摘要/Abstract

对近10年来均相过渡金属、非金属及多相催化剂催化重氮酯O—H插入反应的研究进展进行综述. 重点阐述了各类催化剂的结构、催化体系及其在药物研发和有机合成方面的应用. 底物重氮酯易于制备, 催化剂廉价易得, 反应过程中形成的卡宾中间体反应活性高, 因此O—H插入反应可在温和条件下发生, 高效构筑C—O键, 并获得可观的收率和对映选择性, 有利于手性药物的开发和合成. 最后, 对O—H插入反应及产物的绿色合成进行展望.
关键词: 重氮酯, O—H插入反应, C—O键, 均相催化, 多相催化
The research progress of O—H insertion reaction of diazo esters catalyzed by homogeneous transition metal, nonmetal and heterogeneous catalysts in the past 10 years is reviewed. The structures and catalytic systems of various catalysts and their applications in drug development and organic synthesis are described. The substrate diazo ester is easy to prepare, the catalyst is cheap and easy to obtain, and the carbenoid intermediate formed in the reaction process has high reactivity. Therefore, the O—H insertion reaction can occur under mild conditions with efficient construction of C—O bond in considerable yield and enantioselectivity, which is conducive to the development and synthesis of chiral drugs. Finally, transition-metal- catalyzed O—H insertion and green synthesis are prospected.
Key words: diazo ester, O—H insertion reaction, C—O bond, homogeneous catalysis, heterogeneous catalysis


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