摘要/Abstract
报道了CBr4促进的苯甲酰肼和2,4-戊二酮分子间环化高产率地合成(3,5-二甲基-1H-吡唑-1-基)(苯基)-甲酮. 该方法具有条件温和、良好的官能团耐受性、环境友好、操作简单、成本低、步骤经济、可进行按比例放大等优点, 为广泛应用于药物、生物活性分子和农药中的吡唑类化合物的合成提供了一种实用而有吸引力的策略.
关键词: 苯甲酰肼, 2,4-戊二酮, N-酰基吡唑, 四溴化碳
Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl)(phenyl)-methanones in excellent yields by CBr4 mediated intermolecular cyclization of benzohydrazide and pentane-2,4-dione has been reported. The method shows various advantages such as mild conditions, good functional group tolerance, environmental friendliness, easy operation with cheap reagents, step economy and can be scaled-up, offering a useful and attractive strategy to synthesize N-acylpyrazoles, which is widely presented in drugs, biologically active molecules and pesticides.
Key words: benzohydrazides, pentane-2,4-diones, N-acylpyrazoles, CBr4
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