摘要/Abstract
报道了一类以亚磺酸钠盐和芳基乙酮/茚酮为原料, 在无金属条件下直接C—H键功能化制备β-酮砜的合成方法, 该方法操作步骤简便、反应条件温和, 同时具有良好的官能团兼容性. 该类反应实现了从C(sp3)—H直接到C—S键的构建, 从而避免了使用强氧化剂以及底物的预官能团化. 所得到的β-酮砜类化合物可以作为有机合成中间体进行转化.
关键词: 亚磺酸钠, β-酮砜化合物, C—H键功能化, C—S键, 无过渡金属
An efficient and convenient strategy for the preparation of β-ketosulfone via C—H bond functionalization with sodium sulfite and aryl ethyl ketone/indenone under metal-free condition has been reported. The method has simple operation steps, mild reaction conditions and good functional group compatibility. The reaction enables the direct formation of C(sp3)—H into C—S bonds, thereby avoiding the use of strong oxidants and prefunctionalization of substrates. The β-ketosulfone compounds can be transformed as intermediates in organic synthesis.
Key words: sodium sulfintes, β-keto sulfones, C—H functionalization, C—S bond, transition metal-free
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