摘要/Abstract

吡啶并[1，2-a]苯并咪唑是由三个芳环稠合组成的重要氮杂环化合物之一.由于含有该骨架的分子在药物化学及材料领域中显示出广泛的应用前景，故吡啶并[1，2-a]苯并咪唑类分子的合成在有机化学中倍受关注.基于逆合成分析的思路，依据不同环的构建方式，按照不同结构的反应底物类型，综述了近年吡啶并[1，2-a]苯并咪唑类化合物合成方法的研究进展，并对其未来发展方向进行了展望.
关键词: 氮杂环化合物, 吡啶并[1,2-a]苯并咪唑, 逆合成分析, 金属催化, C—H活化, 串联反应, 2-氨基吡啶, 邻苯二胺
Pyrido[1,2-a]benzimidazole is one of the important azaheterocycles with three fused aromatic rings. These molecules containing this skeleton have wide application prospects in the fields of medicinal chemistry and materials, and their syntheses have attracted much attention in organic chemistry. According to the retrosynthetic analysis on the construction of different rings in target molecules, the research progress on the synthesis of pyrido[1,2-a]benzimidazoles from different types of starting materials is reviewed, and its future development direction is prospected.
Key words: azaheterocycle, pyrido[1,2-a]benzimidazole, retrosynthetic analysis, metal catalysis, C-H activation, tandem reaction, 2-aminopyridine, o-phenylenediamine


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