导师姓名： 孙斐 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属国际和平妇幼保健院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： **
邮编： 200030 邮箱地址： sunfei@shsmu.edu.cn

研究方向 (点击浏览详细信息)
不孕不育的基础和临床研究

社会任职
《Molecular Human Reproduction》编委、《Reproductive Biology and Endocrinology》编委、《Asian Journal of Andrology》编委、《中华男科学杂志》副主编、《生殖医学杂志》编委、中华医学会计划生育学分会委员、男性生育调控学组副组长、中华医学会生殖医学分会精子库管理学组委员、中国中西医结合学会男科、妇产科、生殖医学3个专业委员会常委、中国动物学会生殖生物学分会常务理事等

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018YFC** 精子发生的调节机制 科技部 2018-12~2021-12 2605万元 课题负责人
** CDK2在男性不育中的作用及其机制 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
** 小非编码RNA及其相关蛋白在男性不育发生中的作用及其分子机理 国家自然科学基金重点项目 2015-01~2019-12 340万元 课题负责人
2014CB943104 精子发生与成熟的表观遗传调控 国家重大科学研究计划 2014-01~2019-08 100万元 课题参与人
** 精子发生异常与男性不育 国家****科学基金 2012-01~2015-12 240万元 课题负责人
** miRNAs在小鼠卵泡发育中的作用及其分子机制研究 国家自然科学基金面上项目 2012-01~2015-12 65万元 课题负责人
2009CB941700 环境和遗传因素导致男性不育与出生缺陷的分子机制 国家重大科学研究计划 2009-01~2013-08 339万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhai Y, Yao G, Rao F, Wang Y, Song X, Sun F. （通讯作者） Excessive nerve growth factor impairs bidirectional communication between the oocyte and cumulus cells resulting in reduced oocyte competence. Reprod Biol Endocrinol 2018 16(1):28. doi: 10.1186/s12958-018-0349-7.
Duan Z, Ping P, Wang G, Zhang X, Sun F. （通讯作者） Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. Biosci Rep 2018 Jul 2;38(4). pii: BSR**. doi: 10.1042/BSR**.
Liang AJ, Wang GS, Ping P, Hu SG, Lin Y, Ma Y, Duan ZZ, Wang HS, Sun F （通讯作者） The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia. Asian J Androl 2018 20 (2): 154-159
Jinfei Yang, Xiao Meng, Kai Lu, Zhihao Lu, Minliang Huang, Chengniu Wang and Fei Sun*.. Acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition for the synthesis of quinolines under air RSC Adv 2018 8, 31603-31607
Zhao W, Li Z, Ping P, Wang G, Yuan X, Sun F. （通讯作者） Outer dense fibers stabilize the axoneme to maintain sperm motility. J Cell Mol Med 2018 Mar; 22(3): 1755-1768
Zhao C, Zheng X, Qu W, Li G, Li X, Miao YL, Han X, Liu X, Li Z, Ma Y, Shao Q, Li H, Sun F, Xie S, Zhao S. CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif. Int J Biol Sci 2017 13(12):1470-1478. doi:10.7150/ijbs.21312.
Wang X, Zhang X, Wang G, Wang L, Lin Y, Sun F （通讯作者） Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells Gene 2017 626, 344–353
Zhang H, Wang G, Liu L, Liang X, Lin Y, Lin YY, Chou CF, Liu MF, Huang H, Sun F （通讯作者） KH-type splicing regulatory protein is a new component of Chromatoid body Reproduction 2017 Dec; 154(6): 723-733
Zheng X, Li Z, Wang G, Li Z, Liang A, Wang H, Dai Y, Huang X, Chen X, Ma Y and Sun F Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance of Active DNA Methylation Changes in Rat Sperm Front Genet 2017 207. doi: 10.3389/fgene.2017.00207
Faiza Rao, Hui Tian, Wenqing Li, Helong Hung, Fei Sun （通讯作者） Potential role of punicalagin against oxidative stress induced testicular damage Asian Journal of Andrology 2016 18 (4): 627–632
Duan Z, Huang H, Sun F. （通讯作者） The functional and predictive roles of miR-210 in cryptorchidism Sci Rep 2016 Aug 26;6: 32265. doi: 10.1038/srep32265.
Lin Y, He R, Sun L, Yang Y, Li W, Sun F. （通讯作者） Pentacle gold-copper alloy nanocrystals: a new system for entering male germ cells in vitro and in vivo. Sci Rep 2016 Dec 21;6: 39592.
Lu Wang, Yueshuai Guo, Wenjing Liu, Weidong Zhao, Gendi Song, Tao Zhou, Hefeng Huang, Xuejiang Guo and Fei Sun Proteomic analysis of pachytene spermatocytes of sterile hybrid male mice Biol Reprod 2016 95(3):52, 1–7
Rao F, Zhai Y, Sun F.* （通讯作者） Punicalagin Mollify Lead Acetate Induced Oxidative Imbalance in Male Reproductive system Int J Mol Sci 2016 Aug 11;17(8). 1269.
Wang L, Xu F, Wang G, Wang X, Liang A, Huang H, Sun F。 （通讯作者） C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans Protein Cell 2016 7(10):714-721
Wang G, Zhang H, Wang L, Wang Y, Huang H, Sun F （通讯作者） Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells Sci Rep 2015 5: 12126
Wang Y, Liu W, Du J, Yu Y, Liang N, Liang M, Yao G, Cui S, Huang H, Sun F （通讯作者） NGF promotes mouse granulosa cell proliferation by inhibiting ESR2 mediated down-regulation of CDKN1A Mol Cell Endocrinol 2015 406:68-77
Wang F, Huang GD, Tian H, Zhong YB, Shi HJ, Li Z, Zhang XS, Wang H, Sun F （通讯作者） Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype Sci Rep 2015 5:13050
Lü M, Tian H, Cao YX, He X, Chen L, Song X, Ping P, Huang H, Sun F （通讯作者） Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation Cell Death Dis 2015 6: e1960
Lü M, Ding K, Zhang G, Yin M, Yao G, Tian H, Lian J, Liu L, Liang M, Zhu T, Sun F （通讯作者） MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ Sci Rep 2015 5:8735
Liang M, Li WQ, Tian H, Hu T, Wang L, Lin Y, Li YL, Huang HF, Sun F （通讯作者） Sequential expression of long noncoding RNA as mRNA gene expression in specific stages of mouse spermatogenesis Sci Rep 2014 4(1):5966
Wang L, Liu W, Zhao W, Song G, Wang G, Wang X, Sun F （通讯作者） Phosphorylation of CDK2 on Threonine 160 Influences Silencing of Sex Chromosome During Male Meiosis Biol Reprod 2014 90(6):138,1-7
Yin M, Wang X, Yao G, Lü M, Liang M, Sun Y, Sun F （通讯作者） Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins J Biol Chem 2014 289(26):1823-9
Yao G, Liang M, Liang N, Yin M, Lü M, Lian J, Wang Y, Sun F （通讯作者） MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3 Mol Cell Endocrinol 2014 382(1):244-53
Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F （通讯作者） Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells Sci Rep 2014 4:4260
Liu W, Wang L, Zhao W, Song G, Xu R, Wang G, Wang F, Li W, Lian J, Tian H, Wang X, Sun F （通讯作者） Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice Dev Biol 2014 392(1):108-116
Huang H, Tian H, Duan Z, Cao Y, Zhang XS, Sun F （通讯作者） microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells Cell Signal 2014 26(5):903-11
Wang Y, Liang N, Yao G, Tian H, Zhai Y, Yin Y, Sun F （通讯作者） Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6 Mol Cell Endocrinol 2014 382(2):804-13
Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, Sun F （通讯作者） MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death J Cell Physiol 2013 228(12):2294-304
Tian H, Cao YX, Zhang XS, Liao WP, Yi YH, Lian J,Liu L, Huang HL, Liu WJ, Yin MM, Liang M, Shan G, Sun F （通讯作者） The targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis Cell Death Dis 2013 4: e617
Yin YM, Wang GS, Liang N, Zhang HJ, Liu ZM, Li WQ, Sun F （通讯作者） Nuclear Export Factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells Biochem J 2013 452(1):67-78
Liang M, Yao G, Yin M, Lü M, Tian H, Liu L, Lian J, Huang X, Sun F （通讯作者） Transcriptional cooperation between p53 and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosa cells Mol Cell Endocrinol 2013 370(1-2):119-29
Li WQ, Wang F, Liu ZM, Wang YC, Wang J, Sun F （通讯作者） Gold Nanoparticles Elevate Plasma Testosterone Levels in Male Mice without Affecting Fertility Small 2013 9(9):1708-1714
Li WQ, Sun C, Wang F, Wang YC, Zhai YW, Liang M, Liu WJ, Liu ZM, Wang J, Sun F （通讯作者） Achieving a new controllable male contraception by photothermal effect of gold nanorods Nano Lett 2013 13(6):2477-2484
Liu Z,Li W, Wang F, Sun C, Wang L, Wang J, Sun F （通讯作者） Enhancement of lipopolysaccharide-induced nitric oxide and interleukin-6 production by PEGylated gold nanoparticles in RAW264.7 cells Nanoscale 2012 4(22):7135-7142
Yin M,Lü M,Yao G, Tian H, Lian J,Liu L, Liang M, Wang Y, Sun F （通讯作者） Transactivation of microRNA-383 by Steroidogenic Factor-1 Promotes Estradiol Release from Mouse Ovarian Granulosa Cells by Targeting RBMS1 Mol Endocrinol 2012 26(7):1129-1143
Liang N, Xu YL, Yin YM, Yao GD, Tian H, Wang GS, Lian J, Wang Y, Sun F （通讯作者） Steroidogenic Factor-1 Is Required for TGF-β3-Mediated 17β-Estradiol Synthesis in Mouse Ovarian Granulosa Cells Endocrinology 2011 152(8):213-225
Yao GD, Yin MM, Lian J, Tian H, Liu L,Li X,Sun F （通讯作者） MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cel1 proliferation and granulosa cell function by targeting Smad4 Mol Endocrinol 2010 24(3):540-551
Lian J, Tian H, Liu L, Zhang XS, Li WQ, Deng YM,Yao GD, Yin MM,Sun F （通讯作者） Down-regulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1 Cell Death Dis 2010 1:e94
Lian J, Yin Y, Oliver-Bonet M, Liehr T, Ko E, Turek P, Sun F （通讯作者）, Martin RH Variation in crossover interference levels on individual chromosomes from human males Hum Mol Genet 2008 17(17):2583-94