摘要/Abstract
从海鞭Pseudopterogorgia elisabethae中分离得到的生物碱pseudopteroxazole和ileabethoxazole对结核病病原体——结核分枝杆菌具有良好的抗菌活性.这两种生物碱具有相似的四环骨架，包含四个立体中心、一个全取代苯环和天然产物中少有的苯并噁唑单元.良好的抗结核分枝杆菌活性和独特的分子结构使得对pseudopteroxazole和ileabethoxazole的合成研究得到了广泛关注，综述了国内外对这两生物碱的全合成研究进展.
关键词: 结核分枝杆菌, 生物碱, pseudopteroxazole, ileabethoxazole, 全合成
Two alkaloids of pseudopteroxazole and ileabethoxazole, isolated from sea whip Pseudopterogorgia elisabethae, have significant antimicrobial activity against pathogen of tuberculosis:Mycobacterium tuberculosis. These two alkaloids possess similar tetracyclic skeleton, which containing four stereocenters, a fully substituted aromatic ring and an uncommon benzoxazole unit in natural products. Significant antimicrobial activity and special molecular structures attracted extensive attentions to synthetic study on pseudopteroxazole and ileabethoxazole. The progress in the total synthesis of these two alkaloids is reviewed.
Key words: Mycobacterium tuberculosis, alkaloid, pseudopteroxazole, ileabethoxazole, total synthesis
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