摘要/Abstract

以荧光素为有机光催化剂, K₂S₂O₈为氧化剂, 在室温氮气保护下研究了β-萘酚与二芳基氧化膦的区域选择性邻位C—H膦酰化反应. 该反应条件温和, 官能团适用范围广, 产率高, 区域选择性好, 是β-萘酚改性的理想而实用的选择. 实验结果揭示反应通过自由基途径进行.
关键词: β-萘酚, 二芳基膦氧化物, 光催化, 膦酰化, 自由基反应
A metal-free visible-light-induced regioselective ortho-C—H phosphonylation of β-naphthols with diarylphosphine oxides has been developed using fluorescein as an organophotoredox catalyst in the presence of K₂S₂O₈ at room temperature under N₂ atmosphere. This feature along with mild reaction conditions, sensitive functional group tolerance, good to excellent yields, high regioselectivity, and scale-up synthesis makes it an ideal and practical alternative modification of β-naphthols. The experimental result suggests that a radical pathway is involved in the reaction.
Key words: β-naphthols, diarylphosphine oxide, visible-light catalysis, phosphonylation, radical reaction


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