摘要/Abstract

3,4-二氢吡喃-2-酮和3,4-二氢吡啶-2-酮结构广泛存在于多种天然产物和具有药理活性的分子中, 因此高效合成手性3,4-二氢吡喃-2酮和3,4-二氢吡啶-2酮受到越来越多药物化学和有机化学研究者的关注. 近年来有机小分子催化的不对称反应已成为构建手性杂环化合物的有效方法. 综述了自2003年至今有机小分子催化的不对称反应合成手性3,4-二氢吡喃酮和3,4-二氢吡啶酮衍生物的研究进展, 并根据不同的催化剂类型及反应机理进行分类讨论.
关键词: 有机催化, 不对称催化, 3,4-二氢吡喃酮, 3,4-二氢吡啶酮
3,4-Dihydropyranone and 3,4-dihydropyridinone substructures are widely found in a variety of natural products and pharmacologically active molecules, so the efficient synthesis of chiral 3,4-dihydropyranones and 3,4-dihydropyridinones has received more and more attention from pharmaceutical chemists and organic chemists. In recent years, organocatalytic asymmetric reaction has become an efficient synthetic method for the construction of chiral heterocyclic compounds. In this review, the remarkable progress and advances in organocatalytic asymmetric reactions for the synthesis of 3,4-dihydro- pyranones and 3,4-dihydropyridinones from 2003 to 2020 are summarized and discussed based on the different types of organocatalysts and reaction mechanisms.
Key words: organocatalysis, asymmetric catalysis, 3,4-dihydropyranones, 3,4-dihydropyridinones


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