删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

环己酮选择性构建功能芳烃的研究进展

本站小编 Free考研考试/2022-02-14

摘要/Abstract



环己酮是一类廉价易得的重要的有机化工原料, 含有极性的活泼羰基, 可与亲核试剂进行亲核加成并进一步转化. 此外, 因羰基的活化作用, 其邻位的亚甲基也具有较好的反应活性. 因而, 环己酮可以作为廉价的C2源参与成环及芳构化反应构筑芳香功能分子. 将从环己酮参与的选择性构建单取代芳烃、多取代芳烃以及杂环芳烃三个方面进行阐述, 重点综述近几年环己酮与醛、酮、胺、硫酚等亲核试剂经缩合、脱氢芳构化选择性构建功能芳烃的研究进展, 并对未来进一步开发新型温和绿色的合成方法实现环己酮选择性构建功能芳烃进行了展望.
关键词: 环己酮, 亲核加成, 脱氢芳构化, 缩合, 功能芳烃
Cyclohexanone, a cheap and important organic chemical material with polar active carbonyl group, can construct many functional materials via nucleophilic addition with nucleophiles and subsequent transformation. In addition, the methylene group in the ortho-position of carbonyl group also exhibits good reactivity. Therefore, cyclohexanone can be used as a versatile C2 source for cycloaddition reaction providing various aromatic compounds via subsequent dehydroaro- matization. The cyclohexanone involved reactions to chemoselectively produce monosubstituted aromatics, polysubstituted aromatics and heterocyclic aromatics is discussed. The addition reactions and further dehydroaromatization of cyclohexanone with nucleophiles such aldehydes, ketones, aromatic amines, thiophenols and unsaturated hydrocarbons are discussed in detail as well. The environmentally benign synthesis of aromatic functional molecules with cyclohexanone is prospected at the end of this review.
Key words: cyclohexanone, nucleophilic addition, dehydroaromatization, condensation, functional aromatics


PDF全文下载地址:

点我下载PDF
相关话题/环己酮 芳烃 功能 选择性 羰基