摘要/Abstract

报道了一种在对甲苯磺酸催化下炔丙醇和烯醇硅醚的直接亲核取代反应, 并有效合成 γ-炔基酮类化合物的新方法. 该反应在敞口环境下使用未经干燥处理的溶剂即可获得良好的产率.
关键词: 炔丙醇, 烯醇硅醚, 亲核取代, 催化, 对甲苯磺酸
A novel and efficient synthesis of γ-alkynyl ketones by the direct nucleophilic substitution of propargyl alcohols with enoxysilanes in the presence of a catalytic amount of p-toluenesulfonic acid monohydrate, has been developed. The reactions can be performed in an undried solvent under an air atmosphere to obtain the desired products in good yields.
Key words: Keywords propargyl alcohol, enoxysilane, nucleophilic substitution, catalyzed, p-toluenesulfonic acid


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