导师姓名： 许峰 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 血液病
导师类型： 硕士生导师 专业学位导师：
联系方式： xvfeng3619@163.com
邮编： 200233 邮箱地址： xvfeng3619@163.com

研究方向 (点击浏览详细信息)
骨髓增生异常综合征的发病机制及诊治

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 骨髓微环境SLIT2-ROBO1信号失活促进MDS细胞恶性增殖的作用机制及靶向干预研究 国家自然科学基金委面上项目 2018-01~2021-12 55万元 课题负责人
MYCN在骨髓增生异常综合征白血病转化中的分子机制研究 上海市卫计委面上项目 2017-01~2019-12 5万元 课题负责人
** miR-10a通过RYBP调控MDS克隆细胞凋亡抵抗的分子机制 国家自然科学基金委青年项目 2014-01~2016-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu L, Xu F （共同第一作者）, Chang CK, He Q, Wu LY, Zhang Z, Li X MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21 Cell Death Dis 2017 8(10):e3126
Xu F （共同第一作者）, Wu LY, He Q, Wu D, Zhang Z, Song LX, Zhao YS, Su JY, Zhou LY, Guo J, Chang CK, Li X Exploration of the role of gene mutations in myelodysplastic syndromes through a sequencing design involving a small number of target genes Sci Rep 2017 7:43113
Xu F （共同第一作者）, Zhu Y, He Q, Wu LY, Zhang Z, Shi WH, Liu L, Chang CK, Li X Identification of microRNA-regulated pathways using an integration of microRNA-mRNA microarray and bioinformatics analysis in CD34+ cells of myelodysplastic syndromes Sci Rep 2016 6:32232
Xu F （共同第一作者）, Liu L, Chang CK, He Q, Wu LY, Zhang Z, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Li X. Genomic loss of EZH2 leads to epigenetic modifications and overexpression of the HOX gene clusters in myelodysplastic syndrome Oncotarget 2016 7(7):8119-30
Xu F （共同第一作者）, Wu LY, Chang CK, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X. Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes Nat Commun 2015 6:8806
Xu F, He Q, Li X, Chang CK, Wu LY, Zhang Z, Liu L, Shi WH, Zhu Y, Zhao YS, Gu SC, Fei CM, Guo J, Wu D, Zhou L Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome Sci Rep 2014 4:7310
Xu F, Li X, Chang CK, Guo J, Wu LY, He Q, Zhang Z, Zhu Y, Gu SC, Shi WH, Song LX, Su JY, Zhou LY, Zhang X, Wu D Establishment and validation of an updated diagnostic FCM scoring system based on pooled immunophenotyping in CD34+ blasts and its clinical significance for myelodysplastic syndromes PLoS One 2014 9(2):e88706
Li X, Xiao ZJ, Chang CK, Xu F （共同第一作者）, Wu LY, He Q, Xu ZF, Song LX, Zhang Z, Zhou LY, Su JY, Zhang X, Guo J. Distinct clinical and experimental characteristics in the patients younger than 60 years old with myelodysplastic syndromes PloS one 2013 8(2):e57392
Xu F （共同第一作者）, Guo J, Wu LY, He Q, Zhang Z, Chang CK, Li X Diagnostic application and clinical significance of FCM progress scoring system based on immunophenotyping in CD34+ blasts in myelodysplastic syndromes Cytometry B Clin Cytom 2013 84(4):267-78
Li X, Xu F （共同第一作者）, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin Biol Blood Marrow Transplant 2013 19(8):1210-9
Xu F, Deeg HJ Current status of allogeneic hematopoietic cell transplantation for MDS Curr Pharm Des 2012 18(22):3215-21
Xu F, Yang R, Wu L, He Q, Zhang Z, Zhang Q, Yang Y, Guo J, Chang C, Li X Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome Cancer Lett 2012 317(1):33-40
Xu F, Li X. The role of histone methyltransferase EZH2 in myelodysplastic syndromes Expert Rev Hematol 2012 5(2):177-85
Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y, Zhang Z, He Q, Chang C Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring Ann Hematol 2011 90(6):643-53
Xu F, Li X, Wu L, He Q, Zhang Z, Chang C Flow cytometric scoring system (FCMSS) assisted diagnosis of myelodysplastic syndromes (MDS) and the biological significance of FCMSS-based immunophenotypes Br J Haematol 2010 149(4):587-97
许峰,李晓 骨髓增生异常综合征的表观遗传学改变 中国实验血液学杂志 2010 18(2):531-5
许峰,李晓 骨髓增生异常综合征表观遗传学治疗进展 白血病淋巴瘤杂志 2009 18(11):690-693
Xu F, Li X, Chang C, He Q, Zhang Z, Zhang Q, Wu L A delayed yet durable response to very short lenalidomide therapy and unexpected clone redistribution in a case of myelodysplastic syndrome with del(5q) and del(20q) Leuk Res 2009 33(11):e199-202.