摘要/Abstract

报道了Rh(III)催化的N-甲氧基-1H-吲哚-1-甲酰胺与亚砜型叶立德的选择性C(2)—H活化/环化反应. 该方法为二氢嘧啶并吲哚酮衍生物的制备提供了一种新方法, 产率中等至优良, 具有反应条件简单温和, 催化剂用量低, 底物适应性广等特点.
关键词: 吲哚, 亚砜型叶立德, 环化反应
A Rh(III)-catalyzed, regioselective C(2)—H activation/cyclization of N-methoxy-1H-indole-1-carboxamides and sulfoxonium ylides was developed. This novel synthetic procedure afforded dihydropyrimido[1,6-a]indol-1(2H)-ones in moderate to excellent yields. This reaction proceeds under simple and mild conditions with low catalyst loading and tolerates a wide range of substrates.
Key words: indoles, sulfoxonium ylides, cyclization


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