摘要/Abstract
以廉价易得、商品化的铁粉为反应促进剂, 研究了溴代硝基甲烷与各种醛的Henry型反应, 高效地合成了2-硝基-1-醇. 该反应在PbCl2和四丁基硫酸氢铵(TBAHS)存在下有效地进行, 以中等至良好的产率得到目标产物, 并且该反应具有广泛的官能团耐受性.
关键词: 铁, 二氯化铅, Henry型反应, 溴代硝基甲烷, 2-硝基-1-醇
The Henry-type reaction of bromonitromethane with various aldehydes for the efficient synthesis of 2-nitro-alkan- 1-ols by using inexpensive and commercial iron powder as reaction mediator was developed. The reaction proceeded efficiently in the presence of PbCl2 and tetrabutylammonium hydrogen sulfate (TBAHS) to produce the desired products in moderate to good yield with wide functional group tolerance.
Key words: iron, lead dichloride, Henry-type reaction, bromonitromethane, 2-nitro-alkan-1-ol
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