导师姓名： 周玉传 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属国际和平妇幼保健院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： -18606
邮编： 200030 邮箱地址： zhouyuchuan2017@163.com

研究方向 (点击浏览详细信息)
精子成熟的基因和表观调控
辅助生殖中精子安全性评价

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 附睾头部上皮细胞Dicer1调控精子小RNA影响子代健康及其机制的研究 国家自然科学基金面上项目 2021-01~2024-12 58万元 课题负责人
** NF-κB信号通路抑制剂Bay117082调节精子运动新机制及其应用的研究 国家自然科学基金面上项目 2019-01~2022-12 60万元 课题负责人
2018YFC** ART 对配子表观基因组影响及筛选策略 国家重点研发项目子课题 2018-12~2021-12 48万元 课题参与人
** 利用基因敲除动物模型研究附睾特异性表达基因的功能及其补偿机制 国家自然科学基金面上项目 2017-01~2020-12 61万元 课题负责人
** 利用CRISPR/Cas9敲除技术研究β-防御素在附睾精子成熟中的作用及其分子机制 国家自然科学基金面上项目 2015-01~2018-12 85万元 课题负责人
2014CB943103 精子成熟的表观遗传调控 国家重点基础研究发展计划（973计划） 2014-01~2018-12 445万元 子课题负责人
** 调节精子成熟功能的小分子筛选及其作用机制研究 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
** 附睾特异性羧基酯酶 r615 的功能及其作用的分子机制研究 国家自然科学基金面上项目 2010-01~2012-12 32万元 课题负责人
2009KIP201 丝氨酸肽酶TPPII在精子成熟中的功能及其作用分子机制的研究 中国科学院上海生命科学研究院优秀青年人才领域前沿项目 2009-09~2011-08 21万元 课题负责人
** 整体水平上利用 RNAi 探讨大鼠附睾特异性表达新基因r615 的功能 国家自然科学基金面上项目 2008-01~2008-12 8万元 课题负责人
06JC14075 附睾特异性表达新基因 HongrES1 的功能研究 上海市基础研究重点项目 2006-09~2008-08 20万元 课题负责人
** 在整体水平上研究附睾特异性新基因的功能 国家自然科学基金青年基金 2005-01~2005-12 8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jun Cao, Zuobao Lin, Minghan Tong, Yonglian Zhang, Yiping Li*, Yuchuan Zhou* （通讯作者） Mechanistic target of rapamycin kinase (Mtor) is required for spermatogonial proliferation and differentiation in mice Asian Journal of Andrology 2020 22(2): 169-176
Chen Chu, Lu Yu, Joelle Henry Berger, Yanfei Ru, Ayhan Kocer, Alexandre Champroux, Zhitong Li, Miao He, Shengsong Xie, Wubin Ma, Minjie Ni, Zimei Ni, Yunli Guo, Zhaoliang Fei, Lantao Gou, Qiang Liu, Samanta Sharma, Yu Zhou, Mofang Liu, Charlie Degui Chen, Andrew L Eamens, Brett Nixon, Yuchuan Zhou* （通讯作者）, Joel R Drevet*, Yonglian Zhang Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice Asian Journal of Andrology 2020 22(6): 560-601
Yinlam Li, Li Zhang, Xiaoguo Zheng, Jianing Qian, Yanquan Li, Chong Xie, Xuelian Zhang*, Yuchuan Zhou* （通讯作者）, Hefeng Huang* Dietary restriction and/or exercise training impairs spermatogenesis in normal rats Applied Physiology, Nutrition, and Metabolism 2020 DOI: 10.1139/apnm-2020-0477
Chunhua Tang, Minjie Ni, Shengsong Xie, Yao Zhang, Chaobao Zhang, Zimei Ni, Chen Chu, Ligang Wu, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins Journal of Molecular Cell Biology 2019 11(5): 408-420
Qianqian Yin, Jia Shen, Xiaofeng Wan, Qiang Liu*, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. Impaired sperm maturation in conditional Lcn6 knockout mice Biology of Reproduction 2018 98(1): 28-41
Tongtong Wang, Qianqian Yin, Xuehao Ma, Ming-Han Tong*, Yuchuan Zhou*. （通讯作者） Ccdc87 is critical for sperm function and male fertility Biology of Reproduction 2018 99(4): 817-827
Yuchuan Zhou, Fei Wu, Man Zhang, Zuquan Xiong, Qianqian Yin, Yanfei Ru, Huijuan Shi, Jinsong Li, Shanhua Mao, Yanliang Li, Xinyi Cao, Renming Hu, Chong Wee Liew, Qiang Ding, Xuanchun Wang, Yonglian Zhang. EMC10 governs male fertility via maintaining sperm ion balance Journal of Molecular Cell Biology 2018 10(6): 503-514
Chen Chu, Lu Yu, Bin Wu, Li Ma, Lantao Gou, Miao He, Yunli Guo, Zhitong Li , Wei Gao, Huijuan Shi, Mofang Liu, Hongyan Wang, Charlie Degui Chen, Joel R. Drevet , Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. A sequence of 28S rRNA-derived small RNAs enriched in mature sperm and various somatic tissues and possibly associated with inflammation Journal of Molecular Cell Biology 2017 9(3): 256-259
Xiaofeng Wan, Yanfei Ru, Chen Chu, Zimei Ni, Yuchuan Zhou* （通讯作者）, Shoulin Wang, Zuomin Zhou, Yonglian Zhang*. Bisphenol A accelerates capacitation-associated protein tyrosine phosphorylation of rat sperm by activating protein kinase A Acta Biochimica et Biophysica Sinica 2016 48(6): 573-580
Heguo Yu, Hua Diao, Chunmei Wang, Yan Lin, Fudong Yu, Hui Lu, Wei Xu, Zheng Li, Huijuan Shi, Shimin Zhao*, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. Acetylproteomic analysis reveals functional implications of lysine acetylation in human sperm Molecular & Cellular Proteomics 2015 14(4): 1009-1023
Yanfei Ru, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. Transient receptor potential-canonical 3 modulates sperm motility and capacitation associated protein tyrosine phosphorylation via [Ca2+]i mobilization Acta Biochimica et Biophysica Sinica 2015 47(6): 404-413
Yuchuan Zhou,Yanfei Ru,Huijuan Shi,Yanjiao Wang,Bin Wu,Halmurat Upur,Yonglian Zhang. Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3- Reproduction 2015 150(4): 257-268
Yanfei Ru, Haimin Xue, Zimei Ni, Dong Xia, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat Asian Journal of Andrology 2015 17(2): 292-297
Chunmei Wang, Shuanggang Hu, Yanfei Ru, Guangxin Yao, Wubin Ma, Yihua Gu, Chen Chu, Shoulin Wang, Zuomin Zhou, Qiang Liu, Yuchuan Zhou* （通讯作者）, Yonglian Zhang*. Different Effects of Androgen on the Expression of Fut1, Fut2, Fut4 and Fut9 in Male Mouse Reproductive Tract International Journal of Molecular Sciences 2013 14(11): 23188-23202
Yuchuan Zhou, Yanfei Ru, Chunmei Wang, Shoulin Wang, Zuoming Zhou, Yonglian Zhang. Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor PLoS One 2013 8(6): e66634
Chunmei Wang, Chenyang Huang, Yihua Gu, Yuchuan Zhou* （通讯作者）, Zhengmei Zhu, Yonglian Zhang*. Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system Glycobiology 2011 21(2): 225-234
Yu Chen, Chen Chu, Yuchuan Zhou* （通讯作者）, Yanfei Ru, Hangrong Chen*, Feng Chen, Qianjun He, Yonglian Zhang, Linlin Zhang and Jianlin Shi*. Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting Small 2011 7(20): 2935-44
Ya Ni*, Yuchuan Zhou* （共同第一作者）, Wenying Chen, Min Zheng, Hailong Song, Yonglian Zhang, Qixian Shi. HongrES1, a cauda epididymis-specific protein, is involved in capacitation of gunea pig spermatozoa Molecular Reproduction & Development 2009 76(10): 984-993
Li Zhang, Chunfang Zhu, Qiang Liu*, Yuchuan Zhou* （通讯作者）, Yonglian Zhang. Identification and characterization of an epididymis-specific gene, CES7 Acta Biochimica et Biophysica Sinica 2009 41(10): 809-815
Li Zhang, Qiang Liu*, Yuchuan Zhou* （通讯作者）, Yonglian Zhang. Baculo-expression and enzymatic characterization of CES7 esterase Acta Biochimica et Biophysica Sinica 2009 41(9): 731-736
Yuchuan Zhou, Min Zheng, Qixian Shi, Li Zhang, Wei Zhen, Wenying Chen, Yonglian Zhang. An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility PLoS One 2008 3(12): e4106