摘要/Abstract

与其他溶剂的效果显著不同, 以六氟异丙醇为溶剂时, 低用量三聚氯氰可在室温下高效催化酮肟的贝克曼重排反应得到相应的酰胺产物. 本方法操作简便, 催化剂用量少, 溶剂可回收再利用, 条件温和, 官能团兼容性好, 适用底物范围广, 产物收率高, 是一种制备酰胺化合物的相对绿色实用的方法.
关键词: 酮肟, 贝克曼重排, 三聚氯氰, 六氟异丙醇, 温和条件, 酰胺
By using hexafluoroisopropanol as the solvent, a low loading of cyanuric chloride could effectively catalyze the Beckmann rearrangement of ketoximes to obtain the corresponding amide products under mild conditions, such as room temperature and air atmosphere. The effect of hexafluoroisopropanol was greatly different from that of other solvents. This method has the advantages of simple operation, low catalyst loading, recoverability of solvent, mild conditions, good tolerance of the functional groups, broad substrate scope and high product yields. It is a relatively green and practical method for the preparation of amide compounds.
Key words: ketoxime, Beckmann rearrangement, cyanuric chloride, hexafluoroisopropanol, mild condition, amide


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