导师姓名： 林羿 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属国际和平妇幼保健院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： yilinonline@126.com手机：**
邮编： 200030 邮箱地址： yilinonline@126.com

研究方向 (点击浏览详细信息)
妇产科学

社会任职
上海市免疫学会生殖免疫专业委员会副主任委员(2014.3~)
中华医学会生殖医学分会中青年委员(2007. 10~)
中国免疫学会终身会员(2002. 5~)

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** EVT侵袭力异常导致妊娠失败的机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
2018YFC** 早孕期自然流产病因学及临床防治研究 国家重点研发计划项目（项目负责人） 2018-10~2021-10 1500万元 课题负责人
** Stathmin-1调控胎盘滋养层细胞增殖和迁移的机制 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
2013-49 上海领军人才项目 上海市委组织部、上海市人力资源和社会保障局 2014-01~2016-12 25万元 课题负责人
2013CB967404 性分化异常疾病与生殖干细胞转换相关性和机制研究 国家重大科学研究计划项目（“973”计划项目） 2013-01~2017-08 649万元 课题负责人
12XD** 母-胎免疫识别机制与妊娠相关疾病 上海市优秀学术带头人项目 2012-07~2014-07 20万元 课题负责人
** 蜕膜NK细胞功能多样性与妊娠母-胎识别和耐受机理 国家自然科学基金 2012-01~2015-12 60万元 主要责任人
** 妇产科学——母-胎免疫识别和耐受及相关疾病 国家****科学基金 2012-01~2015-12 240万元 课题负责人
** 调节性NK细胞与妊娠免疫耐受机理 国家自然科学基金 2009-01~2011-12 32万元 主要责任人
** Toll样受体参与的细胞信息传递与妊娠免疫耐受 国家自然科学基金 2007-01~2009-12 28万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Ren J, Zeng W, Tian F, Zhang S, Wu F, Qin X, Zhang Y*, Lin Y*. （通讯作者） Myeloid-derived suppressor cells depletion may cause pregnancy loss via upregulating the cytotoxicity of decidual natural killer cells. Am J Reprod Immunol 2019 81:e13099.
Ren J, Zeng W, Tian F, Wu F, Zhang S, Liu X, Lin Y*. （通讯作者） Differential gene expression profile in monocytic myeloid-derived suppressor cells at maternal-fetal interface in a mouse model of spontaneous abortion. J Cell Physiol 2019 234:10789-10799.
Zhang J#（张静）, Li X, Liu X, Tian F, Zeng W, Xi X*, Lin Y*. （通讯作者） EIF5A1 promotes epithelial ovarian cancer proliferation and progression. Biomedicine and Pharmacotherapy 2018 100: 168-175.
Tian FJ, He XY, Wang J, Li X, Ma XL, Wu F, Zhang J, Liu XR, Qin XL, Zhang Y, Zeng WH*, Lin Y*. （通讯作者） Elevated tristetraprolin impairs trophoblast invasion in women with recurrent miscarriage by destabilization of HOTAIR. Molecular Therapy: Nucleic Acids 2018 2018; 12:600-609.
Zhang J#（张静）, Liu W#, Shen F, Ma X, Liu X, Tian F, Zeng W, Xi X*, Lin Y*. （通讯作者） The activation of microRNA-520h–associated TGF-β1/c-Myb/Smad7 axis promotes epithelial ovarian cancer progression. Cell Death and Disease 2018 9(9): 884. DOI: 10.1038/s41419-018-0946-6
Zhang J(张静), Mo HQ, Tian FJ, Zeng WH, Liu XR, Ma XL, Li X, Qin S, Fan CF, Lin Y. （通讯作者） EIF5A1 promotes trophoblast migration and invasion via ARAF-mediated activation of the integrin/ERK signaling pathway. Cell Death and Disease 2018 9(9): 926. Doi:10.1038/s41419-018-0971-5
Qin X, Chen Y, Chen S, Liu X, Zeng W, Tian F, Lin Y* （通讯作者）, Fan C. Plasmacytoma variant translocation 1 (PVT1) regulates trophoblast viability, proliferation, and migration and is downregulated in spontaneous abortion. Am J Reprod Immunol 2018 e13048. doi: 10.1111/aji.13048.
Zeng W#, Liu X#, Liu Z#, Zheng Y, Yu T, Fu S, Li X, Zhang J, Zhang S, Ma X, Liu X-R, Qin X, Khanniche A, Zhang Y*, Tian F*, Lin Y*. （通讯作者） Deep surveying of the transcriptional and alternative splicing signatures for decidual CD8+ T cells at the first trimester of human healthy pregnancy. Frontiers in Immunology 2018 9:937. doi: 10.3389/fimmu.2018.00937
Zhang SM（张司明）, Tian FJ, Zeng WH, Ma XL, Ren JB, Lin Y*. （通讯作者） XCL1-XCR1 pathway promotes trophoblast invasion at maternal-fetal interface by inducing MMP-2/MMP-9 activity. Am J Reprod Immunol 2018 2018; 80 (3):e12990. DOI: 10.1111/aji.12990
Zeng W#, Liu Z#, Liu X, Zhang S, Khanniche A, Zheng Y, Ma X, Yu T, Tian F, Liu X-R, Fan J, Lin Y*. （通讯作者） Distinct transcriptional and alternative splicing signatures of decidual CD4+ T cells in early human pregnancy. Frontiers in Immunology 2017 8:682. doi:10.3389/fimmu.2017.00682
Ma X-L#（马晓玲）, Li X-C#, Tian F-J, Zhang S-M, Liu X-R, Zhang Y, Fan J-X, Lin Y*. （通讯作者） Effect of the p53–tristetraprolin–stathmin-1 pathway on trophoblasts at maternal–fetal interface. PLoS One 2017 12(6): e**. Doi: 10.1371/journal.pone.**
Wu F#（吴凡）, Tian F, Zeng W, Liu X, Fan J, Lin Y, Zhang Y*. Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis. Cell Death and Disease 2017 8, e2908; doi:10.1038/cddis.2017.301
Gong X#（龚小雯博士后）, Xie H#, Li X, Wu J*, Lin Y*. （通讯作者） Bisphenol A induced apoptosis and transcriptome differences of spermatogonial stem cells in vitro. Acta Biochim Biophys Sin 2017 49(9):780-791.
Qin C-M#（秦传美）, Tian F-J#, Liu X-R, Wu F, Ma X-L, Lin Y*. （通讯作者） CpG oligodeoxynucleotides downregulate placental adiponectin and increase embryo loss in non-obese diabetic mice. Am J Reprod Immunol 2016 76: 38–49.
Zeng W#, Liu Z, Zhang S, Ren J, Ma X, Qin C, Tian F, Zhang Y*, Lin Y*. （通讯作者） Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage induced abortion. Scientific Reports 2016 6:36560. DOI: 10.1038/srep36560
Tian FJ#, Cheng YX#, Li XC, Wang F, Qin CM, Ma XL, Yang J*, Lin Y*. （通讯作者） The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface. J Pathol 2016 239:36-47.
Liu X-R#, Guo Y-N#, Qin C-M, Qin X-L, Tao F, Su F, Tian F-J, Zhang Y*, Lin Y*. （通讯作者） Transcriptomic insights into the response of placenta and decidua basalis to the CpG oligodeoxynucleotide stimulation in non-obese diabetic mice and wild-type controls. International Journal of Molecular Sciences 2016 17, 1281; doi:10.3390/ijms**
Tian FJ, Qin CM,Li XC, Wu F, Liu XR, Xu WM, （通讯作者）, Lin Y. Decreased stathmin-1 expression inhibits trophoblast proliferation and invasion and is associated with recurrent miscarriage. American Journal of Pathology 2015 185(10):2709-2721.
Qin X, Liu X, Shan B, Shi L, Sharma S, Wu J, Lin Y. （通讯作者） Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice. American Journal of Reproductive Immunology 2014 71(3): 229-240.
Lin Y, Liu X, Shan B, Wu J, Sharma S, Sun Y. Prevention of CpG-induced pregnancy disruption by adoptive transfer of in vitro-induced regulatory T cells. PLoS One 2014 2014, 9 (4): e94702.
Li L, Shi L, Yang X, Ren L, Yang J, Lin Y. （通讯作者） Role of invariant natural killer T cells in lipopolysaccharide-induced pregnancy loss. Cellular Immunology 2013 286 (1-2): 1-10.
Li L, Yang J, Ren L, Su N, Fang Y, Lin Y. （通讯作者） Invariant NKT cells increase lipopolysacchride-induced pregnancy loss by a mechanism involving Th1 and Th17 responses. J Matern Fetal Neonatal Med 2013 26 (12): 1212-1218.
Sun Y, Qin X, Shan B, Wang W, Zhu Q, Sharma S, Wu J, Lin Y. （通讯作者） Differential effects of the CpG-TLR9 axis on pregnancy outcome in nonobese diabetic mice and wild-type controls. Fertility and Sterility 2013 99 (6): 1759-1767.
Li LP, Fang YC, Dong GF, Lin Y （通讯作者）, Saito S. Depletion of invariant NKT cells reduces inflammation-induced preterm delivery in mice. Journal of Immunology 2012 188 (9):4681-4689.
Yin G, Li C, Shan B, Wang W, Chen H, Zhong Y, Di J, Lin Q, Lin Y. （通讯作者） Insufficient peroxiredoxin-2 expression in uterine NK cells obtained from a murine model of abortion. Journal of Cellular Biochemistry 2011 112(3):773-781.
Sun Y, Wang W, Shan B, Di J, Chen L, Ren L, Li W, Li DJ, Lin Y. （通讯作者） FTY720-induced conversion of conventional Foxp3-CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. American Journal of Reproductive Immunology 2011 66(5):349-362.
Lin Y （通讯作者）, Li C, Shan B, Wang W, Saito S, Xu J, Di J, Zhong Y, Li D-J. Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion. American Journal of Pathology 2011 178(2):506-514.
Lin Y （通讯作者）, Wang W, Jin H, Zhong Y, Di J, Zeng S, Saito S. Comparison of murine thymic stromal lymphopoietin- and polyinosinic polycytidylic acid-mediated placental dendritic cell activation. Journal of Reproductive Immunology 2009 79(2):119-128.
Lin Y （通讯作者）, Zhong Y, Saito S, Chen Y, Shen W, Di J, Zeng S. Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy. Fertility and Sterility 2009 91(6):2676-2686.
Li C, Wang W, Wang H, Zhong Y, Di J, Lin Y. （通讯作者） Proteomic analysis of proteins differentially expressed in uterine lymphocytes obtained from wild-type and NOD mice. Journal of Cellular Biochemistry 2009 108(2):447-457.
Lin Y （通讯作者）, Nakashima A, Shima T, Zhou X, Saito S. Toll-like receptor signaling in uterine natural killer cells - role in embryonic loss. Journal of Reproductive Immunology 2009 83(1-2):95-100.
Wang W, Lin Y （通讯作者）, Zeng S, Li D-J. Improvement of fertility with adoptive CD25+ natural killer cell transfer in sub-fertile NOD mice. Reproductive BioMedicine Online 2009 18(1):95-103.
Lin Y （通讯作者）, Ren L, Wang W, Di J, Zeng S, Saito S. Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice. Journal of Reproductive Immunology 2009 82(1):12-23.
Lin Y （通讯作者）, Xu L, Jin H, Zhong Y, Di J, Lin Q. CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in NOD mice. Fertility and Sterility 2009 91(6):2687-2696.
Lin Y （通讯作者）, Wang H, Wang W, Zeng S, Zhong Y, Li D-J. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2+ISG20+ natural killer-cell transfer. Reproduction 2009 137(6):943-955.
Lin Y （通讯作者）, Zhong Y, Shen W, Chen Y, Shi J, Di J, Zeng S, Saito S. TSLP-induced placental DC activation and IL-10+ NK cell expansion: Comparative study based on BALB/c×C57BL/6 and NOD/SCID×C57BL/6 pregnant models. Clinical Immunology 2008 126(1):104-117.
Lin Y （通讯作者）, Liang Z, Chen Y, Zeng Y. TLR3-involved modulation of pregnancy tolerance in double-stranded RNA-stimulated NOD/SCID mice. Journal of Immunology 2006 176(7):4147-4154
Lin Y （通讯作者）, Xie M, Chen Y, Di J, Zeng Y. Preterm delivery induced by LPS in syngeneically impregnated BALB/c and NOD/SCID mice. Journal of Reproductive Immunology 2006 71(2):87-101.
Lin Y （通讯作者）, Zeng Y, Zeng S, Wang T. Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption. Fertility and Sterility 2006 85:1125-1129.
Lin Y （通讯作者）, Li H, Huang J, Zeng S. Following the fate of murine epidermal stem cells in a syngeneic dermal equivalent in vivo. Burns 2005 31(8):1007-1012.
Lin Y （通讯作者）, Zeng Y, Di J, Zeng S. Murine CD200+CK7+ trophoblasts in a poly (I: C)-induced embryo resorption model. Reproduction 2005 130(4): 529-537.
Lin Y （通讯作者）, Chen Y, Zeng Y, Wang T, Zeng S. Lymphocyte phenotyping and NK cell activity analysis in pregnant NOD/SCID mice. Journal of Reproductive Immunology 2005 68 (1-2): 39-51.
Lin Y （通讯作者）, Zeng Y, Zhao J, Zeng S, Huang J, Feng Z, Di J, Zhan M. Murine CD45+CD86+ cells isolated from para-aortic lymph nodes in an abortion-prone model. Journal of Reproductive Immunology 2004 64(1-2):133-143.