导师姓名： 刘欣梅 专业代码： 100211
性别： 女 专业名称： 妇产科学
培养单位： 附属国际和平妇幼保健院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： -30303
邮编： 200030 邮箱地址： nanlilac@hotmail.com

研究方向 (点击浏览详细信息)
配子/胚胎源性成人疾病机制研究
生殖医学——胚胎着床及妊娠维持

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018YFC** 获得性性状的生殖传递机制 中华人民共和国科技部 2019-01~2021-12 100万元 课题参与人
2017YFC** 人类胚胎发育中的细胞编程与配子/胚胎源性疾病的发生机制 中华人民共和国科学技术部 2017-07~2020-12 84万元 课题参与人
** 钙调蛋白复合物ANXA1-S100A11调控胚胎着床和妊娠维持的 分子机制研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
YG2015MS44 基于辅助生殖技术出生子代随访的医学信息系统及健康风险智能化管理模型研究 上海交通大学医工交叉面上项目 2016-01~2018-12 21万元 课题负责人
2014CB943300 环境内分泌干扰物对女性生殖功能的影响及其分子机制研究 国家科技部国家重大科学研究计划 2014-01~2018-08 100万元 课题参与人
** IVF 子代脐血管中钙调蛋白S100A6 和S100A10 下调的分子 机制及其对远期血管功能影响的机理研究 国家自然科学基金青年项目 2014-01~2016-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hou M, Gu HC, Wang HH, Liu XM, Zhou CL, Yang Q, Jiang ZR, Lin J, Wu YM, Wu YT, Sheng JZ, Huang HF Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes. J Mol Cell Cardiol 2019 128:1-10.
Chen X, Lin H, Yang D, Xu W, Liu G, Liu X （通讯作者）, Sheng J, Huang H Early-life undernutrition reprograms CD4+ T-cell glycolysis and epigenetics to facilitate asthma J Allergy Clin Immunol 2019 143(6):2038-2051
Yu T, Feng C, Lv P, Xu G, Hong L, Xiong Y, Guo X, Li T, Sheng J, Huang H, Liu XM （通讯作者） Decreased decidual epithelial sodium channel (ENaC) alpha and gamma subunits in recurrent pregnancy loss (RPL). Sci China Life Sci. 2019 62(7):988-990
Guo XY, Shu J, Fu XH, Chen XP, Zhang L, Ji MX, Liu XM, Yu TT, Sheng JZ, Huang HF Improving the effectiveness of lifestyle interventions for gestational diabetes prevention: a meta-analysis and meta-regression. BJOG 2019 126(3):311-320.
Wang YY, Liu Y, Li C, Lin J, Liu XM, Sheng JZ, Huang HF Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study. BMC Endocr Disord 2019 19(1):22.
Zeng W, Liu X （共同第一作者）, Liu Z, Zheng Y, Yu T, Fu S, Li X, Zhang J, Zhang S, Ma X, Liu X R, Qin X, Khanniche A, Zhang Y, Tian F, Lin Y. Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8(+) T Cells at the First Trimester of Human Healthy Pregnancy[J]. Front Immunol 2018 9: 937.
Wang H H, Zhou C L, Lv M, Yang Q, Li J X, Hou M, Lin J, Liu X M, Wu Y T, Sheng J Z, Huang H F Prenatal High Estradiol Exposure Induces Sex-Specific and Dietarily Reversible Insulin Resistance Through Decreased Hypothalamic Endocrinology 2018 159(1): 465-476.
Hu H T, Xu J J, Lin J, Li C, Wu Y T, Sheng J Z, Liu X M （通讯作者）, Huang H F. Association between first caesarean delivery and adverse outcomes in subsequent pregnancy: a retrospective cohort study[J] BMC Pregnancy Childbirth 2018 18(1): 273.
Sun YX, Zhang YX, Zhang D, Xu CM, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet 2017 136(2):227-239.
Zhang Y, Zhang Y, Ding GL, Liu XM, Ye J, Sheng JZ, Fan J, Huang HF Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia. Oncotarget 2017 8(9):15205-15212.
Guo XY, Liu XM, Jin L, Wang TT, Ullah K, Sheng JZ, Huang HF Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertil Steril 2017 107(3):622-631.
Tian S, Lin XH, Xiong YM, Liu ME, Yu TT, Lv M, Zhao W, Xu GF, Ding GL, Xu CM, Jin M, Feng C, Wu YT, Tan YJ, Gao Q, Zhang J, Li C, Ren J, Jin LY, Chen B, Zhu H, Zhang XY, Chen SC, Liu XM, Liu Y, Zhang JY, Wang L, Zhang P, Chen XJ, Jin L, Chen X, Meng YC, Wu DD, Lin H, Yang Q, Zhou CL, Li XZ, Wang YY, Xiang YQ, Liu ZW, Gao L, Chen LT, Pan HJ, Li R, Zhang FH, Xing LF, Zhu YM, Klausen C, Leung PC, Li JX, Sun F, Sheng JZ, Huang HF Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism EBioMedicine 2017 16:275-283
Zeng W, Liu Z2, Liu X1, Zhang S, Khanniche A, Zheng Y, Ma X, Yu T, Tian F, Liu XR, Fan J, Lin Y Distinct Transcriptional and Alternative Splicing Signatures of Decidual CD4+ T Cells in Early Human Pregnancy Front Immunol 2017 8:682.
Liu XM, Shao JZ, Xiang LX, Chen XY. Cytotoxic effects and apoptosis induction of atrazine in a grass carp (Ctenopharyngodon idellus) cell line. Environ Toxicol 2016 21(1):80-9.
Shu J, Xing LL, Ding GL, Liu XM, Yan QF, Huang HF. Effects of ovarian hyperstimulation on mitochondria in oocytes and early embryos. Reprod Fertil Dev. 2015 [Epub ahead of print]
Zhang D, Li J, Xu G, Zhang R, Zhou C, Qian Y, Liu Y, Chen L, Zhu B, Ye X, Qu F, Liu X, Shi S, Yang W, Sheng J, Huang H Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway Aging Cell 2015 14(2):284-7.
Liu, X.-M., Hsiao Chang Chan, Guo-Lian Ding, Jie Cai, Yang Song, Ting-Ting Wang, Dan Zhang, Hui Chen, Mei Kuen Yu, Yan-Ting Wu, Fan Qu, Ye Liu, Yong-Chao Lu, Eli Y. Adashi, Jian-Zhong Sheng, He-Feng Huang . FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway Aging Cell 2015 14(3): 409-20
Liu, X.-M., Dan Zhang, Ting-Ting Wang, Jian-Zhong Sheng, He-Feng Huang. Ion/water channels for embryo implantation barrier. Physiology 2014 29(3):186-95
Lv PP, Meng Y, Lv M, Feng C, Liu Y, Li JY, Yu DQ, Shen Y, Hu XL, Gao Q, Dong S, Lin XH, Xu GF, Tian S, Zhang D, Zhang FH, Pan JX, Ye XQ, Liu ME, Liu, X.-M., Sheng JZ, Ding GL, Huang HF. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. BMC MEDICINE 2014 16;12(1):240
Xu GF, Zhang JY, Pan HT, Tian S, Liu ME, Yu TT, Li JY, Ying WW, Yao WM, Lin XH, Lv Y, Su WW, Ye XQ, Zhang FH, Pan JX, Liu Y, Zhou CL, Zhang D, Liu, X.-M. , Zhu YM, Sheng JZ, Huang HF. Cardiovascular dysfunction in offspring of ovarian hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis. J Clin Endocrinol Metab 2014 99(12):E2494-503
Shu J, Xing L, Ding G, Luo Q, Liu X, Yan Q, Sheng J, Huang H. The effect of peritoneal fluid from patients with endometriosis on mitochondrial function and development of early mouse embryos. PLoS One 2013 26;8(12):e82334.
Liu, X.-M., Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ, Huang HF*. Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure J Clin Endocrinol Metab 2012 97(10):3672-3683
Ruan YC, Guo JH, Liu, X.-M., Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H*, Zhou WL*, Chan HC*. Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation. Nat Med 2012 18(7): 1112-1117
Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu, X.-M., Zhang XH, Chung YW, Huang P, Huang H*, Chan HC*. Impaired CFTR-Dependent Amplification of FSH-Stimulated Estrogen Production in Cystic Fibrosis and PCOS. J Clin Endocrinol Metab 2012 97(3):923-932
Chen XY, Shao JZ, Xiang LX, Liu XM Involvement of apoptosis in malathion-induced cytotoxicity in a grass carp (Ctenopharyngodon idellus) cell line Comp Biochem Physiol C Toxicol Pharmacol 2006 142(1-2):36-45.