xiaofang Sun, Shuqin Chen, Guoxiang Fu* （通讯作者） SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway Cell Proliferation 2020 Jan, 19: e12738
Jun Xu, Feng Feng Pan, Chan Chan Xu, Yuan Zhong, Ting Jun Hu, Guo Xiang Fu* （通讯作者） Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients Artery Research 2019 25(1-2): 65–69
Feng Feng Pan, Chan Chan Xu, Ting Jun Hu, Guo Xiang Fu* （通讯作者）, Yuan Zhong Carotid plague formation is associated with ankle–brachial index in elderly people Aging Clin Exp Res 2019 2019 Nov 23
Fu GX （通讯作者）,Chen AF,Xu QM,Han BB,Huang GZ,Zhong Y Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation Free Radic Res 2017 51((11-12))：932~942.
Fu GX, Ji M, Han LZ, Xu CC, Pan FF, Hu TJ, Zhong Y. Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people. Z Gerontol Geriatr 2017 50(3):233-238
Zhong Yuan,Chen Alex F,Zhao Jian, Gu Ying-Jia, Fu Guo-Xiang （通讯作者） Serum levels of cathepsin D, sirtuin1, and endothelial nitric oxide synthase are correlatively reduced in elderly healthy people AGING CLINICAL AND EXPERIMENTAL RESEARCH 2016 28(4):641~645
Zhong Y, Jin J, Xu CC, Fu GX. （通讯作者） GA to HbA1C ratio, but not HbA1C is associated with cognition in Chinese nondiabetic old adults. Aging Ment Health. 2015 19(9):853-7
Fu GX （通讯作者）,Chen AF,Zhong Y,Zhao J,Gu YJ Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals Aging Clin Exp Res 2015 28(2)：175~180
Zhong Yuan ,Zhao Jian,Gu Ying-Jia,Zhao Yi-Fan,Zhou Yan-Wu,Fu Guo-Xiang （通讯作者） Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2 Archives of Gerontology and Geriatrics 2015 61(2)：285~288
Guo-Xiang Fu, Ya Miao, Hong Yan, Yuan Zhong Common carotid flow velocity is associated with cognition in older adults. The Canadian Journal of Neurological Sciences 2012 39: 502-507.
Guo-Xiang Fu, Chan-Chan Xu, Yuan Zhong, Ding-Liang Zhu, Ping-Jin Gao Aldosterone-induced osteopontin expression in vascular smooth muscle cells involves MR, ERK, and p38 MAPK. Endocrine 2012 42(3):676-83.
Guo-Xiang Fu, Yuan Zhong Is mitral early to late wave ratio a predictor for silent cerebral infarction in elderly patients with coronary artery disease Neurosciences 2010 15 (3), 214-5
Xin Jin*,Guo-xiang Fu* （共同第一作者）, Xiao-dong Li, Ding-liang Zhu, Ping-jin Gao Expression and Function of Osteopontin in Vascular Adventitial Fibroblasts and Pathological Vascular Remodeling PLoS One. 2009 6(9):e23558