摘要/Abstract

报道了一种银催化的N-苯基丙烯酰胺与N-取代草氨酸类衍生物的脱羧氨甲酰化反应, 通过分子间的氨甲酰自由基加成/环化过程, 能够以良好的产率制备一系列3,3-二取代的氨甲酰官能化的吲哚酮类化合物. 该反应具有广泛的官能团兼容性和良好的底物适用范围.
关键词: 氨甲酰化, 吲哚酮, 自由基加成环化
A silver catalyzed decaroxylative amidation of N-arylacrylamides with oxamic acids has been developed. This cascade reaction is an effective way to synthesize various 3,3-disubstitued amide functionalized oxindoles through a sequence of intermolecular carbamoyl radical addition and cyclization in moderate to good yields. This reaction allows a broad range of substrates as well as good functional group compatibility.
Key words: carbamoylation, oxindoles, radical addition cyclization


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