摘要/Abstract

报道了铁催化的烷基过氧酰或者叔丁基过氧酯对1,3-共轭烯烃的Heck型脱羧烷基化反应. 这个方法提供了一个有效的对1,3-共轭烯烃进行Heck型烷基化的途径, 不但收率高, 而且有些情况下具有很高的区位选择性. 此方法也可以用来对生物活性分子进行后期Heck型烷基化修饰.
关键词: 铁催化, 1,3-共轭烯烃, Heck型烷基化, 脱羧反应, 过氧酯, 过氧酰
An iron-catalyzed decarboxylative Heck-type alkylation of conjugate 1,3-dienes with alkyl diacyl peroxides andt-butyl peresters is reported. This method offers an efficient approach to alkylation of 1,3-dienes with good yields, and in some cases with high selectivities. Late-stage alkylation of bioactive compounds was also found to be effective.
Key words: iron catalysis, 1,3-dienes, Heck-type alkylation, decarboxylation, peresters, diacyl peroxides


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